Mediates cells gene expression bone morphogenetic protein 5. Medical search. Frequent questions

We also show that loss of USP15 expression from mouse myoblast cells inhibits BMP-induced osteoblast differentiation. (crick.ac.uk)
Gene transcription is induced during myoblast differentiation, producing all 3 mRNAs. (wikipedia.org)
BMPs are involved in a host of cellular functions including osteogenesis , cell growth and cell differentiation . (wikidoc.org)
BMPR2 is expressed on both human and animal granulosa cells, and is a crucial receptor for bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF 9). (wikidoc.org)
cell differentiation. (ispub.com)
Growth/differentiation factor-5 (GDF-5) belongs to the bone morphogenetic protein (BMP) family, which is expressed in dental pulp tissues. (ispub.com)
Nevertheless, the effect of GDF-5 on odontoblast differentiation from dental pulp tissues remains unknown. (ispub.com)
In this study, we assayed the effect of exogenous mouse recombinant GDF-5 on cell proliferation of dental pulp cells and determined the expression levels of odontoblast differentiation marker genes in the cells of isolated mouse dental pulp tissues in the presence of GDF-5. (ispub.com)
These results indicate that, although GDF-5 may have no effect on cell proliferation in isolated dental pulp tissue, it could promote odontoblast differentiation. (ispub.com)
Growth/differentiation factor-5 (GDF-5) is a member of the bone morphogenetic protein (BMP) family, which is a subgroup of the transforming growth factor- (TGF-) superfamily. (ispub.com)
Here, we investigated the effect of GDF-5 on the proliferation of dental pulp cells and their differentiation into odontoblasts by assaying the expression levels of odontoblast marker genes. (ispub.com)
MicroRNAs regulate target gene expression post-transcriptionally in a myriad of cell types and play critical roles in diverse physiological and pathological processes, including cardiomyocyte development, differentiation, and regeneration. (biomedcentral.com)
Such a prospect is currently hampered, however, in part by an incompletely defined complex of molecular regulators of cardiac cell development and differentiation. (biomedcentral.com)
This commentary discusses the findings from Wagh and colleagues published in this issue of Stem Cell Research and Therapy demonstrating a critical role for miR-363 in post-transcriptional regulation of CM differentiation via the hand and neural crest derivative expressed HAND1 transcription factor [ 1 ]. (biomedcentral.com)
Identifying molecular regulators and critical mediators of cardiac cell type development, proliferation, and differentiation is of great clinical importance, and unraveling such molecular horizons could lead to the development of therapeutic strategies for successful regeneration of the human adult heart. (biomedcentral.com)
miRNAs could thus be the best targets for understanding cardiac specialization during differentiation of human embryonic stem cells (hESCs). (biomedcentral.com)
To this end, the authors performed miRNA expression profiling in undifferentiated hESCs and CMs at day 8 and day 14 after differentiation. (biomedcentral.com)
We subsequently discuss how β-TCP can regulate osteogenic processes to aid bone repair/healing, namely osteogenic differentiation of mesenchymal stem cells, formation of blood vessels, release of angiogenic growth factors, and blood clot formation. (frontiersin.org)
Global transcriptome and chromatin occupancy analyses of ZNF148 revealed a central role in inhibiting cancer cell de-differentiation and migration. (nature.com)
Tumor initiation and progression often involve the dysregulation of developmentally important genes in cancer cells, endowing them with stem cell-like features such as enhanced self-renewal, invasiveness, and an aberrant differentiation state [ 1 ]. (nature.com)
The MYC proto-oncogene is a transcription factor essential in stem/progenitor cell maintenance and differentiation [ 11 ]. (nature.com)
Developmentally, it is well established that expression of the ID members is strongest in stem/progenitor cells, while their levels decrease upon differentiation. (nature.com)
The analysis identified genes whose expression changed dramatically during the differentiation program, including multiple genes functionally related to bone morphogenetic proteins (BMPs). (heightquest.com)
In contrast, BMP-7, previously shown to inhibit growth plate chondrocyte differentiation in cultured fetal metatarsal bones, was found to be expressed at the highest levels in PZ. (heightquest.com)
BMPR1a may mediate the effects of BMPs earlier in the differentiation pathway, especially in the transition from resting to proliferative phenotype, whereas BMPR1b may preferentially mediate the effects of BMPs on hypertrophic differentiation. (heightquest.com)
Functionally, BMP-9-treated HSVSMCs displayed a time-dependent increase in s-mothers against decapentaplegic (SMAD)1 phosphorylation paralleled by an increase in ID1 (encodes inhibitor of differentiation-1) mRNA expression levels indicating that BMP-9 activates the SMAD1 pathway in this cell type. (gla.ac.uk)
The expression of osteogenesis-related gene was increased, which demonstrated that released BMP-2 could effectively induce the cell sheet osteogenic differentiation in vitro. (dovepress.com)
It is a complex and dynamic process to form a continuous construct via the cells' adhesion, proliferation, differentiation, and extracellular matrix (ECM) deposition on a scaffold. (dovepress.com)
2008). Lgr5 deficiency leads to premature Paneth cell differentiation in the small intestine without detectable effects on the differentiation of other cell lineages, or on proliferation or migration (Garcia, et al. (researchsquare.com)
they are capable of stimulating the differentiation of pluripotent mesenchymal cells to osteoprogenitor cells. (allenpress.com)
They are responsible for several biological activities involving tissue morphogenesis, regeneration, healing, and cell differentiation processes. (allenpress.com)
By computing significance with hypergeometric test based on the KEGG pathway database, upregulated DEGs highlight the pathways of T cell receptor signaling and the differentiation of T helpers. (hindawi.com)
Neogenin is a member of the DCC (deleted in colorectal cancer) family which involves in many physiological and pathological processes such as body homeostasis, tissue formation, angiogenesis, iron metabolism, immunoregulation, cell differentiation, proliferation, migration, and apoptosis through interacting with different ligands such as neuronal guidance cues (netrin) and repulsive guidance molecule(RGM). (shsmu.edu.cn)
In this study, we found that BMP-13 inhibited the osteogenic differentiation of human bone marrow multipotent mesenchymal stromal cells (BM MSCs) in vitro. (ijbs.com)
In conclusion, BMP-13 inhibited osteogenic differentiation of MSCs, implying that functional mutations or deficiency of BMP-13 may allow excess bone formation. (ijbs.com)
BMP-13, also known as growth differentiation factor 6 (GDF6) and cartilage-derived morphogenetic protein-2 (CDMP-2), was first identified and isolated as a component of bovine cartilage [ 5 ]. (ijbs.com)
microRNAs (miRNAs) are important regulatory molecules in cellular processes including cell differentiation. (biomedcentral.com)
Experimental studies assessing the promotive/suppressive effect of miRNAs on the differentiation of hDP-MSCs and studies evaluating changes to the expression of miRNAs during the differentiation of hDP-MSCs were included. (biomedcentral.com)
A number of studies have shown that incoming axons can regulate the proliferation and differentiation of their synaptic target cells. (wiringthebrain.com)
In the fly visual system, for example, photoreceptor axons target the developing optic lobe and secrete the morphogen hedgehog, which induces optic lobe progenitor cells to complete a final cell division and undergo neuronal differentiation (Huang and Kunes, 1996). (wiringthebrain.com)
2007). Thus, the final differentiation of cells in the optic lobe requires the prior pathfinding of retinal axons to this area. (wiringthebrain.com)
The osteogenic differentiation of BMSCs was detected by alkaline phosphatase (ALP) staining, and the mRNA expression levels of ALP, OCN, COL, and Runx2 were detected by qPCR. (hindawi.com)
Notably, it promotes the osteogenic differentiation of bone mesenchymal stem cells (BMSCs) [ 15 - 17 ]. (hindawi.com)
Furthermore, mechanical stretch may induce the differentiation of BMSCs into mature osteoblasts and enhance the deposition of the bone matrix [ 18 - 20 ]. (hindawi.com)
Human mesenchymal stem cells (MSCs) are therapeutic for clinical applications because of their excellent immunomodulatory and multiple lineage differentiation abilities at tissue injury sites. (biomedcentral.com)
MSCs have limited pluripotency and capacity for cell differentiation compared to embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). (biomedcentral.com)
Long non-coding RNAs (lncRNAs) and miRNAs belong to a class of non-coding RNAs (ncRNAs) that play important roles and functions in the regulation of the expression of genes in main biological processes, such as cell proliferation, apoptosis, and differentiation. (ac.ir)
7. Gerrard L, Rodgers L, Cui W. Differentiation of human embryonic stem cells to neural lineages in adherent culture by blocking bone morphogenetic protein signaling. (ac.ir)
FGF-10 immunostaining could be related to cell proliferation in epithelium and cell differentiation in epithelium and ectomesenchyme. (bvsalud.org)

