- The Company is developing CTIM-76, a selective Claudin 6 (CLDN6) x CD3 bispecific antibody for CLDN6-positive tumors. (stockhouse.com)
- Its preclinical program, CTIM-76, is an anti-Claudin 6 x anti-CD3 (CLDN6xCD3) antigen bispecific monoclonal antibody (bsAb) that is intended to redirect T-cell-mediated lysis toward malignant cells expressing CLDN6. (stockhouse.com)
- Background CTIM-76 is a bispecific Claudin 6 (CLDN6) T-cell engager antibody in preclinical development for treatment of CLDN6-positive cancers, including ovarian, testicular, and non-small cell lung cancers. (bmj.com)
- Discovery of therapeutic monoclonal antibodies targeting CLDN6 is difficult due to an abundance of closely related family members expressed on healthy tissues and stringent requirements for high specificity. (bmj.com)
- Picomolar T cell-dependent cytotoxicity values were obtained with OV90 and OVCAR3 ovarian cancer lines, and studies in K562 cells over-expressing claudin proteins show at least a 500-fold selectivity for CLDN6 over CLDN3, CLDN4, and CLDN9. (bmj.com)
- Several members of the claudin (CLDN) family are located at tight junctions between epithelial cells, and aberrant expression of CLDN6 may play multiple roles in tumorigenesis and progression. (supportnumber.uk)
- As a member of the claudin family, CLDN6 is considered a "new favorite" for targeted cancer therapy after CLDN18. (supportnumber.uk)
- The candidate combines an autologous chimeric antigen receptor (CAR) T cell therapy targeting the oncofetal antigen Claudin-6 (CLDN6) with a CLDN6-encoding CAR-T cell amplifying RNA vaccine (CARVac). (pipelinereview.com)
- Description: Quantitativesandwich ELISA kit for measuring Human Claudin-2(CLDN2) in samples from serum, plasma, tissue homogenates, cell lysates. (scalegen.com)
- For example, the Claudin 6 (Phospho-Tyr219) ELISA Kit (Catalog # DEIA-XYA431) is a convenient, lysate-free, high-throughput and highly sensitive assay for monitoring the phosphorylation and expression profile of Claudin 6 protein in cells. (supportnumber.uk)
- CTIM-76 is a Claudin 6 and CD3 bispecific antibody capable of binding to tumor cells expressing Claudin 6 and stimulating intra-tumoral T cells by the CD3 arm that is designed to be activated only upon tumor engagement. (stockhouse.com)
- Cell adhesion molecule-1 (CADM1) is a member of the immunoglobulin superfamily that functions as a tumor suppressor of lung tumors. (cancerindex.org)
- The present study also demonstrated that netrin‑1 significantly increased the downregulation of claudin‑5, occludin and ZO‑1 expression levels induced by TBI, which provided a basis for further investigation on the role of netrin‑1 in the integrity of TJs and proper functioning of the BBB. (spandidos-publications.com)
- Haskins J, Gu L, Wittchen ES, Hibbard J and Stevenson BR: ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludin. (spandidos-publications.com)
- Early in his career, Tsukita succeeded in isolating and purifying the adherens junction with his wife Sachiko, an accomplishment that he followed up with an impressive series of discoveries of cell adhesion and cytoskeletal molecules, including what may have been his greatest contribution to the field, the identification of occludin and the claudin family of molecules, which were watershed discoveries in the study of the molecular nature of tight junctions. (rupress.org)
- Claudin 6 is expressed on multiple solid tumors such as ovarian, lung and testicular. (stockhouse.com)
- Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma. (nih.gov)
- BASEL, Switzerland--( BUSINESS WIRE )--Alentis Therapeutics ("Alentis"), a clinical-stage biotechnology company developing treatments for Claudin-1 positive (CLDN1+) tumors and organ fibrosis, announced today that the US Food and Drug Administration (FDA) has granted Fast Track development program for ALE.C04 for the treatment of patients with recurrent or metastatic, CLDN1-positive HNSCC. (businesswire.com)
- Current focuses of the SPORE program include genetic susceptibility for breast cancer subtypes in Black and White patients, targeting infiltrating immune cells in claudin-low and basal-type tumors, development of new therapeutic targets in triple negative breast cancers, and defining kinome activity for development of novel breast cancer therapies. (unc.edu)
