• We conclude that T311 is a specific and sensitive marker for the detection of melanocytic lesions in formalin-fixed paraffin-embedded tissues and a useful serological reagent for diagnostic pathology. (nih.gov)
  • Melanocytic lesions, such as blue nevi, are more common on the palate. (medscape.com)
  • Pigmented lesion are classified as non-melanocytic lesions and melanocytic lesions, and further classified as benign and malignant. (coherentmarketinsights.com)
  • The histological reports were evaluated for parameters associated with the lesion's diameter, location, subtype, operating setting (community clinics vs. hospital) and correlation with possible future appearance of malignant melanocytic lesions.Results. (ispub.com)
  • Such lesions may be a type of melanocytic neoplasm distinct from conventional melanocytic nevi and malignant melanoma [13]. (ispub.com)
  • In the present study we evaluated a series of melanocytic lesions histologically diagnosed as Spitz nevus in an 8-year period. (ispub.com)
  • TERT promoter hypermethylation) alterations of TERT (Telomerase Reverse Transcriptase) in rare cutaneous melanocytic tumors, including spitzoid and blue nevus-like melanomas to gain insights into these challenging melanocytic lesions. (mdanderson.org)
  • Loss of expression of protein kinase a regulatory subunit 1 alpha in pigmented epithelioid melanocitoma but not in melanoma or other melanocytic lesions. (medigraphic.com)
  • Background Even in experienced hands, the classification of some melanocytic lesions of the conjunctiva remains challenging. (bmj.com)
  • Conclusions FISH is very useful in classifying equivocal conjunctival melanocytic lesions, especially those with atypical junctional activity and naevoid melanocytic proliferations of the conjunctiva. (bmj.com)
  • Pathologists' Use of Second Opinions in Interpretation of Melanocytic Cutaneous Lesions: Policies, Practices, and Perceptions. (providence.org)
  • BACKGROUND: Research examining the role of second opinions in pathology for diagnosis of melanocytic lesions is limited. (providence.org)
  • OBJECTIVE: To assess current laboratory policies, clinical use of second opinions, and pathologists' perceptions of second opinions for melanocytic lesions. (providence.org)
  • MATERIALS AND METHODS: Cross-sectional data collected from 207 pathologists in 10 US states who diagnose melanocytic lesions. (providence.org)
  • The web-based survey ascertained pathologists' professional information, laboratory second opinion policy, use of second opinions, and perceptions of second opinion value for melanocytic lesions. (providence.org)
  • CONCLUSION: Use of second opinions in clinical practice is greater than that required by laboratory policies, especially for melanocytic tumors of uncertain malignant potential and atypical Spitzoid lesions. (providence.org)
  • The term benign melanocytic nevus refers to a heterogeneous group of nonmalignant melanocytic nevi manifesting either as pigmented or nonpigmented cutaneous lesions. (medscape.com)
  • Several signaling pathways, including receptor tyrosine kinases, have been recognized to have an etiopathogenetic role in the development and progression of precursor melanocytic lesions and malignant melanoma. (umn.edu)
  • Here we summarize our current understanding of this important receptor tyrosine kinase in normal melanocyte proliferation/motility, in tumor progression and metastasis, its genetic alterations in certain subtype of melanocytic lesions, and how its pathway has been explored for the development of selective inhibitors. (umn.edu)
  • The melanocytic proliferations : : a comprehensive textbook of pigmented lesions / A. Neil Crowson, Cynthia M. Magro, Martin C. Mihm Jr. (who.int)
  • Common non-epithelial neoplasms that may cause malignant effusions include malignant melanoma, sarcomas, and other neoplasms including germ cell tumors [ Figure 1 ]. (cytojournal.com)
  • We have studied the transgenic mouse strain, Tyrp-1-TAg, to try to gain insight into possible molecular mechanisms common to pigmented ocular neoplasms occurring spontaneously in the eyes of these mice and human choroidal melanoma. (molvis.org)
  • An unusual squamo-melanocytic tumor of uncertain biologic behavior: A variant of melanoma? (northwestern.edu)
