• pediatric brain cancer
  • New research published in Nature Communications from scientists at Huntsman Cancer Institute at the University of Utah, in collaboration with the Stanford University School of Medicine, shows a specific protein regulates both the initiation of cancer spreading and the self-renewal of cancer cells in medulloblastoma, a type of pediatric brain cancer. (news-medical.net)
  • vitro
  • By screening ABC substrates against mouse G3 medulloblastoma tumorspheres in vitro, we found that Abcg2 inhibition could potentiate responses to the clinically used drug topotecan, producing a more than 9-fold suppression of cell proliferation. (nih.gov)
  • subtype
  • A targeted therapy already used to treat advanced skin cancer has also been found to be effective when used to treat the most common subtype of adult medulloblastoma. (oncologynurseadvisor.com)
  • Not only is this lesion almost certainly a medulloblastoma (young adults are a definite second peak of incidence, typically in the cerebellar hemisphere rather than vermis) but the SHH subtype can also be predicted with confidence. (radiopaedia.org)
  • inhibit
  • KCC-07 could inhibit medulloblastoma growth in cell culture and in mouse models, and "represents a promising chemical scaffold for further drug development," the researchers conclude. (eurekalert.org)