Melanoma cells with prominent nucleoli. Medical search. Frequent questions

In spindle-B melanoma cells, coarse, granular chromatin and plump, large nuclei are seen. (aao.org)
Their nuclei have a conspicuous nuclear membrane, very coarse chromatin, and large nucleoli. (aao.org)
Microscopically, some loosely cohesive epithelioid cells were uniform with abundant clear cytoplasm, showing predominantly round or oval nuclei with finely stippled chromatin. (biomedcentral.com)
The epithelioid cells were uniform and approximately the same size as the parabasal cells (Fig. 1 A&B), showing predominantly round or oval nuclei with finely stippled chromatin. (biomedcentral.com)
The nucleus has a prominent, electron-dense, granular nucleolus and clumped chromatin. (avma.org)
Apoptosis, on the other hand, is characterized by cell shrinkage, membrane blebbing, condensation, margination of nuclear chromatin, packaging of apoptotic bodies, and engulfment of the immunogenic intracellular proteins by phagocytes and macrophages. (bioradiations.com)
Hairy cells are small to medium-sized lymphoid cells with an oval or indented nucleus with homogeneous and spongy chromatin. (fortuneonline.org)

Only a few tumours have been reported originating from this location including lymphoma, 1 Kaposi's sarcoma, 2 adenocarcinoma, 3 angiofibroma, 4 and squamous cell carcinoma. (bmj.com)
3 While the clinical differential diagnosis commonly includes basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and keratoacanthoma, the histopathological differential also includes trichilemmoma, trichoepithelioma, clear cell SCC, clear cell porocarcinoma, and clear cell hidradenocarcinoma. (jcadonline.com)
AIMS: Current understanding of oral squamous cell carcinoma (OSCC) is incomplete with regard to prognostic factors that lead to the considerable heterogeneity in treatment response and patient outcomes. (bvsalud.org)
Primary squamous cell carcinomas of the thyroid must be distinguished from metastases of squamous cell carcinoma to the thyroid gland and from direct extension of primary squamous cell carcinomas originating from the larynx or trachea. (healthyskinworld.com)
Chronic infections, skin inflammation, HIV and other immune deficiency diseases, chemotherapy, anti-rejection drugs used in organ transplantation, and excessive sun exposure can all lead to a risk of squamous cell carcinoma. (healthyskinworld.com)
Survival rates for sebaceous carcinoma are perhaps slightly worse than those for squamous cell carcinoma but have improved in recent years as a result of increased awareness, earlier detection, more accurate diagnosis, and appropriate treatment. (missionforvisionusa.org)
3. Squamous-cell carcinoma. (poznayka.org)

plump polyhedral nevus cells: Abundant cytoplasm is filled with pigment and has a small round to oval nucleus with bland appearance. (aao.org)
slender spindle nevus cells (Fig 12-16): The cytoplasm contains scant pigment and a small, dark, elongated nucleus. (aao.org)
balloon cells: Abundant, foamy cytoplasm lacks pigment and has a bland nucleus. (aao.org)
Histologically, a melanocytoma is composed of large polyhedral cells with small round to oval nuclei and abundant cytoplasm. (aao.org)
Epithelioid melanoma cells resemble epithelium because of their abundant eosinophilic cytoplasm and enlarged round to oval nuclei. (aao.org)
Note the balloon cells (arrowheads) with abundant foamy cytoplasm. (aao.org)
The most common variant, oncocytic ACC, is characterized by cells with abundant eosinophilic cytoplasm. (cap.org)
Distinct round nucleoli were visible in some cells, notably with numerous melanin pigments in the cytoplasm. (biomedcentral.com)
Microscopically, we observed some loosely cohesive atypical cells arranged in single or clusters and sheets, which exhibited epithelioid morphology with abundant clear cytoplasm. (biomedcentral.com)
Distinct round nucleoli were visible in some cells (Fig. 1 C), notably with numerous melanin pigments in the cytoplasm (Fig. 1 D). The primary diagnosis was atypical cells which were suspected to be melanoma. (biomedcentral.com)
The cell block section showed single or clusters of medium-sized epithelioid cells in a background of fibrinoid fluid, with abundant clear or granular eosinophilic cytoplasm. (biomedcentral.com)
The cells have centrally located nuclei, prominent nucleoli, and abundant clear cytoplasm. (basicmedicalkey.com)
Morphological features with diagnostic significance is the large cell carcinoma of the part or most (at least 10%) cancer cells rich in cytoplasm, eosinophilic, and large round education strong eosinophilic inclusion body. (cancerlive.net)
variant of large cell carcinoma - large cell carcinoma with rhabdoid phenotype electron microscopy: cell cytoplasm is rich in glycogen particles, while the light microscope, the strong eosinophilic inclusion bodies to intermediate filaments in the electron microscope. (cancerlive.net)
immunohistochemistry: a result of cell cytoplasm containing abundant intermediate filaments, gas immunohistochemical staining, cells could simultaneously express vimentin, EMA and cytokeratin, but myogenic standard, antibodies [such as actin (actin) , myoglobin (myoglobin) and HHF-35, etc. (cancerlive.net)
Histopathological examination revealed diffuse infiltration of the pericardium by PMPM, which consisted of epithelioid cells with abundant eosinophilic cytoplasm and large round nuclei with prominent nucleoli, arranged in a tubular-papillary pattern ( Fig. 4A ). (spandidos-publications.com)
In the higher magnification image, the malignant neoplasm features large cells with vesicular bubbly cytoplasm (arrow 6). (missionforvisionusa.org)
The demonstration of lipid within the cytoplasm of tumor cells by special stains is a prerequisite for the diagnosis. (missionforvisionusa.org)
The tumor was composed of sheets of pleomorphic, round to polygonal epithelioid cells with prominent eosinophilic cytoplasm, large nuclei, many multinucleated, and very prominent nucleoli. (biomedcentral.com)

