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  • embryonal
  • Multiple chromosomal translocations were identified by RNA-Seq, and fusion genes included RPLP1-C19MC, potentially deregulating the C19MC cluster, an imprinted locus containing microRNA genes reactivated by gene fusion in embryonal tumors with multilayered rosettes. (ox.ac.uk)
  • blood
  • Whole-exome analysis of genomic DNA from both the tumor and blood indicated no somatic, non-synonymous coding mutations within the tumor, but a heterozygous, unique germline, loss of function mutation in CDKN2A (p16(INK4A), D74A). (ox.ac.uk)
  • primary
  • Exhaustive genomic, transcriptomic, epigenetic and pathological characterization was performed on the excised primary tumor and a derived cell line. (ox.ac.uk)
  • primary tumor
  • Exhaustive genomic, transcriptomic, epigenetic and pathological characterization was performed on the excised primary tumor and a derived cell line. (ox.ac.uk)
  • Multi-agent chemotherapy is the mainstay of treatment, complemented by surgery and radiation for local control of the primary tumor site or isolated metastatic disease. (feinsteininstitute.org)
  • There is also increasing evidence that macrophages play an important role in establishing the "premetastatic niche," altering the stromal environment at sites far from the primary tumor and enhancing extravasation and growth of metastatic cells. (feinsteininstitute.org)
  • lesion
  • In our case, there was no history of a current or prior melanotic skin lesion, and there was no other organ involvement on computed tomography imaging or bone scintigraphy scan. (thefreedictionary.com)
  • classification
  • The WHO classification of CNS tumors is the most widely accepted system for classifying CNS tumors and was based on the histological characteristics of the tumor. (radiopaedia.org)
  • The most recent update (2016) has significantly changed the classification of a number of tumor families, introducing a greater reliance on molecular markers. (radiopaedia.org)
  • Despite a move towards molecular markers for some entities, the classification continues to be organized according to the cell of origin (e.g. ependymal tumors) or anatomical origin (e.g. tumors of the sellar region). (radiopaedia.org)
  • heterogeneous
  • Diffuse large B-cell lymphomas (DLBCLs) are a heterogeneous group of tumor and the most common type of all non-Hodgkin's lymphomas (NHLs). (jomfp.in)
  • pathological
  • The objectives of the study were to analyze the tumor shrinkage pattern on magnetic resonance imaging (MRI) after neoadjuvant chemotherapy and to evaluate whether there is any difference in shrinkage pattern between pathological responder and nonresponder groups. (biomedsearch.com)