• A reporter gene assay with various transcription factor response elements revealed that only nuclear factor-κB (NF-κB) signaling was activated by CXCL14 in NCI-H460 cells, which was blocked by BAPTA-AM, TPCA-1, and brefeldin A. Exogenous expression of some glycoproteins such as syndecan-4, podoplanin, and CD43 in these cells enhanced CXCL14 binding and NF-κB activity. (korea.ac.kr)
  • Collectively, these results demonstrate that CXCL14 binding to glycoproteins harboring heparan sulfate proteoglycans and sialic acids leads proliferation and migration of some cancer cells. (korea.ac.kr)
  • SHINE is characterized by breakdown of the glycocalyx-a network of membrane-bound proteoglycans and glycoproteins that covers the endothelium. (bmj.com)
  • Syndecan is the family name of membrane-intercalated HSPGs. (leonieclaire.com)
  • Heparan sulfate proteoglycans (HSPGs) play critical roles in the development and adult physiology of all metazoan organisms. (hud.ac.uk)
  • APOE associated to the LVP allows the initial virus attachment to cell surface receptors such as the heparan sulfate proteoglycans (HSPGs), syndecan-1 (SDC1), syndecan-1 (SDC2), the low-density lipoprotein receptor (LDLR) and scavenger receptor class B type I (SCARB1) (PubMed:12970454, PubMed:12356718, PubMed:12913001, PubMed:28404852, PubMed:22767607). (proteopedia.org)
  • During normal B-cell development, cells acquire expression of CD138, also known as syndecan-1 (SDC1), a marker highly specific for terminally differentiated normal plasma cells (1). (leonieclaire.com)
  • Syndecan-4 is also called ryudocan or amphiglycan. (wikipedia.org)
  • This PG family consists of four members: syndecan-1,44 syndecan-2/fibroglycan, 45 syndecan-3/N-syndecan, 46 and syndecan-4/amphiglycan/ryudocan, 47,48 all of which are expressed in the CNS. (leonieclaire.com)
  • Syndecans interact with fibronectin on the cell surface, cytoskeletal and signaling proteins inside the cell to modulate the function of integrin in cell-matrix adhesion. (wikipedia.org)
  • More specifically, these core proteins carry three to five heparan sulfate and chondroitin sulfate chains, i.e. they are proteoglycans, which allow for interaction with a large variety of ligands including fibroblast growth factors, vascular endothelial growth factor, transforming growth factor -beta, fibronectin and antithrombin -1. (leonieclaire.com)
  • This secreted protease breaks down proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal hemopexin domain. (cancerindex.org)
  • The MI15 monoclonal antibody specifically binds to CD138 (Syndecan-1), an 85-92 kDa single chain transmembrane protein, which is strongly expressed on multiple-myeloma-derived cell lines and malignant plasma cell populations. (bdbiosciences.com)
  • CD138 is a heparin sulphate proteoglycan that controls tumor cell survival, growth, adhesion and bone cell differentiation in MM (2). (leonieclaire.com)
  • Also known as syndecan-1, CD138 "is "a heparan sulfate proteoglycan expressed on the surface of, and actively shed by, myeloma cells. (healthblogs.org)
  • Syndecan-4 is a protein that in humans is encoded by the SDC4 gene. (wikipedia.org)
  • Matrix molecules, growth factors, and enzymes) Chondroitin sulfate chain Transmembrane domain - self-association C1 domain - actin-association cytoskeleton Variable domain - syndecan-specific C2 domain - attach to PDZ proteins Syndecans normally form homodimers or multimers. (wikipedia.org)
  • Transient transfection of the human breast cancer cell line MDA-MB-231 with the siRNAs for carbohydrate (chondroitin 4) sulfotransferase-11 ( CHST11 ) and chondroitin sulfate proteoglycan 4 ( CSPG4 ) was used to investigate the involvement of these genes in expression of surface P-selectin ligands. (biomedcentral.com)
  • Syndecans have similar structural features: Attach to heparan sulfate chains - interacting factors (e.g. (wikipedia.org)
  • Syndecan-4 also binds to phosphatidylinositol (4,5)-bisphosphate (PIP2) through the variable domain and increases PKC activity ten-fold. (wikipedia.org)
  • Syndecan-4 binds to FGF and mediates interaction with the FGF receptor. (wikipedia.org)
  • The protein is found as a homodimer and is a member of the syndecan proteoglycan family. (wikipedia.org)
  • Syndecan-4 activates protein kinase C (PKC), an enzyme involved in signal transduction. (wikipedia.org)
  • We identified CS modifications of chromogranin-A (CgA), islet amyloid polypeptide, secretogranin-1 and secretogranin-2, immunoglobulin superfamily member 10, and protein AMBP. (scilifelab.se)
  • Additional HS sites were found on syndecan-1, syndecan-4, nerurexin-2, protein NDNF and testican-1. (scilifelab.se)
