Meiotic molecular gene frequency. Medical search. Frequent questions

Prior to the first meiotic division, homologous chromosomes pair, synapse, and recombine to ensure their proper disjunction at anaphase I. Additionally, telomeres tethered at the nuclear envelope cluster in the bouquet configuration where they are subjected to dramatic pulling forces acting from outside of the nucleus. (biorxiv.org)
Surprisingly, the nup2Δ ndj1Δ double mutant failed to segregate chromosomes, even though the meiotic program continued. (biorxiv.org)
A . Schematic of the bouquet configuration of chromosomes during meiotic prophase I. The spatial arrangement of chromosomes with telomeres clustered and attached at the inner nuclear membrane is shown. (biorxiv.org)
Recombination frequency in the proximal regions of most chromosomes of all karyotypes was much lower than in the other regions. (preprints.org)
The strong suppression of recombination in the pericentromeric regions and co-segregation of race specific chromosomes involved in the long chains would be expected to lead to linkage disequilibrium between genes located there. (preprints.org)
Crossing over between homologs is critical for the stable segregation of chromosomes during the first meiotic division. (bvsalud.org)
Another region required the presence of LDN 5B chromosomes in the female for preferential fertilization by male gametes harboring LDN alleles indicating that the corresponding genes in the female gametes can govern genes affecting segregation distortion of male gametes. (usda.gov)
As a result, important data about its genome organization and evolution were obtained, such as the lesser gene density of the large metacentric pair compared with the other metacentric chromosomes, which supports the theory of a sex proto-chromosome pair. (metasystems-international.com)
In addition, chromosomes with a high number of linked genes that are conserved, even in distant species, were detected. (metasystems-international.com)
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. (nature.com)
Because even small segments of chromosomes can span many genes, chromosomal disorders are characteristically dramatic and often fatal. (schleiden-eifel.de)
In the human genome, which is estimated to contain 25 000 genes, DNA is arranged into 24 distinct chromosomes (courtesy U.S. Department of Energy, Genome Management Information System). (thecanadianencyclopedia.ca)
During meiosis homologous chromosomes/sister chromatids and hence genes may move to a common gamete violating law of segregation. (stackexchange.com)

From these males, duplication and deletion alleles were obtained at high frequency by trans-allelic meiotic recombination. (geneimprint.com)
Gene drive alleles, which bias their own inheritance and increase in frequency, show great promise for blocking disease transmission or directly suppressing pest populations. (geneconvenevi.org)
Curated mutant alleles for the specified gene, listed alphabetically. (yeastgenome.org)
At least three distinct meiotic drive alleles, one on each S. kambucha chromosome, independently contribute to hybrid infertility by causing nonrandom spore death. (elifesciences.org)
In addition, it provides further support for models in which genetic conflicts, such as those caused by meiotic drive alleles, can drive speciation. (elifesciences.org)
Discontinuous variation often can be explained genetically by different forms of a gene called alleles: in an example from peas, Y is the allele for the yellow phenotype, and y for green. (thecanadianencyclopedia.ca)
1. Sexually antagonistic (SA) alleles are genes that are advantageous to one sex but detrimental when expressed in the other. (exeter.ac.uk)
The elegant and original use of a probabilistic model of segregating alleles (implemented in the SEX-DETector method) allowed to identify both the sex and self-incompatibility loci [4], while this tool was initially developed for detecting sex-linked genes in species with strictly separated sexes (dioecy) [5]. (peercommunityin.org)
A typical and interesting case is when the fitness depends on the frequency of alleles in the population. (stackexchange.com)
Meiotic drive is a type of intragenomic conflict, whereby one or more loci within a genome will affect a manipulation of the meiotic process in such a way as to favor the transmission of one or more alleles over another, regardless of its phenotypic expression. (stackexchange.com)
A second contributor of variation is single nucleotide polymorphism (SNP), in which two distinct alleles are possible at a single genome position, with each allele appearing at high frequency within the population. (mlo-online.com)

