Megakaryocyte progenitor cells. Medical search. Frequent questions

The shortage of donors and the potential of universal HLA-null platelet products have stimulated research on the ex vivo differentiation of human pluripotent stem cells (hPSCs) to platelets. (hokudai.ac.jp)
Research Objective Our research will determine how aging of human blood stem cells leads to dramatic increases in disorders of platelets, cells that normally prevent bleeding but form harmful clots when dysregulated. (ca.gov)
Stimulates proliferation and differentiation of megakaryocytes from bone marrow progenitor cells, resulting in an increased production of platelets. (medscape.com)
Myeloproliferative neoplasms are a group of diseases of the bone marrow characterized by excessive production of red blood cells, platelets, or certain white blood cells. (merck.com)
Comprehensive phenotyping of human platelets by single-cell cytometry. (umassmed.edu)
Platelets are released from megakaryocytes (MKs) in the bone marrow and circulate as anucleate blood cells with a diameter of about 2-4 μm. (biomedcentral.com)
Identifying causal variants and genes from human genetic studies of hematopoietic traits is important to enumerate basic regulatory mechanisms underlying these traits, and could ultimately augment translational efforts to generate platelets and/or red blood cells in vitro. (biomedcentral.com)
Platelets originate from megakaryocytes, which are the largest progenitor cells of the bone marrow. (teachmephysiology.com)
They have the ability to give rise to all types of blood cells, including white blood cells, red blood cells, and platelets. (differencebetween.com)
Many of the clinical complications of PV relate directly to the increase in blood viscosity associated with red cell mass elevation and indirectly to the increased turnover of red cells, leukocytes, and platelets with the attendant increase in uric acid and cytokine production. (basicmedicalkey.com)

Hematopoietic stem cells can differentiate into one of two progenitor cells: the common lymphoid progenitor and the common myeloid progenitor. (wikipedia.org)
These multipotent progenitor cells differentiate into either common myeloid progenitor (CMP) or common lymphoid progenitor cells (CLP). (differencebetween.com)

Megakaryocyte-erythroid progenitor cells, among other blood cells, are generated as a result of hematopoiesis, which occurs in the bone marrow. (wikipedia.org)
Inducible Gata1 suppression expands megakaryocyte-erythroid progenitors from embryonic stem cells. (uthsc.edu)
CRISPR/Cas9-mediated TPM1 knockout in human induced pluripotent stem cells (iPSCs) enhanced hematopoietic progenitor development, increasing total megakaryocyte and erythroid cell yields. (biomedcentral.com)
The leukemic mice had severe anemia, hepatosplenomegaly, pulmonary hemorrhage and expansion of dysplastic erythroid progenitors. (elsevierpure.com)
MEP)) and erythroid progenitors (CD71 + ) from Jak2 V617F-transduced p53-null leukemic mice had leukemia-initiating capacity, however, myeloid differentiated populations (Mac-1 + ) could not recapitulate the disease. (elsevierpure.com)
Interestingly, recipients transplanted with CD71 + cells rapidly developed erythroid leukemia, which was in sharp contrast to leukemic KSL cells to cause lethal leukemia after the polycythemic state. (elsevierpure.com)
The 40-fold increase in childhood megakaryocyte-erythroid and B-cell leukemia in Down syndrome implicates trisomy 21 (T21) in perturbing fetal hematopoiesis. (ox.ac.uk)
Here, we show that compared with primary disomic controls, primary T21 fetal liver (FL) hematopoietic stem cells (HSC) and megakaryocyte-erythroid progenitors are markedly increased, whereas granulocyte-macrophage progenitors are reduced. (ox.ac.uk)
Commensurately, HSC and megakaryocyte-erythroid progenitors show higher clonogenicity, with increased megakaryocyte, megakaryocyte-erythroid, and replatable blast colonies. (ox.ac.uk)
Biased megakaryocyte-erythroid-primed gene expression was detected as early as the HSC compartment. (ox.ac.uk)