It also inhibits pulmonary arterial proliferation in response to growth factors, which prevents the closing of arteries by proliferating endothelial cells. (wikidoc.org)
There were no significant differences in dental pulp cell proliferation patterns related to the absence or presence of GDF-5 after seven days of culture. (ispub.com)
2003). A previous in-vitro study on the role of GDF-5 in periodontal ligament cells has shown that exogenous GDF-5 promotes cell proliferation while suppressing the activity of alkaline phosphatase (ALP), which is closely related to tissue calcification and which is secreted during the formation of tissue calcifications. (ispub.com)
ZNF148 suppressed cell proliferation and migration and was transcriptionally repressed by MYC in breast cancer. (nature.com)
Depletion of ZNF148 by short hairpin RNA (shRNA) and CRISPR/Cas9 increased triple-negative breast cancer (TNBC) cell proliferation and migration. (nature.com)
6. Modulation of cathepsin S (CTSS) regulates the secretion of progesterone and estradiol, proliferation and apoptosis of ovarian granulosa cells in rabbits.Animals,2021, 11(6). (dxtang.com)
SMAD5 plays a critical role in the signaling pathway by which TGFβ inhibits the proliferation of human hematopoietic progenitor cells. (signalchem.com)
BMP-2 induces chondrocyte proliferation, endochondral bone formation, longitudinal bone growth, and bone and cartilage repair (6, 7). (novusbio.com)
Here, we demonstrated a preconditioning strategy with trophoblast stem cell-derived extracellular vesicles (TSC-EVs) to boost the proliferation and regenerative capacity of MSCs. (biomedcentral.com)
We employed cell proliferation analyses such as CCK8 and BrdU assays to determine the proliferation-promoting role of TSC-EVs on MSCs. (biomedcentral.com)
Histomorphometry revealed that although the bone formation rate and mineralizing surface at the periosteum decreased in Tg mice, they increased at the endosteum, suggesting opposing effects of IGFBP-5 on periosteal and endosteal osteoblasts (by altering proliferation or survival). (westminster.ac.uk)
Finally, EPB41L4A-AS2 inhibited breast cancer cell proliferation, migration and invasion and induced cell apoptosis in vitro. (cancerindex.org)

RGMs can coordinate Smad-dependent and Smad-independent signalling of BMPs in prostate cancer and breast cancer cells. (wikipedia.org)
Along with other BMPs, including BMP-2, -4 and -7, which are well known as potent osteoinductive growth factors, GDF-5 plays important roles in the development of bones, cartilage and tendons, as evidenced by the tendency for the gene and protein expression levels of GDF-5 to increase over time in these tissues. (ispub.com)
Our findings suggest a BMP signaling gradient across the growth plate, which is established by differential expression of multiple BMPs and BMP inhibitors in specific zones. (heightquest.com)
and bone morphogenetic proteins, BMPs) that stimulate tumor growth and bone destruction [ 1 ]. (biomedcentral.com)
It may be feasible in the near future for BMPs to replace autologous and allogenic bone grafts. (allenpress.com)
BMPs comprise the largest subfamily of TGF-beta and belong to a group of noncollagen proteins. (allenpress.com)
Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-β (TGF-β) superfamily, which includes the families of TGF-βs, BMPs, activins and inhibins. (ijbs.com)
BMPs were originally identified because of their ability to induce endochondral bone formation and are important regulators of key events in the process of bone formation during embryogenesis, postnatal growth, remodelling and regeneration of the skeleton [ 1 , 2 , 3 ]. (ijbs.com)
Comparisons with other BMPs known for their ability to stimulate bone growth have suggested that BMP-13 is not strongly osteo-inductive [ 9 , 10 , 11 , 12 ]. (ijbs.com)
The function of BMPs in bone remodelling and fracture repair is associated with the recruitment of stem cells from surrounding tissues and with effects on the osteogenic lineage commitment of these cells. (ijbs.com)
Among them, bone morphogenic proteins (BMPs) are thought to be the most potent osteoinductive factors and play a key role in the process of bone formation during DO. (hindawi.com)
Families of molecules such as those of Wnt, Hh (hedgehog), FGFs (Fibroblast Growth Factor) and BMPs (Bone Morphogenetic Protein, of TGFßs - Transforming Growth Factor family) have been identified, in different proportions and sites, with tissue-specific and stage-specific functions 1-2 . (bvsalud.org)

Fig. 5: RhoA induces glucose transporter SLC2A3 translocation which drives subcellular glycolysis in thrombin-stimulated contractile endothelial cells. (nature.com)
In mature human B cells, bone morphogenetic protein 6 (BMP-6) inhibits cell growth and rapidly induces phosphorylation of SMADs 5 and 8. (signalchem.com)
In addition, secretion of additional signaling molecules induces expression in the optic lobe neurons of adhesion molecules and guidance factors necessary for retinal axons to recognize them as appropriate synaptic targets (Bazigou et al. (wiringthebrain.com)
Recombinant human/mouse/rat BMP-2 (355-BM) induces alkaline phosphatase production in the ATDC5 mouse chondrogenic cell line. (novusbio.com)
By using a PCa/stroma co-culture model, here we show that stromal TGF-β signaling induces comprehensive morphology changes of PCa LNCaP cells. (oncotarget.com)
Furthermore, it induces AR activation in LNCaP cells in the absence of significant levels of androgen, as evidenced by induction of several AR target genes including PSA, TMPRSS2, and KLK4. (oncotarget.com)
MDV3100 effectively blocks DHT-induced, but not stromal TGF-β signaling induced AR activation in LNCaP cells, indicating that stromal TGF-β signaling induces both ligand-dependent and ligand-independent AR activation in PCa. (oncotarget.com)
TGF-β induces the expression of several growth factors and cytokines in prostate stromal cells, including IL-6, and BMP-6. (oncotarget.com)
The field induces a complex reaction between the membrane and the plasmid that is accumulated at the cell interface by electrophoretic forces. (uni-bielefeld.de)
Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer's Disease Model. (stanford.edu)
Here, we show that the blood protein fibrinogen induces spine elimination and promotes cognitive deficits mediated by CD11b-CD18 microglia activation. (stanford.edu)