www.thecanadianencyclopedia.ca/en/article/genetics. (thecanadianencyclopedia.ca)
Genetics may be conveniently divided into 3 areas of study: transmission genetics, molecular genetics and population genetics. (thecanadianencyclopedia.ca)
Transmission genetics is concerned with identifying the genes that affect a particular characteristic, and also the patterns by which these genes are transmitted from generation to generation, or from cell to cell. (thecanadianencyclopedia.ca)
Molecular genetics focuses on the structure and function of the genetic units, ie, the chemical composition of genes and their expression in determining the structure of proteins, the most important functional components of cells. (thecanadianencyclopedia.ca)
Population genetics analyses the pattern of distribution of genes in populations of organisms, and changes in the genetic structure of populations. (thecanadianencyclopedia.ca)
We further discussed the molecular genetics basis of postzygotic reproductive isolation and the evidence derived from analyses of applying population genomic data, including BDMI (Bateson-Dobzhansky-Muller incompatibility), QTLs (quantitative trait loci) analysis, Haldane's rule and the large X-chromosome effects. (biodiversity-science.net)
Embarking on molecular genetics, biochemistry and cytogenetic approaches, the overarching aim of the group is to alter the outcome of meiotic recombination with a focus on barley. (ipk-gatersleben.de)
This article is part of a Special Issue entitled: Molecular Genetics of Human Reproductive Failure. (infertile.com)

Here we identified Nup2 in a pool of enriched proteins that co-purify with tagged Ndj1 from meiotic cell extracts. (biorxiv.org)
Using immunolocalisation of the meiotic proteins, we examined chromosome pairing and recombination in males from the hybrid zone. (preprints.org)
Although senataxin's role in cells is not completely understood, it appears to be involved in the production of proteins from genes (transcription), the processing of RNA molecules, and the repair of damaged DNA. (medlineplus.gov)
Senataxin plays an essential role with DNA damage response proteins in meiotic recombination and gene silencing. (medlineplus.gov)
Occupational exposure limits with proteins such as topoisomerase inhibitors, and mitotic and meiotic spindle poisons. (cdc.gov)

On this examine, human frequent oral epithelial (HNOE) cells, NanoString PanCancer Pathways panel of 770 gene transcripts and quantitative real-time polymerase chain response (qRT-PCR) evaluation had been utilized to hunt out differentially expressed genes (DEG) modulated by WPS. (stjosephs-hospital.com)
RNA-seq analysis displayed a total of 5606 differentially expressed genes (DEGs) in ny1 compared to wild type (H1) during meiosis, of which 2977 were up-regulated and 2629 were down-regulated. (biomedcentral.com)

The events of meiotic prophase follow a specialized round of DNA replication when the meiotic chromosome axis is formed. (biorxiv.org)
this is due to higher rates of degeneration of germ cells during meiotic prophase. (iiab.me)

Allelic gene conversion occurs during meiosis when homologous recombination between heterozygotic sites results in a mismatch in base pairing. (wikipedia.org)
Moreover, 478 meiosis-related genes displayed down-regulation at same stage, including 9 important meiosis-related genes, such as OsREC8, OsSHOC1, SMC1, SMC6a and DCM1 , and their expression levels were validated by qRT-PCR. (biomedcentral.com)

One of the unique insights provided by the growing number of fully sequenced genomes is the pervasiveness of gene duplication and gene loss. (philpapers.org)
In addition, these findings provide further support for models in which conflicts between different genes in genomes can drive the process of speciation. (elifesciences.org)
The ongoing annotation of these genomes should spark a new wave of interest in the DED pathosystem, as it should lead to the formal identification of genes modulating parasitic fitness. (sisef.it)

Here we report our molecular and phenotypic analysis of the 300kb deletion (delta), the structure of which was confirmed by molecular analysis and DNA FISH. (geneimprint.com)
2,3 An additional exciting milestone was even more recently achieved when two independent research teams discovered GAA repeat expansions in an intron of the FGF14 gene, encoding Fibroblast Growth Factor 14, as a cause of another LOCA subtype (SCA27B) with a seemingly broader phenotypic spectrum. (movementdisorders.org)
Individual genes can be identified through phenotypic inheritance patterns, but only if some variation is present in the phenotype. (thecanadianencyclopedia.ca)