It was also found that the expression of the BCL-XL gene was higher during the maturation process of erythrocyte progenitor cells than during their replication process. (sciencedaily.com)
Evidence indicates that LSD1 plays an important role in the maturation of blood cells in the bone marrow," said Dr. Dean Y. Li, president, Merck Research Laboratories. (merck.com)
LSD1 regulates the maturation of bone marrow stem cells and is essential for the differentiation of progenitor cells into mature megakaryocytes and granulocytes and production of blood cells. (merck.com)
Furthermore, the expression of CD42b was higher in non-contact cultures, as compared to contact cultures, indicating an increase in megakaryocyte maturation in non-contact cultures. (amsterdamumc.org)
Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. (epigentek.com)
Formation - maturation - mixed - megakaryocytes in CaS - CA from normal marrow - CA from myelodysplastic syndrome. (bremel.gr)

We recently established expandable immortalized megakaryocyte cell lines (imMKCLs) from hPSCs by transducing MYC, BMI1, and BCL-XL (MBX). (hokudai.ac.jp)
To overcome this issue, we established immortalized megakaryocyte cell lines (imMKCLs) by introducing three transgenes, c-MYC, BMI1, and BCL-XL, sequentially into hematopoietic and megakaryocytic progenitor stage cells derived from iPSCs. (biomedcentral.com)

CD34 is the most commonly used cell surface marker to identify human HSPCs as it is expressed on HSCs, in addition to both multipotent and more differentiated progenitor cells of individual blood cell lineages. (stemcell.com)
Hematopoietic stem cells differentiate into multipotent progenitor cells. (differencebetween.com)
B lood cell differentiation begins with multipotent hematopoietic progenitor cells (HPCs), which are located in the marrow spaces of the bone. (nationalacademies.org)
These committed progenitor cells are difficult to discern from the original multipotent cells but can be cultured to form colonies of specific types of blood cells (Guyton and Hall, 2000). (nationalacademies.org)
Umbilical cord blood is a rich source of these committed progenitor cells and, presumably, multipotent HPCs (Knudtzon, 1974). (nationalacademies.org)
FIGURE 2-1 Formation of the multiple peripheral blood cells from multipotent hematopoietic stem cells. (nationalacademies.org)

MegaCult™-C Collagen and Medium with Lipids kit includes medium and collagen solution for colony-forming unit (CFU) assays of human or mouse megakaryocyte progenitor cells (CFU-Mk). (stemcell.com)
The colony-forming unit (CFU) assay is a clonal, in vitro culture assay that measures the growth and frequency of functionally viable HSPCs by assessing the proliferation and differentiation of individual progenitor cells, resulting in the formation of discrete colonies in a semi-solid methylcellulose medium (such as MethoCult™ ) when supplemented with appropriate cytokines. (stemcell.com)

Drayer AL, Olthof SG, Vellenga E. Mammalian Target of Rapamycin Is Required for Thrombopoietin-Induced Proliferation of Megakaryocyte Progenitors. (rug.nl)
Drayer AL, Boer AK, Los EL, Esselink MT, Vellenga E. Stem cell factor synergistically enhances thrombopoietin-induced STAT5 signaling in megakaryocyte progenitors through JAK2 and Src kinase. (rug.nl)

Interacts with transmembrane domain of human TPO receptor and induces megakaryocyte proliferation and differentiation from bone marrow progenitor cells. (medscape.com)

Administration of low-dose cytarabine results in immediate S-phase arrest and subsequent activation of cell cycling in murine stem cells. (rug.nl)
IL-7 is essential for normal murine B cell development, and plays a key role in regulating the homeostasis and function of the T-cells. (biolegend.com)
Here we show that retroviral overexpression of Jak2 V617F mutant into wild-type p53 murine bone marrow cells induced polycythemia vera (PV) in the recipient mice, whereas Jak2 V617F-transduced p53-null mice developed lethal leukemia after the preceding PV phase. (elsevierpure.com)