10. Transcriptome analysis of differentially expressed genes in rabbits'ovaries by digital gene-expression profiling. (dxtang.com)
In this study, three independent microarray studies of CD were integrated and 9912 differentially expressed genes (DEGs) were analysed by NetworkAnalyst to screen candidate crucial genes. (hindawi.com)
Transcriptomic analysis also provided evidence that specific microRNAs in TSC-EVs and differentially expressed genes (DEGs) in TSC-EV-treated MSCs showed the possibility of TSC-EVs triggering the regenerative abilities of MSCs with cytokine interaction. (biomedcentral.com)

To date, various studies have reported that cells isolated from the dental pulp of various animals can be induced to differentiate into cells of the odontoblastic phenotype by means of various chemicals, growth factors and signaling molecules both in vitro and in vivo ( reviewed in Nakashima and Akamine, 2005). (ispub.com)
Rabkin-Aikawa E, Farber M, Aikawa M, Schoen FJ (2004) Dynamic and reversible changes of interstitial cell phenotype during remodeling of cardiac valves. (springer.com)
Targeting SMC phenotype switch-driven NF with specific pharmacological compounds and gene therapy remain important therapeutic strategies to prolong SVG patency following CABG surgery. (gla.ac.uk)
Moreover, intimal SVG SMCs displayed a decrease in myosin heavy chain (MYH)11 and a trend towards a decrease in calponin expression compared to medial SMCs, suggesting in vivo SMC phenotype switching. (gla.ac.uk)
2007). It has been suggested that the intestinal transcription factor Blimp-1 is a critical driver of the postnatal epithelial phenotype, whose expression loss in the third postnatal week is a likely requirement for the maturation of the neonatal epithelium to adult epithelium (Harper, et al. (researchsquare.com)
The fate or phenotype of each neuron includes the expression of the specific set of ion channels, neurotransmitters and receptors that determine its physiological function. (wiringthebrain.com)
A study from Drosophila (Eade and Allan, 2009) suggests that retrograde signals, in this case involving bone morphogenetic protein (BMP) signaling, may also be required to maintain expression of neuronal phenotype in connecting cells, demonstrated through an effect on expression of a specific neuropeptide. (wiringthebrain.com)

The cells in the dental pulp comprise a heterogeneous mixed population, made up of odontoblasts, fibroblasts, stem cells, and macrophages and other immunocompetent cells. (ispub.com)
The efficient derivation of specialized and functional cardiomyocytes (CMs) from pluripotent stem cells is a primary goal for stem cell-based cardiac regenerative therapies. (biomedcentral.com)
In this review, we introduce the broad application of β-TCP in tissue engineering and discuss the different approaches that β-TCP scaffolds are customized, including physical modification (e.g., pore size, porosity and roughness) and the incorporation of metal ions, other materials (e.g., bioactive glass) and stem cells (e.g., mesenchymal stem cells). (frontiersin.org)
The main challenge for large bone defect repair and regeneration remains the inadequate recruitment of mesenchymal stem cells (MSCs), reduced vascularization, and decreased growth factors stimulation within the scaffold construct to support cell viability and tissue growth. (frontiersin.org)
Despite ZNF148 being an established node of the MYC-network in ES cells, and the significance of MYC in driving cancer stem cells traits, the role of ZNF148 in breast cancer remains elusive. (nature.com)
PEI-al nanocomposites carrying BMP-2 gene could efficiently transfect bone marrow mesenchymal stem cells. (dovepress.com)
Our results suggested that PEI-al nanocomposites efficiently deliver the BMP-2 gene to bone marrow mesenchymal stem cells and that BMP-2 gene-engineered cell sheet is an effective way for promoting bone regeneration. (dovepress.com)
Traditional BTE involves three-dimensional biodegradable scaffolds, stem cells, and osteoinductive growth factors. (dovepress.com)
All intestinal epithelial cells (IECs) originate from intestinal stem cells (ISCs) that reside in niches of the lower crypt. (researchsquare.com)
In addition, Paneth cells provide a niche for leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5)-expressing stem cells in crypts (Sato, et al. (researchsquare.com)
Human dental pulp-derived mesenchymal stem cells (hDP-MSCs), which include human dental pulp stem cells (hDPSCs) and stem cells from human exfoliated deciduous teeth (SHEDs), are promising cell sources for regenerative therapies. (biomedcentral.com)
Mesenchymal stem cells (MSCs) are stromal cells that have two key features, self-renewal and the ability to differentiate along different lineages [ 1 ]. (biomedcentral.com)
hDP-MSCs includes human dental pulp stem cells (hDPSCs) and stem cells from human exfoliated deciduous teeth (SHEDs) which are isolated from the pulp tissue of permanent and deciduous teeth, respectively. (biomedcentral.com)
The effects of erythropoietin (EPO) on the behaviors of bone marrow mesenchymal stem cells (BMSCs) subjected to mechanical stretch remain unclear. (hindawi.com)
After implantation, self-renewal and proliferative cytotrophoblasts appear in the early first trimester (6-9 weeks) and can help identify trophoblast stem cells (TSCs) [ 13 ]. (biomedcentral.com)
In this study, mRNA, miRNA, and lncRNA gene networks were predicted by web-based programs for three ectodermal pathway markers (BMP4, NOG, FGF8) in the mouse embryonic stem cells. (ac.ir)
Mariano García Arranz has the following conflict of interest: MGA is inventor on 2 patents entitled "Identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue" (10157355957US) and "Use of adipose tissue-derived stromal stem cells in treating fistula" (US11/167061). (wjgnet.com)
Disease research and drug development models based on genetically altered human embryonic stem cells. (korea.ac.kr)

Protein kinase ALK3/BMPR1A mediates bone morphogenetic protein (BMP) signalling through phosphorylation and activation of SMADs 1/5/8. (crick.ac.uk)
Bone morphogenetic protein receptor type II or BMPR2 is a serine/threonine receptor kinase . (wikidoc.org)
Whereas TGF-b1 may signal via the activin receptor-like kinase (ALK)5 or ALK1 receptors, BMP-9 mainly signals via the ALK1 receptor. (gla.ac.uk)
van Nieuw Amerongen, G. P., Koolwijk, P., Versteilen, A. & van Hinsbergh, V. W. Involvement of RhoA/Rho kinase signaling in VEGF-induced endothelial cell migration and angiogenesis in vitro. (nature.com)
Preferential activation of microsomal diacylglycerol/protein kinase C signaling during glucose treatment (De Novo phospholipid synthesis) of rat adipocytes. (jci.org)
Glucose has been reported to increase the de novo synthesis of diacylglycerol (DAG) and translocate and activate protein kinase C (PKC) in rat adipocytes. (jci.org)

