Medicines and excipients. Medical search. Frequent questions

Our Excipients are used in drug formulations as Emulsifiers, Rheology Modifiers, Binders, Humectants, Plasticizers etc. for all sorts of pharmaceutical dosage applications. (clariant.com)
Two formulations of P140, differing in the excipients used (mannitol or trehalose), have been evaluated in patients affected by systemic lupus erythematosus in two successive phase IIb clinical trials. (smw.ch)
The SeDeM Diagram Expert System has been used to study excipients, Captopril and designed formulations for their galenic characterization and to ascertain the critical points of the formula affecting product quality to obtain suitable formulations of Captopril Direct Compression SR Matrix Tablets. (ub.edu)
Lack of age-appropriate formulations, inadequate labelling instructions, non-compatible and non-palatable medicines are the main reasons for medication errors in paediatric patients. (ijpsonline.com)
While all drugs on the market are carefully safety tested, NIBR wanted to look at excipients to generate 'the safest formulations for our products', Urban says. (chemistryworld.com)

For the full list of excipients, see section 6.1. (medicines.org.uk)
Hypersensitivity to Amiloride or any of the excipients listed in section 6.1. (janusinfo.se)

These are known as 'inactive' ingredients, or excipients. (health.gov.au)
For most people, these inactive ingredients won't affect their choice of medicine. (health.gov.au)
In addition, the wrong inactive ingredients (excipients) can contribute to poor drug dissolution, bioavailability, and toxicity. (cdc.gov)
Inactive ingredients are listed in the Supplement Facts Panel on dietary supplement labels as "Other Ingredients" (also referred to as "excipients") following the list of Active Ingredients (see Where to Look on the Label ). (consumerlab.com)

You are allergic to any other medicines or other substances such as foods, dyes or preservatives. (mydr.com.au)

Guidance is provided on the documentation expected for sterile finished products, sterile active substances , sterile excipients and sterile primary containers in a new marketing authorisation application or a variation application for a medicinal product . (europa.eu)
All medicines are combined with what are known as 'excipients' -- inactive substances which give them the desired bulk and consistency and their role is restricted to the gut. (sciencedaily.com)
any of various natural substances used in herbal medicine as regulators. (absp.org.uk)
experts contribute to ensuring the quality of active substances and excipients, and of chemical and biological medicines thanks to their individual expertise. (edqm.eu)

In this exclusive Drug Digest video interview, Felicity Thomas, European/Senior Editor, Pharmaceutical Technology Group, interviews experts about small-molecule APIs, excipients, and formulation advances. (pharmtech.com)
Excipients play a critical role in the manufacture of medicines, helping to preserve the efficacy, safety, and stability of active pharmaceutical ingredients (APIs). (biopharminternational.com)

Your doctor has weighed the risks of you taking Lipazil tablets against the benefits the medicine is expected to have for you. (mydr.com.au)
Taking the tablets on an empty stomach ensures the medicine is absorbed faster. (mydr.com.au)
In the case of traditional medicines, such as tablets and capsules, only a limited amount of drug -- thought to be around five to 15 per cent for the majority of compounds -- makes it through the gut into patients' blood. (sciencedaily.com)
Velpaclear medicine manufactured by Abbott, is a fixed dose combination of Sofosbuvir 400mg and Velpatasvir 100mg tablets. (index-china.com)

This guideline applies to human and veterinary medicines. (europa.eu)
Among other things, a label must comply with the requirements of the Labelling Standard or, if there is no Labelling Standard, the Agricultural or Veterinary Labelling Codes made by the Australian Pesticides and Veterinary Medicines Authority (APVMA), as in force from time to time. (apvma.gov.au)
the Director of the Institute hereby promulgates Quality Policy which reflects accord of interests of the stakeholders of the regulation of veterinary medicines and their residues, veterinary non-medicinal products and veterinary technical devices. (uskvbl.cz)