The use of patient-specific induced pluripotent stem cells (iPSCs) in combination with bioengineering advances and genome editing offers unique opportunities for developing personalized disease models and tissues for regenerative medicine," the NIH said. (genomeweb.com)

Research Objective We will develop a biotherapeutic/monoclonal antibody that blocks the growth of human AML cancer stem cells in vitro and in vivo. (ca.gov)
and reprogramming progenitor cells in vivo to treat disease. (genomeweb.com)
IL-7 also controls T cell-dendritic cell interactions that are essential for both T-cell homeostasis and activation in vivo . (biolegend.com)
Hopes for the creation of a more stable transfusion system have centered on the establishment of a technology for large-scale erythrocyte production ex vivo, using for instance iPS cells or ES cells. (sciencedaily.com)
To address this knowledge gap, we developed an in vivo hematopoietic stem cell (HSC)-based large-scale CRISPR knockout screening platform to enable the genetic interrogation of hematopoiesis and broad aspects of immune cell function in vivo. (biorxiv.org)
Together with in vitro and in vivo analysis, we demonstrated that Hcy promoted megakaryocytes (MKs) differentiation via growth hormone (GH)-PI3K-Akt axis. (biomedcentral.com)
AIM AND METHODS: In this study, we examined in vivo engraftment kinetics of PMF patient-derived CD34+ cells in immunecompromised NOD/SCID/IL2rgKO (NSG) mice. (bvsalud.org)
CONCLUSION: A patient-derived xenotransplantation (PDX) model of PMF allows in vivo examination of disease onset and propagation originating from immature CD34+ cells and will support the investigation of pathogenesis and development of therapeutic modalities for the disorder. (bvsalud.org)

Most of the blood cells produced in the bone marrow during hematopoiesis come from megakaryocyte/erythrocyte progenitor cells. (wikipedia.org)
DNMT3A is a critical regulator of hematopoietic stem cell (HSC) differentiation and somatic DNMT3A mutations are frequent in hematologic malignancies and clonal hematopoiesis. (haematologica.org)
In approximately 15% of patients, however, myelofibrosis is accompanied by significant extramedullary hematopoiesis, hepatosplenomegaly, and transfusion-dependent anemia, which are manifestations of stem cell failure. (basicmedicalkey.com)
INTRODUCTION: Primary myelofibrosis (PMF) is a clonal stem cell disorder characterized by myeloid dominant hematopoiesis and dysregulated proliferation of fibroblasts in the bone marrow. (bvsalud.org)

HSCs develop into different types of blood cells in lines called myeloid and lymphoid , which are involved in dendritic cells formation. (differencebetween.com)

Megakaryocyte/erythrocyte progenitor cells must commit to becoming either platelet-producing megakaryocytes via megakaryopoiesis or erythrocyte-producing erythroblasts via erythropoiesis. (wikipedia.org)
By transducing two genes (c-MYC and BCL-XL) into iPS cells and ES cells, a research team has succeeded in producing erythrocyte progenitor cells with almost unlimited ability to replicate in vitro, which they then differentiated successfully into mature erythrocytes. (sciencedaily.com)
During the differentiation process from hematopoietic progenitor cells, chromosomes in the cell nucleus aggregate and the cell becomes a mature erythrocyte by subsequently losing this nucleus (enucleation). (sciencedaily.com)
The research showed that an increase in the expression of the c-MYC gene led to an enhancement of the replication ability of erythrocyte progenitor cells. (sciencedaily.com)
As the c-MYC gene and BCL-XL gene are present within erythrocyte progenitor cells, methods that make use of them actually mimic the body's own system and can therefore be thought of as safer with a view to future clinical application than the previously developed systems for large-scale erythrocyte production using oncogene-derived from Human papillomavirus that are not normally expressed in the human body. (sciencedaily.com)

