Membrane differentiation of cells. Medical search. Frequent questions

Once triggered, it results in the diffusion of proteins from the space between the inner and outer mitochondrial membranes into the cytosol. (wikipedia.org)
The outer mitochondrial membrane, typically permeable to molecules smaller than 5 kDa, forms pores during MOMP that allow it to accommodate proteins larger than 100 kDa. (wikipedia.org)
G ene "expression" translates molecule strings (replicable nucleic acid codes) into the proteins and enzymes needed to run a cell. (umsl.edu)
Immune cells must continually respond to external stimuli, and adjust their levels of key regulatory proteins, to transition between poised and active states. (upenn.edu)
To accomplish this, immune cells can increase protein production, modify existing proteins, or change their rate of protein degradation. (upenn.edu)
Several neurodegenerative diseases, including Alzheimer and prion diseases, result from the misfolding of proteins that traffic through the endoplasmic reticulum (ER) to the cell membrane. (ualg.pt)
Small extracellular vesicles (sEVs) carrying multiple tumor-associated proteins inherited from parental cells play crucial roles in noninvasive breast cancer (BC) diagnosis. (bvsalud.org)
However, it is challenging to assess the subtle variations of surface proteins on sEV membranes due to the highly heterogeneous BC. (bvsalud.org)

VDR-responsive genes are involved in cell proliferation and differentiation, membrane transport, cell adhesion, matrix mineralization, inflammation, and oxidative stress [ 1 ]. (hindawi.com)
It maintains normal hematopoietic function by interacting with hematopoietic stem cells (HSCs) to control their proliferation and differentiation ( Morrison and Scadden, 2014 ). (techscience.com)
However, details regarding the regulation of MSC/MPC proliferation and differentiation status are still unclear and it is likely that regulation involves both biological and mechanical influences in the different environments. (scirp.org)

To date, RUNX2 has been involved in diverse physiological processes, including osteogenic differentiation of mesenchymal stem/stromal cells, chondrocyte hypertrophy, immunomodulation, vascular invasion and endothelial cell migration via modulating a variety of signaling cascades (e.g. (spandidos-publications.com)
This study was therefore aimed at establishing the dose-response effect of EPO stimulation on rat BMSCs and investigating the effects of mechanical stretch combined with EPO on the proliferation and osteogenic differentiation of BMSCs. (hindawi.com)
The proliferation and osteogenic differentiation of rat BMSCs were examined and compared using EPO with different concentrations. (hindawi.com)
The osteogenic differentiation of BMSCs was detected by alkaline phosphatase (ALP) staining, and the mRNA expression levels of ALP, OCN, COL, and Runx2 were detected by qPCR. (hindawi.com)
Mechanical stretch combined with 20 IU/ml EPO promoted proliferation and osteogenic differentiation of BMSCs. (hindawi.com)
EPO was able to promote the proliferation and osteogenic differentiation of BMSCs, and these effects were enhanced when combined with mechanical stretch. (hindawi.com)
Notably, it promotes the osteogenic differentiation of bone mesenchymal stem cells (BMSCs) [ 15 - 17 ]. (hindawi.com)
This study was therefore aimed at addressing three key issues: First, is there a dose-dependent effect of EPO on the proliferation and osteogenic differentiation of BMSCs? (hindawi.com)
Transfection of MDS-MSCs with the miR-103-3p mimic improved osteogenic differentiation and decreased adipogenic differentiation in vitro, while inhibition of miR-103-3p showed the opposite results in NOR-MSCs. (techscience.com)
The miR-103-3p mimics may boost MDS-MSCs osteogenic differentiation while weakening lipid differentiation, thereby providing possible target for the treatment of MDS pathogenesis. (techscience.com)

