Medication clozapine. Medical search. Frequent questions

Blood problems occurred more frequently in participants receiving clozapine (3.2%) compared with those given typical antipsychotics (0%) (n=1031, 13 RCTs, RR 7.09 CI 2.0 to 25.6). (qxmd.com)
Clozapine belongs to a family of medications called antipsychotics . (medbroadcast.com)
The role of clozapine in treatment-resistant schizophrenia was established by a 1988 landmark multicenter double blind study in which clozapine (up to 900mg/d) showed marked benefits compared to chlorpromazine (up to 1800mg/d) in a group of patients with protracted psychosis who had already shown an inadequate response to at least three previous antipsychotics including a prior single blind trial of haloperidol (mean 61+/- 14mg/d for six weeks). (wikipedia.org)
While there are significant side effects, clozapine remains the most effective treatment when one or more other antipsychotics have had an inadequate response. (wikipedia.org)
Compared to other antipsychotics, clozapine has an increased risk of blood dyscrasias, in particular agranulocytosis, in the first 18 weeks of treatment. (wikipedia.org)
Clozapine monotherapy has shown effectiveness in catatonic schizophrenia7 and might be an option after other antipsychotics have failed. (mhaus.org)
Although a wide variety of medications can elicit symptoms, the typical antipsychotics are most often responsible. (medscape.com)
We also found that information on patient adherence patterns to atypical antipsychotics was a better predictor of patient adherence to these three medications than would be the case using patient demographic and clinical characteristics alone. (springer.com)
The Evidence-Based Guide to Antipsychotic Medications provides both a thorough scientific and historical review of antipsychotics and a highly practical clinical summary of the evidence base of the use of these agents across a wide range of psychiatric disorders. (appi.org)
Despite the introduction of new antipsychotics and improved access to Clozapine over the last 50 or so years, the clinical outcome for people with schizophreniform illnesses has shown little demonstrable improvement. (who.int)

Another 99 patients who had discontinued treatment agreed to take clozapine (Clozaril), which is known to be more effective than other second-generation medications but carries a greater risk of side effects. (psychiatrictimes.com)

Of those patients, 49 received open-label treatment with clozapine and 50 were assigned blindly to olanzapine, quetiapine, or risperidone. (psychiatrictimes.com)
In the group that did not receive clozapine, patients treated with risperidone and olanzapine continued taking their medications longer than those who were treated with quetiapine or ziprasidone. (psychiatrictimes.com)
In the group that agreed to try clozapine, patients actually receiving clozapine continued longer than patients taking olanzapine, quetiapine, or risperidone. (psychiatrictimes.com)
Forty-four percent of the clozapine patients continued to take the medication for the duration of the 18-month study, as did 29% of the patients receiving olanzapine. (psychiatrictimes.com)
In addition, the authors noted, 'at 3-month assessments, Positive and Negative Syndrome Scale total scores had decreased more in patients treated with clozapine than in patients treated with quetiapine or risperidone but not olanzapine. (psychiatrictimes.com)
Olanzapine may be used, alone or in combination with other medications, to treat the manic or mixed episodes (but not the depression) of bipolar disorder. (medbroadcast.com)
Medications like olanzapine are thought to work by correcting the balance of neurotransmitters (chemicals that control the function of nerve pathways) in the brain. (medbroadcast.com)
The usual starting dose of olanzapine tablets for adults with bipolar disorder is 10 mg daily (if olanzapine is used in combination with other medications that treat bipolar disorder) or 15 mg daily (if olanzapine is used alone). (medbroadcast.com)
Do not take this medication if you are allergic to olanzapine or any ingredients of the medication. (medbroadcast.com)

