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  • tumors
  • Although a histopathological diagnosis was not available, the magnetic resonance pattern was typical of melanotic tumors. (revespcardiol.org)
  • hop Tumorous-lethal ( Tum-l ) is a gain-of-function mutation that causes dramatic expansion of myeloid cells, which then form lethal melanotic tumors. (g3journal.org)
  • Through an F1 deficiency (Df) screen, we identified 11 suppressors and 35 enhancers of melanotic tumors in hop Tum-l animals. (g3journal.org)
  • Ectopic hematopoietic activation of Yki in otherwise wild-type animals increased hemocyte proliferation but did not induce melanotic tumors. (g3journal.org)
  • However, hematopoietic depletion of Yki significantly reduced the hop Tum-l tumor burden, demonstrating that Yki is required for melanotic tumors in this background. (g3journal.org)
  • These results support a model in which elevated Yki signaling increases the number of hemocytes, which become melanotic tumors as a result of elevated JAK/STAT signaling. (g3journal.org)
  • n the dark amorphous pigment of melanotic tumors, skin, oral mucosa, hair, choroid coat of the eye, and substantia nigra of the brain. (thefreedictionary.com)
  • PPNAD can be associated with a variety of other manifestations, such as myxomas of the skin, heart, breast and other sites, psammomatous melanotic swannomas involving the peripheral nervous system (PNS), lentigines and blue nevi of the skin and mucosae, growth hormone (GH)-producing adenomas of the pituitary, testicular Sertoli cell tumors, and possibly other neoplasms (adrenocortical and thyroid follicular carcinoma, and ovarian cysts). (clinicaltrials.gov)
  • macules
  • Longitudinal melanonychia (also known as melanonychia striata) without associated mucosal melanotic macules is a normal finding in 77% of blacks by age 20 years, and it is seen in 90% of blacks by the fifth decade of life. (medscape.com)
  • skin
  • In our case, there was no history of a current or prior melanotic skin lesion, and there was no other organ involvement on computed tomography imaging or bone scintigraphy scan. (thefreedictionary.com)
  • normal
  • When the melanotic hybrid fish of the first generation (SpSp Aa Bb) are back-crossed to the pure swordtail (spsp AA BB) , half of the brood are normal while the other half are intensely melanotic. (aacrjournals.org)