• COUP-TFII (COUP transcription factor 2), also known as NR2F2 (nuclear receptor subfamily 2, group F, member 2) is a protein that in humans is encoded by the NR2F2 gene. (wikipedia.org)
  • COUP-TFII plays a critical role in controlling the development of a number of tissues and organs including heart, blood vessels, muscles and limbs. (wikipedia.org)
  • The glucocorticoid receptor (GR) stimulates COUP-TFII-induced transactivation while COUP-TFII represses the GR transcriptional activity. (wikipedia.org)
  • COUP-TFII interacts with GATA2 to inhibit adipocyte differentiation. (wikipedia.org)
  • COUP-TFII has been shown to interact with: HDAC1 Lck V-erbA-related gene. (wikipedia.org)
  • Furthermore, enzalutamide-induced YAP1 expression is mediated through the function of chicken ovalbumin upstream promoter transcription factor 2 (COUP-TFII) at the transcriptional and the post-transcriptional levels. (nih.gov)
  • Functional analyses reveal that YAP1 positively regulates numerous genes related to cancer stemness and lipid metabolism and interacts with COUP-TFII to form a transcriptional complex. (nih.gov)
  • Finally, YAP1, COUP-TFII, and miR-21 are detected in the extracellular vesicles (EVs) isolated from EnzaR cells and sera of patients. (nih.gov)
  • Mechanistically, TIE1 deficiency resulted in the decreased expression of venous regulators including TIE2 and COUP-TFII (chicken ovalbumin upstream promoter transcription factor, encoded by Nr2f2, nuclear receptor subfamily 2 group F member 2) while angiogenic regulators were upregulated. (bvsalud.org)
  • This is an important study demonstrating distinct roles for the nuclear receptor genes COUP-TFI and COUP-TFII in hippocampal development. (elifesciences.org)
  • Bioinformatic analysis and molecular biological characterization revealed that VEGF-C is negatively regulated by an orphan nuclear receptor, chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII). (endometriosistreatmentreport.com)
  • Further studies demonstrated that proinflammatory cytokines, via suppression of COUP-TFII level, induce VEGF-C overexpression. (endometriosistreatmentreport.com)
  • Taken together, we identify the vicious cycle of inflammation, COUP-TFII, VEGF-C, and lymphangiogenesis in the endometriotic microenvironment, which opens up new horizons in understanding the pathophysiology of endometriosis. (endometriosistreatmentreport.com)
  • It may have the ability to interact with other HLH-proteins and function as a transcription factor or as a positive transcriptional regulator under the control of Retinoblastoma protein. (nih.gov)
  • These diverse actions of glucocorticoids are mediated by the glucocorticoid receptor (GR), which belongs to the nuclear receptor superfamily and functions as a hormone-dependent transcription factor. (brainimmune.com)
  • Intriguingly, Fpr1 promotes the binding of Fhl1/Ifh1 (forkhead-like 1/interacts with forkhead 1), two key regulators of RPG transcription, to certain RPG promoters independently of and/or cooperatively with Hmo1. (prolekarniky.cz)
  • The Mediator subunit MED1/TRAP220 is required for optimal glucocorticoid receptor-mediated transcription activation. (shengsci.com)
  • Eukaryotic High-Mobility Group B (HMGB) proteins alter DNA elasticity while facilitating transcription, replication and DNA repair. (shengsci.com)
  • Each RNA polymerase requires the assistance of several other proteins or protein complexes, called general (or basal) transcription factors, which must assemble into a complex on the promoter in order for RNA polymerase to bind and start transcription. (stemcelldaily.com)
  • Besides, and studied to a lesser extent, they also depend on non-lectinic properties mediated by interactions of galectins with nucleic acids, proteins, lipids, and complex biomolecules (reviewed in [ 4 ], Table 1 ). (encyclopedia.pub)
  • The most-extensively studied core promoter element in eukaryotes is a short DNA sequence known as a TATA box, found 25-30 base pairs upstream from the start site of transcription. (stemcelldaily.com)
  • In addition, transcription is also regulated by upstream control elements that lie 5′ to the TATA box. (stemcelldaily.com)
  • Ear2 is an orphan nuclear hormone receptor that belongs to the chicken ovalbumin upstream promoter-transcription factors (COUP-TF) gene family [ 14 ]. (biomedcentral.com)
  • Deep RNA-DNA, RNA-protein interaction studies, and phenotype rescue analyses reveal that LETR1 is a nuclear trans-acting lncRNA modulating, via key epigenetic factors, the expression of essential target genes, including KLF4 and SEMA3C , governing the growth and migratory ability of LECs. (nature.com)
  • Eukaryotic RNA polymerases do not terminate transcription at a specific site but rather transcription can stop at varying distances downstream of the gene. (stemcelldaily.com)
  • In an early step, the Dorsocross genes act in parallel with tinman to activate the expression of pannier , a cardiogenic gene encoding a Gata factor. (biologists.com)
  • The alteration of TIE2 level by TIE1 insufficiency was further confirmed by the siRNA-mediated knockdown of Tie1 in cultured endothelial cells. (bvsalud.org)
  • In addition, we demonstrated that shRNA-mediated knockdown of Rasd1 results in further repression of Ear2-mediated renin transcription, whereas induction of Rasd1 by dexamethasone counteracts the effects of shRNA-mediated Rasd1 knockdown. (biomedcentral.com)