RNAi-mediated depletion of USP15 increases ALK3 K48-linked polyubiquitylation, and reduces both BMP-induced SMAD1 phosphorylation and transcription of BMP target genes. (crick.ac.uk)
Additionally, bioinformatic analyses were conducted to discover target genes, signaling pathways and gene ontologies associated with the identified miRNAs. (biomedcentral.com)
In this theoretical bioinformatics study, the miRNAs of the target genes (BMP4, NOG, and FGF8) were extracted and examined by MirWalk and TARGETSCAN databases to finally obtain the common miRNAs of these three genes. (ac.ir)

Pulmonary arterial hypertension (PAH) is a progressive disease characterized by lung endothelial cell dysfunction and vascular remodeling. (surrey.ac.uk)
Induced EndoMT cells exhibited up-regulation of mesenchymal markers, including collagen type I and α-smooth muscle actin, and a reduction in endothelial cell and junctional proteins, including von Willebrand factor, CD31, occludin, and vascular endothelial-cadherin. (surrey.ac.uk)
We show that cellular glycolysis fuels endothelial activation, migration and contraction and that sites of high lactate production colocalize with active cytoskeletal remodelling within an endothelial cell. (nature.com)
RhoA activation triggers a glycolytic burst through the translocation of the glucose transporter SLC2A3/GLUT3 to fuel the cellular contractile machinery, as demonstrated across multiple endothelial cell types. (nature.com)
Our data indicate that Rho-GTPase signalling coordinates energy metabolism with cytoskeleton remodelling to regulate endothelial cell motility. (nature.com)
Fig. 4: Single-cell imaging of lactate production reveals RhoA drives endothelial cell glycolysis, which is necessary for contractions. (nature.com)
Laminar shear stress inhibits endothelial cell metabolism via KLF2-mediated repression of PFKFB3. (nature.com)
Accordingly, Stat3 is needed for endothelial cell survival and their arrangement into new vascular structures, though nuclear Stat3 correlates with enhanced VEGF expression and microvessel density in gastric cancer. (mirnaarray.com)
Stat3 could possibly also advertise neovascularisa tion by mediating endothelial cell responses to other development variables, including granulocyte macrophage purchase Staurosporine stim ulating issue. (mirnaarray.com)

We discuss the rationale of various anti-fibrogenic treatment strategies targeting the clonal hematopoietic stem/progenitor cell, aberrant signaling pathways, fibrogenic cytokines, and the tumor microenvironment. (haematologica.org)
We focus primarily on the role of both types of granulosa cells: mural granulosa cells, which perform endocrine functions, including hormone production and cumulus cells, which provide metabolic support and establish bi-directional communication with the oocyte through various pathways, including direct contact. (juniperpublishers.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)

3. Prevention Decreases the Reproductive Performance and Granulosa Cell Apoptosis via Regulation of CTSB Gene in Rabbits.Frontiers in Physiology, 2022.926795. (dxtang.com)
SMAD5 is up-regulated in gastric epithelial cells during the infection of the pathogen Helicobacter pylori and it mediates apoptosis of gastric epithelial cells induced by H. pylori infection (2). (signalchem.com)
2. Nagasko, T. et al: Up-regulated Smad5 mediates apoptosis of gastric epithelial cells induced by Helicobacter pylori infection. (signalchem.com)
Over 500 products have been investigated for neuroprotective effects including those from the categories of free radical scavengers, anti-excitotoxic agents, apoptosis (programmed cell death) inhibitors, anti-inflammatory agents, neurotrophic factors, metal ion chelators, ion channel modulators, and gene therapy. (researchandmarkets.com)

ISCs give rise to transient amplifying cells that become progenitor cells positioned at the bottom two-thirds of the crypts (Barker and Clevers, 2007). (researchsquare.com)
The activation of Notch signaling targets Hes-1 and Math-1 differentiates the early progenitor cells into absorptive cells and secretory cell lineages, respectively, in IECs (Fre, et al. (researchsquare.com)
Erythropoietin is a glycoprotein hormone that stimulates red blood cell (RBC) production in bone marrow via binding to the cell-surface receptor on hematopoietic progenitor cells, and it has been widely used for treating anemia [ 13 ]. (hindawi.com)

In the present work we present a succinct review of these molecular interactions, including endocrine and paracrine signaling, gene regulation and cell communication. (juniperpublishers.com)
Next, the expression model, prognostic roles, potential biological functions and epigenetic regulation of tumor suppressor long noncoding RNAs were investigated and validated in the breast cancer and pancancer cohorts. (cancerindex.org)
Intestinal microbiota transplantation reveals the role of microbiota in dietary regulation of RegIIIβ and RegIIIγ expression in mouse intestine. (shengsci.com)
Therefore, gene regulation may perhaps be considered as a single molecular mechanism underlying the antihyperalge sic impact of HDACIs seen on this review. (mirnaarray.com)

SMAD6, a transcriptional target of BMP, negatively regulates the BMP pathway by recruiting E3 ubiquitin ligases and targeting ALK3 for ubiquitin-mediated degradation. (crick.ac.uk)
However it has been demonstrated that hemojuvelin interacts with bone morphogenetic protein (BMP), possibly as a co-receptor, and may signal via the SMAD pathway to regulate hepcidin expression. (wikipedia.org)
However, better understanding of the role of increased JAK-STAT signaling [either through activating mutations ( JAK2 , MPL515L/K ) within the signaling pathway, or mutations involving CALR ], the role of deregulated pro-inflammatory cytokine expression, and the impaired bone marrow microenvironment is transforming the treatment approach for MF. (haematologica.org)
Further taking all DEGs together, Gene Set Enrichment Analysis (GSEA) brought out the NOD-like receptor (NLR) signaling pathway which could be regulated by ELAVL1. (hindawi.com)
ELAVL1 possibly acts as a key regulator of T cell activation via the NLR signaling pathway. (hindawi.com)
A miRNA-mRNA network was constructed, and Gene Ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed. (biomedcentral.com)
Hence, we found that NGF/Akt signaling mediated the regenerative effects of TSC-EVs on MSCs as a particular cellular signaling pathway. (biomedcentral.com)
We present a rate equation model for the TGF-b pathway in endothelial cells together with novel measurements. (lu.se)