Use of IHC to label endothelial cells (CD31, CD34, or D2-40) may be helpful in detecting the rim of endothelial cells, thereby confirming the intravascular location of the cells and supporting a diagnosis of metastatic melanoma. (medscape.com)
The diagnosis is oral melanoma. (medscape.com)
Patients with oral malignant melanoma often recall having an existing oral pigmentation months to years before diagnosis, and the condition may even have elicited prior comment from examining physicians and dentists (or healthcare providers, when considering the auxiliaries). (medscape.com)
Immunohistochemical studies were positive for immunological markers HMB45 and S-100 protein, confirming a diagnosis of melanoma. (bmj.com)
The differential diagnosis of a malignant effusion is accordingly broad, especially for the small round blue cell tumors that includes not only mesenchymal tumors, but also non-mesenchymal tumors, such as neuroblastoma and Wilms tumor. (cytojournal.com)
Small uveal lesions are observed for growth before making a diagnosis of melanoma. (cigna.com)
The final pathological diagnosis was PEComa identified by the liquid-based cytology, cell block, cervical biopsy, IHC and FISH result. (biomedcentral.com)
Finally, a tentative diagnosis of PEComa was made by combining cell block and IHC, and with the statement that the final diagnosis will require more representative material. (biomedcentral.com)
Melanoma can be curable when full excision is made after early diagnosis. (waocp.com)
Diagnosis is based on architecture (upward spread in the epidermis, single cells, asymmetry). (librepathology.org)
Characteristics of the cells may not be sufficient in many instances to yield a definitive diagnosis or indicate the probable behavior of the lesion. (merckvetmanual.com)
By definition, large cell undifferentiated carcinoma lacks the microscopic features of the other lung carcinomas, therefore this diagnosis is made by exclusion. (eurocytology.eu)
The cytologic diagnosis of malignancy in large cell undifferentiated carcinoma is not difficult. (eurocytology.eu)
These features might lead to an erroneous diagnosis of high-grade renal cell carcinoma, particularly since intra-tumoral fat can occur in these tumors [ 4 ]. (biomedcentral.com)
The diagnosis of Hairy Cell Leukemia and HCL-like diosrders, including HCL variant (vHCL) and Splenic Diffuse Red Pulp Lymphoma (SDRPL), is based on the examination of the peripheral blood and bone marrow smears allowing the identification of hairy cells and the flow cytometric analysis. (fortuneonline.org)
An accurate diagnosis is necessary given that different clinical management is required: the first step in a definitive diagnosis is based on the examination of the peripheral blood and bone marrow smears allowing the identification of hairy cells and a specific Flow Cytometric Analysis (FCA). (fortuneonline.org)
Diagnosis is typically based on blood tests finding high numbers of mature lymphocytes and smudge cells. (wikipedia.org)
[9] If enlarged lymph nodes are caused by infiltrating CLL-type cells, a diagnosis of small lymphocytic lymphoma (SLL) is made. (wikipedia.org)
The histopathological diagnosis of ovarian fibromatous tumor is usually unequivocal due to their distinct spindle-cell morphology and fascicular growth pattern. (iiarjournals.org)

