Differentially expressed genesOccludinELISA KitMonoclonalSuperfamilyProteinsCLDN6CLDN3DataSetsCLDN25PhosphorylationCellularMutationsNCBISubfamilyAnnotationTightReceptorMetastasisRenalInteractionTumorsAssayGeneticExpression patternsHumanGastricBiologicalMetastasesMRNADescriptionCellTransmembraneFamily memberClinicalProductsCells
Differentially expressed genes2
- Dogs with CE and protein-losing enteropathy had the greatest number of differentially expressed genes. (avma.org)
- 600 genes differentially expressed during Leber congenital amaurosis_Retina_GSE3249 disease perturbation from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. (maayanlab.cloud)
Occludin2
- Early in his career, Tsukita succeeded in isolating and purifying the adherens junction with his wife Sachiko, an accomplishment that he followed up with an impressive series of discoveries of cell adhesion and cytoskeletal molecules, including what may have been his greatest contribution to the field, the identification of occludin and the claudin family of molecules, which were watershed discoveries in the study of the molecular nature of tight junctions. (rupress.org)
- Diffusion of the complex E1/E2-EGFR-SCARB1-CD81 to the cell lateral membrane allows further interaction with Claudin 1 (CLDN1) and occludin (OCLN) to finally trigger HCV entry (PubMed:12970454, PubMed:24038151, PubMed:12913001, PubMed:20375010, PubMed:19182773) (By similarity). (proteopedia.org)
ELISA Kit2
- For example, the Claudin 6 (Phospho-Tyr219) ELISA Kit (Catalog # DEIA-XYA431) is a convenient, lysate-free, high-throughput and highly sensitive assay for monitoring the phosphorylation and expression profile of Claudin 6 protein in cells. (supportnumber.uk)
- Description: Quantitativesandwich ELISA kit for measuring Human Claudin-2(CLDN2) in samples from serum, plasma, tissue homogenates, cell lysates. (scalegen.com)
Monoclonal3
- Human IgG antibody Laboratories manufactures the claudin-5 antibody rabbit monoclonal reagents distributed by Genprice. (exoquick.com)
- The Claudin-5 Antibody Rabbit Monoclonal reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (exoquick.com)
- We tried multiple times previously to create monoclonal and polyclonal antibodies to claudin-2 and MLCK1. (bicellscientific.com)
Superfamily3
- Cell adhesion molecule-1 (CADM1) is a member of the immunoglobulin superfamily that functions as a tumor suppressor of lung tumors. (cancerindex.org)
- CLDN6 has been identified as the origin of cell adhesion signaling and is involved in the regulation of nuclear receptor activity by targeting nuclear receptor superfamily molecules and managing their gene expression. (supportnumber.uk)
- All members of transforming growth factor superfamily are synthesized as pre-pro-peptides that consist of a short N-terminal signalling peptide, a latency-associated protein (LAP) domain and the mature TGF domain [ 42 ]. (springer.com)
Proteins2
- Family members are integral membrane proteins and components of tight junction strands. (exoquick.com)
- Accumulating studies have suggested that miRNAs are frequently dysregulated in tumors compared with normal tissues, resulting in aberrant expression of target genes or proteins and cancer progression 13 . (nature.com)
CLDN63
- Several members of the claudin (CLDN) family are located at tight junctions between epithelial cells, and aberrant expression of CLDN6 may play multiple roles in tumorigenesis and progression. (supportnumber.uk)
- As a member of the claudin family, CLDN6 is considered a "new favorite" for targeted cancer therapy after CLDN18. (supportnumber.uk)
- The candidate combines an autologous chimeric antigen receptor (CAR) T cell therapy targeting the oncofetal antigen Claudin-6 (CLDN6) with a CLDN6-encoding CAR-T cell amplifying RNA vaccine (CARVac). (pipelinereview.com)
CLDN32
- Homo sapiens claudin 3 (CLDN3), mRNA. (dbcls.jp)
- This triggered an increase in paracellular permeability via cellular redistribution of claudin 3 (CLDN3) from TJs into cell nuclei followed by disruption of epithelial integrity and formation of epithelial lesions. (springer.com)
DataSets1
- Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
CLDN253
- Claudin 25 is a protein that in humans is encoded by the CLDN25 gene. (wikipedia.org)
- Homo sapiens claudin 25 (CLDN25), mRNA. (dbcls.jp)
- linear PRI 27-JAN-2013 DEFINITION Homo sapiens claudin 25 (CLDN25), mRNA. (dbcls.jp)
Phosphorylation1
- The kit can be used to measure the relative amount of phosphorylated Claudin 6 in cultured cells as well as to screen for the effects of various treatments, inhibitors (i.e., siRNAs or chemical reagents) or activators on Claudin 6 phosphorylation. (supportnumber.uk)
