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Acid PhosphatasePhosphoprotein PhosphatasesTartratesProtein Tyrosine PhosphatasesProtein Phosphatase 2MembranesCell MembraneProtein Phosphatase 1Membrane LipidsIntracellular MembranesPhosphoric Monoester HydrolasesMembrane PotentialsMembranes, ArtificialGlucose-6-PhosphataseLysosomesIsoenzymesErythrocyte MembraneMembrane FluidityMolecular Sequence DataAmino Acid SequenceHistocytochemistryMicroscopy, ElectronCell Membrane PermeabilityPhosphatidate PhosphataseBasement MembraneHydrogen-Ion ConcentrationProstateOsteoclastsKineticsCell LinePhosphorylationElectrophoresis, Polyacrylamide GelDual-Specificity PhosphatasesProtein Tyrosine Phosphatase, Non-Receptor Type 11Substrate Specificitycdc25 PhosphatasesProtein Tyrosine Phosphatase, Non-Receptor Type 1Cells, CulturedProtein BindingMembrane GlycoproteinsMolecular WeightMutationAlkaline PhosphataseOkadaic AcidProtein Tyrosine Phosphatase, Non-Receptor Type 6PhosphatesBase SequenceMembrane Transport ProteinsSignal TransductionMyosin-Light-Chain PhosphataseCell FractionationProtein TransportGolgi ApparatusCalciumSequence Homology, Amino AcidEscherichia coliProtein Tyrosine Phosphatases, Non-ReceptorProtein Structure, TertiarySubcellular FractionsBone ResorptionCloning, MolecularCarrier ProteinsPhosphorylase PhosphataseRecombinant Fusion ProteinsGlucuronidaseLiverModels, BiologicalEndoplasmic ReticulumLipid BilayersTime FactorsEnzyme ActivationBinding SitesRabbitsBacterial ProteinsRecombinant ProteinsMitochondrial MembranesCattleReceptor-Like Protein Tyrosine Phosphatases, Class 2CytoplasmNucleotidases4-NitrophenylphosphataseEthers, CyclicTemperatureVacuolesVanadatesSynaptic MembranesEnzyme InhibitorsDetergentsOrganoidsOrganophosphorus CompoundsHydrolasesBlotting, WesternDual Specificity Phosphatase 1Models, MolecularRANK LigandGlycoproteinsEsterasesHexosaminidasesNitrophenolsLiposomes
Alkaline phosphatasePlasma membraneProteinsProteinEnzymePhosphatidate phosphatasePhosphateNucleic AciFattyKinaseACCUMULATIONActivityVesiclesApoptosisCytoplasmicEnzymesSerumAscorbic acidCellPhospholipidSubstrateLiverLipid peroxidationMuscularHumanOuterIntakeConsistsCarbohydratePhysiologicalRespiratoryComponentsDeficiencyFunctionResponseSimilarFoundSpecificPresentType
Alkaline phosphatase12
Plasma membrane6
  • Predicted to be located in plasma membrane. (nih.gov)
  • 7. Serum activities of mitochondrial, plasma membrane, microsomal, lysosomal and cytosol marker enzymes tended to increase post-ligation, particularly at 8 days. (portlandpress.com)
  • As ascertained by plasma membrane marker enzyme activity, the main contaminant could be the plasma membrane components. (rupress.org)
  • However, cytochemical tests for 5'AMPase and for acid phosphatase suggest that a large part of the plasma membrane marker enzyme activity present in the purified lysosome preparation could be associated with the lysosomal membrane. (rupress.org)
  • GFP-tagged PTR5 localizes to the plasma membrane. (or.jp)
  • Taken together, these findings provide strong evidence that the generation of PtdIns(4)P is sufficient to trigger forward transport from the Golgi to the plasma membrane and that Sac1p is critically required for the termination of this signal. (embl.de)
Proteins5
Protein13
  • The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. (wikipedia.org)
  • PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). (wikipedia.org)
  • This protein has been shown to possess membrane associated PAP activity. (wikipedia.org)
  • is a protein that consists of 403-amino acids. (proteopedia.org)
  • One difference from PTEN compared to other know Protein Tyrosine Phosphatases (PTPs) is the location of two Lys residues in the center of the Walker Loop. (proteopedia.org)
  • PTEN is a dual phosphatase and tumor suppressor protein that interacts with LKB-1. (proteopedia.org)
  • Salicylic acid targets protein phosph. (ugent.be)
  • SA directly binds to A subunits of protein phosphatase 2A (PP2A), inhibiting activity of this complex. (ugent.be)
  • Salicylic acid targets protein phosphatase 2A to attenuate growth in plants," CURRENT BIOLOGY , vol. 30, pp. 381-395, 2020. (ugent.be)
