• Chemokines in eosinophil recruitment in asthma, Fifth FASEB on Cytokines and Lipid Mediators, Vermont. (imperial.ac.uk)
  • The inflammatory process in asthma involves the increased expression of various pro-inflammatory chemokines, cytokines, growth factors, lipid mediators, adhesion molecules, enzymes, and receptors for the same inflammatory mediators 21 . (ersjournals.com)
  • It has been suggested that endogenous factors might contribute to the rapid progression of periodontal breakdown such as inappropriate regulation of enzymes, lipid mediators, collagen biosynthesis or T cell immunodeficiency. (bvsalud.org)
  • The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. (genome.jp)
  • CX3CR1 Antibody: CX3CR1 is one of the chemokine receptors that are required as coreceptors for HIV infection. (prosci-inc.com)
  • These dying cells turn up expression of their CCR5 chemokine receptors even as the cells are about to be engulfed by macrophages. (rupress.org)
  • CX3C motif chemokine receptor 1 (CX3CR1), also known as the fractalkine receptor or G-protein coupled receptor 13 (GPR13), is a transmembrane protein of the G protein-coupled receptor 1 (GPCR1) family and the only known member of the CX3C chemokine receptor subfamily. (wikipedia.org)
  • Chemokines such as CXCL10 (IP-10) and CXCL9 may inhibit cancer development. (thomasnet.com)
  • Several inflammatory mediators increased at disease exacerbation although CCL19, CXCL11, CXCL10, IL-10 and IL-1 receptor antagonist were most pronounced. (lu.se)
  • Interestingly, inflammatory cytokine/chemokine levels upon exposure to Me/MeO NPs, with or without UVB pre-treatment, followed similar trends compared to cell/tissue damage i.e. (cdc.gov)
  • Furthermore, other cells at the interface of the innate and the adaptive immune system (e.g cytokine-induced killer cells (CIK) or invariant natural killer T-cells (iNKT)) are important mediators in antitumor-, autoimmune-, and antimicrobial responses and tumor surveillance. (nature.com)
  • Cytokine‐related and chemokine‐related pathways were enriched in tumor types frequently associated with the syndrome. (genengnews.com)
  • this was reduced by a proinflammatory cytokine but increased by proresolution mediators. (rupress.org)
  • Chemokine/cytokine responses in immune complex triggered IFN-α activity was studied in healthy donor peripheral blood mononuclear cells (PBMC). (lu.se)
  • The chemokine CCL2 participates in multiple neuroinflammatory processes, mainly through the recruitment of glial cells. (mdpi.com)
  • Chemokine CCL (CCL2) is a key mediator for activating microglia. (ncbcs.org)
  • As the name suggests, this receptor binds the inflammatory chemokine CX3CL1 (also called neurotactin in mice or fractalkine in humans). (wikipedia.org)
  • The CX3CR1 receptor is part of the G-protein chemokine receptor family with the metabotropic function. (wikipedia.org)
  • Smooth muscle cells in human atherosclerotic plaques express the fractalkine receptor CX3CR1 and undergo chemotaxis to the CX3C chemokine fractalkine (CX3CL1). (prosci-inc.com)
  • IL-15 and IL-2 oppositely regulate expression of the chemokine receptor CX3CR1. (prosci-inc.com)
  • Cannabinoid type-2 (CB 2 ) receptor activation was shown to reduce the production of the monocyte chemotactic protein-2 (MCP-2) chemokine in polyinosinic-polycytidylic acid [poly-(I:C)]-stimulated human keratinocyte (HaCaT) cells, an in vitro model of allergic contact dermatitis (ACD). (aspetjournals.org)
  • Chemokine receptor 5 (CCR5) has gained attention as therapeutic target in various malignancies. (cancerindex.org)
  • The shedded form carries out typical function of conventional chemokines, the chemotaxis, while the membrane-bound protein behaves as adhesion molecule for facilitation of diapedesis. (wikipedia.org)
  • The levels of the inflammatory mediator 5-LO expression increased in DS patients with PD. (bvsalud.org)
  • While circulating plasma mediators (soluble cachectic factors) derived from tumors have been implicated with the pathogenesis of the syndrome, these associations were generally based on plasma concentration rather than tissue‐specific gene expression levels. (genengnews.com)
  • Now, the Boston team shows that some of these chemokine proteins are mopped up by apoptotic cells. (rupress.org)
  • Oral administration of SHE suppressed several atopic symptoms associated with house dust mites (induced with Dermatophagoides farinae extract) in NC/Nga mice and decreased serum levels of inflammatory mediators such as immunoglobulin E, histamine, and inflammatory chemokines. (researchgate.net)
  • In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival. (genome.jp)
  • Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. (genome.jp)
  • The purpose of this study was to determine whether chemokines and chemoattractant cytokines were increased in the lumen of human cerebral aneurysms. (duke.edu)
  • CONCLUSIONS: High plasma concentrations of chemokines (monocyte chemoattractant protein-1, RANTES, MIG, IP-10, and eotaxin) and chemoattractant cytokines (IL8 and IL17) were found in the lumen of human cerebral aneurysms. (duke.edu)