  • Dive into the research topics of 'An unusual squamo-melanocytic tumor of uncertain biologic behavior: A variant of melanoma? (northwestern.edu)
  • Malignant melanoma with prominent pigment synthesis: animal type melanoma a clinical and histologycal study of six cases with a consideration of other melanocytic neoplasms with prominent pigment synthesis. (medigraphic.com)
  • Levene A. Disseminated dermal melanocytosis terminating in melanoma: a human condition resembling equine melanocytic disease. (medigraphic.com)
  • Zembowick A, Mihm C. Pigmented synthesizing melanocytic tumor animal/equine-type melanoma): a low-grade melanoma with marked resemblance to epithelioid blue nevus (Abstract). (medigraphic.com)
  • The "multidimensional" World Well being Group (WHO) classification 2018 of melanocytic tumors encompasses 9 melanoma pathways (seven of which for cutaneous melanoma) in accordance with a development mannequin wherein morphologically intermediate melanocytic tumors are cosidered as simulators and/or precursors to melanoma. (aprofarm.org)
  • Pigmented lesion is a skin disease usually referred to as melanocytic proliferations. (coherentmarketinsights.com)
  • Quality of care in surgical interventions for atypical melanocytic proliferations critically depends on the accuracy of diagnosis in pathology reporting. (providence.org)
  • We did not revealed any unique clinical features distinguishing Spitz nevus from other melanocytic nevi. (ispub.com)
  • Combined melanocytic nevi, comprising a Spitz nevus component in conjunction with another nevus type [usually acquired nevi] are not uncommon (Scolyer et al. (atlasgeneticsoncology.org)
  • The prototypical benign melanocytic nevus is the common acquired nevus, which typically appears within the first 6 months of life, reaches maximal size and number in young adulthood, then disappears with advancing age. (medscape.com)
  • In 1893, Paul Gerson Unna, a German dermatologist, presented the concept of Abtropfung , in which melanocytic nevus cells develop in the epidermis, then "drop off" into the dermis over time. (medscape.com)
  • It is now established that melanocytic nevus precursor cells are derived from neural crest tissue and migrate to and populate the developing epidermis of the embryo. (medscape.com)
  • [ 3 ] Assuming that all precursors reach their final destination, the epidermis would represent the only postnatal source of melanocytic nevus cells, thus supporting the concept of Abtropfung . (medscape.com)
  • Merkel cell carcinoma (MCC), squamous cell carcinoma (SCC), pigmented epithelioid melanocytoma (PEM), and other rare skin neoplasms have a well-known risk to spread to regional lymph nodes. (hindawi.com)
  • The histologic changes may be indistinguishable from conventional blue nevi or epithelioid blue nevi (EBN), a benign dermal-based melanocytic neoplasm with epithelioid morphology and heavily pigmented cytoplasm. (uky.edu)
  • There are several variants of cutaneous melanocytic tumors, characterized by differing clinical and pathologic features. (atlasgeneticsoncology.org)
  • Spitz tumors include a group of cutaneous melanocytic tumors that share certain histologic features. (atlasgeneticsoncology.org)
  • An integrative taxonomy of melanocytic neoplasms have grouped them into two major clades: those that arise from epithelium-associated melanocytes and those that arise from non-epithelium-associated melanocytes. (ubc.ca)
  • [ 10 ] Such alterations in genetic makeup and the cytokine milieu cause impairment of cellular signaling between keratinocytes and melanocytes, which presumably leads to the formation of melanocytic nevi. (medscape.com)
  • Therefore, the TNM (Tumor size, Nodal involvement, Metastases) system used for most non-CNS tumors is not commonly employed in the evaluation of CNS neoplasms. (medscape.com)
  • Due to this change, tumor grades more accurately reflect the cellular behavior and subsequent clinical course of each neoplasm. (medscape.com)
  • Diagnosing non-epithelial malignancies in effusion specimens based entirely upon their cytomorphologic features is difficult because these neoplasms often exhibit considerable morphological overlap and their cytomorphology can differ from the original tumor. (cytojournal.com)
