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  • malignant
  • Lentigo maligna (also known as "lentiginous melanoma on sun-damaged skin") is a melanoma in situ that consists of malignant cells but does not show invasive growth. (wikipedia.org)
  • Flaps can require extensive incision resulting in long scars and may be better done by plastic surgeons (and possibly better again by those with extensive LM or "suspicious of early malignant melanoma" experience. (wikipedia.org)
  • metastases
  • Preclinical proof of concept of the synergic effect of the clinical candidate, DT01, with radiation therapy lead to a first-in-human Phase I, to evaluate the tolerance and efficacy of local DT01 administration in association with RT in patients suffering from in-transit metastases of melanoma. (wikipedia.org)
  • Antibodies
  • A research team at Edith Cowan University in Western Australia conducted a study using blood samples to identify particular antibodies created in the immune response to melanoma. (issels.com)
  • After the team identified a combination of 10 antibodies specific to the presence of melanoma, they were able to detect melanoma patients with 79 percent accuracy and healthy participants with 84 percent accuracy. (issels.com)
  • antibody
  • Monoclonal antibody TA99 (mouse IgG2a), directed against the gp75 antigen present on B16F10 melanoma cells, was purified from hybridoma supernatants by protein A-Sepharose chromatography. (aacrjournals.org)
  • protein
  • The catch is that a patient's cancer must be positive for that protein, called HLA A2 -- which is true in about 45 percent of melanomas, Middleton said. (healthmonitor.com)
  • Rac1 protein is also necessary for glucose uptake in skeletal muscle activated by exercise and muscle stretching Activating mutations in Rac1 have been recently discovered in large-scale genomic studies involving melanoma and non-small cell lung cancer. (wikipedia.org)
  • tackle
  • If we can identify more potent and less toxic drug combinations to tackle melanoma then we could save thousands of lives. (cancerresearchuk.org)
  • Recently there have been some really exciting developments in treating melanoma - but new approaches that tackle the problem of resistance are still needed," she added. (cancerresearchuk.org)
  • growth
  • The transition to true melanoma is marked by the appearance of a bumpy surface (itself a marker of vertical growth and invasion), at which point it is called lentigo maligna melanoma. (wikipedia.org)
  • study
  • This is a landmark study," said Dr. Anna Pavlick, director of the melanoma program at New York University Medical Center's cancer institute, who was not involved in the study. (immunodefence.com)