However, the presence of nevus cells contiguous with a choroidal melanoma on histologic examination provides evidence that melanomas may arise from choroidal nevi. (aao.org)
Choroidal melanoma is the most common primary malignant ocular tumor in human adults. (molvis.org)
We have studied the transgenic mouse strain, Tyrp-1-TAg, to try to gain insight into possible molecular mechanisms common to pigmented ocular neoplasms occurring spontaneously in the eyes of these mice and human choroidal melanoma. (molvis.org)
The typical choroidal melanoma is a brown, elevated, dome-shaped subretinal mass. (cigna.com)
As the tumor enlarges, it may cause distortion of the pupil (iris melanoma), blurred vision (ciliary body melanoma), or markedly decreased visual acuity caused by secondary retinal detachment (choroidal melanoma). (cigna.com)
A large choroidal melanoma is present displacing the ciliary body forward, but not invading the angle of the anterior chamber. (ox.ac.uk)

Figure 12-16 Spindle-cell choroidal nevus (between arrows) is composed of slender spindle-shaped cells with thin, homogeneously staining nuclei. (aao.org)
Spindle-A melanoma cells have slender, elongated nuclei with small nucleoli. (aao.org)
The cells are remarkably uniform with elongated nuclei. (wikipedia.org)
In normal control adult mouse eyes, ETS-1 was mostly present in the nuclei of all neuroretinal layers whereas ETS-2 was mostly localized in the cytosol of the cell bodies of these layers with a smaller amount present in the nuclei. (molvis.org)
Their nuclei are relatively large, round to oval in shape, and show mild pleomorphism with mostly small, round, regular nucleoli. (atlasgeneticsoncology.org)
The Weiss criteria define malignancy based on the presence of three or more of the following features: high-grade nuclei, high mitotic rate (more than 5 mitoses per 50 high-power fields (HPF)), atypical mitotic figures, clear cells comprising less than 25% of cells, diffuse architecture, tumor necrosis, venous invasion, sinusoidal invasion, and capsular invasion. (cap.org)
A few spindled nuclei and melanin pigments were also identified (Fig. 2 A). IHC demonstrated that the epithelioid cells were positive for HMB45 andTFE3 (Fig. 2 B&C), focally positive for Melan-A, while negative for S-100, SOX-10, AE1/AE3, EMA, Desmin, SMA, H-caldesmon. (biomedcentral.com)
Histologically, these tumors are characterized by sheets and nests of large cells with vesicular nuclei and prominent nucleoli. (eurocytology.eu)
The nuclei are enlarged and have prominent nucleoli. (missionforvisionusa.org)

