• PurposeUveal melanoma is the most common primary intraocular malignancy in adults with no effective systemic treatment option in the metastatic setting. (uni-muenchen.de)
  • The most frequently reported adverse events (selumetinib plus dacarbazine v placebo plus dacarbazine) were nausea (62% v 19%), rash (57% v 6%), fatigue (44% v 47%), diarrhea (44% v 22%), and peripheral edema (43% v 6%).Conclusion: In patients with metastatic uveal melanoma, the combination of selumetinib plus dacarbazine had a tolerable safety profile but did not significantly improve PFS compared with placebo plus dacarbazine. (uni-muenchen.de)
  • Among the tests included in the metastatic workup in a patient with choroidal melanoma are: Abdominal examination looking for hepatosplenomegaly . (symptoma.com)
  • associated with choroidal melanomas include vitreous hemorrhages or pigmented vitreous cells, drusen on the surface of the tumor, choroidal neovascular membranes, or even proptosis if the tumor invades the orbit. (symptoma.com)
  • If the melanoma involves the nail fold and the nail bed, complete excision of the nail unit might be required. (wikipedia.org)
  • The latter is likely due to nerve impingement, tissue necrosis or glaucoma (increased intraocular pressure ), caused by the melanoma. (symptoma.com)
  • If your melanoma is thin, your dermatologist may perform the melanoma surgery in a medical office or surgical suite while you are awake. (adv-derm-mohs.com)