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  • stem cells
  • For the stem cells and other undifferentiated blood cells in the bone marrow, the determination is generally explained by the determinism theory of haematopoiesis, saying that colony stimulating factors and other factors of the haematopoietic microenvironment determine the cells to follow a certain path of cell differentiation. (wikipedia.org)
  • it regulates genes whose downstream products encourage differentiating stem cells towards becoming megakaryocytes rather than erythrocytes. (wikipedia.org)
  • proliferate
  • Despite these differences, human cancers arising from hematopoietic cells and from epithelial cells do share many common alterations, including the ability to (1) develop resistance to growth-inhibitory and differentiation factors, (2) proliferate in the absence of exogenous growth signals, (3) evade apoptosis, and (4) evade immunosurveillance. (bloodjournal.org)