Members of the cyclin family cyclin g. Medical search. Frequent questions

Cyclins are eukaryotic proteins that form holoenzymes with cyclin-dependent protein kinases (Cdk), which they activate. (wikipedia.org)
Cyclin A and E dependent kinase complexes also function to inhibit the E3 ubiquitin ligase APC/C activating subunit Cdh1 through phosphorylation, which stabilizes substrates such as cyclin A. The coordinated activation of this sequence of interrelated positive feedback loops through cyclins and cyclin dependent kinases drives commitment to cell division to and past the G1/S checkpoint. (wikipedia.org)
Cyclins function as regulators of CDK kinases. (novusbio.com)
High impact information on E2f Negative regulation of d E 2 F 1 by cyclin- dependent kinases controls cell cycle timing. (wikigenes.org)
Malumbres, M. Cyclin-dependent kinases. (nature.com)
These kinases are expressed throughout the cell cycle, but are only activated upon complex formation with their corresponding cyclins. (shu.edu)
Our results suggest that the combined use of Roscovitine and Kenpaullone may be useful for identifying substrates and physiological roles of cyclin-dependent protein kinases, whereas the combined use of Kenpaullone and LiCl may be useful for identifying substrates and physiological roles of glycogen synthase kinase 3. (nih.gov)
Cyclin-dependent kinases (CDKs), are members of the serine-threonine protein kinase family and are responsible for taking control of cell cycle regulation in eukaryotic cells. (spandidos-publications.com)
CRKs (cdc2-related kinases), Cyclins and CKSs (cdc2-kinase subunit) are involved in the progression through the cell cycle. (lancs.ac.uk)
The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. (cancerindex.org)
Cyclins regulate the cell cycle in association with cyclin dependent kinases (CDKs). (biomedcentral.com)
The progression of cells through the cell cycle is regulated by a family of protein kinases known as the cyclin-dependent kinases (CDKs). (biomedcentral.com)
Protein kinase C (PKC) d, a member of the novel family of PKC serine-threonine kinases, has been implicated in negative regulation of proliferation and apoptosis in a large number of cell types, including breast cancer cell lines, and postulated as a tumor suppressor gene. (conicet.gov.ar)
The laboratory of Dr. Hasan studies the interplay between anti-apoptotic proteins and cyclin dependent kinases and how this interplay can serve as a potential therapeutic target in Acute Myeloid Leukemia (AML). (actrec.gov.in)

Rb reduces its binding to E2F and thereby allows E2F-mediated activation of the transcription of cyclin E and cyclin A, which bind to Cdk1 and Cdk2 respectively to create complexes that continue with Rb phosphorylation. (wikipedia.org)
and (v) pRb phosphorylation and cyclin D1 expression are reduced in K10-transfected cells and increased in K16-transfected cells. (exposed-skin-care.net)
During early G1 phase, mitogenic signals trigger activation of the CDK4/6-cyclin D complex, which partially deactivates Rb by phosphorylation. (shu.edu)
Activation of CDK4 requires binding of a D-type Cyclin and phosphorylation of Thr172 by the CAK kinase complex. (rndsystems.com)
This phosphorylation event drives the cell cycle and promotes cyclin D1 stability and centrosome amplification. (bioskinrevive.com)
The sequential activation of the members of this family and their phosphorylation of certain substrates promotes the progression through the cell cycle. (biomedcentral.com)
The cyclin D1-Cdk4 complex phosphorylates the pRB protein leading to sequential phosphorylation by cyclin E-Cdk2 and release of free E2F. (shu.edu)
In the canonical Wnt/β-catenin signaling, a Wnt ligand binds to a cell surface receptor complex consisting of the members of Frizzled family and the transmembrane protein LRP 5 and 6 to prevent phosphorylation and degradation of β-catenin by the GSK3β/APC/Axin destruction complex. (oncotarget.com)
The various markers that enable assessment of the progression of preneoplastic lesions to spindle cell carcinoma include the p16 protein, which halts the cell cycle and induces apoptosis by pRb-mediated phosphorylation of cyclin-dependent kinase 4 (CDK4). (bvsalud.org)