In this study, we investigated the modulation of pDC differentiation in Flt-3 ligand (Flt3L)-supplemented BM cultures, using highly purified mesenchymal stem cells (MSCs) that were FACS-isolated from murine BM based on surface marker expression and used after in vitro expansion. (nih.gov)
Hematopoietic Stem Cell and Leukaemic Stem Cell environmental stress responses (In vitro biomimicry of hypoxia, normoxia, hypothermia, hyperthermia, hypoglycemia and hyperglycemia): Effect on cellular growth, cell cycle distribution, apoptosis and cellular metabolism. (imperial.ac.uk)
In vitro TNFa induces proliferation and migration but suppresses differentiation of myoblasts. (cdc.gov)
The aim of this study was three-fold, firstly to identify new regulators of tendon development and to analyze their expression in Meox2 mutants, secondly, to analyze the intrinsic regulation of myogenic differentiation by Meox2 transcription factor, and thirdly to establish an in vitro assay to analyze tendon fibroblast-myoblast interactions. (confex.com)
Plasmids encoding these reporters were transfected into C2C12 myoblasts and fluorescence was analyzed as these cells underwent in vitro differentiation. (confex.com)
MUKHERJEE,A,B. "Cells in vivo and in vitro from osteopetrotic mice homozygous for c-src disruption show suppression of synthesis of osteopontin, a multifunctional extracellular matrix protein. (osu.edu)
The combination of the FLEX-NK TM and iNK platforms demonstrated greater in vitro and in vivo anti-tumor activity in HCC models than iNK cells alone, with a favorable in vitro cytokine release and immune cell subset safety profile. (biospace.com)
From this point, protein aggregation, in vitro and in cells, has become my main interest. (ualg.pt)
The latter encompass human skin regenerated on immune deficient mice as well as organotypic constructs with epithelial and stromal cells embedded within architecturally faithful mesenchyma in vitro. (stanford.edu)

Mitochondrial outer membrane permeabilization (MOMP), also known as the mitochondrial outer membrane permeability, is one of two ways apoptosis (programmed cell death) can be activated. (wikipedia.org)
MOMP has been referred to as the point of no return for apoptosis, almost always resulting in the completion of the process, and thus, cell death. (wikipedia.org)
Here, we identified tranylcypromine, which is used to treat refractory depression, caused human-induced pluripotent stem cell-derived brain organoids neurotoxicity, leading to decreased proliferation activity and apoptosis induction. (frontiersin.org)
The tail-anchoring domain of Bfl1 and HCCS1 targets mitochondrial membrane permeability to induce apoptosis. (osu.edu)
The amino-terminal peptide of Bax perturbs intracellular Ca2+ homeostasis to enhance apoptosis in prostate cancer cells. (osu.edu)
Akt pathways have effects on apoptosis, protein synthesis, metabolism and cell cycle. (springer.com)
Ceramides are typically found within the membranes that surround cells and play a role in regulating cell maturation (differentiation), growth and division of cells (proliferation), and controlled cell death (apoptosis). (medlineplus.gov)

Prior studies of acute phosphate restriction during the endochondral phase of fracture healing showed delayed chondrocyte differentiation was mechanistically linked to decreased bone morphogenetic protein signaling. (researchgate.net)
A) Clathrin-coated vesicles (CCVs), circular vesicles with a fringe of clathrin protein (arrow), in the cell cytoplasm range in size from 60 nm−100 nm. (cdc.gov)
Full length human recombinant protein of human PDCD1 (NP_005009) produced in HEK293T cell. (origene.com)
This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. (origene.com)
This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. (origene.com)
These observations support the hypothesis that axonal influences affect oligodendrocyte survival, differentiation, and expression of proteolipid protein gene products. (rupress.org)
With my recent join to CCMAR I am planning to focus on proteostasis, i.e., the maintenance of protein folding and function in cells, and how stressors, such as ocean warming and acidification, may disturb cell homeostasis and accelerate proteostasis collapse resulting from protein misfolding and aggregation. (ualg.pt)
DeMarini, and Chapter 20, by Rice and cell death determine the size protein in several signal ing path- and Herceg). (who.int)
Protein translocation across membranes. (lu.se)
By combinatorial screening using H4 and molecules with defined targets, we demonstrated that H4 induces differentiation by the activation of protein kinase C (PKC) signaling pathway, and in line with this, activates PKC phosphorylation and translocation of PKC to the cell membrane. (lu.se)

and regulation of stem cell differentiation. (nih.gov)
Correct development of the musculoskeletal system relies on intricate signaling pathways and gene regulation that facilitate cell differentiation. (confex.com)
Overexpression of Bax induces down-regulation of store-operated calcium entry in prostate cancer cells. (osu.edu)
Ceramides influence various cell functions, and it is likely that abnormal regulation of these processes also contributes to the features of this condition. (medlineplus.gov)
However, differentiation and immune regulation of Th22 cells in tuberculous pleural effusion (TPE) remain unknown. (atsjournals.org)
Notch signaling pathway is also involved in the regulation of epithelial cell differentiation in various tissues 5-6 . (bvsalud.org)