We determined the presence of EndoMT in the pulmonary vasculature in vivo and the functional effects on pulmonary artery endothelial cells (PAECs) undergoing EndoMT in vitro. (surrey.ac.uk)
By comparing the TB signature with gene expression profiles from human breast metastases and an in vitro osteoclast model, we demonstrate that our model mimics both the human breast cancer bone microenvironment and osteoclastogenesis. (biomedcentral.com)
To enhance the osteogenic potential of stem cell sheet, we fabricated bone morphogenetic protein 2 ( BMP-2 ) gene-engineered cell sheet using a complex of polyethylenimine-alginate (PEI-al) nanocomposites plus human BMP-2 complementary(c)DNA plasmid, and studied its osteogenesis in vitro and in vivo. (dovepress.com)
17 , 19 - 24 BMP-2, −4, and −7 have been shown to stimulate de novo, in vitro, and in vivo bone formation in various animal models. (allenpress.com)
Whether the maturation happens in vivo or in vitro, the environment to which the oocyte and its surrounding cells are exposed, affects the developmental competence of the oocyte and subsequent embryonic development [ 5 ]. (juniperpublishers.com)
In both cases, being able to reproduce the conditions in vitro by recreating the follicle microenvironment using cultured granulosa cells may be necessary for successful oocyte maturation, either before or after freezing. (juniperpublishers.com)
However, insufficient number of cells and lack of regenerative properties during in vitro expansion still limit the clinical applicability of MSC therapies. (biomedcentral.com)
By contrast, Stat3 abla tion in intestinal epithelium in vivo or in tumour cell lines in vitro resulted in cell cycle arrest in the G2/M transition and it is linked with histone H3 phosphorylation asso ciated mitotic arrest. (mirnaarray.com)

These findings are expected to improve our knowledge of the role of GDF-5 in dental tissue development and to provide information that may be useful in the application of GDF-5 as a molecular manipulator in dental tissue regeneration. (ispub.com)
Consequently, in order to develop effective targeted therapy, there is a pressing need to identify all molecular regulators that define cancer stem cell traits in TNBC. (nature.com)
11. Molecular characterization and expression of the GDF9 gene in New Zealand white Rabbits. (dxtang.com)
Our finding provides an insight into the molecular mechanisms and the therapeutic potential of BMP-13 in restricting pathological bone formation. (ijbs.com)
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. (novusbio.com)
Several molecular mechanisms may count for this AR re-activation in CRPC, including AR gene amplification/overexpression, AR mutation, the presence of AR splice variants, enhanced AR co-regulators signaling, alterations in steroid metabolism, growth factor and/or cytokine induced AR activation etc [ 1 ]. (oncotarget.com)

Yet it remains poorly understood how these factors can induce the various types of cells in the dental pulp to engage in a harmonized and coordinated process of dentin regeneration. (ispub.com)
By way of this review, a deeper understanding of the basic mechanisms of β-TCP for bone repair will be achieved which will aid in the optimization of strategies to promote bone repair and regeneration. (frontiersin.org)
Consequently, enhancing the adhesion of MSCs, augmenting the release of growth factors, and promoting angiogenic potential of biomaterial scaffolds after implantation are pivotal for successful bone regeneration. (frontiersin.org)
Regeneration of large bone defects is a common clinical problem. (dovepress.com)
Regeneration of bone remains an important clinical challenge because the regeneration potential of human bone appears to be limited. (dovepress.com)
They have become a likely treatment option, given their action on regeneration and remodeling of bone lesions and increasing the bone response around alloplastic materials. (allenpress.com)
The application of specific growth factors for osteoinduction without using a bone graft constitutes a real impact on bone regeneration. (allenpress.com)
In this review, we will highlight the role of the BMP in bone, periodontal and dental regeneration. (allenpress.com)
Grafting with autogenous bone, guided bone regeneration (GBR), distraction osteogenesis, and tissue engineering have been developed to perform intraoral bone augmentation in dentistry. (allenpress.com)
A variety of growth factors (GFs)-including bone morphogenetic protein (BMP), platelet-derived growth factor (PDGF), and peptides of the parathyroid hormone (PTH)-have been tested for local bone regeneration. (allenpress.com)
It plays a dominant role in embryonic dorsal-ventral patterning, organogenesis, limb bud formation, and bone formation and regeneration (1, 2). (novusbio.com)
Following the expansion of stem cell therapy using autologous MSC for tissue regeneration [ 3 ]. (biomedcentral.com)

These two protein signaling molecules and their BMPR2 mediated effects play an important role in follicle development in preparation for ovulation. (wikidoc.org)

The current view holds that osteoarthritis involves not only the articular cartilage but the entire joint organ, including the subchondral bone and synovium. (medscape.com)
In addition, development and genetic studies have shown that GDF-5 null mutation or transgenic mice exhibit abnormal growth patterns or overgrowth of limbs, long bones, cartilage, joints and digits (Storm et al. (ispub.com)
Immunization Grade Collagen type II (CII) protein, purified from fetal bovine articular cartilage, for the induction of arthritis in the Collagen-Induced Arthritis (CIA) model. (mdbioproducts.com)
This is characterized by abnormal cartilage that leads to bone and joint deformities. (mdbioproducts.com)
Expression of BMP-13 has since been detected in a variety of mesenchymal derivatives such as tendon and cartilage, but its biological function is poorly defined [ 6 ]. (ijbs.com)
In vivo, mutational inactivation of the BMP-13 gene is associated with Klippel-Feil syndrome (KFS), characterised by congenital fusion of the cervical spine vertebrae [ 14 ], and caused defects in joint, ligament, and cartilage formation in a transgenic mouse model [ 15 ]. (ijbs.com)

TAR syndrome 1q21.1 deletion syndrome 1q21.1 duplication syndrome RGMc/HJV is a 4-exon gene in mammals that undergoes alternative RNA splicing to yield 3 mRNAs with different 5' untranslated regions (5'UTRs). (wikipedia.org)
MicroRNAs (miRNAs) are small noncoding RNAs (~22 nucleotides in length) that regulate gene expression post-transcriptionally by imperfect binding to the 3′ untranslated region of target mRNAs in a wide variety of cell types. (biomedcentral.com)
BMP-2 stimulated the expression of Sox9, Col2a1, and Aggrecan mRNAs in free-body and synovial cells and that of Runx2, Col1a1, and Osteocalcin mRNAs in the synovial [corrected] cells only. (shengsci.com)
Noggin suppressed the expression of Sox9, Col2a1, Aggrecan, and Runx2 mRNAs in both the free-body and synovial cells. (shengsci.com)