Active ingredients are the chemical compounds in medicines that have an effect on the body. (health.gov.au)
Essentially, they are the ingredients within your medicine that make the medicine work. (health.gov.au)
There are many medicines that have the same active ingredients, but are made by different companies and have different brand names. (health.gov.au)
Prescribing and dispensing medicines by their active ingredient(s) means these ingredients are easier to identify on prescriptions and medicine labels. (health.gov.au)
As well as the active ingredient, the medicine you take may have other ingredients. (health.gov.au)
Vaccine integrity typically depends on a temperature- controlled supply chain, and, unlike medicines with stated amounts of active ingredients, the potency of vaccines is difficult to monitor and therefore easy to counterfeit. (cdc.gov)
Active pharmaceutical ingredients and excipients are the two most important ingredients in the production of a medicine. (researchandmarkets.com)
Generic medicines work in the same way and have the same safety profile as innovator medicines, but may use different non-active ingredients (excipients). (medsafe.govt.nz)
Provides can also be used to increases compound are generally ingredients of Clenbuterol Sopharma The medicine contains the excipient lactose. (nlpconference.co.uk)
Some ingredients that help keep medicines stable and get them into our bodies could also have previously unknown biological effects. (chemistryworld.com)
US researchers who studied 639 of these ingredients , known as excipients, have found 38 that interact with medically relevant proteins. (chemistryworld.com)

It is one of the few excipients available to improve viral stability for vaccines and gene therapies. (invitria.com)
Up-to-date information on vaccines, including additives and excipients, adverse reactions, contraindications, high-risk indications, resident education, and risk communication pearls This app's interface is easy to navigate, and the patient profile tool makes determining which vaccines a patient needs simple. (who.int)

Excipients: not so inert? (smw.ch)
Historically, excipients have been considered inert and devoid of medicinal effect or influence. (smw.ch)
Although MSNs exhibit some special, ideal properties as traditional preparation excipient materials, including both degradable or nondegradable produces, these materials are generally considered inert and harmless to the body. (frontiersin.org)
One should always question assumptions, in this case the concept of inert excipients,' Edwards says. (chemistryworld.com)

Conclusions Many counterfeit and unapproved anti-obesity medicines may be easily bypassing regulatory checks during shipping and are widely circulated through the internet. (bmj.com)
Counterfeit and substandard anti-obesity medicines, orlistat are identified. (bmj.com)
However, the study provides valuable information for regulatory authorities on how unapproved and counterfeit medicines are being circulated through the internet. (bmj.com)
Poor regulatory oversight breeds poor-quality medicines, whether they are counterfeit, falsified, substandard, or degraded ( Box 6-05 ). (cdc.gov)

However, the excipients such as polymers, used to formulate the nanoparticle-encapsulating drugs may exhibit undesired effects when they are absorbed through the gut wall. (sciencedaily.com)

It is difficult today to appreciate the number of potential drugs that have been discarded as a result of limited efficacy due to inappropriate excipients. (smw.ch)
Regarding the need for information on issues pertaining to safety and efficacy of medicines, 53.3% of participants felt that this need was not being met.Conclusion. (bvsalud.org)
All groups had knowledge deficits about the safety, quality and efficacy of generic medicines. (bvsalud.org)

As an excipient in pharmaceutical products, it is also used to control acidity or as a counter ion. (wikipedia.org)

Excipient Stability in Oral Solid Dosage Forms: A Review. (smw.ch)

The authors examine the functionality of mucilage extracted from the leaves of Hibiscus rosa-sinensis Linn as an excipient in a sustained-release tablet formulation. (pharmtech.com)
The application of the Sedem Diagram Expert System enables selecting excipients with in order to optimize the formula in the preformulation and formulation studies. (ub.edu)
This module will include material on the formulation of drugs (small and large molecules) to control and optimise delivery and will include an understanding of the physical and chemical properties of the excipients and drug(s) in the formulation. (otago.ac.nz)