In mice and humans, two more cyclin D proteins have been identified. (wikipedia.org)
The members from the large keratin family of cytoskeletal proteins are expressed in a carefully regulated tissue- and differentiation-specific manner. (exposed-skin-care.net)
Keratins are a large family of proteins which form the intermediate filament (IF) cytoskeleton of epithelial cells and their appendages hairs and nails (reviewed in references 8 and 15). (exposed-skin-care.net)
And the LEF / TCF family transcription factor, along with other proteins, binds to DNA and inhibits gene expression. (researchsquare.com)
The cyclin D1 proteins primarily remains unpredictable until phospho-Pin1 in the nucleus isomerizes cyclin D1 to a well balanced conformation. (bioskinrevive.com)
The Rho category of GTPases contains 20 members, that are 'Ras-like' proteins. (exposed-skin-care.net)
Cyclin-dependent kinase inhibitors (CDKIs) are proteins that bind to and inhibit the activity of CDKs. (biomedcentral.com)
The SMAD proteins are a family of transcription factors consisting of 8 members, SMAD1-8, which are further subdivided into 3 classes based on structural and functional properties. (shu.edu)
this family of proteins is hereafter called EBF) are a group of DNA-binding transcription factors with the basic helix-loop-helix (bHLH) domain. (aacrjournals.org)
We have previously shown that p63, a member of the p53 family of nuclear proteins, is expressed in proliferative cytotrophoblast (CTB), precursors to terminally differentiated syncytiotrophoblast (STB) in chorionic villi and extravillous trophoblast (EVT) at the implantation site. (ca.gov)
Members of the NLR protein family include the NOD SIGNALING ADAPTOR PROTEINS. (bvsalud.org)

In proliferating cells, cyclin D-Cdk4/6 complex accumulation is of great importance for cell cycle progression. (wikipedia.org)
Namely, cyclin D-Cdk4/6 complex partially phosphorylates retinoblastoma tumor suppressor protein (Rb), whose inhibition can induce expression of some genes (for example: cyclin E) important for S phase progression. (wikipedia.org)
Other than Rb, viral cyclin D-Cdk6 complex also targets p27Kip, a Cdk inhibitor of cyclin E and A. In addition, viral cyclin D-Cdk6 is resistant to Cdk inhibitors, such as p21CIP1/WAF1 and p16INK4a which in human cells inhibits Cdk4 by preventing it from forming an active complex with cyclin D. Cyclin D possesses a tertiary structure similar to other cyclins called the cyclin fold. (wikipedia.org)
Cyclin D levels in proliferating cells are sustained as long as the growth factors are present, a key player for G1/S transition is active cyclin D-Cdk4/6 complexes. (wikipedia.org)
One of the best known substrates of cyclin D/Cdk4 and -6 is the retinoblastoma tumor suppressor protein (Rb). (wikipedia.org)
One model proposes that cyclin D quantities, and thus cyclin D- Cdk4 and -6 activity, gradually increases during G1 rather than oscillating in a set pattern as do S and M cyclins. (wikipedia.org)
This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. (genetex.com)
Cyclin D1 and CDK4/6 are downstream of signaling pathways which lead to cellular proliferation. (shu.edu)
Cyclin-dependent Kinase 4 (CDK4) is a 303 amino acid (aa) member of the Ser/Thr kinase family with a predicted molecular weight of 33.7 kDa. (rndsystems.com)
The CDK4/Cyclin D complex is also negatively regulated by p21/CIP1/CDKN1A and p27/Kip1. (rndsystems.com)
The p16 family (p15, p16, p18 and p19) binds to and inhibits the activities of CDK4 and CDK6. (biomedcentral.com)
P15 INK4 is a cyclin dependent kinase inhibitor that blocks the activity of Cyclind-CDK4,6, inhibiting it from hypophosphorylating Rb, thereby, rendering the cell cycle unresponsive to external proliferation signals. (shu.edu)
Full holoenzyme activity of the cyclin D1-Cdk4 complex is induced by mitogen recruitment of CAK. (shu.edu)
BACKGROUND: : Inherited mutations in the CDKN2A tumor suppressor gene, which encodes the p16(INK4a) protein, and in the cyclin-dependent kinase 4 (CDK4) gene confer susceptibility to cutaneous malignant melanoma. (lu.se)
We analyzed families with two or more cases of melanoma for germline mutations in CDKN2A and CDK4 to elucidate the contribution of these gene defects to familial malignant melanoma and to the occurrence of other cancer types. (lu.se)
METHODS: : The entire CDKN2A coding region and exon 2 of the CDK4 gene of an affected member of each of 52 families from southern Sweden with at least two cases of melanoma in first- or second-degree relatives were screened for mutations by use of polymerase chain reaction-single-strand conformation polymorphism analysis. (lu.se)