Clozapine versus typical neuroleptic medication for schizophrenia. (qxmd.com)
To evaluate the effects of clozapine compared with typical antipsychotic drugs in people with schizophrenia. (qxmd.com)
Clozapine may be more effective in reducing symptoms of schizophrenia, producing clinically meaningful improvements and postponing relapse, than typical antipsychotic drugs - but data are weak and prone to bias. (qxmd.com)
It is used to treat schizophrenia when other medications are not effective. (medbroadcast.com)
For many years, researchers have found that clozapine is substantially more effective than other antipsychotic medications in patients with treatment-resistant schizophrenia. (smiadviser.org)
Overall, despite the concerns relating to blood and other side effects, clozapine use is associated with a reduced mortality, especially from suicide which is a major cause of premature death in people with schizophrenia. (wikipedia.org)
Clozapine became widely available in the early 1990s and remains the only treatment likely to be effective in treating resistant schizophrenia. (wikipedia.org)
After 30 years, Mr. S' catatonic schizophrenia finally responds to medication, but the drug causes a precipitous WBC decrease. (mhaus.org)
The Clozapine Consultation Clinic at Johns Hopkins Hospital offers a one-time, second opinion evaluation for patients with schizophrenia who may benefit from clozapine. (hopkinsmedicine.org)
The Evidence-Based Guide to Antipsychotic Medications is designed to provide both clinicians and residents with focused, comprehensive, and clinically relevant information regarding the use of antipsychotic medications to treat a broad range of psychiatric conditions-from mood and anxiety disorders to substance abuse, personality disorders, and schizophrenia. (appi.org)
Clozapine is the only treatment proven effective for treatment-resistant schizophrenia, and is FDA-approved to decrease suicidal behavior associated with schizophrenia. (va.gov)
Only 20% of Veterans with treatment-resistant schizophrenia in the VA receive clozapine, implying that about 80% are receiving less effective treatments. (va.gov)
This cost-benefit analysis sought to simulate potential cost savings for VA that would result from increasing the use of clozapine among Veterans with treatment-resistant schizophrenia. (va.gov)
Modest increases in clozapine use could result in significant cost savings for VA. Among Veterans with treatment-resistant schizophrenia, VA would save $22,444 per Veteran over the first year of treatment, primarily from 18.6 fewer inpatient hospitalization days per patient. (va.gov)
Given this finding, if current clozapine use was doubled from 20% of patients with treatment-resistant schizophrenia to 40%, VA would accrue an estimated cost savings of $80 million over the first year. (va.gov)
If all Veterans with treatment-resistant schizophrenia initiated clozapine, it would result in an additional 743 serious adverse drug reactions (ADRs) in year one. (va.gov)
If all Veterans with treatment-resistant schizophrenia initiated clozapine, 19 suicides would be averted, while there would be a total of 18 additional deaths, 3 due to clozapine-related agranulocytosis and 15 due to ileus (blockage of the intestines). (va.gov)
Findings suggest VA should strongly consider initiatives to substantially increase clozapine use among Veterans with treatment-resistant schizophrenia. (va.gov)
Antipsychotic medication is typically used in the treatment of all types of schizophrenia and can help alleviate most symptoms. (mentalhealth.com)
Clozapine is increasingly seen as the gold standard for treatment-refractory schizophrenia , although meta-analyses of clozapine for this condition are lacking. (medscape.com)
Now a team of investigators [ 1 ] from the University of Queensland, Australia, have conducted a systematic review and meta-analysis of clozapine treatment for people with treatment-refractory schizophrenia. (medscape.com)
Clozapine is relatively underutilized in patients who have schizophrenia in the United States, and other recent studies have suggested it should be the treatment of choice for all patients who have had a single failed trial of a different first- or second-generation antipsychotic. (medscape.com)
The authors of this meta-analysis concluded that clozapine is superior to other drug treatments for treatment-refractory schizophrenia, but that if there is no response by 6 months, medications with lower adverse reactions should then be considered. (medscape.com)
If you are not prescribing clozapine in at least 6-month trials for your patients with treatment-refractory schizophrenia, you need to change your practice and start doing so. (medscape.com)
Cite this: Clozapine vs the Rest for Treatment-Refractory Schizophrenia - Medscape - Feb 24, 2017. (medscape.com)
Clozapine Best Antipsychotic for Schizophrenia? (medscape.com)
The Case for Clozapine in the Treatment of Schizophrenia Why is it that clozapine remains underutilized in the treatment of treatment-resistant schizophrenia, despite unanimous guideline recommendations? (medscape.com)

