• The activation of Ca2+-permeable N-methyl-D-aspartic acid (NMDA) receptor channels (NMDARs) is crucial for the development and survival of neurons, but many cancers use NMDAR-mediated signaling as well, enhancing the growth and invasiveness of tumors. (tu-darmstadt.de)
  • Kwon, YH , Esguerra, M & Sur, M 1991, ' NMDA and non-NMDA receptors mediate visual responses of neurons in the cat's lateral geniculate nucleus ', Journal of neurophysiology , vol. 66, no. 2, pp. 414-428. (umn.edu)
  • The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel found in neurons. (wikipedia.org)
  • Collectively, these results suggest that prenatal exposure to morphine altered kinetic properties of synaptic NMDA receptors in hippocampal CA1 pyramidal neurons of rat offspring during early life. (tmu.edu.tw)
  • Schlief et al found that copper is protective and copper chelation exacerbates NMDA-mediated excitotoxic cell death in hippocampal neurons. (medscape.com)
  • beta-Amyloid-induced dynamin 1 degradation is mediated by N-methyl-D-aspartate receptors in hippocampal neurons. (alzforum.org)
  • Many structures and processes are involved in the development of a seizure, including neurons, ion channels, receptors, glia, and inhibitory and excitatory synapses. (medscape.com)
  • To understand better the cellular mechanisms of NE and its adrenergic receptors in the LA, we used antibodies directed against dopamine beta-hydroxylase (DβH), the synthetic enzyme for NE, or against two different isoforms of the beta-adrenergic receptors (βARs), one that predominately recognizes neurons (βAR 248) and the other astrocytes (βAR 404), to characterize the microenvironments of DβH and βAR. (frontiersin.org)
  • Reduction of functional NMDA Receptor in neurons by RNase P-mediated cleavage of the NR1 mRNA. (bcm.edu)
  • Magnesium Acts as a Second Messenger in the Regulation of NMDA Receptor-Mediated CREB Signaling in Neurons. (rochester.edu)
  • It also represses translation of a reporter RNA in transfected neurons and stimulates translation in response to NMDA. (nih.gov)
  • We also review current models for the mechanisms of GABA-mediated synchronization of neural activity, focusing on parvalbumin-positive GABA neurons, which are altered in schizophrenia and whose function has been strongly linked to the production of neural synchrony. (hindawi.com)
  • NMDA receptor blockade ameliorates abnormalities of spike firing of subthalamic nucleus neurons in a parkinsonian nonhuman primate. (albany.edu)
  • Major G, Polsky A, Denk W, Schiller J, Tank DW (2008) Spatiotemporally graded NMDA spike/plateau potentials in basal dendrites of neocortical pyramidal neurons. (yale.edu)
  • Matsuzaki M, Ellis-Davies GC, Nemoto T, Miyashita Y, Iino M, Kasai H (2001) Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons. (yale.edu)
  • Schiller J, Major G, Koester HJ, Schiller Y (2000) NMDA spikes in basal dendrites of cortical pyramidal neurons. (yale.edu)
  • In such cases, the dendrites (a neuron's receiving branches) on the postsynaptic neurons release neurotransmitters that affect receptors on the presynaptic neurons. (msdmanuals.com)
  • Beta-endorphinergic neurons in nucleus arcuatus and nucleus tractus solitarii mediated depressor-bradycardia effect of â Tinggongâ 2Hz-electroacupuncture. (bvsalud.org)
  • These results of equal changes of AMPA and NMDA receptor- mediated components of the field EPSP in association with LTD, and the consistent parallelism of effects or noneffects on these components by various receptor antagonists and enzyme inhibitors, seem more easily explained by a presynaptic locus for LTD than by a postsynaptic one. (jneurosci.org)
  • We have examined the effects of iontophoresing specific antagonists to excitatory amino acid receptors on the visual responses of cells in lamina A or A1 of the cat's lateral geniculate nucleus (LGN). (umn.edu)
  • The N-methyl-D-aspartate (NMDA) receptor antagonists D-2-amino-5-phosphonovaleric acid (D-APV) and 3-((±)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP), when iontophoresed at doses that specifically antagonized NMDA-induced responses but not kainate-induced responses, reduced the responses of all cell types in the LGN, including X and Y cells, lagged and nonlagged cells, and ON- and OFF-center cells. (umn.edu)
  • The main problem with the utilization of NMDA receptor antagonists for neuroprotection is that the physiological actions of the NMDA receptor are essential for normal neuronal function. (wikipedia.org)
  • To be clinically useful NMDA antagonists need to block excessive activation without interfering with normal functions. (wikipedia.org)
  • At concentrations of ≥100 nM, clozapine, but not haloperidol, produced bursts of excitatory postsynaptic potentials (EPSPs), which were blocked by glutamate receptor antagonists, suggesting that these EPSPs were the result of increasing release of excitatory amino acids. (aspetjournals.org)
  • In vitro and in vivo studies suggest that the use of selective NMDA receptor antagonists or Ca2+ channel blockers should be useful in preventing or at least abating neuronal loss in the retina. (nih.gov)
