Member of the mucin protein. Medical search. Frequent questions

In the present study we demonstrate that one such group of genes, termed TcSMUG L , codes for previously unrecognized mucin-type glycoconjugates anchored to and secreted from the surface of insect-dwelling epimastigotes. (silverchair.com)

Mucin 2, oligomeric mucus gel-forming, also known as MUC2, is a protein that in humans is encoded by the MUC2 gene. (wikipedia.org)
Finally, we demonstrate that the ex vivo tracheae can be used to generate high mucus protein yields for subsequent studies, which are currently limited by in vivo mucus collection techniques. (bvsalud.org)
The interactions between commensal microbiota and host mucins drive intestinal colonization, while at the same time, the microbiota can utilize the glycans on mucins and affect the colonic mucus properties. (bvsalud.org)
Pharmacological reduction of the ER stress or activation of the unfolded protein response (UPR) in mice, regardless of autophagy activation, lead to excess mucus secretion. (bvsalud.org)
The tools developed in this study will help us test strategies to improve mucus clearance in several important diseases where clearance fails," said lead author Brian Button, PhD, associate professor of biochemistry and biophysics and member of the UNC Cystic Fibrosis Research and Treatment Center at UNC-Chapel Hill. (unc.edu)
Less than 1 percent of ordinary mucus consists of long, sticky, chain-like proteins called mucins, which give mucus its gel-like properties. (unc.edu)
CF, chronic bronchitis, and other "muco-obstructive" diseases feature mucus dramatically more viscous and elastic than normal, almost gelatin-like because it is loaded with mucins. (unc.edu)
In CF mucus, for example, the amount of mucins jumps to 10 percent and the amount of water decreases to 79 percent. (unc.edu)
While CF mucus is still mostly water, even small changes in mucin content can have dramatic effects on mucus viscoelasticity. (unc.edu)
We found that the adhesive and cohesive strengths of mucus increase dramatically when the ratio of mucins to water is higher than normal," Button said. (unc.edu)
This gene provides instructions for making a protein called mucin 1, which is one of several mucin proteins that make up mucus. (medlineplus.gov)
In addition to its role in mucus, mucin 1 relays signals from outside the cell to the cell's nucleus. (medlineplus.gov)

The genome of the nairoviruses consists of 3 segments of negative-sense, single-stranded RNA, small (S), medium (M), and large (L), which encode the nucleocapsid protein, glycoproteins (Gn and Gc), and viral polymerase, respectively. (cdc.gov)
Mammalian mucins, glycoproteins that are major constituents of the glycocalyx that covers mucosal epithelium. (embl.de)
Professor Chakraborty and her team aim to enhance existing glycan modeling tools and develop new in silico techniques to understand the intricate structural dynamics of glycoproteins, particularly mucins. (northeastern.edu)
The parasite surface is heavily coated by glycoproteins such as glycosylphosphatidylinositol (GPI)-anchored mucins (tGPI-mucins), which display highly immunogenic terminal nonreducing α-galactopyranosyl (α-Gal)-containing glycotopes that are entirely absent or cryptic in humans. (utep.edu)
There, she used mass spectrometry and glycobiology to investigate mucinase activity on glycoproteins, with the ultimate goal of characterizing cancer-derived mucins. (malakerlab.com)

This gene encodes a member of the mucin protein family. (wikipedia.org)
This gene encodes GalNAc transferase 7, a member of the GalNAc-transferase family. (nih.gov)
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. (cubebiosystems.com)
This gene encodes a Golgi protein which is a member of the polypeptide N-acetylgalactosaminyltransferase (ppGalNAc-Ts) protein family. (nih.gov)

185 genes in signature reported in the publication with PubMedID mRNA_KAT5_22196727 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. (maayanlab.cloud)

Along this line, gene that encodes Mx protein, a member of the large GTPases family, known to be exclusively induced by IFNs [48], was also down-regulated (Table 2). (mingsheng88.org)
encodes a protein that belongs to the mucin family of. (mingsheng88.org)

Mucins, which are densely glycosylated proteins, are central players in numerous biological processes, disease conditions, and potential therapies. (northeastern.edu)
Her laboratory is focused on establishing methods and technology to study mucins, a class of densely O-glycosylated extracellular proteins, by MS. Additionally, the laboratory studies mucins in a biological context, since these proteins are integral in numerous diseases including cancer, cystic fibrosis, and inflammatory bowel diseases. (malakerlab.com)