Clozapine is known for agranulocytosis so my doc didnt recommend it. (schizophrenia.com)
The risk of clozapine related agranulocytosis and neutropenia warranted the mandatory use of stringent risk monitoring and management systems, which have reduced the risk of death from these adverse events to around 1 in 7,700. (wikipedia.org)
The association between clozapine use and specific blood dyscrasias was first noted in the 1970s when eight deaths from agranulocytosis were noted in Finland. (wikipedia.org)
In 1975, 16 cases of agranulocytosis leading to 8 deaths in clozapine-treated patients, reported from 6 hospitals mostly in southwestern Finland, led to concern. (wikipedia.org)
We start clozapine, 400 mg/d, and order twice-monthly blood tests to check for clozapine-induced agranulocytosis. (mhaus.org)

Clozapine is a psychiatric medication and is the first atypical antipsychotic (also called second-generation antipsychotic) to be discovered. (wikipedia.org)
Inhibition of glucose transport in PC12 cells by the atypical antipsychotic drugs risperidone and clozapine, and structural analogs of clozapine. (jabfm.org)

I've been on clozapine about 1.75 years now, and it's been the best medication for psychosis, self-harm, and suicidal ideation that I've ever been on. (schizophrenia.com)
Increased Mortality in Elderly Patients with Dementia-Related Psychosis: Clozapine is not approved for this condition. (nih.gov)
Is clozapine more effective than other antipsychotic medications in individuals with treatment-resistant psychosis? (smiadviser.org)
The use of this drug can rarely result in clozapine-induced gastric hypomotility syndrome which may lead to bowel obstruction and death, and in older people with psychosis, as a result of dementia it may lead to an increased risk of death. (wikipedia.org)
When used only in the short term, clozapine was superior for positive and negative symptoms, with higher baseline psychosis scores predicting better outcomes for clozapine. (medscape.com)

We found clozapine to be more acceptable in long-term treatment than conventional antipsychotic drugs (n=982, 16 RCTs, RR 0.60 CI 0.5 to 0.7, NNT 15 CI 12 to 20). (qxmd.com)
However, some more recent studies and studies comparing clozapine with second-generation antipsychotic medications have not found clozapine to more effective. (smiadviser.org)

Also, participants given clozapine had fewer relapses than those on typical antipsychotic drugs (n=1303, RR 0.62 CI 0.5 to 0.8, NNT 21 CI 15 to 49). (qxmd.com)
In a 2013 network comparative meta-analysis of 15 antipsychotic drugs, clozapine was found to be significantly more effective than all other drugs. (wikipedia.org)
It can weaken antipsychotic drugs like lithium and clozapine, but boost the effects -- and side effects -- of others. (webmd.com)

I also had severe side effects on clozapine so I switched to risperidone. (schizophrenia.com)

We found no significant difference in the effects of clozapine and typical neuroleptic drugs for broad outcomes such as mortality, ability to work or suitability for discharge at the end of the study. (qxmd.com)
Researchers used this cohort approach with clozapine, and found that despite clozapine patients being more severely ill, clozapine was associated with lower hospitalization risk and better symptom and illness outcomes. (smiadviser.org)
The use of clozapine is associated with multiple improved outcomes, including a reduced rate of all-cause mortality, suicide and hospitalization. (wikipedia.org)

When prescribed appropriately, most psychotropic medications are fairly safe. (appi.org)
A wide variety of psychotropic medications have been reported in the literature to treat individuals with HD and aggressive behaviour. (researchgate.net)
GLP-1 Agonists for Weight Loss: What You Need to Know Many psychotropic medications can cause weight gain or metabolic dysregulation. (medscape.com)