  • Of particular importance for future clinical use of NMDA receptor antagonists in the treatment of acute vascular insults is the finding that some drugs can prevent glutamate-induced neurotoxicity, even when administered a few hours after the onset of retinal ischemia. (nih.gov)
  • Potent glycine-site NMDA receptor antagonists. (rndsystems.com)
  • N-methyl-D-aspartate receptor (NMDAR) activation is implicated in the malignant progression of many cancer types, as validated functionally through the use of NMDAR antagonists. (cam.ac.uk)
  • Interestingly, the non-NMDA receptor antagonists reduced epilepsy-like synchronous hyperactivity to the normal activity level. (scialert.net)
  • NMDA receptor antagonists sustain LTP and spatial memory: Active processes mediate LTP decay. (bvsalud.org)
  • 12. Yonehara N. Influence of serotonin receptor antagonists on substance P and serotonin release evoked by tooth stimulation with electroacupuncture in the trigeminal nucleus caudalis of the rabbit. (bvsalud.org)
  • The induction of the LTDs of both AMPA and NMDA receptor-mediated EPSPs was blocked by the NMDA receptor antagonist D(-)-2-amino-5- phosphonopentanoic acid and by the phosphatase inhibitor okadaic acid. (jneurosci.org)
  • On the other hand, the L-type calcium channel blocker nifedipine, the metabotropic glutamate receptor antagonist (RS)-alpha-methyl-4- carboxyphenylglycine, the nitric oxide synthase inhibitor N omega-nitro- L-arginine, and the heme oxygenase inhibitor protoporphyrin IX zinc(II) had no effect on LTD of either the AMPA or the NMDA receptor-mediated component. (jneurosci.org)
  • The non-NMDA receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), when applied at doses that specifically antagonized kainate-induced responses but not NMDA-induced responses, also reduced the visual responses of each of the cell types in the LGN. (umn.edu)
  • Since 1989, memantine has been recognized to be an uncompetitive antagonist of the NMDA receptor, entering the channel of the receptor after it has been activated and thereby blocking the flow of ions. (wikipedia.org)
  • Ketamine, a channel blocking NMDA receptor antagonist, is used off-label for its psychedelic effects, which may arise from a combination of several inter-related actions. (berkeley.edu)
  • A GluN2D-subunit preferring NMDA receptor antagonist, UBP145, has a similar pharmacological profile. (berkeley.edu)
  • The present data show that the new psychoactive substance, ephenidine, is a ive NMDA receptor antagonist with a voltage-dependent profile similar to ketamine. (erowid.org)
  • CNQX(6-cyano-7-nitroquinoxaline-2,3-dioneis) is a potent, competitive AMPA/kainate receptor antagonist. (sigmaaldrich.com)
  • It is a quinoxaline derivative and also an antagonist for non-N-methyl-d-aspartate (non-NMDA) glutamate receptor. (sigmaaldrich.com)
  • Potent, competitive AMPA/kainate receptor antagonist. (sigmaaldrich.com)
  • L-689,560 is a very potent antagonist at the glycine-NMDA site. (rndsystems.com)
  • ACET is a highly potent and specific kainate receptor antagonist: characterisation and effects on hippocampal mossy fibre function. (rndsystems.com)
  • The NMDA receptor antagonist MK-801 was intrathecally administrated. (iasp-pain.org)
  • Whole-cell patch-clamp recordings of pharmacologically isolated N-methyl-D-asparate (NMDA) receptor-mediated evoked excitatory postsynaptic currents (EPSCs) were made, to study whether prenatal exposure to morphine affected functional properties of synaptic NMDA receptors in hippocampal slices of 2-week-old rat offspring from morphine-addicted mothers. (tmu.edu.tw)
  • In experiments of extracellular recording of field excitatory postsynaptic potentials (fEPSPs) from area CA1 of rat hippocampal slices, ephenidine, 1 and 10 μM, respectively, produced a 25 and a near maximal inhibition of the NMDA receptor mediated fEPSP after 4 h superfusion. (erowid.org)
  • First, it was found that when a large proportion of the excitatory synaptic input to dendritic spines is carried by NMDA channels, the pyramidal cell responds preferentially to spatially clustered, rather than random, distributions of activated synapses. (mit.edu)
  • Recent research indicates that neurotoxicity is caused by excessive stimulation of receptors for excitatory amino acids (EAAs). (nih.gov)
  • Glutamate mediates the majority of excitatory neurotransmission in the brain. (scialert.net)
  • Depending on the receptor, the response may be excitatory or inhibitory. (msdmanuals.com)
  • The greater contribution of NMDA receptors to the responses of lagged cells is consistent with the large contribution made by these receptors to the late response components of lagged cells. (umn.edu)
  • Firstly, reductions of the contribution of NMDA receptors to afferent information from external and internal sensory inputs may distort sensations and their processing in higher brain centres. (berkeley.edu)
  • In 2002, it was discovered by Hilmar Bading and co-workers that the cellular consequences of NMDA receptor stimulation depend on the receptor's location on the neuronal cell surface. (wikipedia.org)
  • And extremely soon afterwards, it became clear that NMDA receptor-mediated excitotoxity was physiologically relevant because it was implicated in contributing to neuronal loss and dysfunction in acute disorders, particularly stroke and traumatic brain injury. (hstalks.com)