Bone marrow fibrosis is a central pathological feature and World Health Organization major diagnostic criterion of myelofibrosis. (haematologica.org)
Although bone marrow fibrosis is seen in a variety of malignant and non-malignant disease states, the deposition of reticulin and collagen fibrosis in the bone marrow of patients with myelofibrosis is believed to be mediated by the myelofibrosis hematopoietic stem/progenitor cell, contributing to an impaired microenvironment favoring malignant over normal hematopoiesis. (haematologica.org)
Increased expression of inflammatory cytokines, lysyl oxidase, transforming growth factor-β, impaired megakaryocyte function, and aberrant JAK-STAT signaling have all been implicated in the pathogenesis of bone marrow fibrosis. (haematologica.org)
A number of studies indicate that bone marrow fibrosis is an adverse prognostic variable in myeloproliferative neoplasms. (haematologica.org)
However, modern myelofibrosis prognostication systems utilized in risk-adapted treatment approaches do not include bone marrow fibrosis as a prognostic variable. (haematologica.org)
The specific effect on bone marrow fibrosis of JAK2 inhibition, and other rationally based therapies currently being evaluated in myelofibrosis, has yet to be fully elucidated. (haematologica.org)
Hematopoietic stem cell transplantation remains the only curative therapeutic approach that reliably results in resolution of bone marrow fibrosis in patients with myelofibrosis. (haematologica.org)
Here we review the pathogenesis, biological consequences, and prognostic impact of bone marrow fibrosis. (haematologica.org)
Bone marrow fibrosis (BMF) is characterized by the increased deposition of reticulin fibers and in some cases collagen fibers. (haematologica.org)
6 Causes of early death include leukemic transformation, complications arising from progressive bone marrow failure, portal/pulmonary hypertension, infections, thrombosis and bleeding. (haematologica.org)
European consensus on the grading of bone marrow fibrosis. (haematologica.org)
Conditions associated with bone marrow fibrosis. (haematologica.org)

To test the hypothesis that IGFBP-5 promotes the acquisition of bone mineral density (BMD), we generated transgenic (Tg) mice overexpressing Igfbp5 using a cytomegalovirus enhancer and β-actin promoter (CMV/βA). (westminster.ac.uk)

7. Influence of cecotrophy on fat metabolism mediated by caecal microorganisms in New Zealand white rabbits. (dxtang.com)
Directly linking cell motility to cell metabolism is technically challenging but biologically important. (nature.com)
Fig. 3: Single-cell metabolism links migratory cell phenotypes to glycolysis states. (nature.com)

In this study, we identified and used a TB microenvironment-specific gene expression signature from this model to extend our understanding of the metastatic bone microenvironment in human disease and to predict potential therapeutic targets. (biomedcentral.com)
Characterization of the gene expression signature specific to the TB interface in our model revealed signaling mechanisms operative in human breast cancer metastases and predicted a therapeutic inhibitor of cancer-mediated osteolysis. (biomedcentral.com)
Even though the bisphosphonate class of drugs (which target the tumor-bone interface) have been shown to improve the quality of life and disease-free survival in some patients, more therapeutic targets and agents are desirable [ 6 ]. (biomedcentral.com)
Therapeutic effects of anti-Bone Morphogenetic Protein and Activin Membrane-Bound Inhibitor treatment in psoriasis and arthritis. (mdbioproducts.com)
but the overall therapeutic process lasts for a relatively long period, and a variety of complications may arise, such as pin loss, infection around the transmucosal pin, bone fracture, and restriction in joint motion [ 8 ]. (hindawi.com)
Considering the fact that Stat3 inhibition also blocks VEGF expression in tumours characterized by aberrant activation of Src, therapeutic focusing on of Stat3 may well inhibit neovascularisation in tumours associ ated with extreme signaling through epidermal development issue receptor. (mirnaarray.com)

The Inhibitor of DNA binding 3 ( ID3 ) is a member of the ID protein family, consisting of four members ( ID1 to ID4 ). (nature.com)
The increase in ALP, mineral deposition, and osteoblastic genes induced by the mechanical stretch-EPO combination was inhibited by U0126, an ERK1/2 inhibitor. (hindawi.com)

The endogenous BMP-13 gene expression in MSCs was examined under expansion conditions. (ijbs.com)
Gronthos and co-workers were the first to report the isolation and characterization of MSCs from the pulp tissue of third molar teeth [ 5 ]. (biomedcentral.com)
Osteogenic effects of TSC-EVs on MSCs were assessed by alkaline phosphatase (ALP) activity, calcium assays, and calvarial bone defect animal models. (biomedcentral.com)

Crypts begin to form around day 7 of postnatal mice (P7), and Paneth cells usually appear within the first 2 weeks. (researchsquare.com)
Paneth cell dysfunction has been reported to correlate with Crohn's disease-like inflammation, showing narrow crypts or loss of crypt architecture in mice. (researchsquare.com)
Mice that are homozygous for a targeted disruption of the LDL receptor gene (LDLR-/- mice) were fed a diet that contained 1.25% cholesterol, 7.5% cocoa butter, 7.5% casein, and 0.5% cholic acid. (jci.org)
Expression of these peptides is reportedly decreased by high-fat diet (HFD) and increased by indigestible oligosaccharides in mice. (shengsci.com)
A few of these genes associated with modification of nociceptive hypersensitivity could be sub deletion on the more bonuses HDAC5 gene, but not the HDAC9 gene, success inside a hypersensitive response to continual cocaine reward or pressure in mice. (mirnaarray.com)

Single-cell motility is spatially heterogeneous and driven by metabolic energy. (nature.com)
Here, we use single-cell metabolic imaging to measure glycolysis in individual endothelial cells with genetically encoded biosensors capable of deciphering metabolic heterogeneity at subcellular resolution. (nature.com)
E6 and Metabolic syndrome and risks of colon and rectal renal cell carcinoma. (who.int)

Here, we combined overexpression approaches with protein analysis and functional studies in cultured primary human trophoblast (PHT) cells to test the hypothesis that SLC7A5 overexpression increases the uptake of essential amino acids and activates mTOR signaling in PHT cells. (bvsalud.org)

14. Polymorphisms of the bone morphogenetic protein 7 gene(BMP7) and association analysis with sow productive traits. (dxtang.com)

There are three critical promoter elements responsible for transcriptional activation in skeletal muscle (the tissue that has the highest level of RGMc expressesion per weight), comprising paired E-boxes, a putative Stat and/or Ets element, and a MEF2 site, and muscle transcription factors myogenin and MEF2C stimulate RGMc promoter function in non-muscle cells. (wikipedia.org)
Recently, stem cell sheet has been an emerging strategy in bone tissue engineering. (dovepress.com)
2 , 3 Bone tissue engineering (BTE) attempts to solve the referred problems mentioned. (dovepress.com)
xCell found decreased naïve and differentiated T cell proportions in the peripheral blood of CD patients suggesting T cell migration to the intestinal tissue and/or exhaustion. (hindawi.com)
A number of similarities exist between pathological calcification in cardiovascular tissue and physiological calcification in bone, termed osteogenesis. (edu.pl)
The expression of the identified long noncoding RNAs was downregulated in cancer tissue samples compared with normal tissue samples, and these long noncoding RNAs correlated with a favorable prognosis in breast cancer patients and the patients in the pancancer cohort. (cancerindex.org)
Despite improved surgical techniques, the tendon-to-bone healing rate is unsatisfactory due to difficulties in restoring the delicate transitional tissue between bone and tendon. (wjgnet.com)

A small number of patients have mutations in the hepcidin (HAMP) gene. (wikipedia.org)
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
Mutations of the COL2A1 gene affect the synthesis of type II collagen and cause chondrodysplasias. (mdbioproducts.com)
In the light of a recent report that mutations in the BMP-13 gene are associated with spine vertebral fusion in Klippel-Feil syndrome, we hypothesized that BMP-13 signaling is crucial for regulating embryonic endochondral ossification. (ijbs.com)
Scope includes mutations and abnormal protein expression. (cancerindex.org)