The effects of erythropoietin (EPO) on the behaviors of bone marrow mesenchymal stem cells (BMSCs) subjected to mechanical stretch remain unclear. (hindawi.com)

TNFa delivers its signals to target cells by binding to specific cell surface membrane receptors (TNFR1 and TNFR2). (cdc.gov)
iNK cells expressed a favorable combination of multiple activation and few inhibitory receptors that corresponded to more potent cytolytic activity against HCC targets. (biospace.com)
Normal neuromuscular junction showing a presynaptic terminal with a motor nerve ending in an enlargement (bouton terminale): Synaptic cleft and postsynaptic membrane with multiple folds and embedded with several acetylcholine receptors. (medscape.com)

MCP-1) and adhesion molecules (VCAM-1), in proliferating or differentiating C2C12 cells and primary myoblasts. (cdc.gov)
CD117 by immunohistochemical methods sion molecules, involved in cell-cell and in order to clarify the role of the infiltrating cell matrix interactions and thought to take inflammatory cells in the pathomechanisms part in cell motility [ 2,3 ]. (who.int)
Aim: To detect the expression of molecules associated with Notch signaling pathway in stem cells from human exfoliated deciduous teeth (SHED) cultured in specific differentiation medium, namely, keratinocyte growth medium (KGM). (bvsalud.org)
RNA was reverse-transcribed to obtain the cDNA and then proceeded with PCR using specific primers for the Notch signaling pathway molecules (Notch1, Jagged-1, Jagged-2 and, Hes1) as well as stem cell marker (Nanog). (bvsalud.org)
Since the Notch signaling pathway molecules play an important role in differentiation of epithelial cells, it is important to identify the presence of notch signaling molecules in SHED during the process of cell differentiation. (bvsalud.org)
The aim of this study was to detect the expression of molecules associated with Notch signallng pathway in SHED cultured in specific differentiation medium, namely, KGM. (bvsalud.org)
Knowledge on the expression analysis of Notch signaling pathway molecules in SHED cultured in KGM could highlight its involvement in controlling the biological activity of these stem cells, particularly during odontogenesis and other developmental process. (bvsalud.org)
Transport of small molecules across membranes. (lu.se)
BACKGROUND AND OBJECTIVES: Polymorphic molecules expressed on the surface of certain blood cells are traditionally categorized as blood groups and human platelet or neutrophil antigens. (lu.se)
Deficiencies are highly variable with regard to symptoms, phenotype, genotype, severity, etc, because many cells and molecules are required for both natural and adaptive immunity . (lu.se)

they may be located on the cell surface membrane or within the cytoplasm (see table Some Types of Physiologic. (msdmanuals.com)

We are currently pursuing studies of the dominant signaling and gene regulatory networks that control this process, including the Ras/MAPK cascade, which is required for stem cell-mediated self-renewal and the p53 transcription factor family member, p63, which is required for epidermal differentiation. (stanford.edu)
this finding indicates that the gene for NFJ syndrome is not located in the epidermal differentiation complex, the type II keratin cluster, or the desmosomal cadherin cluster, respectively. (medscape.com)

While abnormal keratin filament structure and function can explain hypohidrosis and epithelial differentiation abnormalities, the absence of dermatoglyphics is not well understood. (medscape.com)
How the MP is set upon epithelial differentiation is unknown. (bvsalud.org)

In stratified epithelia proliferative basal cells adherent to the underlying basement membrane undergo cell cycle arrest then outward migration and terminal differentiation. (stanford.edu)

Ovarian cancer immuno-reactive antigen domain containing 1 (OCIAD1), a key player in ovarian cancer cell adhesion. (nih.gov)
Little is known about molecular mecha- desmosomal glycoproteins, resulting in the nisms affecting mast cell and T lympho- loss of keratinocyte cell-cell adhesion [ 1 ]. (who.int)

Membrane localized CAAX-Cherry showed expression in multiple membrane compartments, not only the plasma membrane. (confex.com)
M1-type macrophages predominantly sequester nanoceria near the plasma membrane, whereas nanoceria are more uniformly distributed throughout M2 macrophage cytoplasm. (cdc.gov)

