Melanotic neuroectodermal tumor of infancy is a very rare oral cavity tumor that is seen in patients usually at or around birth. (wikipedia.org)
The only noteworthy laboratory value documented in some but not all patients with melanotic neuroectodermal tumor of infancy (MNTI) is an increase in the urinary level of vanillylmandelic acid (VMA). (medscape.com)
Plain dental radiography, CT scanning, and MRI have been used to evaluate the content and the extent of melanotic neuroectodermal tumor of infancy (MNTI). (medscape.com)
Upon completion of the clinical examination of the patient and the imaging studies and urinalysis, the definitive diagnosis of melanotic neuroectodermal tumor of infancy (MNTI) is based on the histologic evaluation of a surgical specimen. (medscape.com)
[ 28 ] Additionally, entrapped developing tooth buds may be noted in the specimen as the melanotic neuroectodermal tumor of infancy (MNTI) grows in and around the odontogenic apparatus. (medscape.com)
Epithelial7
The lesional cells will show cross reactivity with several different families of immunohistochemistry markers (polyphenotypic), including neural, melanocytic, and epithelial. (wikipedia.org)
While most tumors metastatic to the serous membranes are of epithelial origin, cytologists should be aware that non-epithelial neoplasms can also cause malignant effusions including sarcomas, melanomas, germ cell tumors, and, more rarely, brain tumors. (cytojournal.com)
Diagnosing non-epithelial malignancies in effusion specimens based entirely upon their cytomorphologic features is difficult because these neoplasms often exhibit considerable morphological overlap and their cytomorphology can differ from the original tumor. (cytojournal.com)
Most tumors metastatic to the serous membranes are of epithelial origin. (cytojournal.com)
Common non-epithelial neoplasms that may cause malignant effusions include malignant melanoma, sarcomas, and other neoplasms including germ cell tumors [ Figure 1 ]. (cytojournal.com)
Other rare non-epithelial malignancies that may be encountered in effusion cytology include neuroblastoma, Wilms tumor, and metastatic brain tumors. (cytojournal.com)
The classification of epithelial tumors of the kidney has in particular undergone substantial progress in the last two decades with major contributions from genetic typing of renal cell carcinomas (RCCs). (abdominalkey.com)
Neuroblastoma1
The differential diagnosis of a malignant effusion is accordingly broad, especially for the small round blue cell tumors that includes not only mesenchymal tumors, but also non-mesenchymal tumors, such as neuroblastoma and Wilms tumor. (cytojournal.com)
Lymphoma1
It is important in this age group to exclude other tumors that can have a similar appearance, such as rhabdomyosarcoma, lymphoma, Ewing sarcoma (primitive neuroectodermal tumor), or even a melanoma (although they are very very rare in infants). (wikipedia.org)
Pediatric2
The first section will cover those tumors that characteristically are associated with the pediatric population. (abdominalkey.com)
Comparative RNA-seq analysis aids in diagnosis of a rare pediatric tumor. (beds.ac.uk)
Immunohistochemistry1
The role of genotyping and ancillary tools, in particular immunohistochemistry, in correctly classifying these tumors is highlighted in the section on Renal Cell Carcinoma. (abdominalkey.com)
Neural1
It is thought to be derived from neural crest, which is one of the embryologic tissue types. (wikipedia.org)
Arise3
These melanocytic cells are of neuroectodermal origin, and melanocytic tumors may arise from these cells. (medscape.com)
A diverse array of tumors can arise in the human kidney. (abdominalkey.com)
Wilms tumor is believed to arise from embryonic tissues called nephrogenic rests that fail to undergo normal involution ( 7 ). (abdominalkey.com)
Malignant1
[ 12 ] The bone is destroyed as the tumor advances, suggesting a malignant process. (medscape.com)
Tissue1
A tumor (abnormal growth of tissue) of the nervous system. (beds.ac.uk)
Liver1
Wiedemann-Beckwith syndrome is related to abnormalities on chromosome 11p15 and characterized by multiple craniofacial anomalies, abdominal wall defects, and tumors of the genitourinary tract, liver, adrenal gland, and central nervous system among other abnormalities. (abdominalkey.com)