- Human IgG antibody Laboratories manufactures the claudin-5 antibody rabbit monoclonal reagents distributed by Genprice. (exoquick.com)
- The Claudin-5 Antibody Rabbit Monoclonal reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (exoquick.com)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Claudin 2 (CLDN2) in tissue homogenates, cell lysates and other biological fluids. (scalegen.com)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Claudin 2 (CLDN2) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (scalegen.com)
- Description: Claudin-5, also known as BEC1, is a protein that in humans is encoded by the CLDN5 gene. (exoquick.com)
- Description: A competitive ELISA for quantitative measurement of Rabbit Claudin 5(CLDN5) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (exoquick.com)
- Description: A sandwich quantitative ELISA assay kit for detection of Human Claudin 5 (CLDN5) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids. (lotusbiotechnologies.com)
- Claudin 25 is a protein that in humans is encoded by the CLDN25 gene. (wikipedia.org)
- All members of transforming growth factor superfamily are synthesized as pre-pro-peptides that consist of a short N-terminal signalling peptide, a latency-associated protein (LAP) domain and the mature TGF domain [ 42 ]. (springer.com)
- In fact, while fibrotic lungs showed decreased expression of endothelial tight gap junction protein Claudin-5, the fibrotic kidneys had an elevated expression of Claudin-5. (tmc.edu)
- 2012). CLDN16 has 5 coding exons that encode the renal tight junction protein claudin 16. (preventiongenetics.com)
- This triggered an increase in paracellular permeability via cellular redistribution of claudin 3 (CLDN3) from TJs into cell nuclei followed by disruption of epithelial integrity and formation of epithelial lesions. (springer.com)
- Homo sapiens claudin 3 (CLDN3), mRNA. (dbcls.jp)
- We found that claudin-19, a novel member of the claudin family (TJ adhesion molecules in epithelia), constituted these structures. (archive.org)
- These findings have indicated that, similar to epithelial cells, Schwann cells also bear claudin-based TJs, and they have also suggested that these TJs are not involved in the polarized morphogenesis but are involved in the electrophysiological 'sealing' function of Schwann cells. (archive.org)
- The kit can be used to measure the relative amount of phosphorylated Claudin 6 in cultured cells as well as to screen for the effects of various treatments, inhibitors (i.e., siRNAs or chemical reagents) or activators on Claudin 6 phosphorylation. (supportnumber.uk)
- Tissue mRNA levels for each studied claudin reflected changes within cell lineage and, at the same time, mirrored the ratio between various cell types. (figshare.com)
- Homo sapiens claudin 25 (CLDN25), mRNA. (dbcls.jp)
- linear PRI 27-JAN-2013 DEFINITION Homo sapiens claudin 25 (CLDN25), mRNA. (dbcls.jp)
- Homo sapiens claudin 22 (CLDN22), mRNA. (dbcls.jp)
- linear PRI 23-MAR-2013 DEFINITION Homo sapiens claudin 22 (CLDN22), mRNA. (dbcls.jp)
- Homo sapiens claudin 9 (CLDN9), mRNA. (dbcls.jp)
- linear PRI 24-MAR-2013 DEFINITION Homo sapiens claudin 9 (CLDN9), mRNA. (dbcls.jp)
- Homo sapiens claudin 20 (CLDN20), mRNA. (dbcls.jp)
- linear PRI 14-APR-2013 DEFINITION Homo sapiens claudin 20 (CLDN20), mRNA. (dbcls.jp)
- Homo sapiens claudin 17 (CLDN17), mRNA. (dbcls.jp)
- linear PRI 17-APR-2013 DEFINITION Homo sapiens claudin 17 (CLDN17), mRNA. (dbcls.jp)
- Homo sapiens claudin 18 (CLDN18), transcript variant 1, mRNA. (dbcls.jp)
- linear PRI 17-APR-2013 DEFINITION Homo sapiens claudin 18 (CLDN18), transcript variant 1, mRNA. (dbcls.jp)
- In patients with inflammatory bowel disease (IBD), disease activity-dependent changes in expression of certain claudins have been noted, thus making certain claudin family members potential therapy targets. (figshare.com)
- This change in conductance properties indicated that, without claudin-19, the myelin sheath of Schwann cell appeared to be inadequately sealed from the environment. (rupress.org)
- Interestingly, the overall morphology of Schwann cells lacking claudin-19 expression appeared to be normal not only in the internodal region but also at the node of Ranvier, except that TJs completely disappeared, at least from the outer/inner mesaxons. (archive.org)