MAPK pathways refer to various cellular functions, including cell proliferation, differentiation and migration. (springer.com)
Borlongan, C.V., Glover, L.E., Tajiri, N., Kaneko, Y. and Freeman, T.B. (2011) The Great Migration of Bone Marrow-Derived Stem Cells towards the Ischemic Brain: Therapeutic Implications for Stroke and Other Neurological Disorders. (scirp.org)
Li, L. and Jiang, J. (2011) Regulatory Factors of Mesenchymal Stem Cell Migration into Injured Tissues and Their Signal Transduction Mechanisms. (scirp.org)

The E3 ubiquitin ligase Itch restricts antigen-driven B cell responses. (upenn.edu)
The impacts of proinflammatory cytokines and antigen presentation by pleural mesothelial cells (PMCs) on Th22-cell differentiation were explored. (atsjournals.org)
Moreover, PMCs were able to stimulate CD4 + T-cell proliferation and Th22-cell differentiation by presenting tuberculosis-specific antigen. (atsjournals.org)
In particular, PMCs were able to function as antigen-presenting cells to stimulate CD4 + T-cell proliferation and Th22-cell differentiation. (atsjournals.org)
Pleural mesothelial cells stimulate CD4 + T-cell proliferation and Th22 cell differentiation in response to tuberculosis antigen. (atsjournals.org)
Naive CD4 + T cells can develop into various helper T (Th) subsets with different cytokine profiles and play a discriminative role in translating antigen-specific immune responses into tissue functions or immunopathology. (atsjournals.org)
SIV antigen has been demonstrated by immunohistochemical methods in lymph node sinus histiocytes, macrophages, and giant cells (14) as well as in macrophage-derived cells in brain tissue from diseased monkeys (8). (cdc.gov)

Differentiation: ribosomes along the endoplasmic reticulum may be confused with viral spikes. (cdc.gov)

Because human mesenchymal stem cells are known to be sensitive to their mechanical environments, we investigated the mechanotransductive potential of Descemet membrane-like microtopography (DLT) to differentiate human mesenchymal stem cells into CEC-like cells. (lww.com)
Master molds with inverted DLT were produced by 2-photon lithography (2-PL). To measure the mechanotransductive potential of DLT, mesenchymal stem cells were cultivated on silicone or collagen imprints with DLT. (lww.com)
The pathogenesis of myelodysplastic syndrome (MDS) may be related to the abnormal expression of microRNAs (miRNAs), which could influence the differentiation capacity of mesenchymal stem cells (MSCs) towards adipogenic and osteogenic lineages. (techscience.com)
The bone marrow microenvironment (BMME) is a complex network system primarily comprising stromal cells such as mesenchymal stem cells (MSCs), osteoprogenitor cells, vascular endothelial cells, monocytes, macrophages, and cytokines. (techscience.com)
Batsali, A.K., Kastrinaki, M.C., Papadaki, H.A. and Pontikoglou, C. (2013) Mesenchymal Stem Cells Derived from Wharton's Jelly of the Umbilical Cord: Biological Properties and Emerging Clinical Applications. (scirp.org)

In the present model, the bioelectric context of cells and tissue is the field responsible for organization, as it regulates cell proliferation and the level of communication driving the system's evolution. (nature.com)
The Notch signaling pathway provides important intercellular signaling mechanisms essential for cell fate specification and it regulates differentiation and proliferation of stem or progenitor cells by para-inducing effects 3-4 . (bvsalud.org)

NF-κB pathways are associated with immunity, inflammation and cell survival. (springer.com)
Ando, W., Heard, B., Nakamura, N., Frank, C.B. and Hart, D.A. (2012) Ovine Synovial Membrane-Derived Mescenchymal Progenitor Cells Retain the Phenotype of the Original Tissue That Was Exposed to in Vivo Inflammation: Evidence for a Suppressed Chondrogenic Differentiation Potential of the Cells. (scirp.org)

