7 Pentavalent antimonials such as sodium stibogluconate and meglumine antimoniate are the most commonly prescribed treatment and are the first-line treatment in many parts of the world but are not available in the US. (dermatologyadvisor.com)
Alternatives include amphotericin B deoxycholate and pentavalent antimony compounds ( sodium stibogluconate or meglumine antimoniate) if disease was acquired in areas where Leishmania species are likely to be susceptible. (msdmanuals.com)
In addition to this, the widespread adoption of effective drugs, such as sodium stibogluconate and meglumine antimoniate, since they work by inhibiting the mitochondrial function of unhealthy organisms and preventing disease progression, is acting as another significant growth-inducing factor. (imarcgroup.com)
Systemic meglumine3
The patient, who had not previously undergone any treatment for cutaneous leishmaniasis, was treated with systemic meglumine antimoniate (Glucantime, Aventis, France) 20 mg/kg per day intramuscularly for 20 days. (who.int)
This patient had also not been treated for leishmaniasis before and was treated similarly with systemic meglumine antimoniate (Glucantime, Aventis, France) 20 mg/kg per day intramuscularly for 20 days. (who.int)
It was the use of PCR that for leishmaniasis before and was treated al owed us to establish the diagnosis similarly with systemic meglumine anti- and identify the parasite responsible for moniate (Glucantime, Aventis, France) the lesions as L. major . (who.int)
Leishmaniasis3
Imiquimod in combination with meglumine antimoniate for cutaneous leishmaniasis: a randomized assessor-blind controlled trial. (ac.ir)
Las leishmaniasis son enfermedades infecciosas desatendidas de gran importancia en la Región de las Américas debido a su morbilidad, mortalidad y amplia distribución geográfica. (bvsalud.org)
The authors are all members of the Leishmaniasis East Africa Platform and are currently engaged in the clinical development of paromomycin for treatment of visceral leishmaniasis. (plos.org)
and two new medicines have been included in the WHO Model List of Essential Medicines (17th edition) (paromomycin in 2007, and liposomal amphotericin B in 2008). (who.int)
Topical1
Other drugs that can be used include pentamdine isethionate, topical paramomycin and allopurinol. (ijpmonline.org)
Treatment1
We determine the peak of infection after an oral challenge, the efficacy of paromomycin treatment, the intestinal tract localization, and the cues that trigger excystation. (bvsalud.org)
Disease1
Infected mice treated with paromomycin, an antibiotic used against noninvasive intestinal disease, do not become colonized by E. muris. (bvsalud.org)
Glucantime1
Since the use of pentavalent antimonial compounds such as meglumine antimoniate (Glucantime, MA) for the treatment of CL has side effects, naloxone as a new treatment in the footpad of Leishmania major (L. major)-infected BALB/c mice was investigated by evaluating the lesion size and the parasite burden. (bvsalud.org)
Miltefosine1
Thirty-two compounds were developed following an economical synthetic route, achieving small molecules, with structural characteristics similar to those present in antileishmanial drugs such as miltefosine (MIL) and paromomycin (PMN). (bvsalud.org)
Lesions3
Fourteen patients with a total of 84 lesions received national standard treatment of weekly intralesional meglu- mine antimoniate with biweekly cryotherapy, or daily intramuscular meglumine antimoniate (20 mg/kg/day for 14 days), and topical Lip-AmB 0.4% twice daily for 28 days. (who.int)
Thirty patients with a total of 68 lesions received national stand- ard treatment of weekly intralesional meglumine antimoniate (to blanch around the lesion) and biweekly cryotherapy. (who.int)
METHODS: Travelers with 1-10 lesions of confirmed CL were prospectively treated with the paromomycin-gentamicin formulation (WR279396, 2012-2017, Group 1) and carefully follow up, or treated with a locally produced paromomycin-only cream (2018-2022, Group 2). (bvsalud.org)