1994. Control by pulse parameters of electric field-mediated gene transfer in mammalian cells. (uni-bielefeld.de)
Control by pulse parameters of electric field-mediated gene transfer in mammalian cells", Biophysical Journal , vol. 66, 1994, pp. 524-531. (uni-bielefeld.de)

Paneth cells are antimicrobial peptide-secreting epithelial cells located at the bottom of the intestinal crypts of Lieberkühn. (researchsquare.com)
RegIIIβ and RegIIIγ are antimicrobial peptides expressed in intestinal epithelial cells. (shengsci.com)

However, conflicting results indicate the clinical use of β-TCP for bone repair remains questionable in several specific experiment models. (frontiersin.org)
Pre-clinical and clinical studies have demonstrated that dedifferentiated smooth muscle cells (SMCs) are the main contributor to NF. (gla.ac.uk)
Recently, stem cell- and gene-based therapy has been applied in BTE and achieved some good clinical results. (dovepress.com)
However, GBR has different clinical limitations, including increased treatment time, 1 limited predictability for vertical bone augmentation, 1 risk of infection subsequent to membrane exposure, 2 and technique sensitivity. (allenpress.com)

However, in human granulosa-like tumor cell line (KGN), treatment with FSH increased BMPR2 expression. (wikidoc.org)
Large bone loss as a result of trauma, tumor removal, infection, and developmental congenital disorders, often leads to delayed healing or non-union, and remains a critical challenge for orthopedic surgeons. (frontiersin.org)
These findings uncover a previously unknown tumor suppressor role for ZNF148, and a transcriptional regulatory circuitry encompassing MYC, ZNF148, and ID1/3 in driving cancer stem cell traits in aggressive breast cancer. (nature.com)
These metastases are predominantly osteolytic and develop when tumor cells interact with bone. (biomedcentral.com)
Previously, we developed a mouse model of tumor-bone interaction in which three mouse breast cancer cell lines were implanted onto the calvaria. (biomedcentral.com)
Analysis of tumors from this model revealed that they exhibited strong bone resorption, induction of osteoclasts and intracranial penetration at the tumor bone (TB)-interface. (biomedcentral.com)
Within the osteolytic lesions of bone metastases, tumor cells interact with osteoclasts (bone resorbing cells) and osteoblasts (bone forming cells), thereby inhibiting normal bone development and ultimately leading to bone destruction [ 1 - 4 ]. (biomedcentral.com)
However, there is no single animal model that ideally replicates the entire metastatic process from primary breast tumor to bone metastasis. (biomedcentral.com)
Mechanistically, EPB41L4A-AS2, acting at least in part as a tumor suppressor, upregulated tumor suppressor gene expression. (cancerindex.org)

RGMs may play inhibitory roles in prostate cancer by suppressing cell growth, adhesion, migration and invasion. (wikipedia.org)
The MYC proto-oncogene ( MYC ) is one of the most frequently overexpressed genes in breast cancer that drives cancer stem cell-like traits, resulting in aggressive disease progression and poor prognosis. (nature.com)
We previously reported a MYC-centered regulatory network in mouse embryonic stem (ES) cells that accounts for the similarity between the ES cells and cancer cells, and is associated with a worse prognosis in cancer, including cancers of the breast [ 20 ]. (nature.com)
During the advanced stages of disease, many breast cancer patients suffer from bone metastasis. (biomedcentral.com)
In vivo models that mimic the breast cancer-specific osteolytic bone microenvironment are limited. (biomedcentral.com)
Our mouse breast cancer model morphologically and genetically resembles the osteoclastic bone microenvironment observed in human disease. (biomedcentral.com)
Bone is one of the most common sites for metastasis in human breast cancer. (biomedcentral.com)
While a number of strategies exist to treat breast cancer bone metastases (e.g., surgery, radiation and/or chemotherapy), none are curative. (biomedcentral.com)
Several animal models have been developed to study the mechanisms governing cancer-mediated osteolysis. (biomedcentral.com)
Bone loss caused by congenital defects, traumatic injury, cancer, reconstructive surgery, or periodontal disease has aroused widespread concern all over the world. (dovepress.com)
Cancer Lett, 300:215-224.doi:10.1016/j. squamous cell carcinoma in north-eastern Iran. (who.int)
E7 from human papil omavirus type 16 cooperate to cancer: the European prospective investigation into doi:10.1093/carcin/bgp321 PMID:20047954 target the PDZ protein Na/H exchange regulatory cancer and nutrition study. (who.int)
99:209 -215.doi:10.1007/s11060 - 010 - 0129 -5 cell carcinoma-a population-based study in with and without cervical cancer in Tbilisi, Georgia. (who.int)

Exportin-5 mediates thenuclear export of pre-microRNAs and short hairpin RNAs. (edu.pl)

Using a combination of biochemical and cell-based approaches, it has demonstrated that BMP-2 could interact in biochemical assays with the single-chain HJV species, and also could bind to cell-associated HJV. (wikipedia.org)
Various approaches have been tested to promote bone formation in order to shorten the DO period. (hindawi.com)

2002). It has also been reported that the GDF-5 gene is expressed in dental sac, periodontal ligament, dental pulp cells, and odontoblasts during tooth development (Morotome et al. (ispub.com)

Nevertheless, several models that represent various aspects of bone metastasis have been used successfully to study specific features of the disease. (biomedcentral.com)
The construction and analysis of ceRNA network and patterns of immune infiltration in mesothelioma with bone metastasis. (ac.ir)

It binds Bone morphogenetic proteins , members of the TGF beta superfamily of ligands, which are involved in paracrine signalling . (wikidoc.org)
Transforming growth factor (TGF)-b1 and bone morphogenetic protein (BMP)-9 are both pleiotropic growth factors which are members of TGF-b superfamily. (gla.ac.uk)
SMAD5 is a member of the SMAD family and mediates signaling by the transforming growth factor-beta (TGFβ) superfamily and related ligands (1). (signalchem.com)
Bone morphogenetic protein 2 (BMP-2) is a member of the BMP subgroup of the TGF-beta superfamily. (novusbio.com)

Indeed, BMP-13 expression was absent from osteoblasts or newly formed osteocytes, rather BMP-13 was strongly detected in chondrocytes in a human osteophyte (bone spur) study [ 13 ]. (ijbs.com)

To further test the osteogenic potential of the cell sheet in vivo, enhanced green fluorescent protein or BMP-2-producing cell sheets were treated on the cranial bone defects. (dovepress.com)
thus, this study provides the first in vivo evidence, by genetic manipulation, for IGF-independent actions of IGFBP-5 in bone function. (westminster.ac.uk)

The coordinate development of both granulosa cell types is necessary to fulfill oocyte requirements. (juniperpublishers.com)