To label myoblasts for use in the tendon fibroblast-myoblast co-cultures, we investigated the potential use of a variety of fluorescently labeled cellular reporters, such as: Golgi-GFP, nuclear histoneH2B-Cherry, and membrane localized CAAX-Cherry. (confex.com)
The peptide hormone insulin, produced by pancreatic β-cells, is critical for maintaining normal blood glucose levels and acts to regulate cellular metabolism and growth by facilitating glucose uptake by peripheral tissues. (diabetesjournals.org)
We combine this information with genetic, cellular and biochemical approaches to define how ubiquitin enzymes regulate immune cell biology. (upenn.edu)
Cellular immunity, particularly of CD4 + T cells, IFN-γ and tumor necrosis factor (TNF)-α, has a central role in the control of and protection against Mycobacterium tuberculosis (MTB) infection ( 1 ). (atsjournals.org)
The cell cycle and cellular differentiation in bacteria. (lu.se)

Study of biological processes at the suborganismal level including cell chemistry, metabolism, reproduction, genetics, and complex tissue physiology. (mnsu.edu)
Concentrations of cholesterol and triglycerides are strongly correlated in the adipocyte, but little is known about mechanisms regulating cholesterol metabolism in fat cells. (jci.org)
Additionally, we have determined that these adaptors regulate T cell activation, CD4 differentiation and effector function, and Treg cell metabolism and lineage stability. (upenn.edu)

During MOMP, it takes about five minutes for all mitochondrial membranes within a cell to permeabilize. (wikipedia.org)
For incomplete MOMP, mitochondrial membranes become permeable in most, but not all, the cell's mitochondria. (wikipedia.org)
Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells. (nih.gov)

Erythropoietin is a glycoprotein hormone that stimulates red blood cell (RBC) production in bone marrow via binding to the cell-surface receptor on hematopoietic progenitor cells, and it has been widely used for treating anemia [ 13 ]. (hindawi.com)
TrkA is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. (thermofisher.com)

Is Adipocyte Differentiation the Default Lineage for Mesenchymal Stem/Progenitor Cells after Loss of Mechanical Loading? (scirp.org)
Mesenchymal stem/progenitor cells (MSC/MPC) are found in many tissues and fluids including bone marrow, adipose tissues, muscle, synovial membranes, synovial fluid, and blood. (scirp.org)
Hart, D. (2014) Is Adipocyte Differentiation the Default Lineage for Mesenchymal Stem/Progenitor Cells after Loss of Mechanical Loading? (scirp.org)

The peri-islet membrane, which encapsulates the islets, separates the endocrine cells from the exocrine pancreas and serves as a barrier from immune cell infiltration to the islets. (nature.com)
Our focus is on defining new mechanisms that regulate immune cell activation and protective immune responses. (upenn.edu)
During pathogenic infection, immune cells collaborate to remove invading organisms while minimizing collateral damage. (upenn.edu)
We use systems biology approaches to define changes in ubiquitylation as activation states change, and to identify ubiquitin ligases that regulate immune cell fate. (upenn.edu)
We are now poised to define how cullin ligases form distinct ubiquitin complexes in T cells or other immune cells, and the unique set of substrates targeted by these complexes. (upenn.edu)
Cytovia focuses on harnessing the innate immune system by developing complementary and disruptive NK-cell and NK-engager antibody platforms. (biospace.com)
Moreover, the delivery device has been shown to protect cells from a recipient's immune system. (ca.gov)
Macrophage differentiation into functional phenotypes influences the fate of nanomaterials taken up by these immune cells. (cdc.gov)
2) T cell deficiencies affect the function in killing infected cells or helping other immune cells. (lu.se)

Our recent work has employed systems biology approaches in which we intrgrated transcriptome, proteome and ubiquitome information to identify Cullin E3 ubiquitin ligases that are particularly active as T cells transition from resting to activated states. (upenn.edu)

Synovial sarcomas encompass both biphasic (epithelial and spindle cell components) and monophasic (purely spindle cell) variants. (medscape.com)

The vascular BM surrounds the islet capillary network and directly contacts mouse endocrine cells. (nature.com)
Thus, human endocrine cells are not in direct contact with the vascular BM components but with the invaginated peri-islet membrane. (nature.com)
Hnf6 is initially expressed throughout the pancreatic epithelium but is downregulated in endocrine cells at late gestation and is not expressed in postnatal islets. (diabetesjournals.org)
When the cells in the device (combination product) are implanted under the skin, they become pancreatic endocrine cells, including insulin-producing beta cells that respond to elevated blood glucose by releasing insulin in a physiologic manner. (ca.gov)