CXCL16 is a member of the CXC chemokine family and signals through the CXCR6 receptor. (peprotech.com)
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. (nih.gov)
The protein encoded by this gene acts as a membrane receptor for both the human hepatitis A virus (HHAV) and TIMD4. (transcriptionfactor.org)
The protein encoded by this gene is an antagonist of angiopoietin 1, and both angiopoietin 1 and angiopoietin 2 are ligands for the endothelial TEK receptor tyrosine kinase. (transcriptionfactor.org)
STAT proteins induce transcription of IFN-stimulated genes upon binding of type I interferon to its heterodimeric receptor [43]. (mingsheng88.org)
T cell immunoglobulin and mucin domain-containing protein 3 (TIM3), a member of the TIM family, was originally identified as a receptor expressed on interferon-γ-producing CD4+ and CD8+ T cells. (hostforstudent.com)

MUC16, a transmembrane mucin, facilitates pancreatic adenocarcinoma progression and metastasis. (oncotarget.com)
Oestrogen-induced pS2 protein is similar to pancreatic spasmolytic polypeptide and the kringle domain. (xenbase.org)

The protein encoded by this gene, also called mucin 2, is secreted onto mucosal surfaces. (wikipedia.org)
The enzyme encoded by this gene controls the initiation step of mucin-type O-linked protein glycosylation and transfer of N-acetylgalactosamine to serine and threonine amino acid residues. (nih.gov)
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. (transcriptionfactor.org)
The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. (transcriptionfactor.org)
The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. (transcriptionfactor.org)
The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. (transcriptionfactor.org)

Displays activity toward mucin-derived peptide substrates such as Muc2, Muc5AC, Muc7, and Muc13 (-58). (nih.gov)
xP2, a new member of the P-domain peptide family of potential growth factors, is synthesized in Xenopus laevis skin. (xenbase.org)
Inspired by mucosal gels, Professor Chakraborty and her team will use their computational tools to design novel mucin-like nanomaterials constructed from glycan-peptide heteropolymer networks. (northeastern.edu)
MASPpep-KLH is composed of a 20-mer peptide (DAENPGGEVFNDNKKGLSRV) found in some members of the mucin-associated surface protein (MASP) of T. cruzi trypomastigotes, coupled to keyhole limpet hemocyanin as carrier protein. (utep.edu)
During this time, she worked at the Protein Structure Facility, performing peptide synthesis and using mass spectrometry for quality control. (malakerlab.com)

This disease, previously referred to as MCKD type 1, is due to a mutation in the variable-number tandem repeat region of the MUC1 (Mucin 1) gene. (medscape.com)

Mucin and cadherin-like protein (MUCDHL), also known as μ-protocadherin, is a 100 kDa type I transmembrane protein belonging to the protocadherin family of cell adhesion molecules. (rndsystems.com)
This enzyme is a type II transmembrane protein and shares common sequence motifs with other family members. (nih.gov)

Structurally, KIM-1 is a member of the immunoglobulin gene superfamily most reminiscent of mucosal addressin cell adhesion molecule 1 (MAdCAM-1). (scienceopen.com)
CTLA-4 is a member of the immunoglobulin superfamily that is expressed by activated T cells and transmits an inhibitory signal to T cells. (hostforstudent.com)

Understanding mucins' role in diseases such as cystic fibrosis, mucosal inflammation, lung and GI infection, and mucin-mediated cancers has been a challenging task. (northeastern.edu)

A member of this protein family, RipD (Rv1566c) from M. tuberculosis described in the present study, displays sequence alterations in the NlpC/p60 catalytic triad and carries a pentapeptide repeat at its C-terminus. (scilifelab.se)
In contrast with previously known members of the NlpC/p60 family, RipD does not show peptidoglycan hydrolase activity, which is consistent with the sequence alterations at the catalytic site. (scilifelab.se)

This protein may function as a follow-up enzyme in the initiation step of O-glycosylation. (nih.gov)
Using their cutting-edge computational tools, the researchers will build interconnected mucin glycoprotein gel systems that mimic the natural glycosylation patterns. (northeastern.edu)

The extracellular domain of mature mouse MUCDHL contains four cadherin domains plus three repeat regions that constitute a mucin stalk (aa 541‑614). (rndsystems.com)
The extracellular portion of CXCL16 contains a chemokines domain and an extended C-terminal mucin-like stalk sequence. (peprotech.com)

Kidney Injury Molecule-1 (KIM-1, HAVCR1) is a class I integral membrane glycoprotein that belongs to the TIM family of proteins. (transcriptionfactor.org)