These results suggest that cyclin E, cdk2, cdk5 and E 2 F - 1 play. (wikigenes.org)
Activation of the CDK2-cyclin E complex results in hyperphosphorylation of Rb and fully releases E2F. (shu.edu)
Cyclin A binds to S phase CDK2 and is required for the cell to progress through the S phase. (signalchem.com)
CDK2/Cyclin A is inhibited by the complex p21CIP. (signalchem.com)
Cyclin E forms complexes during this interval with CDK2. (biomedcentral.com)
p27 is a cyclin dependent kinase inhibitor that blocks the activity of Cyclin E-CDK2, which phosphorylates pRb, thereby ushering the cell from G1 into S phase through the Restriction point (Figure 2). (shu.edu)
It also blocks Cyclin A-CDK2 from further phosphorylating pRb to maintain S phase. (shu.edu)

Upstream inhibitors, including members of the Ink4 and Cip/Kip families, inhibit the mitogenic action of CDKs. (shu.edu)
CDKs show their action by interacting with cyclins and different CDK-cyclin complexes regulate the cell cycle in the G1, S and G2/M phases ( 1 ). (spandidos-publications.com)
CDKs are under inhibitory control of cyclin dependent kinase inhibitors (CDKIs). (biomedcentral.com)
Cyclins function as the positive regulators of CDKs. (biomedcentral.com)
D-type and E-type cyclins assemble with CDKs during the G1 phase and these holoenzymes act as rate-limiting controllers to regulate passage through the restriction point and the subsequent onset of DNA replication [ 2 , 3 ]. (biomedcentral.com)
Cyclins and CDKs assemble into complexes with one another as cells progress through G1 phase, cyclins being required to activate the serine-threonine kinase activity of their catalytic partners. (biomedcentral.com)
Furthermore, CDK-activating kinase (CAK) phosphorylates cyclin-bound CDKs on a single threonine residue, a modification that is essential for their activity [ 6 - 9 ]. (biomedcentral.com)

MEN 4 is caused by an inactivating mutation of the CDKN1B gene, which codes for the cyclin dependent kinase inhibitor 1B protein, also known as p27 or p27KIP1. (msdmanuals.com)

Dysregulation of CDK8 (Cyclin-Dependent Kinase 8) and its regulatory partner CycC (Cyclin C) , two subunits of the conserved Mediator (MED) complex, have been linked to diverse human diseases such as cancer. (sdbonline.org)
Apoptosis-related protein-1 acts as a tumor suppressor in cholangiocarcinoma cells by inducing cell cycle arrest via downregulation of cyclin-dependent kinase subunits. (nih.gov)
The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. (cancerindex.org)

The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. (antibodies-online.com)
mixed-lineage kinase 3 (MLK3) a MAP3K family member phosphorylates Pin1 on a Ser138 site to increase its catalytic activity and nuclear translocation. (bioskinrevive.com)

The expression of cyclin-dependent kinase inhibitors was profoundly affected with early activation and then repression of p21 cip1/waf1 and persistent activation of both p27 kip1 and p57 kip2 , whereas genes involved in cell survival and proliferation were suppressed. (aacrjournals.org)
Several hallmarks of cellular senescence, such as cell cycle arrest, expression of cyclin-dependent kinase inhibitors, DNA damages, and senescence-associated secretory profile were evaluated. (aging-us.com)
SnCs exhibit irreversible growth arrest accompanied by increased expression of cyclin-dependent kinase inhibitors (CDKi) such as p16 INK4a , and p21 Cip1 , accumulation of DNA damages, and secretion of diverse bioactive molecules known as the senescence-associated secretory phenotype (SASP). (aging-us.com)
This is going to give you a question to ponder in your high-risk, ER-positive patients who are appropriate to consider for adjuvant cyclin-dependent kinase inhibitors. (medscape.com)