Cellular1
- Regulates the activity of cellular genes, including c-myc and c-fos (By similarity). (proteopedia.org)
Mutations4
- Testing is also indicated for family members of patients who have known CLDN16 mutations. (preventiongenetics.com)
- Causative genetic defects of CLDN16 throughout the whole coding region include missense, nonsense, splicing site mutations, small deletion/insertions (Human Gene Mutation Database). (preventiongenetics.com)
- Germline mutations in the NOTCH1 , NOTCH2 and NOTCH3 genes cause Adams-Oliver syndrome, Alagille syndrome and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, respectively ( 4 ), and DLL4-NOTCH3 signaling in human vascular organoids induces basement membrane thickening and drives vasculopathy in the diabetic microenvironment ( 5 ). (spandidos-publications.com)
- Mutations in this gene have been associated with hereditary spastic paraplegia. (bicellscientific.com)
NCBI1
- From NCBI Gene: This gene encodes a member of the claudin family. (nih.gov)
Subfamily1
- Potassium voltage-gated channel subfamily A member 2 (KCNA2), also known as Kv1.2, is a shaker-related voltage-gated potassium channel that is encoded by the KCNA2 gene in human. (bicellscientific.com)
Annotation1
- Search results: The pahtway p3258 has 419 genes in the original annotation. (uth.edu)
Tight2
- In fact, while fibrotic lungs showed decreased expression of endothelial tight gap junction protein Claudin-5, the fibrotic kidneys had an elevated expression of Claudin-5. (tmc.edu)
- 2012). CLDN16 has 5 coding exons that encode the renal tight junction protein claudin 16. (preventiongenetics.com)
Receptor3
- 80%) and biological pathways (such as adipocytokine, Notch, Hedgehog and NOD-like receptor signaling) were not identified by previous gene array studies. (mdpi.com)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human G Protein Coupled Receptor, Family C, Group 5, Member A (GPRC5A) in Tissue homogenates, cell lysates and other biological fluids. (worldcarecouncil.org)
- A 21-gene module ( BV ) was identified in estrogen-receptor-positive breast cancers with metasynchronous metastasis to bone and viscera (area under the curve = 0.77), and its expression increased the risk of bone and visceral metasynchronous spread in this population. (biomedcentral.com)
Metastasis1
- Using histopathology, microarrays, gene expression by polymerase chain reaction, ELISA, chemokine array, and in vitro experiments we demonstrate that despite the pro-tumorigenic environment, kidney fibrosis does not redirect metastasis to the non-organotropic damaged organ. (tmc.edu)
Renal2
- Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma. (nih.gov)
- Renal hypomagnesemia 3 is an autosomal recessive disorder caused by defects in the CLDN16 (alternatively PCLN-1 ) gene (Simon et al. (preventiongenetics.com)
Interaction4
- LAPMT5 is a lysosomal membrane protein preferentially expressed in immune cells ( 5 , 6 ) and hematopoietic cells ( 7 ), having a close interaction with the Nedd4 ( 8 ), a member of the E3 ubiquitin ligases family ( 8 ). (spandidos-publications.com)
- This is the first indication of a direct interaction between a candidate gene for T1D and the activation of a specific downstream proapoptotic pathway in β-cells. (diabetesjournals.org)
- Interaction with transcription factor OCT2 octamer ATGCAAAT nucleotides is critical and decisive for the expression of immunoglobulin genes. (samatashkhis.com)
- A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry. (medscape.com)
Tumors2
- For 1 with the tamoxifen treated animals, no tumors selelck kinase inhibitor were observed in the finish from the study and for an additional two animals the remaining tumor was as well modest for RNA extraction, leaving a representative choice of 9 tumors from five tamoxifen treated animals for gene expression analyses. (tcr-signal.com)
- The geometric suggest with the SRC 1 mRNA ranges relative to the house trying to keep gene TBP in tamoxifen taken care of tumors was 1. (tcr-signal.com)
Assay3
- Results of quantitative reverse transcriptase PCR assay for select genes were similar to those for microchip array analysis. (avma.org)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Claudin 2 (CLDN2) in tissue homogenates, cell lysates and other biological fluids. (scalegen.com)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Claudin 2 (CLDN2) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (scalegen.com)