This is expected, and for most medicines this can be managed with a change in dose. (medsafe.govt.nz)
Take this medicine at the dose and duration advised by your doctor. (index-china.com)

BOSTON, Sept. 19, 2023 (GLOBE NEWSWIRE) -- Rhythm Pharmaceuticals, Inc. (Nasdaq: RYTM), a commercial-stage biopharmaceutical company focused on transforming the lives of patients and their families living with hyperphagia and severe obesity caused by rare melanocortin-4 receptor (MC4R) pathway diseases, today announced that the European Medicines Agency (EMA) has issued a positive opinion on the Company's orphan drug designation request for setmelanotide as a treatment for acquired hypothalamic obesity. (fox2now.com)
Rhythm's lead asset, IMCIVREE (setmelanotide) is approved by the U.S. Food and Drug Administration (FDA) and authorized by the European Commission (EC) and the UK's Medicines & Healthcare Products Regulatory Agency (MHRA) for use in accordance with product labeling. (fox2now.com)
A molecular basis for innovation in drug excipients. (smw.ch)
Details about drug properties, excipient selection and taste masking approaches were described. (ijpsonline.com)
It aims to change the specificity and pharmacokinetics of the drug by combining it with various drug carriers, excipients and medical devices. (cede.ch)
The synthesis and design of effective drug delivery systems (DDS) is critical for healthcare and medicine. (cede.ch)
The API is the active ingredient in the medicine, whereas the excipient is a substance that isn't the drug but acts as a medium to aid in its absorption by the body. (researchandmarkets.com)
To test the strength of a medicine on humans or in laboratory circumstances, every drug must first receive FDA approval. (researchandmarkets.com)
Professor Kumar, whose team's research article has been published in the journal PLOS ONE , said: "Nanotechnology's role in drug delivery has the power to transform the way patients are given medicines over the next decade or so. (sciencedaily.com)
As a result of an interview and podcast on RNZ (Katherine Eban: Fraud in the generic drug industry), Medsafe has received several questions from healthcare professionals, consumers and the media regarding generic medicines. (medsafe.govt.nz)
The drug is contraindicated in cases of allergy to sofobuvir, velpatasvir and other excipients of the drug. (index-china.com)
Material in medicinal chemistry, pharmacology, pharmaceutical sciences and biopharmaceutics will be delivered in three integrated modules that progress from learning about drug molecules, to how to formulate the drug into a medicine and deliver it to a patient, and then finally focusing on the medicine in the patient. (otago.ac.nz)
Meanwhile, scientists at NIBR screened 73 widely used excipients against 28 toxicity-related target proteins linked to drug safety in lab tests. (chemistryworld.com)
The medicines were purchased in pharmacies to evaluate the sweeteners listed on the drug labels. (bvsalud.org)
On the other hand, carbon nanotubes can be readily functionalized and several studies on the use of carbon nanotubes as versatile excipients for drug delivery and imaging of disease processes have been reported, suggesting that carbon nanotubes may have a place in the armamentarium for treatment and monitoring of cancer, infection, and other disease conditions. (cdc.gov)
ABSTRACT The Maltese Medicines Authority was tasked with developing a reporting form that captures high- quality case information on adverse drug reactions (ADRs) and medication errors in order to fulfil its public-health obligations set by the European Union (EU) legislation on pharmacovigilance. (who.int)

For instance, in July 2021, Delhi Pharmaceutical Science and Research University (DPSRU) and All India Institute of Ayurveda (AIIA) collaborated to focus on evaluating application of medicinal plant-based and ayurvedic drugs in modern medicine. (medgadget.com)

In 2013 there were major changes to misuse and occupational exposure are ror reporting form was developed for the regulation of human medicines in also covered by this definition (the term Malta to enable the capture of the best member states of the European Union medication errors is henceforth used quality information. (who.int)
EurdaVigilance At the time of the legislative update, (ADRs) related to medication errors is a tool for the European Medicines national competent authorities who also required a new systematic approach Agency and national medicines author were collaborating with the WHO to how we gathered data related to ADRs ities to use for monitoring the safety of UMC received a report which gave a and medication errors in Malta. (who.int)

