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  • Receptor-Mediated En
  • Receptor-mediated endocytosis (RME), also called clathrin-mediated endocytosis, is a process by which cells absorb metabolites, hormones, other proteins - and in some cases viruses - by the inward budding of plasma membrane vesicles containing proteins with receptor sites specific to the molecules being absorbed (endocytosis). (wikipedia.org)
  • The function of receptor-mediated endocytosis is diverse. (wikipedia.org)
  • The role of receptor-mediated endocytosis is well recognized in the downregulation of transmembrane signal transduction but can also promote sustained signal transduction. (wikipedia.org)
  • However, receptor-mediated endocytosis is also actively implicated in transducing signals from the cell periphery to the nucleus. (wikipedia.org)
  • 2016
  • In May 2016, Mediate won his first senior major championship at the Senior PGA Championship, with a three stroke victory over the defending champion Colin Montgomerie. (wikipedia.org)
  • Immune
  • Immune-Mediated Diseases: Where Do We Stand? (springer.com)
  • Immune- mediated paraneoplasia is identified by antibody activity with any of a small but growing collection of organ-specific antigens demonstrated to have a distinct disease association and an apparent involvement in autoimmunity. (redorbit.com)
  • Immune-mediated paraneoplasia (IMP) is a collection of cancer- associated syndromes that involve pathological immunological activity.1-3 Autoimmunity is implicated by reports of patients displaying abnormal antibody reactions focused on single antigens expressed within the affected organ. (redorbit.com)
  • The autoantigens are organ and cell-specific, and in some cases surgical removal of the neoplasm has resulted in amelioration of immune-mediated paraneoplasia.2,14-18 Gammaglobulin treatment is reported to have beneficial results in some through processes that include anti-idiotype immunomodulation.19 Plasmapheresis and immuno- suppression may provide symptomatic relief in others,3,6,15,20 but no single immunomodulation is universally successful. (redorbit.com)
  • Immune-mediated paraneoplasia commonly involves very few of the many antigens that compose the organ involved, a characteristic of autoimmunity in general that invites further inquiry into the therapeutic use of antigen-specific immunomodulations. (redorbit.com)
  • This can be the direct result of a drug, toxin, blood parasite, virus or other primary cause or it can be an unexplained immune mediated reaction. (vetinfo.com)
  • The CTL-mediated immune system can be divided into two phases. (wikipedia.org)
  • 2002
  • Mediate made the Atlantic Coast Conference Academic Honor Roll in 2002 and 2003 and was a four-time Academic All-District Men's Soccer Team selection Mediate was Columbus Crew's second pick (23rd overall) in the 2005 MLS SuperDraft. (wikipedia.org)
  • Mediate earned his first win since 2002 at the 2010 Frys.com Open by beating Bo Van Pelt and Alex Prugh by one shot. (wikipedia.org)
  • Because of the limitations of mediated communication, Nardi and Whittaker (2002) note, "Many theorists imply that face-to-face communication is the gold standard of communication. (wikipedia.org)
  • occur
  • Through the analytic and social processes of deliberation, the table shows the roles that the media producers and media users need to fulfill in order for the ideal, mediated deliberation to occur. (wikipedia.org)
  • Although nonsense-mediated mRNA decay reduces nonsense codons, mutations can occur that lead to various health problems and diseases in humans. (wikipedia.org)
  • transmit
  • Compared to face-to-face communication, mediated communication engages fewer senses, transmits fewer symbolic cues (most mediated communication does not transmit facial expressions) and is seen as more private. (wikipedia.org)
  • New computerized media, such as mobile telephones or instant messaging, allow mediated communication to transmit more oral and nonverbal symbols than the older generation of tools. (wikipedia.org)
  • The issue is no longer whether mediated texts transmit in/accurate in-formation, but how they act as "vehicles for action", where such actions might include defending someone, accusing someone, confessing to something, or any number of other things besides. (wikipedia.org)
  • analytic
  • Social Process The analytic and social processes for mediated deliberation gives people the opportunity to evaluate the actions of media producers as well as their users. (wikipedia.org)
  • To meet these aims, mediated stylistics has brought together the analytic toolkits of discursive psychology-which is finely attuned to the contextual specificities of interaction-and stylistics-which is finely attuned to the grammatical/rhetorical/narratorial specificities of texts as texts. (wikipedia.org)
  • As a broadly ethnomethodological approach, mediated stylistics is strongly influenced by discursive psychology (DP), as well as the sociology of scientific knowledge (SSK), membership categorization analysis (MCA) and the work of stylisticians like Mick Short, Paul Simpson and Lesley Jeffries in which the analytic utility of stylistics to and for an understanding of data other than strictly 'literary' texts becomes immediately apparent. (wikipedia.org)
  • aims
  • Mediated aims at creating awareness rather than offering ready-made solutions to remedy the intrusion of too much media in our industrial societies. (wikipedia.org)
  • 1995
  • The concept is first documented in his book "The Rise of Mediated Interaction", which was published in 1995 in Cambridge, UK. (wikipedia.org)
  • Drugs
  • This book, containing the proceedings of the 2nd NATO ASI "Receptor-Mediated Targeting of Drugs" held again at Cape Sounion, Greece during 20 June-l July 1983, deals with drug delivery through systems possessing ligands which can recognize and interact with receptors on the target's surface. (springer.com)
  • contexts
  • Unlike other forms of stylistics, then, mediated stylistics is interested not in one-off stories, but in the various iterations of a story that are reproduced over time and across various contexts. (wikipedia.org)
  • rise
  • While nowadays the technology we use is often related to computers, giving rise to the popular term computer-mediated communication, mediated technology need not be computerized as writing a letter using a pen and a piece of paper is also using mediated communication. (wikipedia.org)
  • social
  • Peer-mediated instruction (PMI) is an approach in special education where peers of the target students are trained to provide necessary tutoring in educational, behavioral, and/or social concerns. (wikipedia.org)