However, in the present study we have employed a sensitive reporter-based approach to demonstrate that Pf4-Cre also recombines in a significant proportion of both fetal liver and bone marrow hematopoietic stem cells (HSCs), including the most primitive fraction containing the long-term repopulating HSCs. (nih.gov)
Finally, we show for the first time that Pf4 transcripts are present in adult HSCs and primitive hematopoietic progenitor cells. (nih.gov)
HSCs make up a very small population of the hematopoietic system, however, these cells are invaluable as they have the potential to give rise to all mature blood and immune cell types and sustain life-long blood production. (stemcell.com)
Hematopoietic stem cells (HSCs) are immature cells found in the peripheral blood and bone marrow. (differencebetween.com)
Here, a combination of different cell surface markers is used to separate the rare HSCs. (differencebetween.com)

Furthermore, it has been hypothesized that direct interaction between stroma or stroma-derived extracellular matrix (ECM) and human progenitor cells (HPC) may modulate megakaryocytopoiesis. (amsterdamumc.org)
The percentage of megakaryocytes raised from HPC present in the transwell did not decrease, irrespective of the presence of HPC simultaneous below the transwell in direct contact with stroma. (amsterdamumc.org)
This is due to modulation by adhesive interactions with stroma, stroma-derived ECM or cytokines bound to the membrane of stromal cells, rather than resulting from the production of diffusible cytokines by stromal cells. (amsterdamumc.org)
The bcr-abl oncoprotein has uncontrolled tyrosine kinase activity, which deregulates cellular proliferation, decreases adherence of leukemia cells to the bone marrow stroma, and protects leukemic cells from normal programmed cell death (apoptosis). (msdmanuals.com)

and high-level transgene expression in iPSC-derived megakaryocytes to correct Glanzmann's thrombasthenia and Wiskott-Aldrich syndrome. (genomeweb.com)

The consortium's goal, the NIH said, is to translate recent advances in progenitor cell biology, including those made by the NHLBI's Progenitor Cell Biology Consortium and the Lung Repair and Regeneration Consortium , to develop new treatments for cardiovascular, pulmonary, and hematologic diseases. (genomeweb.com)
Emerging single-cell sequencing technologies will undoubtedly enhance our understanding of the complex biology of pancreatic cancer and pave the way for new directions in its clinical diagnosis and treatment. (frontiersin.org)
The development of a megakaryocyte lineage specific Cre deleter, using the Pf4 (CXCL4) promoter (Pf4-Cre), was a significant step forward in the specific analysis of platelet and megakaryocyte cell biology. (nih.gov)

These primitive cells undergo division and differentiation to form the various peripheral blood cells. (nationalacademies.org)

Hematopoietic progenitor cells (HPCs) are also intermediates in the development of blood cells. (differencebetween.com)

CML is a hematologic cancer that results from an abnormal proliferation of an early myeloid progenitor cell. (mhmedical.com)
CML ensues when an abnormal pluripotent hematopoietic progenitor cell initiates excessive production of all myeloid lineage cells, primarily in the bone marrow but also in extramedullary sites (eg, spleen, liver). (msdmanuals.com)

imMKCLs can act as cryopreservable master cells to supply platelet concentrates. (hokudai.ac.jp)
Since human induced pluripotent stem cell (iPSC)-platelet products can be supplied independently from the donor, it is expected to complement current platelet products. (biomedcentral.com)
To identify putative causal genes from these data, we performed computational modeling using available genome-wide association datasets for platelet and red blood cell traits. (biomedcentral.com)

Such heterogeneity could originate from extrinsic factors, such as cell-to-cell signalling and surrounding temperature and pressure, but also from the intrinsic noise generated by having few copies of molecules involved in transcription and translation. (lu.se)
Progenitor cells are the cells that originate from stem cells and further differentiate to create specialized cell types. (differencebetween.com)