Recent breakthroughs in human pluripotent stem cell-derived cerebral organoids provide a valuable platform for investigating the human brain after different drugs treatments and for understanding the complex genetic background to human pathology. (frontiersin.org)
Hence, recapitulating the islet ECM in both isolated islets and stem-cell-derived β-cells is of high therapeutic value. (nature.com)
We are developing a stem cell-derived replacement cell therapy for insulin-requiring diabetes. (ca.gov)

β-Cells depend on the islet basement membrane (BM). (nature.com)

This inhibition was cell contact-dependent and soluble factor-independent, as indicated by trans-well experiments. (nih.gov)
For TNFa induced inhibition of myoblast differentiation myogenin expression was reduced. (cdc.gov)

Descemet's Membrane Biomimetic Microtopography Differentiate. (lww.com)
Such cells from different sources can proliferate and differentiate into different lineages (e.g. osteogenic, chondrogenic and adipogenic) after suitable stimulation. (scirp.org)
To elucidate the mechanism by which Th22 cells differentiate and recruit into the pleural space. (atsjournals.org)
Although IL-22-producing helper T (Th22) cells have been reported to be involved in human tuberculosis, the mechanisms by which Th22 cells differentiate and are recruited into the pleural space are unknown. (atsjournals.org)
SHED was able to differentiate into epithelial like cells when cultured in keratinocyte growth medium (KGM) 2 . (bvsalud.org)

Skin malignancies, including epidermal squamous cell carcinoma (SCC), alone account for nearly as many cancers as all other tissues combined. (stanford.edu)
Notch-1, Jagged-1, Jagged-2, and stem cell marker Nanog are expressed in SHED cultured in KGM which may be involved in the differentiation into epithelial-like cells in human dental pulp tissues. (bvsalud.org)
Stem cells from human exfoliated deciduous teeth (SHED) are multipotent stem cells derived from the pulp tissues of extracted deciduous teeth 1 . (bvsalud.org)

The bone marrow stromal cell (BMSC) population, which makes up a large part of the hematopoietic microenvironment, encompasses a variety of adherent cell types. (techscience.com)

Proliferation of KRT14 -expressing basal cells leads to development of dermatoglyphics during the first trimester of gestation. (medscape.com)

Carcinogenesis is introduced through a localized event (a spot of depolarized cells) or by random depolarization of cells in the tissue, which returns cells to their initial proliferative state. (nature.com)
This simplified model of embryogenesis, tissue organization and carcinogenesis, based on non-excitable cells' bioelectric properties, can be made more realistic with the introduction of other components, like biochemical fields and mechanical interactions, which are fundamental for a more faithful representation of reality. (nature.com)
IMs are found in the space between the tissue stroma cells and contain, among other components, fibrillar collagens and fibronectin. (nature.com)
As to myeloperoxidase, oxidants derived from the activity of this enzyme such as hypochlorous acid may critically interfere with several cell functions thereby engendering tissue and organ damage. (hindawi.com)
Our experimental focus is on the mammalian setting using multiomics, informatics, mouse genetics, human genetics, single cell studies, and new human tissue platforms. (stanford.edu)
SFTs of the pleura are localized mesenchymal neoplasms composed of fibroblastlike cells believed to arise from the subpleural connective tissue. (medscape.com)
Recent advances in live imaging and genetics of mammalian division, movement and cell differentiation leading to development which integrate observations of biochemical tissue formation [14 ]. (lu.se)
of the most critical events which lead to tissue patterning involves mechanisms going beyond single cells. (lu.se)

Whereas α2 laminins promoted islet cell clustering, they did not affect gene expression. (nature.com)
This was likely due to the fact that we used transiently transfected cells, and so we started selection of stably transfected cells to isolate clones, which show permanent, and strong gene expression to carry out future experiments. (confex.com)
This process is mediated by 2 mutually exclusive programs of gene expression: 1) an undifferentiated program supporting proliferation by stem cells within the basal layer and 2) a differentiation program instructing growth arrest and differentiation-associated programmed cell death in suprabasal layers. (stanford.edu)
Epigenetic control of gene expression lasts through multiple cell divisions without alterations in primary DNA sequence and can occur via mechanisms that include histone modification and DNA methylation. (stanford.edu)
The membrane potential (MP) controls cell homeostasis by directing molecule transport and gene expression. (bvsalud.org)

