MegacolonHirschsprung DiseaseMegacolon, ToxicProto-Oncogene Proteins c-retEnteric Nervous SystemSOXE Transcription FactorsChagas DiseaseReceptor, Endothelin BRectumConstipationColon, SigmoidGlial Cell Line-Derived Neurotrophic Factor ReceptorsColectomyIleostomyEndothelin-3ColonColostomyWaardenburg Syndrome