In addition to mechanisms of microbe-host interaction, the role of cell stress related to unfolded protein responses (UPR) of the endoplasmic reticulum (ER) and mitochondria is characterized in the context of inflammatory and tumorigenic processes using novel tissue-specific mouse models. (intestinal-microbiota.de)

The prebiotic inulin induced other family 1 binding proteins with affinity for intestinal glycans. (escholarship.org)
Some microbiota members are known to encode multiple proteins that are predicted to bind and/or cleave mucin glycans. (bvsalud.org)

Unlike other family members, this enzyme shows exclusive specificity for partially GalNAc-glycosylated acceptor substrates and shows no activity with non-glycosylated peptides. (nih.gov)
The encoded protein has been shown to transfer GalNAc to large proteins like mucins. (nih.gov)

R torques are mucin degraders that induce an increase in other mucin-using bacteria, which can contribute to gut-barrier compromise. (medscape.com)

The PlanHab wash-out period corresponded to a profound life-style change (i.e., reintroduction of exercise) that resulted in stepwise amelioration of the negative physiological symptoms, indicating that exercise apparently prevented the crosstalk between the microbial physiology, mucin degradation and proinflammatory immune activities in the host. (frontiersin.org)
Using Caco-2 cells as a model system, we found that induction of an inflammatory state by long-term stimulation with the proinflammatory cytokine TNFα resulted in an increase of MUC17 protein levels and enhanced insertion of MUC17 and its two phospho-variants into apical membranes. (scilifelab.se)

A pig sperm protein that binds to the extracellular matrix of the egg in a species-specific manner was recently identified and named zonadhesin (Hardy, D. M., and Garbers, D. L. (1995) J. Biol. (embl.de)
The encoded protein is secreted and binds hydroxyapatite with high affinity. (transcriptionfactor.org)

We show that the mouse putative pS2 protein sequence and the physiological pattern of expression of the mouse pS2 gene are well conserved. (xenbase.org)
In recent years, nucleotide and amino acid sequence information has become available so that additional characterization of these viruses is possible, including further analysis of relationships among members of the genus. (cdc.gov)
Full-length sequence data are now available for CCHFV, Hazara virus (HAZV) and Dugbe virus (DUGV), and partial sequences are available for many other members of the genus. (cdc.gov)
Its genome sequence revealed an overabundance of the Family 1 of solute binding proteins (F1SBPs), part of ABC transporters and associated with the import of oligosaccharides. (escholarship.org)

Members from the TSG-6 (anti-inflammatory) antigen 5/Sharp and CCL28-like (antimicrobial) proteins households had been also sequenced. (academicediting.org)
preferentially, post-translational amino-acid JmjC increases are activated provided and conserved to regulate pentose cell polysaccharides with antimicrobial program protein and Clot positions. (erik-mill.de)

The present study has identified many potential immune-related genes in A. mylitta some of which are vertebrate homologues and others are hitherto unreported putative defence proteins. (biomedcentral.com)

Growth on HMO induced the expression of specific binding proteins that import HMO isomers, but also bind blood group and mucin oligosaccharides, suggesting coregulated transport mechanisms. (escholarship.org)
CTLA-4 is homologous to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. (hostforstudent.com)

infantis (B. infantis) is a common member of the infant intestinal microbiota, and it has been characterized by its foraging capacity for human milk oligosaccharides (HMO). (escholarship.org)

Mucin 2 is particularly prominent in the gut where it is secreted from goblet cells in the epithelial lining into the lumen of the large intestine. (wikipedia.org)
Transmembrane mucin MUC17 is an integral part of the glycocalyx as it covers the brush border membrane of small intestinal enterocytes and presents an extended O-glycosylated mucin domain to the intestinal lumen. (scilifelab.se)

The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. (cubebiosystems.com)
The human transmembrane mucin MUC17 responds to TNFα by increased presentation at the plasma membrane. (scilifelab.se)

The surface of the protozoan Trypanosoma cruzi is covered by a dense coat of mucin-type glycoconjugates, which make a pivotal contribution to parasite protection and host immune evasion. (silverchair.com)
Notably, Irg1 protein is usually localized in mitochondria, a cellular compartment recently recognized as a platform orchestrating anti-inflammatory and immune cell defense mechanisms [51]. (mingsheng88.org)
A protein found on T cells (a type of immune cell) that helps keep the body's immune responses in check. (hostforstudent.com)
We also identified several unknown proteins, some of which could have probable immune-related functions based on the results of the ProDom analysis. (biomedcentral.com)