In general, all stages of the cell cycle are chronologically separated in humans and are triggered by cyclin-Cdk complexes which are periodically expressed and partially redundant in function. (wikipedia.org)
This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. (novusbio.com)
Lundberg, A. S. & Weinberg, R. A. Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. (nature.com)
New anticancer therapy strategies refer to the inhibition of CDK-cyclin complexes as an important target to prevent uncontrolled proliferation and induce apoptosis in cancer cells ( 2 ). (spandidos-publications.com)
The p21 family (p21, p27, p28 and p57) can bind to broad range of CDK-cyclin complexes and inhibit their activities. (biomedcentral.com)

Immunocytochemistry/ Immunofluorescence: Cyclin H Antibody (1B8) [H00000902-M01] - Analysis of monoclonal antibody to CCNH on HeLa cell. (novusbio.com)
Immunohistochemistry-Paraffin: Cyclin H Antibody (1B8) [H00000902-M01] - Analysis of monoclonal antibody to CCNH on formalin-fixed paraffin-embedded human testis. (novusbio.com)
Western Blot: Cyclin H Antibody (1B8) [H00000902-M01] - CCNH monoclonal antibody (M01), clone 1B8 Analysis of CCNH expression in HeLa. (novusbio.com)
Sandwich ELISA: Cyclin H Antibody (1B8) [H00000902-M01] - Detection limit for recombinant GST tagged CCNH is approximately 1ng/ml as a capture antibody. (novusbio.com)
WB analysis of HeLa cell lysate using GTX33611 Cyclin D1 antibody [RM241]. (genetex.com)
IHC-P analysis of human tonsil tissue using GTX33611 Cyclin D1 antibody [RM241]. (genetex.com)
There are currently no references for Cyclin D1 antibody [RM241] (GTX33611) . (genetex.com)
Anti-Cyclin A Antibody was produced by repeated immunizations with a recombinant protein corresponding to the human cyclin A. (signalchem.com)
Immunohistochemistry using Rabbit Anti-Cyclin A antibody. (signalchem.com)
Fixation: formalin fixed paraffin embedded.Antigen retrieval: not required.Primary antibody: Anti-Cyclin A at 1:500 for 1 hr at RT. (signalchem.com)
Western Blot of Rabbit Anti-Cyclin A antibody. (signalchem.com)
Primary antibody: Anti-Cyclin A at 1:400 for overnight at 4°C. Predicted/Observed size: 60kDa for Cyclin A. (signalchem.com)
The Anti-Cyclin-A antibody is ideal for investigators involved in cell signaling, cell biology and signal transduction research. (signalchem.com)

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. (novusbio.com)
This gene encodes a member of the cyclin-dependent protein kinase family. (antibodies-online.com)
the endogenous cyclin E gene is activated following expression of the E 2 F 1 product encoded by a recombinant. (wikigenes.org)
Cloning and subcellular localization of apr-1--a new gene of tumor specific antigen family]. (nih.gov)
Earlier studies using a candidate gene approach, family linkage studies and gene expression profiling uncovered a number of T2DM genes, but the genetic basis of common T2DM remained unknown. (scialert.net)
To overcome the shortcomings of the candidate gene studies, investigators have applied a genome-wide linkage scan strategy in which regularly spaced markers are traced in families and sibling pairs for segregation with T2DM. (scialert.net)
This MHC phenotype is dominantly enhanced by removal of rok or of other members of the PCP effector gene family. (uni-wuerzburg.de)
Positional cloning efforts revealed that this locus contains the SWI/SNF related, matrix-associated, actin-dependent regulator of chromatin, subfamily B, member 1 ( SMARCB1 ) gene, also known as human sucrose non-fermenting gene number 5 ( hSNF5 ), integrase interactor 1 ( INI1 ) , or 47-Kd Brg1/Bam -associated factor ( BAF47 ). (medscape.com)