- Mice lacking functional claudin-19 showed behavioral and morphological abnormalities suggestive of peripheral nerve damage and disruption of the tight junction-like structures. (rupress.org)
- Claudin-19-deficient mice were generated, and they exhibited behavioral abnormalities that could be attributed to peripheral nervous system deficits. (archive.org)
- Claudin-19 (green) helps form tight junction structures that seal PNS myelin sheaths. (rupress.org)
- Description: A competitive ELISA for quantitative measurement of Human Claudin 2(CLDN2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (scalegen.com)
- Of all breast cancer types, triple-negative breast cancer (TNBC) is the most aggressive metastatic subtype, accounting for 15~20% with the basal-like and claudin-low features, and lack of effective targeted therapies due to the absence of cell membrane receptors. (mtu.edu)
- Recently, our group made a significant advancement in the field of EpCAM structural biology by solving the crystal structure of the extracellular part of EpCAM, which enabled us to explain various aspects of its biology, however many questions remain, particularly regarding its oligomerization, association with claudin-7 into cell-proliferation enhancing signaling complexes, and the impact of cytoskeleton-tethering interaction with alpha-actinin. (cobiss.net)
- We continue to advance our pipeline of antibodies against Claudin-1, an extraordinary target with therapeutic potential across indications in oncology and organ fibrosis. (businesswire.com)
- Claudin expression by human mononuclear cells isolated from lamina propria has been confirmed by Western blot and flow cytometry. (figshare.com)
- For some programs this is an essential step while others match successful applicants with faculty members within the first year of study. (ubc.ca)
- Identify specific faculty members who are conducting research in your specific area of interest. (ubc.ca)
- Read up on the faculty members in the program and the research being conducted in the department. (ubc.ca)
- Address the faculty members by name. (ubc.ca)
- Faculty members receive dozens of requests from prospective students and you may have less than 30 seconds to pique someone's interest. (ubc.ca)
- Our physicians are faculty members of the UNC School of Medicine and include leaders across multiple areas of breast cancer research, including breast cancer genomics with a focus on triple negative disease, drug discovery and early phase clinical research, large clinical trials of new treatments, geriatric oncology, and cancer care delivery research with a focus on improving the equity of breast cancer care. (unc.edu)
- The claudin expression pattern in uninflamed and inflamed colon varied between species and murine strains. (figshare.com)
- In IBD and both animal models, diverse alterations in claudin expression by epithelial and inflammatory cells were recorded. (figshare.com)
- 690) AUTHORS Lal-Nag,M. and Morin,P.J. TITLE The claudin s JOURNAL Genome Biol. (dbcls.jp)
- and Blasig,I.E. TITLE Structure and function of claudin s JOURNAL Biochim. (dbcls.jp)
- 2708) AUTHORS Lal-Nag,M. and Morin,P.J. TITLE The claudin s JOURNAL Genome Biol. (dbcls.jp)
- 1209) AUTHORS Lal-Nag,M. and Morin,P.J. TITLE The claudin s JOURNAL Genome Biol. (dbcls.jp)
- Ahlstrom,R. and Yu,A.S. TITLE Biology of claudin s JOURNAL Am. J. Physiol. (dbcls.jp)
- Expression Patterns of Claudin Family Members During Tooth Development and the Role of Claudin-10 ( Cldn10 ) in Cytodifferentiation of Stratum Intermedium. (bvsalud.org)
- In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. (lu.se)
- Convey the specific ways the program/lab/faculty member is a good fit for the research you are interested in/already conducting. (ubc.ca)
- By use of yeast artificial chromosomes, Claudin-5 is localized between polymorphic markers D22S944 and D22S941 on chromosome 22q11, both of which are deleted in more than 80% of VCFS patients. (exoquick.com)
- Compose an error-free and grammatically correct email addressed to your specifically targeted faculty member, and remember to use their correct titles. (ubc.ca)
- Include a brief outline of your academic background, why you are interested in working with the faculty member, and what experience you could bring to the department. (ubc.ca)