  • However, protein levels of components of cell membranes, vesicles and synapses, RNA modulation, and cellular structures (including tau and tubulin filaments) are markedly altered from the age of 75. (ibecbarcelona.eu)
  • encodes a putative lipoprotein, designated outer membrane protein P4 (OmpP4). (biomedcentral.com)
  • The circadian protein Nocturnin (NOCT) belongs to the exonuclease, endonuclease and phosphatase superfamily and is most similar to the CCR4-class of deadenylases that degrade the poly-adenosine tails of mRNAs. (rhea-db.org)
  • Protein modules such as FVYE domains and PH domains that bind specifically to PtdIns 3-phosphate (PtdIns-3-P) and polyphosphoinositides, respectively, can direct such membrane targeting. (embl.de)
Enzyme3
  • The LPIN1 gene encodes the muscle-specific phosphatidic acid phosphatase, a key enzyme in triglyceride and membrane phospholipid biosynthesis. (huji.ac.il)
  • Phytase is an enzyme (phosphatase) that increases the Material and methods bioavailability of phosphorous of plant origin in Study group animal feeds. (cdc.gov)
  • Maple syrup urine disease (MSUD) is an aminoacidopathy secondary to an enzyme defect in the catabolic pathway of the branched-chain amino acids leucine, isoleucine, and valine. (medscape.com)
Phosphatidate phosphatase2
Phosphate3
  • The N-terminal is a Phosphatase Domain, it's job is to remove phosphate groups from a phosphorylated amino acid. (proteopedia.org)
  • It also works to remove phosphate groups from specific amino acids, such as dephosphorylating tyrosine, serine, and threonine phosphorylated peptides. (proteopedia.org)
  • apoptosis lipid phosphate phosphatase ( LPP ) lysophosphatidic acid (LPA) signalling sphingosine 1-phosphate (S1P) sphingosine kinase (SK) Mammalian LPPs (lipid phosphate phosphatases) are integral membrane. (silverchair.com)
Nucleic Aci1
Fatty8
  • The aim of this study was to analyze the ability of curcumin to protect against the mitochondrial impairment induced by high free fatty acids (HFFAs) and to determine the underlying mechanism for this cytoprotection. (spandidos-publications.com)
  • This syndrome is characterized by steatosis in hepatocytes and elevated serum levels of free fatty acids (FFAs) ( 1 ). (spandidos-publications.com)
  • Although the mechanisms responsible for fatty liver are not fully elucidated, an increased delivery and transport of FFAs into the liver, and augmented hepatic fatty acid synthesis are likely to play a significant role in the pathogenesis of NAFLD. (spandidos-publications.com)
  • Hepatocellular lipid accumulation is thought to simultaneously stimulate mitochondrial fatty acid oxidation and the production of ROS, thereby promoting lipid peroxidation and damage of mitochondrial DNA (mtDNA) ( 3 ). (spandidos-publications.com)
  • Omega-3 fatty acids (n-3 PUFAs) are essential for the functional maturation of the brain. (nature.com)
  • Among these, arachidonic acid (AA, 20:4n-6) and docosahexaenoic acid (DHA, 22:6n-3) are the principal forms of the long chain (LC) polyunsaturated fatty acids, omega-6 and omega-3 (referred to as n-6 or n-3 PUFAs) of the grey matter. (nature.com)
  • AA and DHA are either biosynthesized from their respective dietary precursors, linoleic acid (LA, 18:2n-6), and α-linolenic acid (ALA, 18:3n-3), or directly sourced from the diet (mainly meat and dairy products for AA, fatty fish for DHA) 2 . (nature.com)
  • Recurrent episodes of life-threatening myoglobinuria in childhood are caused by inborn errors of glycogenolysis, mitochondrial fatty acid beta-oxidation, and oxidative phosphorylation. (huji.ac.il)
Kinase4
  • Similarly, marked modifications occur in the larger phosphoprotein clusters involving cytoskeleton and neuronal structures, membrane stabilization, and kinase regulation in the late elderly.Present findings may increase understanding of human brain proteostasis modifications in the elderly in the subpopulation of individuals not having AD neuropathological change and any other neurodegenerative change in any telencephalon region. (ibecbarcelona.eu)