Viral cyclin D binds human Cdk6 and inhibits Rb by phosphorylating it, resulting in free transcription factors which result in protein transcription that promotes passage through G1 phase of the cell cycle. (wikipedia.org)
Build up of cytoplasmic -catenin leads to its translocation towards the nucleus, where it binds to transcription elements such as for example lymphoid enhancing element (LEF)/T cell element (TCF) to create a transcriptionally energetic complicated that focuses on genes such as for example those encoding MYC, cyclin D1, MMP3 and Compact disc44 [17]. (exposed-skin-care.net)

One of the members of the pathways, MAPK activates a transcription factor Myc, which alters transcription of genes important in cell cycle, among which is cyclin D. In this way, cyclin D is synthesized as long as the growth factor is present. (wikipedia.org)
Subsequently released E2F factors mediate expression of pro-proliferative genes including cyclin E and Cdc25A. (shu.edu)
The expression of further E2F target genes, as cyclin A, facilitates progression through S phase. (shu.edu)
Myb-Related Protein B (MYBL2), a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. (avivasysbio.com)
It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. (avivasysbio.com)
ETS family members transcription factors control the appearance of oncogenes, tumor suppressor genes, and various other genes linked to vessel development, invasion, and metastasis, and expression of the elements correlates with poor survival [7C10] often. (columbiagypsy.net)

Cyclin D is a member of the cyclin protein family that is involved in regulating cell cycle progression. (wikipedia.org)

p38γ shares high sequence homology, inhibition sensitivity and substrate specificity with CDK family members. (nature.com)

Concurrent deletion of cyclin E1 and cyclin-dependent kinase 2 in hepatocytes inhibits DNA replication and liver regeneration in mice. (nature.com)
We show that, in primary CTB, p63 levels are reduced as cells differentiate into STB, and that forced expression of p63 maintains cyclin B1 and inhibits STB differentiation. (ca.gov)

Localization: Cyclin A is nuclear and cytoplasmic.Staining: Cyclin A as precipitated red signal with hematoxylin purple nuclear counterstain. (signalchem.com)

Downregulation of MAGE family member H1 enhances hepatocellular carcinoma progression and serves as a biomarker for patient prognosis. (nih.gov)
Transportation of LAPTM5 from Golgi to lysosome could be inhibited by deficiency of Nedd4, a key member of E3 ubiquitin ligase family overexpressing in invasive BCa and promoting its progression. (spandidos-publications.com)
In contrast, cyclin A binding to E2F-1 impedes PRMT1 methylation and augments PRMT5 methylation, thus ensuring that E2F-1 is locked into its cell-cycle progression mode. (embl.de)
The laboratory of Dr. Teni also focuses on understanding the regulation of tumor progression by p53 family members and their downstream targets in oral and cervical cancer progression. (actrec.gov.in)

The CDK9/cyclin-K complex also has kinase activity towards CTD of RNAPII and can substitute for CDK9/cyclin-T P-TEFb in vitro. (thermofisher.com)

The combined use of SU 6656 and either PP1 or PP2 may be useful for identifying substrates of Src family members. (nih.gov)

Cdk5 is named after its structural similarity to members of the serine/threonine cyclin-dependent kinase family. (frontiersin.org)

Despite extensive genetic analysis, the function of TEAD factors in muscle differentiation has proved elusive due to redundancy amongst the family members. (nih.gov)
In contrast, TEAD4 represses expression of the growth factor CTGF and Cyclin D1 to promote differentiation. (nih.gov)

[ 2 ] SMARCB1 encodes a member of the human SWI/SNF complex. (medscape.com)

Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. (novusbio.com)

However, it is composed of different amino acid residues as the same patch in cyclins E, A, and B. Growth factors stimulate the Ras/Raf/ERK that induce cyclin D production. (wikipedia.org)
These turned on transcription elements could act in the cyclin D1 promoter to induce its transcription. (bioskinrevive.com)