If it has been more than two days since the patient last took clozapine, their dosage should be substantially reduced. (smiadviser.org)

Clozapine is an antipsychotic drug, which is claimed to have superior efficacy and to cause fewer motor adverse effects than typical drugs for people with treatment-resistant illnesses. (qxmd.com)
Clozapine carries a significant risk of serious blood disorders, which necessitates mandatory weekly blood monitoring at least during the first months of treatment. (qxmd.com)
Thirty-four per cent of treatment-resistant participants had a clinical improvement with clozapine treatment. (qxmd.com)
Participants were more satisfied with clozapine treatment than with typical neuroleptic treatment. (qxmd.com)
But bare in mind that you run the risk that the Clozapine maybe won't work again if you have to restart Clozapine treatment. (schizophrenia.com)
Patients initiating and continuing treatment with clozapine must have a baseline blood absolute neutrophil count (ANC) measured before treatment initiation and regular ANC monitoring during treatment ( 2.1 , 5.1 ). (nih.gov)
tell your doctor if you have previously received radiation therapy or treatment with other chemotherapy medications or if you have or have ever had seizures or a head injury. (medlineplus.gov)
Clozapine is regarded as the gold-standard treatment when most other medications are ineffective and its use is recommended by multiple international treatment guidelines, after resistance to two other antipsychotic medications. (wikipedia.org)
Costs of treatment for SMI alone exceed US$300 billion annually to the healthcare system [ 20 ], while hospitalizations due to medication non-adherence cost more than $100 billion annually [ 21 ]. (springer.com)
These consultations are ideal for questions about diagnosis, medication strategies, and non-pharmacological treatment options. (hopkinsmedicine.org)
At the same time, the results underscore the limitations of most antipsychotic medications for long-term treatment of chronically ill patients. (psychiatrictimes.com)
If you are using this medication, speak with your doctor or pharmacist for information about your treatment options. (medbroadcast.com)
Designed to be easily referenced, chapters are arranged alphabetically and feature sections on recognition and detection, culprit medications, assessment, management, and follow-up treatment. (appi.org)
Choosing Medication Type for Opioid Use Disorder Patients Learn more about a proposed treatment rule that would help to optimally match these patients with medication type and reduce the risk of returning to regular opioid use. (medscape.com)

2 Carrillo JA, Herraiz AG, Ramos SI, Benitez J. Effects of caffeine withdrawal from the diet on the metabolism of clozapine in schizophrenic patients. (naturalnews.com)

In 2020, a group of researchers reviewed numerous medications and how they were affected by coffee. (yahoo.com)

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. (medbroadcast.com)
If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor. (medbroadcast.com)
If it becomes necessary to stop this medication, the dose should be reduced gradually to prevent withdrawal effects. (medbroadcast.com)
If you miss a dose of this medication and remember within 2 hours, take it as soon as possible. (medbroadcast.com)
You may need to start taking the medication at a lower dose than you were taking previously. (medbroadcast.com)
We reduced clozapine dose and side effects went away. (schizophrenia.com)
How does one dose or titrate clozapine dosage when starting on this medication? (smiadviser.org)
You will receive each dose of phenytoin injection in a medical facility, and a doctor or nurse will monitor you carefully while you are receiving the medication and afterwards. (medlineplus.gov)
The flecainide trough level should be checked 3-5 days after starting the medication and less than one hour before the following dose. (medscape.com)

Clozapine participants experienced more drowsiness, hypersalivation, or temperature increase, than those given conventional neuroleptics. (qxmd.com)

