• Immunopolarization of CD4+ and CD8+ T cells to Type-1-like is associated with melanocyte loss in human vitiligo. (ox.ac.uk)
  • High frequencies of melanocyte-reactive cytotoxic T cells in the peripheral blood of vitiligo patients and the observed correlation between perilesional T-cell infiltration and melanocyte loss in situ suggest the important role of cellular autoimmunity in the pathogenesis of this disease. (ox.ac.uk)
  • Perilesional T-cell clones (TCC) derived from patients with vitiligo exhibited a predominant Type-1-like cytokine secretion profile, whereas the degree of Type-1 polarization in uninvolved skin-derived TCC correlated with the process of microscopically observed melanocyte destruction in situ. (ox.ac.uk)
  • They are larger than typical melanocytes, do not have dendrites, and have more abundant cytoplasm with coarse granules. (wikipedia.org)
  • The way the researchers chose to target the enzymes in the melanocytes was through the topical compound forskolin, a derivative of the plant Coleus forskoleii. (cosmeticsandtoiletries.com)
  • 2 Presumably, it can arise from nests of melanocytes located either within the epithelium of the lacrimal sac or in the underlying stroma. (bmj.com)
  • Electron micrographs show no detectable differences in melanosome morphology or maturation between dilute and wild-type melanocytes. (pnas.org)
  • The symptoms of type II Griscelli syndrome have shown that Rab27 is involved in melanosome transport in melanocytes and in cytotoxic killing activity in cytotoxic T lymphoblasts. (wikipedia.org)
  • The melanocyte phenotype has been described as adendritic, since hair bulb and Harderian gland melanocytes appear to be rounded in tissue sections. (pnas.org)
  • In this way the melanocytes and kerationocytes together protect the tissue with melanin serving as a toxic defence- and cleaning agent. (wikipedia.org)
  • E ditor ,-Although the presence of melanocytes located within and under the epithelium of the nasal cavity and paranasal sinuses has been reported, it appears to be a rare finding. (bmj.com)
  • We have tested this hypothesis by culturing primary melanocytes from dilute mutant and wild-type mice. (pnas.org)
  • Melanocyte-stimulating hormone (MSH) activity was measured in the pituitaries of genetically obese and lean control mice using the frog skin bioassay. (springer.com)