RESULTS: : CDKN2A mutations were found in 10 (19%) of the 52 families. (lu.se)
0001). Families with breast cancer also had a propensity for multiple melanomas in females, suggesting that a sex-dependent factor may modify the phenotypic expression of CDKN2A alterations. (lu.se)
CONCLUSIONS: : Our findings confirm that the majority of CDKN2A-associated melanoma families in Sweden are due to a single founder mutation. (lu.se)
They also show that families with the CDKN2A 113insArg mutation have an increased risk not only of multiple melanomas and pancreatic carcinoma but also of breast cancer. (lu.se)

Cyclin D has no effect on G1/S transition unless it forms a complex with Cdk 4 or 6. (wikipedia.org)
This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. (novusbio.com)
The cell cycle is a tightly regulated process that is controlled by the conserved cyclin-dependent kinase (CDK)-cyclin protein complex 1 . (nature.com)
CDK9 is a member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex. (thermofisher.com)
PCNA is a co-factor of cyclin-D and it makes a complex with cyclin-D, a cyclin dependent kinase (CDK), and a cyclin dependent kinase inhibitor (CDKI). (biomedcentral.com)

Mutant K-RAS has been shown to have both tumor-promoting and -suppressing functions, and growing evidence suggests that the RASSF family of tumor suppressors can act as RAS apoptosis and senescence effectors. (cancerindex.org)

Purvalanol, a novel cyclin-dependent kinase inhibitor, is referred to as a strong apoptotic inducer which causes cell cycle arrest in various cancer cells such as prostate, breast and colon cancer cell lines. (spandidos-publications.com)
Tan IIA inhibited proliferation of mouse keratinocytes in a dose- and time-dependent manner and induced apoptosis, resulting in S phase arrest accompanied by down-regulation of pCdk2 and cyclin A protein expression. (hindawi.com)

The abundance of cyclins is generally regulated by protein synthesis and degradation through APC/C- and CRL-dependent pathways. (wikipedia.org)

Activation of PKCd with a phorbol ester leads to elevated cyclin D1 expression and an hyperphosphorylated Rb state. (conicet.gov.ar)

The cyclin-dependent kinase inhibitor, p21 cip1/waf1 (p21), maintains hematopoietic stem cell quiescence, and we evaluated its role in the regenerative response of neural tissue after ischemic injury using the mice deficient in p21. (rupress.org)

Nine families carried an identical alteration consisting of the insertion of arginine at position 113 of p16(INK4a), and one carried a missense mutation, in which the valine at position 115 was replaced with a glycine. (lu.se)

The synthesis of cyclin D is initiated during G1 and drives the G1/S phase transition. (wikipedia.org)
The synthesis of another G1 phase cyclin, cyclin E, increases in late G1 and decreases once DNA replication is initiated. (biomedcentral.com)

The structural diversity found in this family of compounds led to the division into different categories, from simple coumarins to many other kinds of policyclic coumarins such as furocoumarins and pyranocoumarins. (benthamscience.com)

The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. (antibodies-online.com)

The first five-helix bundle is a conserved cyclin box, a region of about 100 amino acid residues on all cyclins, which is needed for Cdk binding and activation. (wikipedia.org)
Fli-1, a known person in the ETS transcription aspect family members, is also the mark of insertional activation by Friend murine leukemia trojan (F-MuLV) and it is preferentially portrayed in vascular endothelial cells and hematopoietic tissue [6]. (columbiagypsy.net)

Anatomy11

Organisms3

Diseases4

Chemicals and Drugs80

Analytical, Diagnostic and Therapeutic Techniques and Equipment11

Phenomena and Processes39

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science3

Kinases14

Phosphorylation9

Proteins11

Cdk416

Cdk27

Cdks7

Dependent kinase inhibitor 1B1

Subunits3

Phosphorylates2

Inhibitors4

Complexes5

Antibody13

Gene8

Binds2

Genes6

Involved in regulating cell cycle1

Inhibition1

Inhibits2

Localization1

Progression4

Kinase activity1

Substrates1

Cdk51

Differentiation2

Encodes1

Distinct1

Induce2

CDKN2A4

Complex5

Tumor1

Arrest2

Abundance1

Expression1

CIP11

INK4a1

Synthesis2

Compounds1

Transcription factors1

Activation2