The offer also included a desire to contribute towards the EMA's costs, and mutual recognition of qualified persons (QP) and qualified persons for pharmacovigilance (QPPV) in each territory, as well as the regulatory experts at the Medicines and Healthcare products Regulatory Agency (MHRA). (europeanpharmaceuticalreview.com)
A few products do not have a marketing authorisation (licence) as a medicine and therefore there is no PIL. (gosh.nhs.uk)

The pharmaceutical industry includes it in the composition of many drugs and excipients, to improve taste, color, texture, etc. (botanical-online.com)
This paper addresses fundamental concepts required for pharmacists to understand the chemical, physical and biological properties of drugs, how they are formulated into medicines and how the medicines are delivered to patients in order to achieve desired clinical outcomes. (otago.ac.nz)

The use of generic medicines to reduce healthcare costs has become a mandated policy in South Africa. (bvsalud.org)
An increase in the use of generics can be achieved through improved knowledge, attitudes and perceptions of generic medicine among healthcare professionals. (bvsalud.org)

Overall, systematic biological data suggested that intravenous injection of nanoparticles of pharmaceutical excipients substantially affected hepatic metabolism function and induced oxidative stress and inflammation, whereas oral administration exhibited milder effects compared with intravenous injection. (frontiersin.org)
The Institute of Medicine recently concluded that "the biological evidence is of moderate strength that SV40 exposure could lead to cancer in humans under natural conditions. (educate-yourself.org)

Pharmaceutical 3D printing (3DP) is one of the emerging enabling technologies of personalised medicines as it affords the ability to fabricate highly versatile dosage forms. (pharmaexcipients.com)

RÉSUMÉ L'Autorité maltaise pour les médicaments ( Maltese Medicines Authority ) a été chargée d'élaborer un formulaire de notification visant à recueillir des informations de haute qualité sur les réactions indésirables aux médicaments et les erreurs de médication afin de satisfaire à ses obligations de santé publique définies par la législation de l'Union européenne sur la pharmacovigilance. (who.int)

Chakraborty A, Dhar P. A review on potential of proteins as an excipient for developing a nano-carrier delivery system. (smw.ch)
Shoichet's team computationally predicted targets for 639 excipients from among 3000 medically relevant proteins, finding 69 possible excipient-protein pairings. (chemistryworld.com)

People who are hypersensitive to Dihydrotestosterone or its excipients (Carbomer 934, triethanolamine, Alcohol 95%) should discuss using this medicine with their doctor. (gosh.nhs.uk)
Dihydrotestosterone is applied externally so it should not react with any other medicines. (gosh.nhs.uk)

It will also make it easier for you to talk to your health professional about your choices for different medicines that have the same active ingredient, including whether there is a cheaper option available. (health.gov.au)
You may need to take different amounts of your medicine or you may need to take different medicines. (mydr.com.au)

The medicines that have sucrose as a sweetening agent possess high viscosity. (bvsalud.org)

Consequently, substandard and fake medicines are a public health concern in these locations. (cdc.gov)

Like all medicines with consent to be supplied in New Zealand, generic medicines are subject to a rigorous regulatory scheme that is administered by Medsafe. (medsafe.govt.nz)
Generic medicines must meet high standards with regards to their quality, equivalent to brand name (innovator) medicines. (medsafe.govt.nz)
Medsafe's approval process and post-market quality and safety monitoring ensures that New Zealand patients can be confident that the generic medicines they take are of good quality, and are safe and effective. (medsafe.govt.nz)
Allowing generic medicines in New Zealand ensures there are alternative suppliers of medicines. (medsafe.govt.nz)
How does Medsafe ensure the quality of generic medicines supplied in New Zealand? (medsafe.govt.nz)
How does Medsafe ensure that generic medicines are manufactured properly? (medsafe.govt.nz)
Because the company making the innovator has already shown that the active ingredient works and is acceptably safe, generic medicines don't need clinical trials. (medsafe.govt.nz)
How are generic medicines tested? (medsafe.govt.nz)
A total of 90.0% of students had heard of generic medicines, with 20.9% of them agreeing that generic medicines are less effective than brand-name medicines. (bvsalud.org)
Concerning safety, 30.4% believed that brand-name medicines are required to meet higher safety standards than generic medicines. (bvsalud.org)