  • It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. (lookformedical.com)
  • 79 Spitz nevi were excised between the years 1996-2004 out of 12,714 melanocytic nevi removed at the same period. (ispub.com)
  • In skin pathology, the recent application of fluorescence in situ hybridisation (FISH) has been demonstrated to be of use for the analysis and diagnosis of ambiguous melanocytic neoplasms of the skin. (bmj.com)
  • Detailed Pathology section describes common neoplasms in horses, cites research literature, and describes what is generally known about each condition. (vet-ebooks.com)
  • however, melanocytic hyperplasias or hamartomas are rare. (medscape.com)
  • Future research should examine the extent to which second opinions improve accuracy of melanocytic lesion diagnosis. (providence.org)
  • Melanocytic neoplasms occur spontaneously in many animals and are particularly frequent in certain breeds of horses, pigs, and dogs. (cancer.gov)
  • Congenital nevocellular (also called melanocytic) nevi can occur on the eyelids (Fig 17-12) and may cause visual deprivation amblyopia. (aao.org)
  • Because neoplasms in the CNS have widely varying features, clinical courses, and prognoses, a robust and reliable grading system is essential for the proper evaluation of CNS tumors. (medscape.com)
  • His clinical interests include melanocytic neoplasms, photoaging, and chronic venous insufficiency. (easterassociates.com)
  • Tyrosinase is a key enzyme in melanin biosynthesis and represents a marker of melanocytic differentiation. (nih.gov)
  • On the cellular level, melanocytic hyperplasia and increased melanin production are common observations in sun-exposed skin. (medscape.com)
  • Pathologists' Use of Second Opinions in Interpretation of Melanocytic " by Berta M Geller, Paul D Frederick et al. (providence.org)
  • While most tumors metastatic to the serous membranes are of epithelial origin, cytologists should be aware that non-epithelial neoplasms can also cause malignant effusions including sarcomas, melanomas, germ cell tumors, and, more rarely, brain tumors. (cytojournal.com)
  • As malignant cells have a tendency to round up in body fluids these non-epithelial neoplasms can therefore mimic reactive mesothelial cells and metastatic adenocarcinoma. (cytojournal.com)
  • 4 Malignant effusions caused by non-epithelial neoplasms are more frequently encountered in children than in adults. (cytojournal.com)
  • A primary malignant neoplasm of epithelial liver cells. (lookformedical.com)
  • Through my work, I aspire to contribute significantly to the field of Dermatopathology and ultimately improve patient outcomes by facilitating accurate diagnoses and prognostic assessments for cutaneous neoplasms. (mdanderson.org)
  • Histologic and Genetic Features of 51 Melanocytic Neoplasms With Protein Kinase C Fusion Genes. (nih.gov)
  • [ 2 ] This hypothesis detailed the sequential development of junctional, compound, and finally purely dermal melanocytic nevi. (medscape.com)
  • Melanocytic neoplasms represents a group of biologically distinct subtypes that display a wide phenotypic variation. (ubc.ca)
  • Aunque el melanocitoma epitelioide pigmentado frecuentemente metastatiza en los ganglios linf ticos, tiene mejor pron stico que los melanomas metast sicos convencionales. (medigraphic.com)
  • These biomarkers serve a dual purpose: to enhance diagnostic accuracy in routine Dermatopathology practice and to offer potential prognostic value in various cutaneous neoplasms. (mdanderson.org)
  • The pathogenesis of leiomyoma is characterized by benign smooth muscle neoplasm . (wikidoc.org)
  • FISH is an important diagnostic adjunct for melanocytic neoplasms. (uky.edu)
  • A Physician's Guide to the Use of Gene Expression Profile Ancillary Diagnostic Testing for Cutaneous Melanocytic Neoplasms. (cdc.gov)
  • Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. (lookformedical.com)
  • Melanocytic density has a regional variation. (medscape.com)
  • Methods 18 unequivocal retrospective melanocytic controls were exposed to FISH. (bmj.com)
  • Immunoreactivity was limited to cells of melanocytic differentiation and no immunostaining was present in unrelated normal tissues and tumors. (nih.gov)