The expression of Prx1 has been used as a marker to define the skeletal stem cells (SSCs) populations found within the bone marrow and periosteum that contribute to bone regeneration. (researchgate.net)
In contrast, culturing on Laminin-421 induced the expression of β-cell genes, including Ins1 , MafA , and Glut2 , and significantly improved glucose-stimulated insulin secretion. (nature.com)
These experiments demonstrated that expression of any of the Meox variants strongly inhibited myogenic differentiation, as measured by the fusion index. (confex.com)
We now define the mechanism whereby maintenance of Hnf6 expression postnatally leads to β-cell dysfunction. (diabetesjournals.org)
Sustained expression of Hnf6 also results in downregulation of the β-cell-specific transcription factor MafA and a decrease in total pancreatic insulin. (diabetesjournals.org)
These results suggest that downregulation of Hnf6 expression in β-cells during development is essential to achieve a mature, glucose-responsive β-cell. (diabetesjournals.org)
Thus, the expression of miR-103-3p decreases in MDS BM plasma and MDS-MSCs, significantly impacting MDS-MSCs differentiation. (techscience.com)

Nanoceria increased spleen lymphoid white pulp cell density in BALB/c but not C57BL/6 mice. (cdc.gov)
Microenvironments in haemopoietic and lymphoid differentiation. (who.int)

Mathematical modeling of stem and leukemic cell bioprocessing. (imperial.ac.uk)

A variety of imaging and analytical methods have been developed to study nanoparticles in cells. (cdc.gov)
MATERIALS AND METHODS: Surface markers were monitored by flow cytometry on developing cells during the erythroid culture of CD34+ cells. (lu.se)

The recurrence and drug resistance of breast cancer are intractable due to the presence of breast cancer stem cells (BCSCs), which are adequate to initiate tumor formation and refractory to conventional remedies. (spandidos-publications.com)
For instance, RUNX2 is involved in the progression of various tumor types, such as osteosarcoma, renal cell carcinoma, gastric cancer and breast cancer ( 15 - 20 ). (spandidos-publications.com)
Cytovia's GPC3-directed NK-engager in combination with iPSC-derived NK cells demonstrated impressive anti-tumor activity in mice that merits clinical development," added Dr. Michael Friedman , a member of Cytovia's Board of Directors. (biospace.com)
IL-1β, IL-6, and/or tumor necrosis factor-α promoted Th22-cell differentiation from CD4 + T cells. (atsjournals.org)

CD14 is expressed on monocytes, interfollicular macrophages and some dendritic cells. (thermofisher.com)
We also found that the same ferritin biomineralization mechanism occurs after the uptake of Ce-ions into polarized macrophages and into unpolarized human monocytes and murine RAW 264.7 cells. (cdc.gov)

Loss of corneal endothelial cells (CECs) bears disastrous consequences for the patient, including corneal clouding and blindness. (lww.com)
1 If the number of corneal endothelial cells (CECs) falls below a certain threshold because of traumatic injury, disease, or normal aging processes, functionality of the CE is decreased, and the cornea swells and becomes milky, leading to eventual vision loss. (lww.com)
While some islet BM components are produced by endothelial cells (ECs), the source of others remains unknown. (nature.com)

This co-relates with fewer Col+ cells in the hematopoietic stem cell niche of asrij mutants. (nih.gov)
Mathematical modeling of Hematopoietic Stem Cell and Leukaemic Stem Cell culture systems. (imperial.ac.uk)

We further found that the pericytic laminin isoforms differentially regulate mouse β-cells. (nature.com)

Microstructure and morphology of the polymer film has direct influence on the proton conducting mechanisms and ultimate performance of the membrane. (aiche.org)

SHED has the ability to be differentiated to specific cell lineages such as odontoblasts and osteoblasts as well as epithelial like cells. (bvsalud.org)

The Onecut homeodomain transcription factor hepatic nuclear factor 6 (Hnf6) is necessary for proper development of islet β-cells. (diabetesjournals.org)
Ident- cult to deduce interaction rules from observations of the ified transcription factors for specific cell fates are, for entire system. (lu.se)

These data support further development of CYT-338 as a therapeutic for targeting CD38 expressing multiple myeloma cells. (biospace.com)