Clinical improvements were seen more frequently in those taking clozapine (n=1119, 14 RCTs, RR 0.72 CI 0.7 to 0.8, NNT 6 CI 5 to 8). (qxmd.com)
However, clozapine patients experienced fewer motor adverse effects (n=1433, 18 RCTs, RR 0.58 CI 0.5 to 0.7, NNT 5 CI 4 to 6).The clinical effects of clozapine were more pronounced in participants resistant to typical neuroleptics in terms of clinical improvement (n=370, 4 RCTs, RR 0.71 CI 0.6 to 0.8, NNT 4 CI 3 to 6) and symptom reduction. (qxmd.com)
The clinical effect of clozapine, however, is, at least in the short term, not reflected in measures of global functioning such as ability to leave the hospital and maintain an occupation. (qxmd.com)
The clinical effects of clozapine were more pronounced in participants resistant to typical neuroleptics in terms of clinical improvement (n=370, 4 RCTs, RR 0.71 CI 0.6 to 0.8, NNT 4 CI 3 to 6) and symptom reduction. (edu.au)
With the substantial number of known pharmacogenes, many affecting response to commonly prescribed medications, and the availability of clinical pharmacogenetic (PGx) tests and guidelines for interpretation, the collection of family medication history can inform testing decisions. (mdpi.com)
Both FDA-approved and off-label use of antipsychotic medications are addressed, reflecting the reality of clinical practice on the front lines. (appi.org)

2 Hagg S, Spigset O, Mjorndal T, Dahlqvist R. Effect of caffeine on clozapine pharmacokinetics in healthy volunteers. (naturalnews.com)

Severe Neutropenia: Clozapine can cause severe neutropenia, which can lead to serious and fatal infections. (nih.gov)

The only thing is one must come off clozapine very gradually or the withdrawal symptoms will be severe. (schizophrenia.com)
So yes you can come off clozapine but make sure your pdoc helps you off it gradually. (schizophrenia.com)
The dosage of clozapine is titrated up gradually, to minimize side effects and maximize effectiveness. (smiadviser.org)

Phenytoin is in a class of medications called anticonvulsants. (medlineplus.gov)
tell your doctor and pharmacist if you are allergic to phenytoin, other hydantoin medications such as ethotoin (Peganone) or fosphenytoin (Cerebyx), any other medications, or any of the ingredients in phenytoin injection. (medlineplus.gov)
Your doctor will probably not want you to receive phenytoin injection if you are taking this medication. (medlineplus.gov)
Antiseizure medications , such as phenytoin and gabapentin. (clevelandclinic.org)

Therefore, it can be more informative to examine cohort studies that compare patients treated naturalistically with clozapine against a group of other patients. (smiadviser.org)

Each pale yellow, round, bevelled-edged tablet, with 'CZ25' on one side and 'G/G' (pressure sensitive bisect) on the other side, contains 25 mg of clozapine. (medbroadcast.com)
Each pale yellow, oblong, normal convex tablet with 'CZ200' on one side and 'G/G' on the other side, contains 200 mg of clozapine. (medbroadcast.com)
This medication comes in tablet and extended-release capsule forms. (rxwiki.com)

tell your doctor and pharmacist if you are allergic to busulfan, any other medications, or any of the ingredients in busulfan tablets. (medlineplus.gov)
tell your doctor and pharmacist if you are allergic to safinamide (mouth or tongue swelling, shortness of breath), any other medications, or any of the ingredients in safinamide tablets. (safemedication.com)

Clozapine is not normally associated with tardive dyskinesia (TD) and is recommended as the drug of choice when this is present, although some case reports describe clozapine-induced TD. (wikipedia.org)

Do not give this medication to people who are in a severely sedated or comatose state. (medbroadcast.com)

It is important to take this medication exactly as prescribed. (medbroadcast.com)
For this medication to be effective, it is very important to use this medication exactly as prescribed by your doctor. (medbroadcast.com)
It is important to take this medication exactly as prescribed by your doctor to ensure that you are getting the maximum benefit from the medication. (medbroadcast.com)

Fluvoxamine is a prescription medication used to treat obsessive compulsive disorder (OCD). (rxwiki.com)