Within the past 15 years, evaluation of SLNs has become the most popular method for early staging of several malignancies, including breast carcinoma, gastrointestinal carcinoma, and melanoma. (medscape.com)
Prominent (large) red nucleoli (like in serous carcinoma of the ovary). (librepathology.org)
Marked nuclear pleomorphism - variation in cell size, shape & staining (like in serous carcinoma of the ovary). (librepathology.org)
Serous carcinoma - both serous carcinoma and melanoma have a large nucleolus . (librepathology.org)
type II consists of serous carcinoma, clear cell carcinoma, and carcinosarcoma. (karger.com)
Trichilemmal carcinoma shows many histologic features reminiscent of follicular ORS-notably, its glycogen-rich clear cells, trichilemmal keratinization, and similar immunostaining profile. (jcadonline.com)
Prostate-specific membrane antigen (PSMA) expression is found to be associated with endothelial cells or tumor neovasculature in malignant AdCC and salivary duct carcinoma. (bvsalud.org)
the type of cancer cells was eosinophilic intracytoplasmic inclusion bodies with large cell carcinoma, a rare case. (cancerlive.net)
b. malignant melanoma: malignant melanoma cells can be seen with varying amounts of black particles, if necessary, immunohistochemistry, malignant melanoma cells S-100 protein HIIlMB-45-positive, these are associated with large cell carcinoma with rhabdoid table type are different. (cancerlive.net)
The large cell carcinoma with rhabdoid phenotype and the identification of other tumors, according to Zheng and immunohistochemical tissue staining, is not difficult to identify. (cancerlive.net)
It should be noted that the vast majority of neoplasms of the upper aerodigestive tract are epithelial and that some of these can show a spindle cell phenotype, e.g., spindle cell or sarcomatoid carcinoma and myoepitheliomas. (basicmedicalkey.com)
If youve had a basal cell carcinoma you may be more likely to develop a squamous cell skin carcinoma, as is anyone with an inherited, highly UV-sensitive condition such as xeroderma pigmentosum. (healthyskinworld.com)
When sebaceous carcinoma is suspected clinically, the pathologist should be alerted so a strategy can be put in place for documentation of lipid within tumor cells, e.g. glutaraldehyde and paraformaldehyde fixation with osmication or frozen sections for lipid stains. (missionforvisionusa.org)
Positive reactivity to antibodies to CAM5.2 and EMA are often positive in sebaceous carcinoma and negative in squamous carcinoma and basal cell carcinoma, respectively. (missionforvisionusa.org)
The excision examples show a normal mole (upper row, benign appearance) and a superficial basal cell carcinoma (lower row, suspected malignancy). (patholines.org)
2. Signet-ring cell carcinoma, scirrhous carcinoma, solid carcinoma (poorly-differentiated). (poznayka.org)
Microscopically, it may be an adenocarcinoma or signet-ring cell carcinoma, extensively infiltrating the stomach wall, but due to marked desmoplasia cancer cells may be difficult to find. (poznayka.org)
carcinoma contains abundant pools of mucin in which are seen a small number of tumor cells, sometimes having signet-ring appearance. (poznayka.org)
The epithelioid cells in EAML can be quite pleomorphic and the appearance of a carcinoma-like pattern is frequently observed. (biomedcentral.com)

Mucosal melanoma, also a spindled-cell tumor in many cases, has pleomorphism (more variety in shape/size of tumor cells), intranuclear inclusions, and prominent nucleoli. (wikipedia.org)
By immunohistochemistry, the tumor cells are positive for inhibin and negative for chromogranin and S100. (cap.org)
Oftentimes, ACCs have thick capsules, broad fibrous bands, tumor cells arranged in disordered nests and trabeculae, and necrosis. (cap.org)
Upon immunohistochemistry (IHC), the tumor cells were positive for HMB45 and TFE3, focally positive for MelanA, while negative for muscle marker. (biomedcentral.com)
Special staining: a rhabdoid phenotype in tumor cells. (cancerlive.net)
Electron microscopic examination of tumor cells confirmed the presence of premelanosome-like granules. (biomedcentral.com)

Figure 12-17 Posterior uveal melanoma. (aao.org)
Figure 12-18 Posterior uveal melanoma. (aao.org)
Figure 12-19 Posterior uveal melanoma. (aao.org)
Relevant mouse models of human uveal melanoma still remain to be developed. (molvis.org)
The mean age-adjusted incidence of uveal melanoma in the United States is approximately 4.3 new cases per million people, with no clear variation by latitude. (cigna.com)
Uveal melanoma is diagnosed mostly at older ages, with a progressively rising, age-specific incidence rate that peaks near age 70 years. (cigna.com)
In view of these susceptibility factors, numerous observational studies have attempted to explore the relationship between sunlight exposure and risk of uveal melanoma. (cigna.com)
3 ] Similarly, there is no consistent evidence that occupational exposure to UV light or other agents is a risk factor for uveal melanoma. (cigna.com)
A small uveal melanoma cannot be distinguished from a nevus. (cigna.com)

METHODS: Immunohistochemistry was performed to quantitatively assess cell densities of CD3+, CD20+, CD4+, CD8+ and FOXP3+TIL subsets in 50 surgically treated OSCC cases. (bvsalud.org)
If the mother striated muscle cells, myoglobin immunohistochemistry (myogfobin), medium protein (desmin) was positive. (cancerlive.net)

