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  • viscosity
  • Losartan, are also known to alter membrane viscosity. (wikipedia.org)
  • Given that the calculated fast reorientational correlation times and the "microscopic" lateral diffusion of the lipids show excellent agreement with the experimental results, it is concluded that the apparently high viscosity of the membrane is more closely related to molecular interactions on the surface rather than in the interior. (sciencemag.org)
  • cellular functions
  • The discussion of this evidence could easily occupy my entire presentation, but I thought that in the context of this symposium it might be more useful to adopt the model as a working hypothesis of membrane structure and consider what it might imply about the mechanisms of a variety of important cellular functions and activities. (springer.com)
  • Rather, specialized microdomains associated with different cellular functions can exhibit fluidity values that significantly deviate from the average. (bio-protocol.org)
  • cell
  • The biological analogue, 'lipid raft', is hypothesized to exist in cell membranes and perform biological functions. (wikipedia.org)
  • H.K. Kimelberg, The influence of membrane fluidity on the activity of membrane-bound enzymes, in: Cell Surface Reviews, G. Poste and G.L. Nicolson, eds. (springer.com)
  • Now new research, published in Mutation Research - Genetic Toxicology and Environmental Mutagenesis , has shown that increased fluidity within the cell membrane can enhance the ability of auranofin to induce increased DNA damage and cellular oxidation in these cells. (eurekalert.org)
  • Cell membranes consist of a phospholipid bilayer, which protects a cell from its surroundings and controls the movement of substances. (eurekalert.org)
  • But in order to try and build resistance to this, cancer cells evolve by changing their genetic properties and cell membrane rigidity could be one of the confounding factors through which they become resistant to treatment. (eurekalert.org)
  • Previous research has shown that chemo-resistant cancer cells demonstrate greater rigidity of the cell membrane, with the current study suggesting that greater uptake of auranofin could be influenced by increased membrane fluidity. (eurekalert.org)
  • The specific level of membrane fluidity is not uniform across the bacterial cell membrane. (bio-protocol.org)
  • Assessing changes in the overall membrane fluidity and formation of membrane microdomains is therefore pivotal to understand both the functional organization of the bacterial cell membrane as well as antibiotic mechanisms. (bio-protocol.org)
  • Here, we used mosaic analysis for paqr-2 and iglr-2 , and tissue-specific paqr- 2 expression, to show that membrane homeostasis is achieved cell non-autonomously. (genetics.org)
  • Specifically, we found that expression of paqr-2 in hypodermis, gonad sheath cells or intestine is sufficient to suppress systemic paqr-2 mutant phenotypes including: tail tip morphology, membrane fluidity in intestinal cells, cold and glucose intolerance, vitellogenin transport to the germ line, germ cell development and brood size. (genetics.org)
  • Finally, we show that the cell non-autonomous regulation of membrane homeostasis is conserved in human cells: HEK293 cells that express AdipoR2, a homolog of paqr-2 , are able to normalize membrane fluidity in distant cells where AdipoR2 has been silenced. (genetics.org)
  • Finally, using C. elegans mutants and siRNA against SCD in HEK 293 cells, we show that Δ9 desaturases are essential for the cell non-autonomous maintenance of membrane fluidity. (genetics.org)
  • However, the mechanism of nisin interaction with cancer cell membranes remains unexplored. (rsc.org)
  • dynamics
  • On the 100-picosecond time scale of the present simulations, there is effectively no difference in the reorientational dynamics of the carbons in the membrane interior and in pure hexadecane. (sciencemag.org)
  • Share
  • We conclude that cells are able to share membrane components even when they are not in direct contact with each other, and that this contributes to the maintenance of membrane homeostasis in C. elegans and human cells. (genetics.org)
  • phase
  • its hydrophobic end is embedded in the hydrophobic membrane interior and its hydrophilic end protrudes into the aqueous phase. (springer.com)