In this fashion, IL-7 induces cell activation, survival, and proliferation of T lymphocytes. (biolegend.com)
CD4 T cell lymphopenia increases the expression of circulating IL-7, and TGFb induces IL-7 downregulation. (biolegend.com)

Before that, Dr. Weiss was the Associate Director for The Human Embryonic Stem Cell Core Facility at The Children's Hospital of Philadelphia. (uthsc.edu)

Chronic myelogenous leukemia (CML), also known as chronic myeloid leukemia, is a myeloproliferative disorder characterized by increased proliferation of the granulocytic cell line without the loss of their capacity to differentiate. (medscape.com)
The key difference between hematopoietic stem cells and progenitor cells is that hematopoietic stem cells have the ability to differentiate into different types of cells while progenitor cells are more specific and they differentiate into target cells. (differencebetween.com)
Progenitor cells are descendants of stem cells that further differentiate into specialized cell types. (differencebetween.com)
Some cells differentiate into targeted cells, while other cells have the ability to differentiate into more than one type of cell. (differencebetween.com)
On the other hand, progenitor cells are more specific than hematopoietic stem cells and can differentiate into target cells. (differencebetween.com)

For example, beta-glucan binds to macrophages and other phagocytic white blood cells at certain receptors and activates their anti-infection and anti-tumor activity by stimulating the production of free radicals. (herbnet.com)

For each group, the use of stem cells as a treatment of antibody-labeled CD34+ stem cells, lymphocytes, and leukocytes was conducted. (bvsalud.org)
RESULTS: A statistically significant positive correlation was observed in CD34+ stem cells in proportion to lymphocytes in the moderate (0.80), in the advanced (0.75), and in the toothless groups (0.70). (bvsalud.org)

His research interests are to better understand the mechanisms of normal red blood cell development and use this information to treat common blood disorders, including sickle cell disease and betathalassemia. (uthsc.edu)

Although granulocyte production predominates, the neoplastic clone includes red blood cells, megakaryocytes, monocytes, and even some T cells and B cells. (msdmanuals.com)

02:32 what makes us Ella stem cell? (yale.edu)
Angiocrine is developing a cell therapy aimed to improve the availability and engraftment of blood stem cell transplants for cancer patients who have had their cancerous bone marrow removed by chemotherapy. (ca.gov)
Impact Treatment of the cancer stem cell driven disease Acute Myelogenous Leukemia (AML) will be impacted. (ca.gov)
M, Peterson C. 2018 Haematopoietic stem suggests that during differentiation a stem cell approaches a stable equili- cells: entropic landscapes of differentiation. (lu.se)
Single cells in these populations exhibit different com- stem cell differentiation, Shannon information binations of regulator activity that suggest the presence of multiple theory, entropy configurations of a potential differentiation network as a result of multiple entry points into the committed state. (lu.se)
Recommend the appropriate treatment for patients with MM, recognizing the importance of combination therapy and the role of autologous hematopoietic stem cell transplant. (mhmedical.com)
Chronic myeloid leukemia (CML) occurs when a pluripotent stem cell undergoes malignant transformation and clonal myeloproliferation, leading to a striking overproduction of mature and immature granulocytes. (msdmanuals.com)
Myelosuppressive drugs (eg, hydroxyurea ), stem cell transplantation, and interferon alfa are also sometimes used. (msdmanuals.com)

A team at Children's Hospital of Los Angeles is testing the feasibility of providing these immune suppressed patients with engineered T-cells to fight these viruses. (ca.gov)
The cancer cells use that protein to evade the component of our immune system that routinely destroys tumors. (ca.gov)
When the two were incubated together, beta-glucan enhanced the growth of myeloid and megakaryocyte progenitor cells, which develop into immune cells, and triggered a burst of free radicals in white blood cells, enhancing the cells' antibacterial activity. (herbnet.com)
The data allow for direct and controlled comparison of gene expression in cell types shared between tissues, such as immune cells from distinct anatomical locations. (ucsc.edu)
Objective: Circulating progenitor cells possess immune modulatory properties and might mitigate inflammation that is characteristic of patients with coronary artery disease. (bvsalud.org)