Such patients may have a family history of medication-related acute dystonia. (medscape.com)

Clozapine was also associated with greater risk for weight gain and type two diabetes. (smiadviser.org)
If you mix your coffee with sugar or milk, that could lead to a spike in blood sugar and impact how well your diabetes medication works. (yahoo.com)
With those numbers, it's no surprise that millions of people take diabetes medications daily. (yahoo.com)
However, clozapine is associated with side effects including significant weight gain, diabetes, and myocarditis, as well as significant adverse drug reactions that require compliance with an FDA-mandated risk mitigation and evaluation strategy program. (va.gov)

More community-based long-term randomised trials are needed to evaluate the efficacy of clozapine on global and social functioning as trials in special groups such as people with learning disabilities. (qxmd.com)

What side effects are possible with this medication? (medbroadcast.com)
Many medications can cause side effects. (medbroadcast.com)
A side effect is an unwanted response to a medication when it is taken in normal doses. (medbroadcast.com)
To cut a long story short I have had it tolerating the side effects of clozapine. (schizophrenia.com)
If you take busulfan with other medications that may cause a low blood count, the side effects of the medications may be more severe. (medlineplus.gov)
Your doctor may need to change the doses of your medications or monitor you carefully for side effects. (medlineplus.gov)
Using this medication improperly or without the advice of a doctor can result in serious side effects or death. (drugs.com)
Side effects may be increased if you take biotin with medications that are changed by the liver. (healthline.com)
The concomitant presence of these different pathologies can be explained either by their intertwined pathophysiological mechanisms, or by the side effects of the various medications taken in the context of these chronic diseases. (who.int)

All survey participants aged 2 months and older are eligible for the Sample prescription medication questions. (cdc.gov)
However, for both the household youth and adult questionnaires if a particular medication reported in the prescription medication section of the questionnaire was available in both prescription and non-prescription strengths (e.g., ibuprofen), the staff assumed it was a prescription medication and left it in this section. (cdc.gov)
See the notes associated with this variable in the data file layout for a detailed discussion of the prescription medication product code. (cdc.gov)
Valtrex is a prescription medication that contains the active ingredient Valacyclovir. (canadapharmacy.com)

Twenty-one papers with 25 comparison treatments were included, and the researchers found that clozapine was superior for treating positive symptoms in both the short and long term. (medscape.com)

Severe gastrointestinal adverse reactions have occurred with the use of clozapine. (nih.gov)

Within the context of trials, the potentially dangerous white blood cell decline seems to be more frequent in children and adolescents and in the elderly than in young adults or people of middle-age.The existing trials have largely neglected to assess the views of participants and their families on clozapine. (qxmd.com)
The existing trials have largely neglected to assess the views of participants and their families on clozapine. (edu.au)
A concern with these recent studies has been that, when medications are readily available, patients who enroll in randomized controlled trials are often not representative of the larger population with the illness. (smiadviser.org)
Further trials took place in 1972 when clozapine was released in Switzerland and Austria as Leponex. (wikipedia.org)

Diseases4

Chemicals and Drugs24

Analytical, Diagnostic and Therapeutic Techniques and Equipment8

Psychiatry and Psychology6

Phenomena and Processes3

Health Care9

Geographicals1

Antipsychotics10

Clozaril1

Olanzapine9

Schizophrenia27

Agranulocytosis5

Atypical antipsychotic2

Psychosis5

Found clozapine2

Antipsychotic drugs3

Risperidone1

Outcomes3

Psychotropic medications3

Substantially1

Treatment14

Metabolism1

20201

Dose9

Hypersalivation1

Clinical6

Pharmacokinetics1

Neutropenia1

Gradually3

Phenytoin4

Patients treated1

Tablet3

Allergic2

Tardive dyskinesia1

Severely1

Exactly as prescribed3

Fluvoxamine1

Acute1

Diabetes4

Efficacy1

Side9

Prescription medication4

Researchers1

Adverse reactions1

Trials4