  • CASK is an evolutionarily conserved gene which encodes for a member of the membrane-associated guanylate kinase (MAGUK) protein family [ 31 ]. (biomedcentral.com)
  • HA is synthesized in the absence of a protein core at the inner face of the plasma membrane and consequently found in the form of free chains whereas other GAG types are covalently bound into protein cores to form proteoglycans (PGs). (hindawi.com)
  • Proteoglycans (PGs) are complex macromolecules composed of a core protein and covalently linked polysaccharide chain(s) which play a critical role in cell-cell and cell-matrix interactions. (oncotarget.com)
  • For example ESCd >70 and PHTd cells expressed similar members of the hydroxysteroid dehydrogenase family (HSD) gene family (SI Appendix, Fig. S5A). (ack1inhibitor.com)
  • This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). (cancerindex.org)
  • This study was performed to identify the carrier proteoglycan (PG) and the sulfotransferase gene involved in synthesis of the surface P-selectin-reactive CS-GAGs in human breast cancer cells with high metastatic capacity, as well as to determine a direct role for CS-GAGs in metastatic spread. (biomedcentral.com)
  • The higher expression of gremlin 1 and HIF1a genes after exposure to dragonfly larvae indicated an in vivo hypoxic reaction, while down-regulation of syndecan-2 may indicate impairment of angiogenesis. (biomedcentral.com)
  • A tumor necrosis factor superfamily member that plays a role in the regulation of B-LYMPHOCYTE survival. (rush.edu)
  • The degree of oligomerization correlates with the activity of kinases, so the degree of clustering of syndecan-4 correlates to PKC activity. (wikipedia.org)
  • Syndecans are thought to function predominantly as coreceptors for other receptors such as integrins, members of the fibroblast growth factor family, vascular endothelial cell growth factor, and transforming growth factor β, which need heparin sulfate for signaling. (leonieclaire.com)
  • Syndecan-1-positive plasma cells and proteoglycan-rich non-haematopoietic cells displayed specific, heparin-sensitive binding to APRIL. (cancer-ecosystem.com)
  • Thus, syndecans participate in cell matrix adhesion. (archive.org)
  • In addition, it has been widely speculated that syndecans participate in cell-cell adhesion. (archive.org)
  • However, there has been no direct evidence demonstrating that syndecans can mediate cell-cell adhesion. (archive.org)
  • The authors of this paper have shown the first evidence that syndecan-1 or other members of the syndecan family can mediate cell-cell adhesion. (archive.org)
  • The syndecans comprise a family of heparan sulfate bearing transmembrane proteoglycans that arise from four distinct genes within mammals. (archive.org)
  • 5′-aza-dC and/or Trichostatin A resulted in transcriptional upregulation of the genes, suggesting that low expression of ECM components, proteoglycan core proteins and HS biosynthetic system is due to epigenetic suppression in type I cells. (oncotarget.com)
  • Thus, GAGs/PGs may modulate downstream signaling of key cellular mediators including insulin growth factor receptor (IGFR), epidermal growth factor receptor (EGFR), estrogen receptors (ERs), or Wnt members. (hindawi.com)
  • However, whether a specific HSPG (such as syndecan) contains HS modifications that differ from another HSPG (such as glypican) has remained largely unresolved. (hud.ac.uk)
  • As a co-receptor or regulator, mutated certain proteoglycans could cause severe developmental defects, like disordered distribution or inactivation of signaling molecules. (wikipedia.org)
  • All members of the syndecan family have 5 exons. (leonieclaire.com)
  • What are the members of the syndecan family? (leonieclaire.com)
  • Belongs to the syndecan proteoglycan family. (affbiotech.cn)
  • In contrast, the transmembrane and cytoplasmic domains are highly conversed both as members of the syndecan family and among different species. (archive.org)
  • CXCL14 is a chemokine family member that is involved in various cellular responses in addition to immune cell activation. (korea.ac.kr)
  • Essentially, all members of the MMP family have been linked to disease development, notably to cancer metastasis, chronic inflammation and the ensuing tissue damage as well as to neurological disorders. (evelinvahter.com)
  • In this review, we will give an overview of 23 members of the human MMP family and describe functions, linkages to disease and structural and mechanistic features. (evelinvahter.com)