  • Structure and function of NAD kinase and NADP phosphatase: key enzymes that regulate the intracellular balance of NAD(H) and NADP(H). (rhea-db.org)
  • The key enzymes involved in the regulation are NAD kinase and NADP phosphatase. (rhea-db.org)
  • The BCKD complex, which is associated with the inner mitochondrial membrane, has 3 different catalytic components (ie, E1, E2, E3) and 2 associated regulatory enzymes (ie, BCKD phosphatase, BCKD kinase). (medscape.com)
ACCUMULATION2
  • Analysis of phospholipid content disclosed accumulation of phosphatidic acid and lysophospholipids in muscle tissue of the more severe genotype. (huji.ac.il)
  • Accumulation of these 3 amino acids and their corresponding keto acids leads to encephalopathy and progressive neurodegeneration in untreated infants. (medscape.com)
Activity4
  • Glucose 6-phosphatase activity and ribonucleic acid, which are localized predominantly in the rough endoplasmic reticulum, were increased. (portlandpress.com)
  • The acid phosphatase activity was not subject to photoregulaton but its presence prevented further characterization of the K+-ATPase and its photoregulation. (eurekamag.com)
  • Crystal Structure of the PTEN Tumor Suppressor: Implications for Its Phosphoinositide Phosphatase Activity and Membrane Association. (proteopedia.org)
  • The application of ascorbic acid reduced cell membrane damage and increased catalase activity in water-stressed trees of both cultivars. (frontiersin.org)
Vesicles1
Apoptosis1
  • α-lipoic acid inhibits TNF-α-induced apoptosis in human bone marrow stromal cells. (zju.edu.cn)
Cytoplasmic1
  • The cytoplasmic portion contains two phospho-tyrosine-phosphatase domains. (beckman.com)
Enzymes1
  • Lipoproteins have been demonstrated to have roles in preserving membrane structure, functioning as enzymes, and serving as transporters or toxins. (biomedcentral.com)
Serum2
  • The tissue-nonspecific alkaline phosphatases form most of the fraction circulating in serum and, therefore, are of clinical interest. (statpearls.com)
  • Organ coefficients, serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), hexadecenoic acid (HA), laminin (LN), procollagen type III (PCIII), hydroxyproline (Hyp), glutathione (GSH‑Px), malondialdehyde (MDA), superoxide dismutase (SOD) and transforming growth factor β1 (TGF‑β1) levels were measured in rats with hepatic fibrosis. (spandidos-publications.com)
Ascorbic acid6
  • The goal of this research was to study if ascorbic acid applications could improve physiological mechanisms associated with water stress tolerance in young fruit trees. (frontiersin.org)
  • Upon rewatering, CO 2 assimilation and stomatal conductance of water-stressed 'Scarletprince' trees sprayed with ascorbic acid (one or two applications) were similar to those of well-irrigated trees, but water-stressed trees that had not received ascorbic acid did not recover photosynthetical functions. (frontiersin.org)
  • On the other hand, water-stressed 'CaroTiger' trees needed two applications of ascorbic acid to reach values of CO 2 assimilation similar to control trees but these applications did not improve their water status. (frontiersin.org)
  • In general terms, different response mechanisms to cope with water stress in presence of ascorbic acid were found in each cultivar, with 'Scarletprince' trees preferentially using proline as compatible solute and 'CaroTiger' trees relying on stomatal regulation. (frontiersin.org)
  • These results suggest that foliar applications of ascorbic acid could be used as a management practice for improving water stress tolerance of young trees under suboptimal water regimes. (frontiersin.org)
  • 1985. The effects of dietary L-ascorbic acid on the absorption and utilization of Na75Se03 of silver-treated rats. (cdc.gov)
Cell5
  • In addition, curcumin contributed to cell survival, as indicated by the restoration of the mitochondrial membrane potential (MMP) and the inhibition of the mitochondrial biogenesis induced by HFFA. (spandidos-publications.com)
  • In this study, we investigated the response of TRPV1 expressed on human HepG2 cell membranes following stimulation with Hydroxy-α-sanshool. (bvsalud.org)