Bone1
however, most often, this nonencapsulated tumor shows local infiltration into the adjacent bone. (medscape.com)
Rare4
In rare cases, chemotherapy may be used for recurrent or residual tumors. (wikipedia.org)
This tumor is extremely rare, with fewer than 500 cases reported world wide. (wikipedia.org)
Together with mucus-secreting goblet cells within the stratified epithelium, melanocytic cells are found in the basal layer of the conjunctiva. (medscape.com)
Patients1
Patients with Beckwith-Wiedemann syndrome and Denys-Drash syndrome have an increased risk of developing Wilms tumor ( 5 , 6 ). (abdominalkey.com)
Brain1
1 - 3 Intracranial brain tumors, most commonly medulloblastoma [ Figure 2 ], can metastasize to the peritoneal cavity via ventriculo-peritoneal shunts used to divert excess cerebrospinal fluid. (cytojournal.com)
Group1
In this chapter, these will be covered using an approach that has become a standard one in dealing with this group of tumors. (abdominalkey.com)
Cell1
There are two cell types present (biphasic), arranged in alveolar or tubular configurations. (wikipedia.org)
9. Extrarenal rhabdoid tumors of soft tissue: a clinicopathologic and immunohistochemical study of 18 cases. (nih.gov)
As illustrated herein, the utilization of methylation profiling in the diagnostic process of some carefully selected unclassifiable soft tissue neoplasms may lead to an increased detection rate of such extremely rare soft tissue tumors and enable their better characterization. (bvsalud.org)
Cutaneous3
19. Ex vivo quality-switched ruby laser irradiation of cutaneous melanocytic lesions: persistence of S-100-, HMB-45- and Masson-positive cells. (nih.gov)
While CSM was first described as a cutaneous tumor, singular non-cutaneous cases have since been reported in bone. (bvsalud.org)
While the majority of tumors (75%, n = 18) occurred in skin, a significant subset (25%, n = 6) arose in non-cutaneous sites, including bone (n = 3), bronchus/trachea (n = 2), and interosseous membrane of tibia/fibula (n = 1). (bvsalud.org)
Melanoma1
It is important in this age group to exclude other tumors that can have a similar appearance, such as rhabdomyosarcoma, lymphoma, Ewing sarcoma (primitive neuroectodermal tumor), or even a melanoma (although they are very very rare in infants). (wikipedia.org)
Gastrointestinal2
Multiple dysplastic nevi and lentigines were reduced in number in a patient with familial gastrointestinal stromal tumors syndrome after treatment with imatinib mesylate. (medscape.com)
20. [Clinicopathologic and molecular characteristics of malignant gastrointestinal neuroectodermal tumors]. (nih.gov)
We report a case of a high-grade epithelioid tumor involving the synovium and soft tissues of the knee in a 74-year-old male patient. (bvsalud.org)
Clinical1
Even though there is often a very dramatic and rapidly enlarging, destructive tumor, there is usually a benign clinical course after complete local excision (usually by partial maxillectomy) with clear or free surgical margins. (wikipedia.org)
Extremely rare1
This tumor is extremely rare, with fewer than 500 cases reported world wide. (wikipedia.org)
Size1
Tumor size ranged from 0.4 to 5.9 cm. (bvsalud.org)
Cases2
In rare cases, chemotherapy may be used for recurrent or residual tumors. (wikipedia.org)
5. Clinicopathological, immunohistochemical, and ultrastructural study of 13 cases of melanotic schwannoma. (nih.gov)
Cell types4
There are two cell types present (biphasic), arranged in alveolar or tubular configurations. (wikipedia.org)
HER2, a tyrosine kinase receptor, is overexpressed by many cancer cell types. (nih.gov)
Upon administration of mipasetamab uzoptirine, mipasetamab binds to AXL, which is expressed on the surfaces of a variety of cancer cell types. (nih.gov)
DLL3, a Notch pathway protein, is overexpressed on a variety of cancer cell types. (nih.gov)
Found1
therapeutic_agents C1909 therapeutic_agents A C177537 GDC Value Terminology C175858 Tarlatamab A bispecific T-cell engager (BiTE) antibody composed of two single-chain variable fragments (scFv), one directed against the tumor-associated antigen (TAA) delta-like protein 3 (DLL3) fused to one that is directed against the CD3 antigen found on T-lymphocytes, with potential immunostimulating and antineoplastic activities. (nih.gov)