  • Metzincins are a ubiquitously expressed family of multi-domain zinc (II)-dependent endopeptidases (Stocker and Bode 1995 ), the members of which include well-known metalloproteases such as the matrix metalloproteases (MMPs) (Nagase and Woessner 1999 ), a disintegrin and metalloproteases (ADAMs) (White 2003 ), the ADAMs with a thrombospondin motif (ADAMTS) (Tang 2001 ), the bacterial serralysins (Nakahama et al. (evelinvahter.com)
  • The focus of our research is on understanding the molecular mechanisms governing the activity of estrogen receptor (ER), a member of the nuclear receptor transcription factor family that is critical in normal reproduction and is implicated in the pathogenesis of breast cancer. (wisc.edu)
  • Also, syndecans bind to FGFs and bring them to the FGF receptor on the same cell. (wikipedia.org)
  • Syndecan-4 is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. (wikipedia.org)
  • El ligando es específico para el RECEPTOR 4-1BB y puede desempeñar un papel en la indución de la proliferación de los LINFOCITOS T activados de la sangre periférica. (bvsalud.org)
  • Monoclonal antibody MI15 blocks the binding of clone B-B4 but not clone DL-101 (other anti-syndecan-1 antibodies) by flow cytometric analysis. (bdbiosciences.com)
  • Syndecan 4 Antibody detects endogenous levels of total Syndecan 4. (affbiotech.cn)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Syndecan 3 (SDC3) in Tissue homogenates and other biological fluids. (hudsen.org)
  • Syndecan-4 is also a regulator of fibroblast growth factor-2 (FGF-2) signaling. (wikipedia.org)
  • Description: Quantitativesandwich ELISA kit for measuring Human Syndecan-3(SDC3) in samples from serum, plasma, tissue homogenates. (hudsen.org)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Syndecan 3 (SDC3) in samples from tissue homogenates or other biological fluids. (hudsen.org)
  • Syndecan-4 expression is upregulated in the endometrium of women suffering from endometriosis, and its downregulation in endometriotic cells results in a decrease of invasive growth, and reduced expression of the small GTPase Rac1, Activating transcription factor 2 (ATF2), and MMP3. (wikipedia.org)
  • BCMA, a member of the tumor necrosis factor (TNF) superfamily, is exclusively expressed in a subpopulation of B cells, normal plasma cells, and malignant plasma cells. (biomedcentral.com)
  • During the course of their studies, members of the Audhya laboratory demonstrated that two oncogenic fusion proteins, TFG-NTRK1 and TFG-ALK, created by distinct chromosomal translocation events, localize to subdomains of the endoplasmic reticulum (sites of COPII vesicle formation) and dramatically upregulate ERK activity. (wisc.edu)
  • Proteoglycan profiling of human, rat and mouse insulin-secreting cells. (scilifelab.se)
  • He is a board member of the French Society for Angiogenesis (SFA). (sfbmec.fr)
  • The authors found that following their transfection with cDNA for syndecan-1 or syndecan-4, human B lymphoid cell line (ARH-77) forms large multicellular aggregates in suspension culture and stain intensely for the syndecans at sites of cellcell contact. (archive.org)
  • Description: A sandwich ELISA for quantitative measurement of Human Syndecan 3(SDC3) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (hudsen.org)
  • The difference in size of the syndecans is credited to the variable length of exon 3, which encodes a spacer domain [1, 14]. (leonieclaire.com)
  • Growth factor signaling may be disrupted by changes in syndecan-4 expression. (wikipedia.org)
  • The carrier proteoglycan CSPG4 was highly expressed on the aggressive breast cancer cell lines and contributed to the P-selectin binding and CS-A expression. (biomedcentral.com)
  • Syndecan-2 plays a role in the cancer development. (joplink.net)
  • In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. (lu.se)
  • Cell surface proteoglycan that bears heparan sulfate. (joplink.net)
  • 3) Lack of integrin α 11 and syndecan-4 protects against adverse remodelling following aortic banding. (norheart.no)
  • Syndecan-4 has more widespread distribution than other syndecans and it is the only syndecan that has been found consistently in focal adhesions. (wikipedia.org)
  • Where is syndecan found? (leonieclaire.com)
  • This is due to a number of reports indicating that syndecans are often found at sites of cell-cell contact. (archive.org)
  • Because the tight correlation between syndecan-4 and growth factors, the efficiency of angiogenic therapies have been thought to relate to syndecan-4. (wikipedia.org)
  • The cellular uptake, trafficking, and nuclear localization of FGF-2 could be increased by co-delivery of syndecan-4 proteoliposomes. (wikipedia.org)