Research Objective LGR5-antibody drug conjugate to target LIC in B cell tumors that undergo self-renewal Impact LIC were only defined in myeloid leukemia, while LIC populations in B cell tumors remain elusive. (ca.gov)
Patient-derived induced pluripotent stem cells recapitulate hematopoietic abnormalities of juvenile myelomonocytic leukemia. (uthsc.edu)
Open-Label Phase II Prospective, Randomized, Controlled Study of Romyelocel-L Myeloid Progenitor Cells to Reduce Infection During Induction Chemotherapy for Acute Myeloid Leukemia. (uchicago.edu)
Interestingly, chemotherapy, including hydroxyurea, has been associated with acute leukemia in JAK2 V617F-negative stem cells in some PV patients. (basicmedicalkey.com)
Morphology - colony formation - staining - aging - physiological comparison, with acute leukemia marrow fat cells. (bremel.gr)

In this context, in the undifferentiated state, the entropy would be large since fewer constraints exist on the gene expression programmes of the cell. (lu.se)
The activities of transcription factors and other genes involved in cell fate decisions can be measured by a number of different gene expression quantification experiments. (lu.se)
Until recently, and due to technical limitations, for a given cell type such experiments had to be done on an ensemble of many cells and, hence, gene expression quantifi- cations represented the average over a given population. (lu.se)
In lymphopoiesis, T21 FL lymphoid-primed multipotential progenitors and early lymphoid progenitor numbers are maintained, but there was a 10-fold reduction in committed PreproB-lymphoid progenitors and the functional B-cell potential of HSC and early lymphoid progenitor is severely impaired, in tandem with reduced early lymphoid gene expression. (ox.ac.uk)

This antibody is useful for western blotting and for immunofluorescent labelling of cells for fluorescence microscopy or flow cytometry. (bdbiosciences.com)
Engrafted human cells were analyzed with flow cytometry, and proliferation of fibroblastic cells and bone marrow fibrosis were assessed with the histo-pathological examination. (bvsalud.org)

Cell markers, or surface antigens, are molecules located on a cell's membrane used to identify specific cell types, their lineage, and their stage in the differentiation process according to the presence or absence of the expression of defined markers. (stemcell.com)

Also making up a part of the hematopoietic system are short-term repopulating progenitor cells, which give rise to lineage-specific cell types. (stemcell.com)

Other uses of the CFU assay include studying the effects of stimulatory and inhibitory growth factors, screening novel compounds to predict potential toxicity to the hematopoietic system, and testing the effects of various in vitro manipulations (e.g. cell processing, cryopreservation, gene transduction, and transmission) on cellular products used in hematopoietic cell transplantation. (stemcell.com)

Research hematology with an emphasis on understanding the mechanisms of normal blood cell development associated diseases. (uthsc.edu)
The principal defect is thought to be absent or arrested development of the megakaryocyte progenitor cell or a progenitor cell with a maturational defect as there is minimally deleted region on chromosome 1q21.1 (deletion/duplication syndrome). (radiopaedia.org)
For that purpose, we studied megakaryocytic development of HPC, obtained from patients with hematological malignancies in complete remission or solid tumors without bone marrow involvement, under the influence of megakaryocyte growth and development factor (MGDF, a pegylated, truncated molecule related to the endogenous Mpl ligand). (amsterdamumc.org)
Cost-effective blood cell generation will require novel strategies based on better knowledge of underlying mechanisms driving in vitro development. (biomedcentral.com)
It acts at a late stage of megakaryocyte development. (epigentek.com)
Progenitor cells are an intermediary step in the development of mature cells in tissues, organs, blood, and the central nervous system. (differencebetween.com)
They play a role in cell development and differentiation. (differencebetween.com)
Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21. (ox.ac.uk)