Here, we show that MSH2 is a master regulator of meiotic DSB repair in Arabidopsis, with antagonistic effects on interfering and non-interfering crossovers, which shapes the crossover landscape in relation to interhomolog polymorphism. (bvsalud.org)
Here, we establish and decipher the function of the Arabidopsis thaliana HEIP1 homolog in meiotic crossover formation and report its wide conservation in eukaryotes. (bvsalud.org)
We show that the loss of Arabidopsis HEIP1 elicits a marked reduction in meiotic COs and their redistribution toward chromosome ends. (bvsalud.org)
We use mathematical modelling and quantitative super-resolution microscopy to explore and mechanistically explain meiotic crossover pattering in Arabidopsis lines with full, incomplete, or abolished synapsis. (bvsalud.org)
Deciphering the Impact of a Bacterial Infection on Meiotic Recombination in Arabidopsis with Fluorescence Tagged Lines. (metasystems-international.com)
High temperature increases centromere-mediated genome elimination frequency and enhances haploid induction in Arabidopsis. (ipk-gatersleben.de)
TurboID-based proteomic profiling of meiotic chromosome axes in Arabidopsis thaliana. (ipk-gatersleben.de)

Contained in the nematode Caenorhabditiselegans one injection into every of the 2 gonad arms of an grownup hermaphrodite exposes tons of of meiotic germ cells to modifying mixtures, allowing the restoration of a number of indels or small precision edits from every successfully injected animal. (stjosephs-hospital.com)

Recombination also occurs between homologous sequences present at different genomic loci (paralogous sequences) which have resulted from previous gene duplications. (wikipedia.org)
NEW YORK (GenomeWeb) - As liquid biopsy products make further inroads in the clinic and in clinical research, rather than coalescing around a few dominant technologies or platforms, investigators and entrepreneurs are continuing to explore and advance a wide range of methods for examining genomic and other molecular biomarkers non-invasively. (genomeweb.com)

Using molecular markers, we evaluated segregation distortion and recombination frequency along chromosome 5B in wheat. (usda.gov)
Segregation distortion genes are widespread in plants and animals and function by their effect on competition among gametes for preferential fertilization. (usda.gov)
In this study, we evaluated the segregation distortion of molecular markers in multiple reciprocal backcross populations derived from unique cytogenetic stocks involving the durum cultivar Langdon (LDN) and wild emmer accessions that allowed us to study the effects of chromosome 5B in isolation. (usda.gov)

This study [4] paves the way for identifying the genes controlling the sex and self-incompatibility phenotypes and for understanding why and how self-incompatibility is only expressed in hermaphrodites and not in males. (peercommunityin.org)

The mechanism that has carried the derived inversion haplotypes to such high allele frequencies remains elusive. (biomedcentral.com)
The main topics that will be covered are the basic laws of allelic distribution, the processes that change allele frequencies, with special emphasis on mutation and recombination, and the mechanisms of extinction and speciation. (jku.at)

Over the summer, I will phenotype and genotype experimental males from a Drosophila miranda population with a putative meiotic driver and perform a Quantitative Trait Locus (QTL) analysis to identify the region(s) in the genome associated with meiotic drive. (berkeley.edu)
The recent evolutionary history of the Y chromosome in Drosophila simulans, a worldwide species of Afrotropical origin, is closely linked to that of X-linked meiotic drivers (Paris system). (geneconvenevi.org)
Others, for example the famous 3RP inversion of Drosophila melanogaster, are several megabases in size, include several percent of the entire genome and span hundreds or thousands of genes. (schleiden-eifel.de)
Drosophila pseudoobscura (X-linked meiotic driver genes causing female biased sex ratios) and D. melanogaster and D. simulans (the cytoplasmic maternally inherited bacterium Wolbachia causing reduced hatching success, CI). (exeter.ac.uk)

At least 125 mutations in the SETX gene have been found to cause ataxia with oculomotor apraxia type 2. (medlineplus.gov)
DNA/RNA helicase gene mutations in a form of juvenile amyotrophic lateral sclerosis (ALS4). (medlineplus.gov)
Inversions are intrachromosomal structural mutations which result in the reversal of gene order (and no change in the genic content of a chromosome) [ 4 ]. (biomedcentral.com)

