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  • MEF2C
  • MEF2C specifically interacts with Myocardin-93S, which is highly enriched in the heart, yet the transcripfional targets and mechanisms of synergy facilitated by the Myocardin-MEF2 complex have not been identified. (grantome.com)
  • This enhancer contains two bona fide MEF2 binding sites that function together in a multiplicative fashion in response to Myocardin-93S and MEF2C. (grantome.com)
  • Using transgenic mouse, cell culture, biochemical, and mass spectrometry approaches, this work will define determinants of MEF2-Myocardin transcripfional synergy, will identify additional interaction partners for MEF2C and Myocardin through interactome mapping, and will identify in vivo targets ofthe Myocardin-MEF2 complex. (grantome.com)
  • myogenesis
  • C. elegans appears to have evolved a developmental program of myogenesis that is independent of MEF2 functions. (sdbonline.org)
  • sequence
  • CRX recruits MEF2D away from canonical MEF2 binding sites by promoting MEF2D binding to retina-specific enhancers that lack a strong consensus MEF2 binding sequence. (harvard.edu)
  • MEF2 family members A-D bind as homodimers and heterodimers to the DNA consensus sequence CTA(A/T) 4 TA(G/A) ( Naya and Olson, 1999 ). (jneurosci.org)
  • stimulation
  • More specifically, the present invention shows that Ca++ stimulation of the hypertroplic response is mediated through MEF2. (google.com)
  • β-AR stimulation modulated MEF2 cellular localization in cardiomyocytes and this effect was reversed by β-blocker treatment. (nih.gov)
  • role
  • We have shown that a MEF2 binding site precisely overlaps the TFIID binding site (TATA box) in the Xenopus MyoDa (XMyoDa) promoter and appears to play an important role in muscle-specific activity of this promoter. (nih.gov)
  • promoter
  • After one month of brainstorming and three months of hard lab working, the SJTU-BioX-Shanghai team has successfully submitted 13 new parts, of which a large portion, such as the PfdhF promoter , MEF2-JeT promoter and CRE-JeT promoter , are new parts that are demonstrated capable of working as expected. (igem.org)
  • levels
  • Dampening iron toxicity, inhibiting sphingolipid synthesis by Myriocin, or reducing Pdk1 or Mef2 levels, all effectively suppress neurodegeneration in fh mutants. (curefa.org)