In the past 2 years, national medicines regulatory authorities have held consultations with external stakeholders to adapt regulatory frameworks to embrace point-of-care manufacturing. (pharmaexcipients.com)

The leaves are used in traditional medicines as emollients and aperients to treat burning sensations, skin disease, and constipation (25). (pharmtech.com)

Diethylene glycol and ethylene glycol are hazardous chemicals that have been used, both accidentally and deliberately, as cheaper substitutes for pharmaceutical-grade solvents like propylene glycol, glycerol and sorbitol in the production of liquid oral medicines. (who.int)
Therefore, the frequency of use and the sugar content in pediatric oral medicines can determine their cariogenic potential. (bvsalud.org)

Learn about what is, and what is not an active ingredient in prescription medicines. (health.gov.au)
Knowing what the active ingredient is in a medicine is an important part of being safe when you take your medicines. (health.gov.au)
For most situations, it is best practice to prescribe medicines using the active ingredient name. (health.gov.au)
you are not taking the same active ingredient in other medicines. (health.gov.au)
This will lower your chance of taking more than one medicine with that active ingredient by mistake. (health.gov.au)
In fact, excipients are seldom neutral and some of them have been found to play a significant role, for example by initiating or participating in chemical and physical interactions with the active substance, leading in certain cases to compromise its therapeutic activity. (smw.ch)
The manufacturer of the generic medicine performs a bioequivalence study to demonstrate that the active ingredient gets into the body the same way as the innovator medicine in most people who take it. (medsafe.govt.nz)
Combining their findings, they discovered that 38 of the excipients were biologically active, many of them interacting with more than one protein. (chemistryworld.com)

Natural gums and mucilage are preferred to semisynthetic and synthetic excipients because of their lack of toxicity, low cost, availability, soothing action, and nonirritant nature (5-8). (pharmtech.com)

With a positive and progressive track-record in the pharmaceutical industry, Clariant has a wide product portfolio of Excipients beneath the brands VitiPure® , Polyglykols , Lanogen® and Motusflex® supported by our high-quality standards to maximize the potential in medicines. (clariant.com)
Objective To explore the circulation of anti-obesity medicines via the internet and their quality. (bmj.com)
Quality of online anti-obesity medicines. (bmj.com)
Concerted efforts of authentic manufacturers and medicine regulatory authorities are a must to combat counterfeits and ensure access of quality medicines to online consumers. (bmj.com)
For a generic medicine the company must provide information demonstrating that the quality of the medicine meets acceptable standards and functions as well as the respective innovator. (medsafe.govt.nz)
All data relating to the quality of medicines must be scientifically produced by manufacturing and testing sites that hold valid certification from Medsafe or Medsafe-recognised international regulatory authorities showing that they comply with Good Manufacturing Practice (GMP). (medsafe.govt.nz)
Medsafe works closely with other medicines regulators to identify and discuss data quality issues. (medsafe.govt.nz)
Manufacturers of medicines must conduct validated tests at various steps of the manufacturing process, to ensure the quality meets acceptable standards. (medsafe.govt.nz)
standards, used in over 130 countries, that make it possible for millions of people to have access to quality medicines. (edqm.eu)

Primary and secondary outcome measures The authenticity of the samples was investigated in collaboration with the manufacturers of the samples and medicine regulatory authorities. (bmj.com)
Regulatory authorities should take measures to prevent these medicines from entering countries to safeguard their citizens. (bmj.com)