Inactivity and hypoxia resulted in a significant increase in the genus Bacteroides in HBR, in genes coding for proteins involved in iron acquisition and metabolism, cell wall, capsule, virulence, defense and mucin degradation, such as beta-galactosidase (EC3.2.1.23), α-L-fucosidase (EC3.2.1.51), Sialidase (EC3.2.1.18), and α-N-acetylglucosaminidase (EC3.2.1.50). (frontiersin.org)
The fact that the genus Bacteroides and proteins involved in iron acquisition and metabolism, cell wall, capsule, virulence and mucin degradation were enriched at the end of HBR suggest that both constipation and EC decreased intestinal metal availability leading to modified expression of co-regulated genes in Bacteroides genomes. (frontiersin.org)
Species diversity in the structure of zonadhesin, a sperm-specific membrane protein containing multiple cell adhesion molecule-like domains. (embl.de)
Among the differentially expressed mRNAs, members of conjunctival mucins (MUC13, MUC15, MUC21, and MUC20), carcinoembryonic antigen-related cell adhesion molecules (CEACAM1, CEACAM6, CEACAM7), and cytokeratins (KRT6 and KRT10) were significantly altered in pterygium. (arvojournals.org)
Mucins in cancer: protection and control of the cell surface. (scienceopen.com)
The protein has 7 transmembrane regions and is located on the cell surface. (transcriptionfactor.org)
The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. (transcriptionfactor.org)
Bioinformatics analysis revealed RipD-like proteins in eleven mycobacterial genomes, whereas similar pentapeptide repeats occur in cell-wall-localized bacterial proteins and in a mycobacteriophage. (scilifelab.se)
Surface receptors such as cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), programmed cell death protein 1 (PD-1) and nuclear transcription factors attenuate T cell responses, where CTLA-4 competes with CD28 for binding to CD80/86, resulting in inhibitory downstream signalling [ 6 ] . (encyclopedia.pub)
Mucins are highly glycosylated proteins that serve a variety of roles in organisms from lubrication to cell-signaling to defense 7 . (nature.com)
The proteins of such MAPKs increased and were then repress UniProt differential download Sarkozy, Israël et whereby steps include to the spliced group before any further cell. (erik-mill.de)
Mucin 1 lies on the tubular cell apical surface and has a role in signal transduction pathways. (medscape.com)

The mucin 2 protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. (wikipedia.org)
The subgroup A proteins TSP-1 and -2 contain an N-terminal domain, a VWFC domain, three TSP1 repeats, three EGF-like domains, TSP3 repeats and a C-terminal domain. (embl.de)
Here, we focus on the salivary mucin-7 gene ( MUC7 ) to study the evolution and functional impact of subexonic repeats. (nature.com)
These repeats can be particularly well studied in this gene because the repeats are relatively short and few in number compared to other mucins. (nature.com)

Most of these GC-balanced genes encode Cryptosporidium-specific proteins that have intrinsically disordered regions and are involved in host-parasite interactions. (cdc.gov)

We have now cloned a mouse homolog of the human pS2 cDNA to dispose of an animal model to study the pS2 protein function, which remains unknown at the present time. (xenbase.org)

Expression of mouse zonadhesin mRNA is evident only within the testis, and the protein is found exclusively on the apical region of the sperm head. (embl.de)
We have previously demonstrated that MUC17 is anchored to the apical membrane domain via an interaction with the scaffolding protein PDZK1. (scilifelab.se)

This gene is a member of the caudal-related homeobox transcription factor gene family. (transcriptionfactor.org)

Besides displaying substantial homology to TcSMUG S products, which provide the scaffold for the major Gp35/50 mucins also present in insect-dwelling stages of the T. cruzi lifecycle, TcSMUG L products display unique structural and functional features, including being completely refractory to sialylation by parasite trans -sialidases. (silverchair.com)

A number of pS2 similar peptides, designated as P-domain peptides, have been described, notably the porcine ( PSP ), murine ( mSP ), and human (hSP) spasmolytic polypeptides, which correspond to duplicated pS2 proteins. (xenbase.org)
Taxonomic distribution of proteins containing TSP1 domain. (embl.de)
The complete taxonomic breakdown of all proteins with TSP1 domain is also avaliable . (embl.de)
Click on the protein counts, or double click on taxonomic names to display all proteins containing TSP1 domain in the selected taxonomic class. (embl.de)
Taxonomic distribution of proteins containing VWD domain. (embl.de)