  • These two LC PUFAs are found predominantly in the form of phospholipids and constitute the building blocks of brain cell membranes 1 . (nature.com)
  • The human alkaline phosphatases (hALP) are found anchored on the cell membrane by glycosylphosphatidylinositol. (statpearls.com)
  • This ruffled cell border is an extensively folded cell membrane that increases the cell surface for secretion and resorption. (biologyonline.com)
Phospholipid1
  • Phospholipid Phosphatase 4 promotes proliferation and tumorigenesis, and activates Ca(2+)-permeable Cationic Channel in lung carcinoma cells. (nih.gov)
Substrate1
  • Phytochrome may indirectly affect K+-ATPase by affecting membrane permeability and substrate availability. (eurekamag.com)
Liver1
  • 5. Liver catalase and d-amino acid oxidase activities showed a slight increase at 1 day post-ligation but a significant fall by 8 days. (portlandpress.com)
Lipid peroxidation1
  • Ferulic acid alleviates lipid peroxidation in diabetic rats. (zju.edu.cn)
Muscular1
  • HN - 2008 BX - Lateral Sinus MH - Atrial Septum UI - D054087 MN - A07.541.459.249 MS - The thin membrane-like muscular structure separating the right and the left upper chambers (HEART ATRIA) of a heart. (bvsalud.org)
Human1
  • Human type 2 phosphatidic acid phosphohydrolases. (wikipedia.org)
Outer1
  • One such lipoprotein, OmpP4, is homologous to the outer membrane lipoprotein e (P4) of H. influenzae . (biomedcentral.com)
Intake1
  • [ 3 ] Snyderman et al initiated the first successful dietary treatment of MSUD by restricting intake of branched-chain amino acids. (medscape.com)
Consists1
  • The non-restricted CD45, Leucocyte Common Antigen (LCA) consists of an extracellular sequence, proximal to the membrane, which is common to all CD45 isoforms. (beckman.com)
Carbohydrate1
  • These isoforms have extracytoplasmic sequences ranging from 391 to 552 amino acids long with numerous N-linked carbohydrate attachment sites. (beckman.com)
Physiological1
  • Even though alkaline phosphatases are present in many tissues throughout the body, their precise physiological function remains largely unknown. (statpearls.com)
Respiratory1
  • Together with pH determination, bicarbonate measurements are used in the diagnosis and treatment of numerous potentially serious disorders associated with acid-base imbalance in the respiratory and metabolic systems. (cdc.gov)
Components1
Deficiency2
  • Acid maltase deficiency (Pompe disease) is seen in approximately 1 in 40,000 people. (medscape.com)
  • MSUD is caused by a deficiency of the BCKD complex, which catalyses the decarboxylation of the alpha-keto acids of leucine, isoleucine, and valine to their respective branched-chain acyl-CoAs. (medscape.com)
Function1
  • In addition, the double mutant (Y42A/L48Q) of the PX domain of Vam7p, reported to cause vacuolar trafficking defects in yeast, has a dramatically decreased level of binding to PtdIns-3-P. These data reveal that the membrane targeting function of the Vam7p PX domain is based on its ability to associate with PtdIns-3-P, analogous to the function of FYVE domains. (embl.de)
Response1
  • Salicylic acid (SA) is a major defense signal in plants, and the perception mechanism as well as downstream signaling activating the immune response are known. (ugent.be)
Similar1
  • Similar defects in membrane trafficking are caused by the overexpression of PIK1. (embl.de)
Found1
  • Alkaline phosphatases found in the intestine, placenta, and germinal tissue are tissue-specific. (statpearls.com)
Specific1
  • Alkaline phosphatases are classified as tissue-specific and tissue-nonspecific types. (statpearls.com)
Present1
  • Although alkaline phosphatases are present in different body tissues and have different physiochemical properties, they are true isoenzymes because they catalyze the same reaction. (statpearls.com)
Type1
  • These observations are in contrast to the findings in the rheumatoid synovial membrane of a prevalence of interdigitating type, HLA-DR+ cells and the predominance of helper (OKT4+) type T cells. (nih.gov)