Genetic1
- Susceptibility to T1D is linked to genetic factors, but T1D-predisposing genes have low penetrance and only a small proportion of individuals genetically at risk will develop the disease. (diabetesjournals.org)
Expression patterns1
- Last, we performed microarray gene expression profiling analysis and found distinct gene expression patterns between erastin-resistant and erastin-sensitive cells that will help uncover the underlying mechanism of erastin-resistance. (mtu.edu)
Human3
- By contrast, somatic alterations in the genes encoding Notch signaling components drive various types of human cancer, such as breast cancer, small-cell lung cancer (SCLC) and T-cell acute lymphoblastic leukemia (T-ALL) ( 6 - 9 ). (spandidos-publications.com)
- Effects Evaluation of CDCA3 expression in OSCC derived cell lines and main OSCCs To investigate mRNA and protein expression of CDCA3 recognized being a cancer connected gene pop over to this site in our earlier microarray information, we carried out actual time quantita tive reverse transcriptase polymerase chain response and Western blot analyses applying 6 OSCC derived cell lines and major cultured human regular oral keratinocytes. (tcr-signal.com)
- Description: A competitive ELISA for quantitative measurement of Human Claudin 2(CLDN2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (scalegen.com)
Gastric1
- gastric cancer, is a novel member of CLAUDIN gene family JOURNAL Int. J. Mol. (dbcls.jp)
Biological1
- Description: A competitive ELISA for quantitative measurement of Rabbit Claudin 5(CLDN5) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (exoquick.com)
Metastases1
- This case-control study of WG-DASL global expression profiles from FFPE tumour samples, after careful quality control and RNA selection, revealed that gene modules in the primary tumour have differing risks for clinical patterns of metasynchronous first metastases. (biomedcentral.com)
MRNA10
- Homo sapiens claudin 22 (CLDN22), mRNA. (dbcls.jp)
- linear PRI 23-MAR-2013 DEFINITION Homo sapiens claudin 22 (CLDN22), mRNA. (dbcls.jp)
- Homo sapiens claudin 9 (CLDN9), mRNA. (dbcls.jp)
- linear PRI 24-MAR-2013 DEFINITION Homo sapiens claudin 9 (CLDN9), mRNA. (dbcls.jp)
- Homo sapiens claudin 20 (CLDN20), mRNA. (dbcls.jp)
- linear PRI 14-APR-2013 DEFINITION Homo sapiens claudin 20 (CLDN20), mRNA. (dbcls.jp)
- Homo sapiens claudin 17 (CLDN17), mRNA. (dbcls.jp)
- linear PRI 17-APR-2013 DEFINITION Homo sapiens claudin 17 (CLDN17), mRNA. (dbcls.jp)
- Homo sapiens claudin 18 (CLDN18), transcript variant 1, mRNA. (dbcls.jp)
- linear PRI 17-APR-2013 DEFINITION Homo sapiens claudin 18 (CLDN18), transcript variant 1, mRNA. (dbcls.jp)
Description1
- Description: Claudin-5, also known as BEC1, is a protein that in humans is encoded by the CLDN5 gene. (exoquick.com)
Cell4
- The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. (cancerindex.org)
- Importantly, the regulatory functions of 4 DEmiRNAs and 3 verified target genes on cell proliferation and migration were explored in TNBC cell lines. (nature.com)
- We presently evaluated the mechanisms by which PTPN2 , a candidate gene for T1D, modulates β-cell apoptosis after exposure to type I and II interferons (IFNs), cytokines that contribute to β-cell loss in early T1D. (diabetesjournals.org)
- Of all breast cancer types, triple-negative breast cancer (TNBC) is the most aggressive metastatic subtype, accounting for 15~20% with the basal-like and claudin-low features, and lack of effective targeted therapies due to the absence of cell membrane receptors. (mtu.edu)
Transmembrane1
- GSE76211) ( 3 , 4 ), revealing a significantly upregulated gene in BCa tissues, the lysosomal-associated protein multispanning transmembrane 5 (LAPTM5). (spandidos-publications.com)
Family member2
- Wnt family member 2 [So. (gsea-msigdb.org)
- ABI family member 3 bin. (gsea-msigdb.org)
Clinical1
- Their blood samples were collected for testing clinical characteristics and fecal samples were tested for bacterial DNA using 16 S ribosomal RNA gene sequencing targeting the V3 and V4 region. (bvsalud.org)
Products1
- Other Claudin-5 products are available in stock. (exoquick.com)
Cells2
- We describe the first report of RNA sequencing of 5' capped (Pol II) RNAs isolated from acutely hepatitis C virus (HCV) infected Huh 7.5 cells that provides a general approach to identifying differentially expressed annotated and unannotated genes that participate in viral-host interactions. (mdpi.com)
- It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. (bicellscientific.com)