[ 11 ] The characteristic capsular location of these nevus deposits and the lack of significant cytologic atypia distinguishes them from the common subcapsular location of metastatic melanoma. (medscape.com)
Since analysis of the cytomorphologic features of such nevus cells in the lymph node is so important, it is always recommended to compare these cells with the melanoma cells in the primary lesion. (medscape.com)
Those nevus cells lack gp100 expression (with HMB-45) and show very low Ki67 expression (features characteristic of benign melanocytes). (medscape.com)
plump fusiform dendritic nevus cells: Morphology is intermediate between that of plump polyhedral and slender spindle. (aao.org)
Because the nevus cells are so heavily pigmented, it is usually necessary to apply melanin bleaching techniques to sections to accurately study the cytologic features (see Chapter 15, Fig 15-12D). (aao.org)
however, a tumor consisting entirely of spindle-A cells is considered a nevus. (aao.org)
2004). Less common are histologic variants such as desmoplastic/sclerosing, angiomatoid, myxoid and plexiform Spitz nevi (Lyon, 2010), and pigmented spindle cell nevus (Ferrara et al. (atlasgeneticsoncology.org)
Pigmented spindle cell nevus from right thigh of 11 year old female, 7mm in diameter. (atlasgeneticsoncology.org)
We report a case of conjunctival blue nevus that clinically resembled primary acquired melanosis and gave rise to conjunctival melanoma. (jamanetwork.com)
Nevus with fat: clinical characteristics of 100 nevi containing mature adipose cells. (librepathology.org)
A dermal nevus infrequently shows multinucleated giant cells as shown. (patholines.org)
Compound nevus , with nevus cells in both dermis and epidermis. (patholines.org)

The cause of oral melanoma or melanoma of any mucosal surface remains unknown, and the incidence has remained stable for more than 25 years. (medscape.com)
In contrast to cutaneous melanomas, which are etiologically linked to sun exposure, risk factors for mucosal melanomas are unknown. (medscape.com)
Mucosal melanoma represents 1-2% of all melanomas, 6 with 25-50% in the head and neck-that is, upper respiratory tract, oral cavity, and pharynx. (bmj.com)
Wide local excision of malignant mucosal melanoma. (bmj.com)
Melanoma arises from the malignant transformation of the melanocyte and cutaneous melanomas are the most common followed by ocular, mucosal and melanoma of unknown primary site. (waocp.com)
Here we present a case of a 54 year old male who presented with a pigmented lesion on the palate, a type of mucosal melanoma. (waocp.com)

Primary oral malignant melanoma (POM) is a rare, very aggressive neoplasm of melanocytic origin characterized by the proliferation of atypical melanocytes at the epithelial-connective tissue interface, associated with upward migration into the epithelium and by invasion of the underlying connective tissue. (waocp.com)

Tumors composed of a mix of spindle-A and spindle-B melanoma cells are designated spindle cell melanomas . (aao.org)
While most tumors metastatic to the serous membranes are of epithelial origin, cytologists should be aware that non-epithelial neoplasms can also cause malignant effusions including sarcomas, melanomas, germ cell tumors, and, more rarely, brain tumors. (cytojournal.com)
Common non-epithelial neoplasms that may cause malignant effusions include malignant melanoma, sarcomas, and other neoplasms including germ cell tumors [ Figure 1 ]. (cytojournal.com)
Only some of these characteristics are seen in atypical Spitz tumors and spitzoid melanomas. (atlasgeneticsoncology.org)
Perivascular epithelioid cell tumors (PEComas) are a rare group of mesenchymal neoplasms characterized by the presence of histologically and immunohistochemically distinctive perivascular epithelioid cells [ 1 ], which can occur in any part of the body. (biomedcentral.com)
Neuroendocrine neoplasms (NENs) are rare tumors originating from neuroendocrine cells and include a series of heterogeneous tumors. (biomedcentral.com)
Although this most common gynecologic cancer carries the best prognosis, it is important to differentiate between the classic endometrioid tumors that tend to be estrogen dependent and well differentiated, from other less common high-risk uterine malignancies, such as uterine papillary serous carcinomas (UPSCs), clear cell carcinomas, mixed mullerian tumors (MMTs), or sarcomas, which appear to have a different biology. (medmuv.com)
Squamous cell carcinomas are typically large tumors that replace the thyroid extensively. (healthyskinworld.com)
One of the most important characteristics to differentiate these tumors from other renal cell neoplasms is their typical reactivity to premelanosome antigens. (biomedcentral.com)
It is thought that leiomyoma is the result of either transformation of normal uterine muscle cells into abnormal cells through somatic mutations , or through the growth of abnormal uterine muscle cells into tumors. (wikidoc.org)