The Fxy or Mid1 gene in some mammals closely related to house mice (humans, rats, and other Mus species) is located in the sex-linked region of the X chromosome. (wikipedia.org)
A total of 93 BAC clones were used to localize the chromosome complement of the species and 588 genes were annotated, thus almost reaching the 2.5% of the genome sequences. (metasystems-international.com)
in specimens were genetically characterized at the species level by PCR-restriction fragment length polymorphism analysis of the small subunit rRNA gene ( 14 ) and at the subtype level by DNA sequence analysis of the gp60 gene ( 15 ). (cdc.gov)
These annotations have been derived from physical molecular interaction evidence extracted from the literature and cross-referenced in the entry, or by curator inference from information on homologs in closely related species or by inference from scientific background. (yeastgenome.org)
Nina's work on fruit flies demonstrates that so-called sperm competition controls the number of selfish genes in a population and stops species from going extinct. (exeter.ac.uk)

Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis. (medlineplus.gov)
Nonetheless, the underlying molecular pathways and/or objective genes accountable for the carcinogenic course of are nonetheless unknown. (stjosephs-hospital.com)

1 However, in 2019, a new milestone in the field was reached when biallelic repeat expansions (mainly involving AAGGG repeats) were found in an intron of the RFC1 gene, encoding Replication Factor C subunit. (movementdisorders.org)
The meiotic topoisomerase VI B subunit (MTOPVIB) is essential for meiotic DNA double-strand break formation in barley (Hordeum vulgare L.). Plant Reprod. (ipk-gatersleben.de)

Meiotic crossovers can be formed through the interfering pathway, in which one crossover prevents another from forming nearby, or by an independent non-interfering pathway. (bvsalud.org)
The shuffling of genetic material facilitated by meiotic crossovers is a critical driver of genetic variation. (bvsalud.org)
Many environmental, genetic, and epigenetic factors are known to affect the frequency and positioning of meiotic crossovers (COs). (earlham.ac.uk)

Retrospective studies of the survivors of famines, such as those exposed to the Dutch Hunger Winter of 1944-45, have linked exposures around conception to later disease outcomes, some of which correlate with DNA methylation changes at certain genes. (frontiersin.org)

In silico evaluation was carried out to analysis the have an effect on of those genes in HN most cancers affected explicit particular person's biology and consequence. (stjosephs-hospital.com)
With stem cell biology and molecular understanding of reproductive failure, new therapies for previously untreatable infertility are currently on the near horizon. (infertile.com)

The cluster organization of the NLR gene family could favor sequence exchange between NLR genes via recombination, favoring their evolutionary dynamics. (metasystems-international.com)
Identifying the molecular and evolutionary bases of hybrid sterility is necessary for understanding the mechanisms of speciation. (elifesciences.org)

These analyses have also helped identify genes that were differentially expressed in DED fungi grown under defined experimental conditions. (sisef.it)

Meiotic recombination is initiated through formation of a double-strand break (DSB). (wikipedia.org)

Taken together, these results will aid in identifying the key genes associated with pollen fertility, which offered insights into the molecular mechanism underlying pollen development in tetraploid rice. (biomedcentral.com)
However, the molecular mechanism of these genes underlying pollen fertility process remained largely unknown in tetraploid rice. (biomedcentral.com)
Transcriptome analysis can provide valuable insights into rice pollen development by detecting gene regulation. (biomedcentral.com)
The characteristics of genetic regulation in pollen development have been analyzed using reliable pollen development networks and novel pollen development-related genes. (biomedcentral.com)
Development and application of Crystal Digital PCR-based single pollen nucleus genotyping to measure meiotic recombination rates in barley (Hordeum vulgare) in high-throughput. (ipk-gatersleben.de)
High throughput measuring of meiotic recombination rates in barley pollen nuclei using Crystal Digital PCR TM. (ipk-gatersleben.de)

The fragile Y hypothesis: Y chromosome aneuploidy as a selective pressure in sex chromosome and meiotic mechanism evolution. (philpapers.org)
Using experiments and computer simulation, we show that the molecular mechanism relies on a self-organizing system, which is able to generate particular patterns (different numbers of spores) in dependency on one single stimulus (gradually increasing amounts of SPB constituents). (rupress.org)
However, the molecular genetic mechanism underlying the fertility remains largely unknown. (biomedcentral.com)

The sex ratio (SR) X-linked meiotic drive system in stalk-eyed flies destroys Y-bearing sperm. (geneconvenevi.org)
Somatic and gonadal mosaicism of the Huntington disease gene CAG repeat in brain and sperm. (nature.com)
Sperm samples not leading to a pregnancy, in particular in the OAT group, had significantly more epimutations in the paternally methylated GTL2 gene than samples leading to a live birth. (uni-wuerzburg.de)