  • Angiopoietin, Tie, and particularly the molecular pathways they mediate have all been the subject of recent studies that have established their diagnostic, prognostic, and therapeutic potential. (bvsalud.org)
  • Since glucocorticoids are essential for life, other cellular signaling pathways strongly regulate GR actions in many different ways, such as physical interaction via their effector transcription factors and epigenetic modifications including phosphorylation and acetylation. (brainimmune.com)
  • Transcription in eukaryotes is a complex and highly regulated process that ensures accurate and timely expression of genes. (stemcelldaily.com)
  • In all these organisms, cardiac induction in the lateral mesoderm involves the concerted action of signals mediated by Bmp, Wnt and Fgf family members, which act upon cardiogenic genes encoding NK homeodomain, Gata and T-box transcription factors (reviewed by Zaffran and Frasch, 2002 ). (biologists.com)
  • Angiogenesis has been recognized as a critical factor in developing solid tumors and hematological malignancies. (bvsalud.org)
  • To further explore the molecular function of Rasd1, we performed a yeast two-hybrid screen and identified Ear2, a negative regulator of renin transcription, as an interaction partner of Rasd1. (biomedcentral.com)
  • Finally, our study showed that Rasd1 missense mutations not only attenuate their physical interaction with Ear2 but also abolish their ability to counteract repression of renin transcription mediated by Ear2. (biomedcentral.com)
  • Ectopic expression of DOCK8 regulates lysosome-mediated pancreatic tumor cell invasion. (mayo.edu)
  • These findings describe a contribution of the axon guidance molecule, EphA4, in mediating TBI microvascular dysfunction through negative regulation of Tie2/Akap12 signaling. (bvsalud.org)
  • Transcription is the process by which the information in a strand of DNA is copied into a new molecule of RNA. (stemcelldaily.com)
  • Aims: The aim of this study was to sensitize the resistant breast adenocarcinoma cells towards Tumour Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-induced apoptosis. (eurekaselect.com)
  • The TATA box is recognized by a transcription factor called TATA-binding protein (TBP), which is part of a larger complex called TFIID. (stemcelldaily.com)
  • Notably, Fpr1 orthologues from other species also inhibit TORC1 when bound to rapamycin, but do not regulate transcription in yeast, which suggests that these two functions of Fpr1 are independent of each other. (prolekarniky.cz)
  • Structure-function analysis of Hmo1 unveils an ancestral organization of HMG-Box factors involved in ribosomal DNA transcription from yeast to human. (prolekarniky.cz)
  • GLI1, a novel target of the ER stress regulator p97/VCP, promotes ATF6f-mediated activation of XBP1. (mayo.edu)
  • Lavigne MD, Konstantopoulos D, Ntakou-Zamplara KZ, Liakos A, Fousteri M. 2017 , "Global unleashing of transcription elongation waves in response to genotoxic stress restricts somatic mutation rate" , Nat Commun. (fleming.gr)
  • Neurobiological consequences of traumatic brain injury (TBI) result from a complex interplay of secondary injury responses and sequela that mediates chronic disability. (bvsalud.org)
  • Cardiac remodelling is a key risk factor for the development of heart failure in the chronic phase following myocardial infarction. (omeka.net)
  • 2917366 . RA Buratowski S., Hahn S., Guarente L., Sharp P. A. RT Five Intermediate Complexes in Transcription Initiation by RNA Polymerase II RL Cell 56:549-561 (1989). (genexplain.com)
  • During development, the blood vascular system arises from endothelial cell progenitors that differentiate from mesodermal cells, mostly through the expression of the transcription factor (TF) ETV2. (nature.com)
  • Transcription in eukaryotes is the elaborate process that eukaryotic cells use to copy genetic information stored in DNA into units of transportable complementary RNA replica. (stemcelldaily.com)
  • Moreover, real-time RT-PCR showed upregulation of endogenous renin transcription in As4.1 cells over-expressing Rasd1. (biomedcentral.com)
  • Herein, we identified that vascular endothelial growth factor (VEGF)-C, a potent lymphangiogenic factor, is up-regulated in endometriotic cells and contributes to increased lymphangiogenesis. (endometriosistreatmentreport.com)
  • Thus, abnormalities in this pathway could mediate maternal smoking effects. (biomedcentral.com)
  • Taken together, these results suggest that YAP1 might be a crucial factor involved in the development of enzalutamide resistance and can be an alternative therapeutic target in prostate cancer. (nih.gov)
  • We have shown that TIE2 is required for vein development while little is known about its homologue TIE1 (tyrosine kinase with immunoglobulin-like and EGF [epithelial growth factor]-like domains 1) in this process. (bvsalud.org)
  • I became interested in vascular biology and development during my graduate training with Shaun Coughlin at UCSF and in epigenetics and transcription during my postdoctoral training with Terry Magnuson at UNC-Chapel Hill. (omrf.org)
  • Current data indicates that anti-tumor T cell-mediated immunity correlates with a better prognosis in cancer patients. (encyclopedia.pub)