This variant should be differentiated from oncocytic adenoma which may exhibit atypical features that are components of the Weiss criteria including high nuclear grade, less than 25% clear cells, and diffuse architecture. (cap.org)
This entity was first identified and documented by Headington 9 in 1976, who described an epidermal-based tumor composed of atypical clear cells derived from adnexal keratinocytes. (jcadonline.com)

Sarcoma - as may have spindle cells. (librepathology.org)
Clear cell sarcoma ( AKA melanoma of the soft parts). (librepathology.org)

Interestingly, some recent studies have shown better prognosis and lower rate for positivity of SLN in those patients with regression in their melanoma lesions. (medscape.com)
Choroidal melanomas typically start as dome-shaped lesions and, as they grow and break through Bruch membrane, they acquire a mushroom or collar-button shape (Fig 12-20). (aao.org)
It fits into the larger category of melanocytic lesions which includes many benign entities, a number of which can be difficult to distinguish from melanoma. (librepathology.org)
OBJECTIVES: To describe the morphologic characteristics of skin lesions, extent of extracutaneous disease, and outcomes in patients with neonatal presentation of Langerhans cell histiocytosis (LCH), and to examine clinical predictors of disease prognosis. (thedoctorsdoctor.com)

The cytoplasmic melanin content in melanoma cells can vary considerably. (aao.org)
This effect is due to the depth and density of the pigmented cells (or melanin granule dispersion) and the physical properties of light absorption and reflection described by the Tyndall light phenomenon or effect. (medscape.com)

As malignant cells have a tendency to round up in body fluids these non-epithelial neoplasms can therefore mimic reactive mesothelial cells and metastatic adenocarcinoma. (cytojournal.com)

Histopathological analysis of the biopsy showed sheets of epithelioid cells with prominent nucleoli and vesicular cells on a routine haematoxylin and eosin stain (fig 3). (bmj.com)

Oral melanomas are uncommon (1.2 cases per 10 million population per year in the United States), and, similar to their cutaneous counterparts, they are thought to arise primarily from melanocytes in the basal layer of the squamous mucosa. (medscape.com)
In the oral mucosa, melanocytes are observed in a ratio of about 1 melanocyte to 10 basal cells. (medscape.com)
1998). Pagetoid intraepidermal scatter of single melanocytes or nests of melanocytes (a feature often also present in melanomas) in the central portion of the lesion is not uncommon. (atlasgeneticsoncology.org)
it shows pigmented cells close to the neoplasm but these cells have the appearance of normal dendritic melanocytes of the uvea: the large cells with prominent nucleoli representing the outer limit of the tumour are found close by but not within the scleral loop. (ox.ac.uk)

Approximately 20% of patients with primary cutaneous melanoma will have metastatic melanoma in their SLN. (medscape.com)
According to most published data, patients in whom the SLN contains metastatic melanoma have a poorer prognosis. (medscape.com)
Macrophages, pigmented or not, may resemble metastatic melanoma in the sentinel lymph nodes (SLN). (medscape.com)
Approximately 50% of metastatic melanoma patients harbor BRAF mutations. (oncotarget.com)

Invasive melanoma of the skin , has more atypia and dysplasia (see table in the grading section ). (patholines.org)

The cells have prominent nucleoli and areas of necrosis and mitoses are present. (cap.org)

Haematoxylin and eosin stain showing epithelioid cells and vesicular cells and pigment. (bmj.com)

The mitotic rate in posterior uveal melanomas tends to be quite low, and mitotic counts by the pathologist typically require 40 high-power fields. (aao.org)

The most common primary intraocular malignancy in adults is melanoma arising from the ciliary body and/or choroid. (aao.org)
Melanoma of the uveal tract (iris, ciliary body, and choroid), though rare, is the most common primary intraocular malignancy in adults. (cigna.com)
Uveal melanomas can arise in the anterior (iris) or the posterior (ciliary body or choroid) uveal tract. (cigna.com)
The sections show a large nodule of malignant melanoma apparently centred in the anterior choroid extending from the vicinity of the equator to the middle portion of the ciliary body, the latter being reflected axially by the tumour. (ox.ac.uk)