  • time and s
  • Thus, Davis defines mediated communication as the use of any technical medium for transmission across time and space. (wikipedia.org)
  • Face-to- people share time and space, since they are co-present and mediated interaction the sending of the message and its reception are separated in time and space. (wikipedia.org)
  • although
  • For although literary and mediated texts both tell stories, they do so in differing ways. (wikipedia.org)
  • Although indium mediated allylations can be carried out in aqueous media, a variety of other solvents may be used including THF (tetrahydrofuran), DMF (dimethylformamide), room temperature ionic liquids, NMF (n-methylformamide), and others. (wikipedia.org)
  • People
  • The disassociation and disinhibition associated with mediated communication can cause people who are being deceived to have trouble interpreting the reactions of the deceiver since information sent through media instead of face-to-face can lose or have change the nonverbal cues within it, and, with that, signs of deception. (wikipedia.org)
  • It is easier to trust someone else through mediated communication, but people with less trust can detect deception better online. (wikipedia.org)
  • forms
  • Lundby (2009) distinguished between three forms of mediated communication: mediated interpersonal communication, interactive communication, and mass communication. (wikipedia.org)
  • Varying forms of peer-mediated instruction and interventions have been conducted in a great range of settings over the decades. (wikipedia.org)
  • producers
  • To achieve an effective mediated deliberation, it requires collective responsibility from the media producers, including newspapers, television broadcasters, and the internet. (wikipedia.org)
  • communication
  • According to Jürgen Habermas, a German philosopher, "no modern political process could function effectively without the "professionals of the media system" and the various elites who produce mediated political communication. (wikipedia.org)
  • Historically, mediated communication was much rarer than the face-to-face method. (wikipedia.org)
  • Whatever the tradition, face-to-face interaction has begun to steadily lose ground to mediated communication. (wikipedia.org)
  • There are only a few ways that mediated communication and face-to-face communication function similarly. (wikipedia.org)
  • One of them is that interpersonal coordination is present in both face-to-face and mediated communication. (wikipedia.org)
  • However, mediated communication has vast differences and limitations compared with face-to-face communication. (wikipedia.org)
  • Also, no nonverbal cues can be sent through mediated communication, so received information can be harder to understand. (wikipedia.org)
  • Mediated communication has been, however, described as more preferable in some situations, particularly where time and geographical distance are an issue. (wikipedia.org)
  • For example, in maintaining long-distance friendship, face-to-face communication was only the fourth most common way of maintaining ties, after mediated communication tools of telephone, email and instant messaging. (wikipedia.org)
  • however
  • Mediated stylistics, however, in taking seriously the idea that journalists are the "professional storytellers of our age", orients towards the types of creativity and innovation in language-use that are required in and for the construction of mediated stories. (wikipedia.org)
  • media
  • Mediated: How the Media Shapes Your World and the Way You Live in It is a non-fiction book by anthropologist Thomas de Zengotita published in 2005 by Bloomsbury about the effect of the media in the Western world. (wikipedia.org)
  • Mediated deliberation is a form of deliberation that is achieved through the media which acts as a mediator between the mass public and elected officials. (wikipedia.org)
  • Benjamin Page proposes mediated deliberation be a "division of labor" with the idea of using the media to deliver information between the elected officials and the public because modern problems make it impossible to rely on the elected officials to deliberate for the public. (wikipedia.org)
  • Mediated stylistics is a new and still emerging approach to the analysis of media texts (e.g. news programs, newspaper articles). (wikipedia.org)
  • shown
  • Though the rate is shown as a monetary CPM value, mediated house ads are always free. (google.com)
  • Recent research in which mediated stylistics has been put to work, for instance, has shown that and how mediated representation of issues like sexism, sexualisation, alleged rape and violence against women can differ, and differ in rhetorically consequential ways, from the original un-mediated source material. (wikipedia.org)
  • date
  • Mediated house ad campaigns aren't required to have a set end date, though you may set one if desired. (google.com)
  • changes
  • Oxidation increased KVS-1 conductance, which would decrease the excitability of the neuron, a change that was due to Cys 113 , because a C113S mutant channel was resistant to oxidation-mediated changes in electrophysiological properties. (sciencemag.org)
  • Tour
  • Mediate returned to the Tour in 1996 playing under a special medical extension and performed steadily. (wikipedia.org)
  • Mediate has PGA Tour career earnings of over $16 million. (wikipedia.org)
  • Mediate joined the Champions Tour for 2013 after turning 50 and his exemption for his 2010 PGA Tour win ended. (wikipedia.org)
  • On October 9, 2006, it was announced that Mediate would become an on-course reporter for The Golf Channel's 2007 PGA Tour coverage. (wikipedia.org)
  • high
  • Mediate grew up in Southlake, Texas, attended Carroll High School, played club soccer for Dallas Solar, and played college soccer at the University of Maryland, making 3 consecutive College Cup appearances. (wikipedia.org)
  • Mediate attended Hempfield Area High School. (wikipedia.org)
  • virtual
  • A mediated VPN is a virtual private network topology where two or more participants connect to a central switchboard server managed typically by a third party in order to create a virtual private network between them, as distinct from a typical VPN arrangement whereby clients of an organisation connect to a VPN concentrator managed by the same organization. (wikipedia.org)
  • issues
  • Through this ideal model, mediated deliberation should promote public knowledge on important issues as well as encouraging public opinion through enlightenment. (wikipedia.org)