  • METHODS: The concentrations of chemokines and other inflammatory molecules in blood samples drawn from the lumen of human cerebral aneurysms of 16 consecutive patients (harboring 18 aneurysms) were compared with blood samples from the femoral arteries of the same patients. (duke.edu)
  • gamma-PGA NPs are efficiently internalized by immature MoDCs and strongly stimulate production of chemokines and inflammatory cytokines as well as up-regulation of co-stimulatory molecules and immunomodulatory mediators involved in efficient T cell priming. (lu.se)
  • This results in a complex microenvironment within the periodontium, consisting of immune surveillance response, cellular damage and repair, and the production of cytokines, chemokines and other inflammatory mediators 10 . (bvsalud.org)
  • Here, we hypothesized that tumor gene expression profiling of cachexia‐inducing factors (CIFs) in human cancers with different prevalence of cachexia could reveal potential cancer‐specific cachexia mediators and biomarkers of clinical outcome," write the investigators. (genengnews.com)
  • A comprehensive characterization of the expression profiling of secreted genes in different human cancers revealed pathways and mediators with a potential role in cachexia within the tumor microenvironment. (genengnews.com)
  • Salmonella enterica Typhimurium SipA induces CXC-chemokine expression through p38MAPK and JUN pathways. (umassmed.edu)
  • Myocardial damage is caused by vasculitis, leading to coronary occlusion due to the release of toxic mediators by activated eosinophils causing direct myocardial damage, or by replacement of the myocardium with granulomas and scar tissue. (medscape.com)
  • Eotaxin-3, a chemokine highly secreted by endothelial and inflammatory cells in CSS patients' damaged tissues, seems to directly target eosinophils toward affected tissues. (medscape.com)
  • Stimulation with SARS-CoV-2 spike protein or LPS triggered exaggerated prostanoid-, type I IFN-, and chemokine responses in post COVID-19 MDM. (nature.com)
  • If CCR5 was knocked out or antagonized, however, fluid from resolving infections had higher chemokine levels. (rupress.org)
  • BUD and FORM suppress RV-induced chemokines and growth factors in bronchial epithelial cells in a concentration-dependent, synergistic or additive manner. (nih.gov)
  • Anaphylaxis is an acute, potentially fatal, multiorgan system reaction caused by the release of chemical mediators from mast cells and basophils. (medscape.com)
  • The result was more chemokine binding to late apoptotic cells. (rupress.org)
  • Thus it appears that the dying cells are mopping up chemokines and taking them to the grave. (rupress.org)
  • Acute alcohol intoxication suppresses the pulmonary ELR-negative CXC chemokine response to lipopolysaccharide. (umassmed.edu)
  • By studying transcriptome- and lipid mediator profiles in MDM of convalescent SARS-CoV-2-infected individuals with previous mild disease, we show that inflammatory gene expression and eicosanoid profiles as well as altered responsiveness to inflammatory cues are maintained at 3-5 months post infection as well as throughout macrophage differentiation. (nature.com)
  • Furthermore, DS patients with PD presented high levels of 5-LO expression, suggesting the presence of leukotriene B4 (LTB4) in PD, thus demonstrating that the changes in NE function due to the elevation of inflammatory mediators contribute to PD. (bvsalud.org)
  • Arterial-venous network formation during brain vascularization involves hemodynamic regulation of chemokine signaling. (umassmed.edu)
  • Levels of chemokines/cytokines and galectin-9 were measured by immunoassays. (lu.se)
  • RVs infect the lower airways and induce the production of pro-inflammatory and remodelling-associated mediators. (nih.gov)
  • Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production. (genome.jp)
  • The production of inflammatory mediators is important to prevent changes in brain homeostasis. (bvsalud.org)
  • Scholars@Duke publication: Localized increase of chemokines in the lumen of human cerebral aneurysms. (duke.edu)
  • In general, the host response to bacterial stimuli leads to a cascade of inflammatory mediators such as cytokines (TNF-α), chemokines (IL-8) as well as prostaglandins and leukotrienes, which are metabolites from arachidonic acid. (bvsalud.org)
  • Exposure of EpiDerm FT to Me/MeO NP caused tissue damage, oxidative stress and accumulation of inflammatory mediators. (cdc.gov)
  • UVB exposure alone induced significant tissue damage and secretion of cytokines/chemokines. (cdc.gov)
  • Rheumatoid arthritis causes damage mediated by cytokines, chemokines, and metalloproteases. (msdmanuals.com)
  • This study evaluates galectin-9 and an array of chemokines/cytokines in their potential as surrogate markers of type I IFN and/or SLE disease activity. (lu.se)
  • IFN-α and disease activity (SLEDAI-2K) were correlated (rho=0.20) at cross-sectional analysis, but no significant associations were found between SLEDAI-2K and galectin-9 or chemokines. (lu.se)