Although the lesion was pale, pigment was visible on the haematoxylin and eosin stain, suggestive of melanoma. (bmj.com)

Its prominent properties are A lack of cell differentiation Local invasion of adjoining tissue Metastasis, which is spread to distant sites through. (msdmanuals.com)

Primary malignant melanoma of the oral cavity is a rare malignancy with an incidence of 0.2 to 8% of all melanomas. (waocp.com)

Histologically, posterior uveal melanomas are composed of spindle cells and/or epithelioid melanoma cells (Figs 12-17, 12-18, 12-19). (aao.org)

Definitions: A low-grade spindle-cell neoplasm of the sinonasal tract associated with overlying respiratory epithelium and showing S100 protein and actin immunoreactivity The tumor often affects multiple sites within the upper aerodigestive tract, frequently showing extension into the orbit (25%) or through the cribriform plate (11%) of the ethmoid sinus into the skull base. (wikipedia.org)
The neoplastic cells are usually strongly reactive with S100 protein, SOX10, HMB45, Melan-A, and tyrosinase, while negative for SMA or MSA. (wikipedia.org)

Less commonly, balloon cells similar to those seen in choroidal nevi may be present. (aao.org)

It accounts 0.2 to 8% of all melanomas, 1.6% of all head and neck malignancies, and 0.5% of all oral neoplasia [1,2]. (waocp.com)

Histologically, the tumor is composed of sheets of cells with nuclear pleomorphism and areas of oncocytic appearance. (cap.org)

Histological regression is one or more areas within a tumor in which neoplastic cells have disappeared or decreased in number. (patholines.org)
In this case, it means complete or partial disappearance of neoplastic cells from areas of the dermis (and occasionally from the epidermis), which have been replaced by fibrosis, accompanied by melanophages, new blood vessels, and a variable degree of inflammation. (patholines.org)

6 ] Most uveal tract melanomas originate in the choroid. (cigna.com)

The cell morphology is mixed. (ox.ac.uk)
The HCL-Japanese variant form (jpHCL) is rare and less well defined: there are common points with vHCL but several aspects are different in terms of morphology of hairy cells, degree of leukocytosis or clinical course. (fortuneonline.org)

No abstract avDendritic cells (DC) are the most important antigen presenting cells and play a pivotal role in host immunity to infectious agents by acting as a bridge between the innate and adaptive immune systems. (uni-wuerzburg.de)

Diffuse distribution of cells, clear state. (cancerlive.net)

On microscopic histopathological analysis, elongated and spindle-shaped cells with a cigar-shaped nucleus are characteristic findings of leiomyoma. (wikidoc.org)

Clinical - think about malignant melanoma . (librepathology.org)

Inasmuch as artificial box C/D RNAs decreased viability of transfected human cells, we propose that natural snoRNAs as well as their artificial analogues can influence the maturation of complementary pre-mRNA and can be effective regulators of vital cellular processes. (hindawi.com)

3B-C) Lesion is composed of large epithelioid and oval cells admixed with abundant collagenous stroma. (atlasgeneticsoncology.org)

The patient received 20 sessions of radiotherapy (50 Gy) to the right maxillary antrum, and also immunological therapy (vaccination with autologous dendritic cells pulsed with allogenic tumour lysate, and whole body hyperthermia accompanied by low dose interferon). (bmj.com)

mix of small nests of cells, single cells. (librepathology.org)

Careful examination by an experienced clinician remains the most important test to establish the presence of intraocular melanoma. (cigna.com)

Unlike necrosis, an unregulated form of cell death caused by external physicochemical stress, necroptosis is highly regulated and acts as a defense mechanism or escape route for cells infected with viruses that inhibit apoptosis signaling proteins (examples of these viruses include the murine cytomegalovirus, West Nile virus, human immunodeficiency virus-1 (HIV-1), and herpes simplex virus). (bioradiations.com)

Splenic marginal zone lymphoma with circulating villous lymphoid cells (SMZL) is a distinct and very different pathological entity since the WHO 2008 classification: it is characterized by an expansion of the splenic white pulp with the infiltration of the red pulp. (fortuneonline.org)
For the gene family, see B-cell CLL/lymphoma . (wikipedia.org)

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