First, we screened 513 natural compounds on primary AML cells and identified a novel diterpene (H4) that preferentially induced differentiation of FLT3 wild-type AMLs, while FLT3-ITD/mutations conferred resistance. (lu.se)

Several signaling pathways control blood cell (hemocyte) development in the Drosophila lymph gland. (nih.gov)

In contrast, both macrophage phenotypes show identical nanoceria biotransformation to cerium phosphate nanoneedles and simultaneous nanoceria with ferritin co-precipitation within the cells. (cdc.gov)

Of note, other studies have also indicated the involvement of RUNX2 in breast cancer stem cells (BCSCs) and breast cancer progression ( 22 , 23 ). (spandidos-publications.com)
The origins and basis for these fat deposits are largely unknown, but there is a possibility that the altered mechanical and biological environments lead to dysregulation of MSC/MPC and progression to preferential differentiation towards the adipocyte lineage. (scirp.org)

The absence of significant MSC-mediated inhibitory effects on myeloid DC differentiation was confirmed by additional experiments in GM-CSF/IL-4-supplemented BM cultures. (nih.gov)

This study demonstrates for the first time that electrospun silk fibroin membrane can serve as a supportive biocompatible platform for human podocyte differentiation and propagation. (duke.edu)
That's why only eukaryotes are able to do cool things like assemble a bobcat or human from a single cell. (umsl.edu)
2 Despite having high metabolic activity, human CECs (hCECs) do not proliferate in vivo because these cells arrest in the G1 phase of the cell cycle. (lww.com)
The molecular study of fat cell development in the human body is essential for our understanding of obesity and related diseases. (mdpi.com)
Recent breakthroughs in human pluripotent stem cells (hPSCs)-derived cerebral organoids offer a promising approach for investigating the mystery of human brain ( 19 ). (frontiersin.org)
Staining of normal human peripheral blood cells with Mouse IgG1 K Isotype Control Super Bright 645 (Product # 64-4714-82) (blue histogram) or Anti-Human CD14 Super Bright 645 (purple histogram). (thermofisher.com)
Applications Tested: This 61D3 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. (thermofisher.com)
Gimble, J.M., Bunnell, B.A. and Guilak, F. (2012) Human Adipose-Derived Cells: An Update on the Transition to Clinical Translation. (scirp.org)
Stem cells from human exfoliated deciduous teeth (SHED) (ALLCells, Alameda, CA, USA) were employed in the current study. (bvsalud.org)
Also, SIV is distinct from simian T-cell lymphotropic virus type I (STLY-I) which shares extensive genomic sequences with human T-lymphotropic virus type I and is associated with T-cell lymphomas in nonhuman primates (12). (cdc.gov)
Strains of SIV have been successfully cultured in human lymphocyte cell lines (e.g. (cdc.gov)

Loss of asrij causes hyperproliferation of lymph gland lobes coupled with increased hemocyte differentiation, thereby depleting the pool of quiescent hemocyte precursors. (nih.gov)

Anatomy69

Organisms12

Diseases2

Chemicals and Drugs72

Analytical, Diagnostic and Therapeutic Techniques and Equipment30

Phenomena and Processes67

Disciplines and Occupations1

Technology, Industry, Agriculture5

Information Science3

Health Care1

Proteins8

Proliferation and differentiation3

Osteogenic differentiation10

Vitro9

Apoptosis7

Protein10

Regulation6

Bone marrow mesenchymal stem1

Receptors3

Molecules10

Surface membrane1

Epidermal differentiation2

Epithelial differentiation2

Terminal Differentiation1

Adhesion2

Plasma membrane2

Migration3

Antigen7

Endoplasmic reticulum1

Mesenchymal Stem5

Regulates2

Inflammation2

Cellular5

Metabolism3

Mitochondrial3

Receptor2

Progenitor cells3

Immune9

Biology1

Synovial1

Endocrine cells4

Stem cell-derived3

Basement membrane1

Inhibition2

Differentiate5

Tissues3

Stromal cell1

Basal cells1

Tissue8

Gene expression5

Expression7

Lymphoid2

Leukemic1

Methods2

Tumor4

Macrophages2

Endothelial3

Hematopoietic2

Pericytic1

Mechanisms1

Osteoblasts1

Transcription2

Therapeutic1

Flt31

Pathways1

Phenotypes1

Progression2

Myeloid1

Human11

Precursors1