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  • gene
  • Subsequent cloning studies showed that the mesothelin gene encodes a precursor protein that is processed to yield mesothelin which is attached to the cell membrane by a glycophosphatidylinositol linkage and a 31-kDa shed fragment named megakaryocyte-potentiating factor (MPF). (wikipedia.org)
  • membrane
  • The demarcation membrane system forms to demarcate platelets , which soon break off from the megakaryocyte and move to the peripheral blood. (biology-online.org)
  • Studies of cultured megakaryocytes will include evaluation of granule membrane and soluble proteins using fluorescent antibodies and immunoelectron microscopy and comparison of RNA and protein expression patterns between normal and patient cells. (clinicaltrials.gov)
  • nucleus
  • As a result, the nucleus of the megakaryocyte may contain up to 32 copies of the normal complement of DNA in a human cell. (sciencephoto.com)
  • Anticentriole antibody (Fig. 3 A, c) and anti-α-tubulin antibody (Fig. 3 A, b) stainings confirmed that multiple mitotic spindle poles were formed and assembled outside the nucleus in a megakaryocyte in prophase, as described above. (nih.gov)
  • development
  • This review attempts to provide an overview about the SOCE dynamics in megakaryocyte development, with a focus on most recent findings related to its involvement in physiological and pathological thrombopoiesis. (mdpi.com)
  • primary
  • A number of primary megakaryocytes treated with TPO were stained with DAPI, anti-α-tubulin antibody, anti-γ-tubulin antibody, anticentriole antibody, or anticentromere antibody. (nih.gov)