Most of the current knowledge on gene expression and regulation during plant embryo. (earlham.ac.uk)
DNA methylation is an epigenetic modification that plays an important role in gene regulation. (uni-wuerzburg.de)

In contrast, interactions between genes and the environment cannot usually be studied using conventional mapping populations in which each animal is unique. (nervenet.org)
We inferred that selfing or inbreeding could drive speciation via either increasing population genetic differentiation or impeding gene flow between populations of different mating systems, or both. (biodiversity-science.net)
Fig. 3 Allopatric speciation: The two populations evolve independently due to geographical isolation (without gene flow) and eventually produce reproductive isolation. (biodiversity-science.net)

We identified by linkage disequilibrium and recombination analyses only limited genetic recombination, which occurred exclusively within the 60-kDa glycoprotein gene subtype IbA10G2, a predominant subtype for outbreaks in industrialized nations and a virulent subtype in the study community. (cdc.gov)

Genic differentiation, together with the high frequency of pairing aberrations in male carriers of the long chains, might contribute to maintenance of the narrow hybrid zone. (preprints.org)

Such changes may result in quantitative alteration of genes or rearrangement of genes. (schleiden-eifel.de)
In this study, we performed quantitative methylation analyses of six differentially methylated imprinted genes (H19, MEG3, LIT1, NESP55, PEG3 and SNRPN), one hypermethylated pluripotency gene (OCT4) and one hypomethylated tumor suppressor gene (APC) in chorionic villus, fetal and adult cortex, and adult blood samples. (uni-wuerzburg.de)
Quantitative PCR and high-throughput methods, such as expressed sequence tag analysis, have been used for measuring gene expression and identifying subsets of elm genes that are differentially expressed in the presence of O. novo-ulmi . (sisef.it)

In all tested intervals, no significant difference in genetic recombination frequency between infected and control plants was observed. (metasystems-international.com)

In this paper, we review current understanding of gene family evolution including: methods for inferring copy number change, evidence for adaptive expansion and adaptive contraction of gene families, the origins of new families and deaths of previously established ones, and finally we conclude with a perspective on challenges and promising directions for future research. (philpapers.org)

Certain mammalian genes undergoing concerted evolution (for example, ribosomal operons, tRNAs, and histone genes) are very GC-rich. (wikipedia.org)
It has been shown that GC content is higher in paralogous human and mouse histone genes that are members of large subfamilies (presumably undergoing concerted evolution) than in paralogous histone genes with relatively unique sequences. (wikipedia.org)

Since then, "homeostasis" has been offered as the explanation for a variety of observations that demonstrate a degree of independence of crossover frequency (and sometimes crossover interference) from the frequency of double-strand breaks. (fieldofscience.com)

Gene conversion is the process by which one DNA sequence replaces a homologous sequence such that the sequences become identical after the conversion event. (wikipedia.org)
Gene conversion occurring between paralogous sequences (ectopic gene conversion) is conjectured to be responsible for concerted evolution of gene families. (wikipedia.org)
Indeed, several metrics now suggest that rates of gene birth and death per gene are only 10-40% lower than nucleotide substitutions per site, and that per nucleotide, the consequent lineage‐specific expansion and contraction of gene families may play at least as large a role in adaptation as changes in orthologous sequences. (philpapers.org)

Genome Variation and Molecular Epidemiology of Salmonella enterica Serovar Ty. (earlham.ac.uk)

Both average methylation level and range of methylation variation depended on the gene locus, tissue type and/or developmental stage. (uni-wuerzburg.de)
the greater the number of genes involved, the greater the possible range of variation. (thecanadianencyclopedia.ca)

Stalk-eyed flies in the genus Teleopsis carry selfish genetic elements that induce sex ratio meiotic drive (SR) and impact the fitness of male and female carriers. (geneconvenevi.org)

For example, butanol pathway genes from Clostridia were introduced into E. While the introduction of what is better generic or brand starlix 60mg heterologous buy starlix without prescription genes is well established, a major challenge is the disruption of competing metabolic fluxes. (east.ru)
For example, butanol pathway genes from Clostridia were introduced into E. While the introduction of heterologous genes is well established, a major what is better generic or brand starlix 60mg challenge is the case of bioethanol. (east.ru)