Good manufacturing practices for bulk pharmaceutical excipients. (smw.ch)

If you want to ask a question or request information from EMA, please Send a question to the European Medicines Agency . (europa.eu)
The UK Government's Chequers Plan and White Paper in July were widely praised by the pharma industry, which viewed it as a big step forward in maintaining regulatory alignment with the EU and, notably, a unilateral statement of intent to work with and accept the rules of the European Medicines Agency (EMA). (europeanpharmaceuticalreview.com)
A review of existing ADR forms was carried out and recommendations from the European Medicines Agency and World Health Organization audits integrated. (who.int)

Manufacturers of medicines for New Zealand must meet the high standards of Good Manufacturing Practice (GMP) and be regularly inspected and certified by medicine regulators who use the same standards as Medsafe. (medsafe.govt.nz)

These include medicines that you buy without a prescription from a pharmacy, supermarket or health food shop. (mydr.com.au)

The objective of this study was to extract mucilage from the leaves of Hibiscus rosa-sinensis Linn and examine the various pharmaceutical properties of the dried mucilage to assess its functionality as an excipient. (pharmtech.com)

Participants Anti-obesity medicines were purchased using relevant keywords on Japanese Google search engine. (bmj.com)

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate. (medlineplus.gov)

We are pleased with this EMA positive opinion as it underscores the significant unmet need for these patients and the potential of setmelanotide to bring a precision medicine approach that may benefit patients with this disease across Europe. (fox2now.com)
will all the medicines get to the patients? (europeanpharmaceuticalreview.com)
The instruction for the patients to brush their teeth after using a sweet medicine was reported by one professional only. (bvsalud.org)

Your doctor or pharmacist has a complete list of medicines to avoid while you are taking Lipazil. (mydr.com.au)

It is a first step toward understanding what molecular effects, if any, these excipients might have. (chemistryworld.com)

The UK would also continue to recognise qualified person certification and release of human medicines carried out in the EU, without the need for re-testing in the UK. (europeanpharmaceuticalreview.com)

Castor oil is orally used as a laxative and topically as an anti-inflammatory medicine on the skin. (e-lactancia.org)
a laxative (medicine). (absp.org.uk)
In natural medicine is mainly used as a laxative and in slimming cures. (botanical-online.com)

The aim of this study was to assess the knowledge and attitude of university hospital pediatricians in respect of the presence of sucrose in medicines used regularly and long-term by children, and to identify the presence of sucrose in frequently prescribed medicines. (bvsalud.org)
Study will be conducted in the Institute of Sports Medicine, Colombo 07. (who.int)

A variety of custom declarations were made for the shipments of the samples: personal health items, supplement, medicines, general merchandise, tea and others. (bmj.com)

Organisms3

Chemicals and Drugs44

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes13

Disciplines and Occupations17

Anthropology, Education, Sociology and Social Phenomena8

Technology, Industry, Agriculture9

Humanities1

Information Science1

Health Care4

Formulations5

Section 6.12

Inactive ingredients4

Preservatives1

Substances4

APIs2

Tablets4

Veterinary medicines3

Ingredients11

Vaccines2

Inert4

Counterfeit4

Polymers1

Efficacy3

Pharmaceutical Products1

Stability1

Formulation3

Dose2

Drug16

Medicinal1

Medication2

Products2

Drugs2

Healthcare2

Biological2

Dosage forms1

Authority1

Proteins2

Dihydrotestosterone2

Different medicines2

Viscosity1

Substandard1

Generic medicines10

National medicines1

Traditional medicines1

Oral2

Active8

Toxicity1

Quality9

Authorities2

Bulk1

European Medici3

Regulators1

Pharmacy1

Examine1

Search1

Scientific1

Patients3

List1

Molecular1

Human1

Laxative3

Study2

Supplement1