Consequently, the peripheral blood cell profile shows an increased number of granulocytes and their immature precursors, including occasional blast cells. (medscape.com)

We used single-cell RNA sequencing (scRNA-seq) to characterize the impact of Hcy on transcriptome, cellular heterogeneity, and developmental trajectories of megakaryopoiesis from human umbilical cord blood (hUCB) CD34 + cells. (biomedcentral.com)

Schepers H, Wierenga AT, Eggen BJ, Vellenga E. Oncogenic Ras blocks transforming growth factor-beta-induced cell-cycle arrest by degradation of p27 through a MEK/Erk/SKP2-dependent pathway. (rug.nl)
The IL-3R plays an important role in hematopoietic progenitor cell growth and differentiation. (bdbiosciences.com)

In adult mice, IL-7/IL-7R signaling up regulates expression of early B cell factor (EBF), and EBF in turn regulates expression of B cell-specific genes required for the transition from lymphoid progenitor to pro-B cells. (biolegend.com)
NOD-SCID-Gamma (NSG) mice) and measuring the presence of human blood cells in the blood or bone marrow (BM) after extended periods of engraftment, e.g., 20 weeks or longer. (stemcell.com)

To validate this putative candidate gene and to explore its function, we used CRISPR/Cas9 genome editing to discover that cultured TPM1 -deficient induced pluripotent stem cells enhanced hematopoietic progenitor cell formation. (biomedcentral.com)

The aryl hydrocarbon receptor directs hematopoietic progenitor cell expansion and differentiation. (umassmed.edu)

Stem cells have the ability to change into many different types of cells and grow definitely in the human body. (differencebetween.com)
Cell culture of 5637 human cell line (cancerous bladder epithelium). (bremel.gr)
Cell culture of the human osteoblastic line SaOS-2 ( osteosarcoma). (bremel.gr)
Fibrotic bone marrow contained CD45-vimentin+ cells of both human and mouse origin, suggesting that circulating malignant CD34+ subsets contribute to myelofibrotic changes in PMF through direct and indirect mechanisms. (bvsalud.org)

Colonies derived from different types of progenitor cells are classified and counted based on morphological and phenotypic criteria. (stemcell.com)

CD34 is a transmembrane phosphoglycoprotein that was first identified on HSPCs, but its expression is also present on other cell types, such as vascular tissue. (stemcell.com)

Single-cell sequencing is a high-throughput technique that enables detection of genomic, transcriptomic, and epigenomic information at the individual cell level, offering significant advantages in detecting cellular heterogeneity, precise cell classification, and identifying rare subpopulations. (frontiersin.org)
They are commonly described as cellular fragments - they are not true cells as they do not contain a nucleus or carry nuclear DNA, although they do contain mitochondria. (teachmephysiology.com)
These cell types are used in cell culture studies to analyze cellular responses in different clinical and physiological settings. (differencebetween.com)

Anatomy21

Organisms3

Diseases4

Chemicals and Drugs24

Analytical, Diagnostic and Therapeutic Techniques and Equipment10

Phenomena and Processes20

Platelets10

Common lymphoid progenitor2

Erythroid10

Maturation6

Immortalized megakaryocyte cell lines2

Multipotent6

Colony form2

Thrombopoietin2

Proliferation and differentiation1

Murine3

IPSCs1

Vivo8

Hematopoiesis4

Dendritic cells1

Erythrocyte5

HSCs5

Stroma4

IPSC-derived1

Biology3

Primitive1

HPCs1

Abnormal2

Platelet3

Originate2

Induces2

Embryonic1

Differentiate5

Macrophages1

Lymphocytes2

Sickle cell di1

Monocytes1

Stem cell8

Immune5

Leukemia5

Gene expression4

Flow Cytometry2

Differentiation process1

Lineage specific1

Hematopoietic system1

Development8

Granulocytes1

Umbilical cord1

Growth2

Mice2

Pluripotent1

Receptor1

Human4

Colonies1

CD341

Cellular3