Sexual selection could make the genes expressed in males evolve more rapidly than the genes expressed in females. (biodiversity-science.net)
Caenorhabditis elegans gene him-8 , high Incidence of Males, encoding HIM-8 like family member. (nih.gov)

Unfortunately, over the last ten years databases of RI genotypes have accumulated a high frequency of errors. (nervenet.org)
1] Saumitou-Laprade P, Vernet P, Vassiliadis C, Hoareau Y, Magny G de, Dommée B, Lepart J (2010) A Self-Incompatibility System Explains High Male Frequencies in an Androdioecious Plant. (peercommunityin.org)
This is the reason behind deviation of dihybrid test cross ratio from 1:1:1:1 and occurrence of parental combination in high frequencies. (stackexchange.com)
High frequency of genetic/epigenetic disorders in short stature children born with very low birth weight. (cdc.gov)
The 21-Gene Recurrence Score in Clinically High-Risk Lobular and Ductal Breast Cancer: A National Cancer Database Study. (cdc.gov)

No visible phenotype was observed upon paternal or maternal transmission of the deletion, which encompasses the Th gene. (geneimprint.com)

A distinct ZmFCP1-FEA3 ligand-receptor combination, originally identified in maize, prevents WUS gene expression in the region below the OC (also called rib zone, RZ), thus confining WUS expression within the OC of meristems 6 . (nature.com)

Gene conversion can be either allelic, meaning that one allele of the same gene replaces another allele, or ectopic, meaning that one paralogous DNA sequence converts another. (wikipedia.org)
Ia, Ib, Id, Ie, If, Ig) identified by sequence analysis of the 60-kDa glycoprotein (gp60) gene, the Ib subtype is the major subtype responsible for waterborne and foodborne outbreaks of cryptosporidiosis in many countries. (cdc.gov)
Basic sequence-derived (length, molecular weight, isoelectric point) and experimentally-determined (median abundance, median absolute deviation) protein information. (yeastgenome.org)
Epigenetic marks are heritable DNA modifications that can influence gene expression without changing the DNA sequence. (frontiersin.org)
Until recently, however, functional analysis of the DED fungi was hampered by the lack of protocols for efficient gene knockout and by the unavailability of a full genome sequence. (sisef.it)

The recessive genes are exposed in XY individuals to produce sterility or infertility but are masked by dominant genes in XX individuals. (biodiversity-science.net)

These results indicate the existence of different distorter/meiotic drive elements among different genotypes and show that distortion factors along wheat chromosome 5B differ in chromosomal location as well as underlying mechanisms. (usda.gov)

This is reflected in the widespread use of the aCGH platform, a molecular cytogenetic approach for detecting and locating any net gains or losses of genetic material. (mlo-online.com)

However, particularly in cereal crops including barley meiotic recombination events are limited and skewed towards chromosome ends whereby a large portion of the genetic information keeps untapped in breeding programs. (ipk-gatersleben.de)

may be especially important in our own evolution since it appears that the "revolving door" of gene duplication and loss has undergone multiple accelerations in the lineage leading to humans. (philpapers.org)
Phylogenetic information inferred from the study of homologous genes helps us to understand the evolution of genes and gene families, including the identification of ancestral. (earlham.ac.uk)

However, few meiotic drive systems have been characterized at the molecular genetic level, thus limiting the development of synthetic drivers. (berkeley.edu)
Gene drive technology could see this become a reality. (mdpi.com)
The realisation of robust gene drive strategies in vertebrate pests has the potential to revolutionise biocontrol. (mdpi.com)
The first observations of the skewed inheritance patterns that are characteristic of what we now refer to as 'gene drive' were made by a Russian researcher. (geneconvenevi.org)
In the late 1950's a type of 'gene drive' known as 'meiotic drive' was discovered. (geneconvenevi.org)
Scientists quickly realized that 'meiotic drive' might be used to control insect pests. (geneconvenevi.org)
While notable and important research in the early 21st century is frequently cited as foundational to the history of 'gene drive', the timeline presented here illustrates that important ideas originated long before. (geneconvenevi.org)
Contemporary genetic biocontrol research and development, including gene drive, is a culmination of work beginning in the early 20th century. (geneconvenevi.org)
First proposed the use of homing endonucleases as gene drive platforms. (geneconvenevi.org)
Rhoades (1942) made the first recorded observation of 'meiotic drive' in plants while studying maize. (geneconvenevi.org)
More simply, meiotic drive is when one copy of a gene is passed on to offspring more than the expected 50% of the time. (stackexchange.com)