Full-length HJV is released from the cell surface and accumulates in extracellular fluid, where its half-life exceeds 24 hours. (wikipedia.org)
The predominant membrane-associated isoform, a disulfide-linked two-chain form composed of N- and C-terminal fragments, is not found in the extracellular fluid, and is short-lived, as it disappears from the cell surface with a half-life of (wikipedia.org)
Research progress of adipose-derived mesenchymal stem cell and its extracellular vesicles in osteogenesis [J]. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE), 2020, 40(12): 1672-1676. (shsmu.edu.cn)
A recent study supports the pivotal role of trophoblast exosomes in that extracellular vesicles (EVs) derived from TSCs promote fertility by regulating endometrial cell receptivity [ 17 ]. (biomedcentral.com)
The expression of tenascin (Tn), an extracellular matrix glycoprotein, was analyzed in the human small intestine. (shengsci.com)

Experimental treatment in animal models with estradiol with or without FSH increased BMPR2 mRNA expression while treatment with FSH alone decreased BMPR2 expression. (wikidoc.org)
Results showed that endogenous BMP-13 mRNA expression was higher than BMP-2 or -7 during MSC growth. (ijbs.com)
meanwhile, the mRNA expression levels of Ets-1, C-myc, Ccnd1, and C-fos were detected by reverse transcription and real-time quantitative PCR (qPCR). (hindawi.com)
Integrated analysis of lncRNA-miRNA-mRNA ceRNA network in squamous cell carcinoma of tongue. (ac.ir)
Genome wide analyses by now unveiled that increases in histone acety lation by HDACI even at rest alters mRNA levels of a constrained but still important amount of genes either by upregulation or by downregulation. (mirnaarray.com)

To date, various studies have reported that BMP-family growth factors can induce cells isolated from dental pulp tissues to differentiate into odontoblasts. (ispub.com)
3 To overcome some of these difficulties, research has been driven toward the use of bioactive molecules to induce local bone formation. (allenpress.com)
Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. (novusbio.com)
Pulsing conditions inducing reversible permeabilization of the cell plasma membrane are not sufficient to induce gene transfer. (uni-bielefeld.de)

15. Characterization and expression of bone morphogenetic protein 4 gene in postnatal pigs. (dxtang.com)
Inhibition of H3K27 trimethylation suppressed crypt formation and Paneth cell maturation on organoids derived from ileum of early second postnatal mouse. (researchsquare.com)
Overall, our data show that post-transcriptional modification of histones, particularly H3K27 trimethylation, leads to the structural and functional maturation of Paneth cells during postnatal development. (researchsquare.com)
1997). Within 14 days of postnatal development, Paneth cells mature and express cryptdin proteins as a specific marker (Bry, et al. (researchsquare.com)

Injectable hydrogel loaded with bone morphogenetic protein-2 microspheres for bacteriostasis and osteogenesis [J]. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE), 2020, 40(09): 1184-1192. (shsmu.edu.cn)

[3] However, BMPR2 can't bind BMP15 and GDF9 without the assistance of bone morphogenetic protein receptor 1B (BMPR1B) and transforming growth factor β receptor 1 (TGFβR1) respectively. (wikidoc.org)

Bovine GDF10 gene polymorphism analysis and its association with body measurement traits in Chinese indigenous cattle. (heightquest.com)
The objective of this research was to detect bovine GDF10 gene polymorphism and analyze its association with body measurement traits (BMT) of animals sampled from 6 different Chinese indigenous cattle populations. (heightquest.com)

These results show that different isoforms of RGMc/HJV may play unique physiological roles through defined interactions with distinct signaling proteins and demonstrate that, in some disease-linked HJV mutants, these interactions are defective. (wikipedia.org)
It appears that the hormones estrogen and follicle stimulating hormone (FSH) have roles in regulating expression of BMPR2 in granulosa cells. (wikidoc.org)

GDF-5 also increased the gene expression and enzyme activity of alkaline phosphatase. (ispub.com)
Alkaline phosphatase (ALP) expression and activity, proteoglycan (PG) synthesis and matrix mineralization were assessed by cytological staining or ALP assay. (ijbs.com)

By employing microRNA expression profiling and functional knockdown studies on human embryonic stem cell-derived cardiomyocytes, the authors identified miR-363 as an upstream negative regulator of left ventricular specification transcription factor HAND1 . (biomedcentral.com)

Several of these genes may potentiate hypersensitiv ity whilst a few of them might attenuate hyperactivity to dorsal root ganglion was located to get upregulated after systemic administration of MS 275 or SAHA, and this upregulation most likely mediates the inhibitory effect of these HDACIs on formalin induced hyperalgesia. (mirnaarray.com)

Congenital heart defects affect approximately 1-5 % of human newborns each year, and of these cardiac defects 20-30 % are due to heart valve abnormalities. (springer.com)
A crosslinking study revealed that recombinant human (rh) BMP-9 bound to ALK1, ALK2, bone morphogenetic protein receptor (BMPR)2, ACVR2A/B and endoglin on primary HSVSMCs. (gla.ac.uk)
The System L amino acid transporter, particularly the isoform Large Neutral Amino Acid Transporter Small Subunit 1 (LAT1) encoded by SLC7A5, is believed to mediate the transfer of essential amino acids in the human placenta. (bvsalud.org)
Recombinant full-length human SMAD5 was expressed in E. coli cells using an N-terminal GST tag. (signalchem.com)
Recombinant human BMP-2 and BMP-7 are used clinically to augment bone formation in spinal fusion and many other applications in which bone induction is desired [ 4 ]. (ijbs.com)
were the first to assess nanoparticle-like exosomes released from trophoblasts and determine the functional activity of trophoblast exosomes in human uterine spiral artery remodeling by inducing vascular smooth muscle cell migration for successful pregnancy [ 16 ]. (biomedcentral.com)
8. Britton G, Heemskerk I, Hodge R, Qutub AA, Warmflash A. A novel self-organizing embryonic stem cell system reveals signaling logic underlying the patterning of human ectoderm. (ac.ir)
Expression of tenascin in the developing human small intestine. (shengsci.com)

Anatomy48

Organisms13

Diseases12

Chemicals and Drugs95

Analytical, Diagnostic and Therapeutic Techniques and Equipment28

Phenomena and Processes59

Disciplines and Occupations1

Technology, Industry, Agriculture2

Information Science3

Health Care1

Differentiation49

Proliferation12

BMPs12

Induces11

Differentially expressed genes3

Phenotype7

Stem cells18

Kinase6

Target genes3

Endothelial cell9

Pathways3

Apoptosis4

Progenitor cells3

Regulation4

Pathway8

Vitro8

Molecular6

Regeneration12

Signaling molecules1

Cartilage6

MRNAs4

Marrow12

Promotes1

Metabolism3

Therapeutic6

Inhibitor2

MSCs3

Mice5

Metabolic3

Test the hypothesis1

BMP71

Tissue7

Mutations5

19942

Epithelial2

Clinical4

Tumor9

Cancer13

MicroRNAs1

Approaches2

Periodontal1

Metastasis2

Superfamily4

Osteoblasts1

Vivo2

Granulosa cell1

Extracellular5

MRNA5

Induce4

Postnatal4

Osteogenesis1

BMPR1B1

Bovine2

Roles2

Alkaline phosphatase2

MicroRNA1

Upregulation1

Human8