Overlay analysis of combined miRNA and mRNA expressions suggested that miR-200A might regulate the expression of PHD finger protein 6 (PHF6) and prostaglandin E synthase 3 (PTGES3). (arvojournals.org)
KIM-1 mRNA and protein are expressed at a low level in normal kidney but are increased dramatically in postischemic kidney. (scienceopen.com)

Dr. Brumer's research interests include the discovery, functional and structural characterization, and biotechnological applications of carbohydrate-active enzymes and carbohydrate-binding proteins. (glyco26.org)

Through this cellular signaling, mucin 1 is thought to be involved in the growth, movement, and survival of cells. (medlineplus.gov)

Chemistry and Chemical Engineering Assistant Professor Srirupa Chakraborty has secured a substantial $1.99 million grant from the National Institutes of Health (NIH) for a breakthrough project aimed at transforming our understanding of mucin related diseases and paving the way for innovative biomaterials . (northeastern.edu)

Kiwifruit contains enzymes that facilitate the digestion of proteins, starches, and sugars, as well as calcium oxalate crystals that are thought to enhance mucin production. (acponline.org)

MUC7 provides an opportunity to assess the broader implications of subexonic repeat variation within the context of the functional evolution of the mucin functional group and primate salivary adaptation. (nature.com)

This heavily glycosylated mucin type protein is named for its expression on kidney glomerular epithelial cells known as podocytes. (bdbiosciences.com)

In IBD, the Crohn's and Colitis Canada Genetic, Environmental, Microbial Project research consortium has been studying individuals at increased risk for Crohn's disease because of a first-degree family member with Crohn's disease. (medscape.com)

Be on the lookout for: Tumor Protein 53. (cubebiosystems.com)

It was found in the thrombospondin protein where it is repeated 3 times. (embl.de)
Finally, some of these proteins were found to be adherent to intestinal epithelial cells in vitro. (escholarship.org)
They also found that the MUC20 protein could be potentially impacted by an already FDA-approved drug offered by Amgen called cabozantinib. (healthtree.org)
The former encompasses the trisaccharide Galα1,3Galβ1,4GlcNAcα (Galα3LNα), an immunodominant glycotope found on the trypomastigote mucins, coupled to a maleimide-modified human serum albumin as carrier protein. (utep.edu)

The recombinant protein is N-terminally truncated, thermostable, has optimal activity at pH ~6 and 66°C, and is more efficient in ochratoxin A hydrolysis than carboxypeptidase A and Y, the two previously known enzymes capable of degrading this mycotoxin. (scilifelab.se)

The frameshift mutation results in the formation of a truncated protein which cannot fold properly, promoting aggregation, and subsequent deposition in tubular cells. (medscape.com)

This table could be seen as a data source accessible online being a hyperlinked worksheet and shows biochemical taxonomic and gene ontology factors for each category of proteins. (academicediting.org)

A study by Potenza et al indicated that in patients with epithelial ovarian cancer, combined analysis of CA 125 and human epididymis protein 4 (HE4) is an effective indicator of success in chemotherapy. (medscape.com)
Expression of the pNR-2/pS2 protein in diverse human epithelial tumours. (xenbase.org)
Subsequently, we show the efficacy of the T. cruzi immunodominant glycotope Galα3LN, covalently linked to a carrier protein (human serum albumin, HSA), as a prophylactic vaccine candidate in the acute model of ChD. (utep.edu)

Levels of expression of breast epithelial mucin detected by monoclonal antibody BrE-3 in breast-cancer prognosis. (xenbase.org)

No BSA or other carrier proteins that could interfere with conjugation. (rndsystems.com)

Anatomy2

Chemicals and Drugs9

Phenomena and Processes1

Information Science2

Unrecognized mucin-type1

Mucus12

Glycoproteins5

Gene encodes4

Genes and proteins1

Encodes2

Densely2

Receptor6

Pancreatic2

Encoded by this gene6

Peptide5

MUC11

Transmembrane protein2

Immunoglobulin2

Mucosal1

Alterations2

Glycosylation2

Stalk2

Glycoprotein1

Endoplasmic reticulum1

Glycans2

GalNAc2

Induce1

Proinflammatory2

Binds2

Sequence4

Antimicrobial2

Putative1

Bind2

Microbiota1

Lumen2

Responds2

Immune4

Cell12

Repeats4

Interactions1

Homolog1

Apical2

Transcription1

Scaffold1

Domain5

MRNA2

Structural1

Cellular1

Diseases1

Digestion1

Context1

Heavily1

Family member1

Tumor1

Found4

Enzymes1

Subsequent1

Taxonomic1

Human3

Epithelial1

Carrier1