2000). The main advantage in this context is that the complex genetic and epigenetic correlations among interconnected parts of the brain can be explored using complementary molecular, developmental, structural, pharmacological, and behavioral techniques. (nervenet.org)
DNA methylation is the most commonly studied epigenetic mark in humans, as it is well recognised as a stable, heritable mark that can affect genome function and influence gene expression. (frontiersin.org)

This phenotype was rescued by providing exogenous L-DOPA during gestation, to bypass the requirement for the deleted tyrosine hydroxylase gene. (geneimprint.com)

This is regulated by the concentration of three structural meiotic SPB components, which is dependent on available amounts of carbon source. (rupress.org)

Low frequency of ESRRA-C11orf20 fusion gene in ovarian carcinomas. (nih.gov)

Inactivation of the mouse Huntington's disease gene homolog hdh . (nature.com)
While the selective inactivation of Ophiostoma genes by insertional mutagenesis remains a challenge, an alternative approach based on RNA interference is now available for down-regulating the expression of targeted genes. (sisef.it)

begingroup$ Another e.g worth including Sex-linked genes, they do not follow mendelian law of Dominance. (stackexchange.com)

Genetic and molecular analyses have led to the identification, cloning and characterization of a few genes that contribute to parasitic fitness in the pathogens. (sisef.it)

developmental language disorders are genetic and is therefore caused (at least in part) by the genes passed on from parents to children. (brookes.ac.uk)

2013), a human cell gene mutation assay in the TK locus (Budinsky et al. (europa.eu)
A human cell gene mutation assay in the HPRT locus is also available, although experimental methodology is limited (Budinsky et al. (europa.eu)
Vinyl acetate was negative in bacterial gene mutation assays using Salmonella typhimurium TA98, TA100, TA1535 and TA1537, with and without rat liver S-9 activation. (europa.eu)
Vinyl acetate was shown to be negative in bacterial gene mutation assays using Salmonella typhimurium TA98, TA100, TA1535 and TA1537, with and without rat liver S-9 activation. (europa.eu)

1 However, CNVs occurring within coding or regulatory regions of the genome can also have an adverse effect on gene expression. (mlo-online.com)

This project has important implications for our understanding of the genetic structure of natural meiotic drivers. (berkeley.edu)

The final consensus maps are based on 1578 microsatellite loci and these maps have a cumulative length of approximately 1400 cM after adjustment for recombination frequencies of RI strains. (nervenet.org)

Anatomy1

Diseases1

Chemicals and Drugs7

Analytical, Diagnostic and Therapeutic Techniques and Equipment10

Psychiatry and Psychology1

Phenomena and Processes25

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Information Science3

Named Groups5

Health Care2

Geographicals1

Chromosomes13

Alleles11

Genetics8

Proteins5

Differentially expressed genes2

Prophase2

Meiosis2

Genomes3

Phenotypic3

Arabidopsis7

Germ cells1

Genomic2

Segregation3

Phenotypes1

Allele frequencies2

Drosophila4

Mutations3

Species5

Pathways2

Subunit2

Crossovers3

Methylation changes1

Biology2

Evolutionary2

Identify genes1

Double-strand break1

Pollen6

Mechanism3

Sperm3

Regulation2

Populations3

Linkage1

Differentiation1

Quantitative3

Recombination frequency1

Adaptive1

Histone2

Crossover Frequency1

Sequences3

Genome Variation1

Variation2

Selfish1

Pathway2

Males2

High5

Paternal1

Distinct1

Sequence5

Sterility1

Genotypes1

Cytogenetic1

Chromosome ends1

Evolution2

Drive11

Epigenetic2

Phenotype1

Structural1

Carcinomas1

Inactivation2

Mendelian1

Analyses1

Developmental1

Mutation4

Expression1

Genetic structure1

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