Loading...
  • stem
  • 1 - 3 High-dose melphalan with autologous stem cell transplant (HDM/SCT) is an effective treatment with high complete hematologic response rates (CR) and is capable of producing durable remissions and prolonged overall survival. (haematologica.org)
  • Stem cell infusion will occur on day 0 and will be at least 20 hours after the infusion of melphalan. (clinicaltrials.gov)
  • Tumor
  • Melphalan is currently being used to treat ocular retinoblastoma , a pediatric solid tumor. (wikipedia.org)
  • Melflufen is a peptidase enhanced cytotoxic (PEnC) with a targeted delivery within tumor cells of melphalan, a widely used classical chemotherapeutic belonging to a group of alkylating agents developed more than 50 years ago. (wikipedia.org)
  • infusion
  • Melflufen rapidly disappeared from plasma after infusion, while melphalan typically peaked a few minutes after the end of infusion. (wikipedia.org)
  • metastatic
  • Delcath Systems, Inc. (NASDAQ: DCTH), a specialty pharmaceutical and medical device company focused on oncology with an emphasis on the treatment of primary and metastatic liver cancers, announced today that the U.S. Food and Drug Administration (FDA) Office of Orphan Products Development (OOPD) has granted Orphan Drug Designation for melphalan for the treatment of cholangiocarcinoma. (news-medical.net)
  • tablet
  • Each film-coated tablet contains 2 mg melphalan and the inactive ingredients colloidal silicon dioxide, crospovidone, hypromellose, macrogol/PEG 400, magnesium stearate, microcrystalline cellulose, and titanium dioxide. (rxlist.com)
  • Melflufen
  • This suggests that melflufen is rapidly and widely distributed to extravasal tissues, in which melphalan is formed and thereafter redistributed to plasma. (wikipedia.org)
  • drug
  • Melphalan can cause serious birth defects if either the man or the woman is taking this drug at the time of conception, or if the woman is taking this drug during pregnancy. (encyclopedia.com)
  • Melphalan should not be taken in combination with any prescription drug, over-the-counter drug, or herbal remedy without prior consultation with a physician. (encyclopedia.com)
  • Bioniche Pharma and Synerx Pharma entered into a definitive agreement whereby Synerx developed and secured the U.S. Food and Drug Administration's approval of Melphalan and Bioniche Pharma has the exclusive rights to market and distribute Melphalan in the United States. (bio-medicine.org)
  • induction
  • Citation: Russell, L.B., Hunsicker, P.R., and Shelby, M.D. Melphalan, a second chemical for which specific-locus mutation induction in the mouse is maximum in early spermatids. (nih.gov)