  • Thus, blockade of non-NMDA-type receptors, the main type of ionotropic glutamate receptors under baseline conditions is expected to eliminate neuronal network activity. (scialert.net)
  • These compensatory adaptations in excitability balance and neuronal intrinsic properties may provide ongoing network activity with homeostatic robustness against an external perturbation of non-NMDA receptors. (scialert.net)
  • The NMDA receptor is one of three types of ionotropic glutamate receptors, the other two being AMPA and kainate receptors. (wikipedia.org)
  • The NMDA receptor is so named because the agonist molecule N-methyl-D-aspartate (NMDA) binds selectively to it, and not to other glutamate receptors. (wikipedia.org)
  • And one particular focus in the lab is on an important source of calcium influx, the NMDA subtype of ionotrophic glutamate receptors. (hstalks.com)
  • And that this calcium influx was mediated by the NMDA receptor, the NMDA subtype of ionotrophic glutamate receptors. (hstalks.com)
  • The slow, but not fast, decay times of synaptic NMDA receptor-mediated currents in morphine-treated offspring became slower than those in vehicle-control offspring. (tmu.edu.tw)
  • The extended duration of synaptic NMDA receptor-mediated currents presumably provided more Ca 2+ entry through NMDA receptors in morphine-treated offspring, and its further prolongation by depolarization in such young offspring strengthened NMDA receptor-dependent functions. (tmu.edu.tw)
  • Blocks NMDA receptor-mediated currents. (abcam.com)
  • To test this, I used electrophysiological assessments of tonic NMDA receptor-mediated currents in cortical pyramidal cells and GABAergic interneurons (INs). (tufts.edu)
  • Chen X, Jia B, Araki Y , Liu B , Ye F, Huganir R , Zhang M. Arc weakens synapses by dispersing AMPA receptors from postsynaptic density via modulating PSD phase separation. (neurotree.org)
  • What happens is you get presynaptic release of glutamate into the synaptic cleft, which causes postsynaptic depolarization mediated by the AMPA subtype of glutamate receptor. (hstalks.com)
  • This postsynaptic depolarization alleviates the voltage-dependent magnesium block on the NMDA receptor. (hstalks.com)
  • The effects of the antipsychotic drugs haloperidol and clozapine on N-methyl- d- aspartate (NMDA) and non-NMDA receptor-mediated neurotransmission were examined and compared in pyramidal cells of the medial prefrontal cortex in rat brain slices by using the techniques of intracellular recording and single-electrode voltage-clamp. (aspetjournals.org)
  • In whole cell patch clamp recordings, from hippocampal pyramidal cells, ephenidine (10 μM) blocked NMDA receptor-mediated EPSCs in a highly voltage-dependent manner. (erowid.org)
  • The NMDA receptor is ionotropic, meaning it is a protein which allows the passage of ions through the cell membrane. (wikipedia.org)
  • Overactivation of the receptor, causing excessive influx of Ca2+ can lead to excitotoxicity which is implied to be involved in some neurodegenerative disorders. (wikipedia.org)
  • NMDA-receptor-mediated toxicity in RGCs is dependent on the influx of extracellular Ca2+. (nih.gov)
  • NMDAR -mediated calcium influx and its downstream signalling depend critically on the dynamics of membrane potential and ambient glutamate concentration. (cam.ac.uk)
  • So a typical glutamatergic synapse, such as the one shown in the cartoon here, the NMDA receptor is a very important source of activity-dependent calcium influx. (hstalks.com)
  • This study suggests that DMT1(-)IRE-mediated iron accumulation is likely to be the downstream event following NMDA receptor activation and Ca influx, contributing to remifentanil-induced hyperalgesia. (iasp-pain.org)
  • Partial blockade of LTD by okadaic acid resulted in equal partial blockade of the LTDs of the AMPA and NMDA receptor-mediated components. (jneurosci.org)
  • In addition, no distinguishable changes in the voltage-dependent nature and the reversal potential of NMDA receptors occurred in morphine-treated offspring, suggesting no alterations of Mg 2+ blockade and ion selectivity to NMDA receptors. (tmu.edu.tw)
  • Finally, blockade of GluN2C/D-containing NMDA receptors with DQP-1105, from P7-9, causes lasting reductions in GABAergic synapse number and IN dendritic complexity as well as an increase in cortical hyperexcitability. (tufts.edu)
  • This group also found that while both receptor subtypes were seen in the membranes and cytoplasm of cell bodies, the β 2 receptor subtype, but not the β 1 , was localized to the nucleus. (frontiersin.org)
  • In particular, the amino acid glutamate has been shown to act as a neurotoxin which exerts its toxic effect on RGCs predominantly through the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor. (nih.gov)
  • The sigma-2 receptor (σR2) subtype has been identified pharmacologically [ 7 ], but has yet to be cloned. (molvis.org)
  • These organelles are defined by the expression of receptors for the second messenger Inositol 1,4,5-trisphosphate. (rochester.edu)
  • An inside job: Annexin 1A-Inositol 1,4,5-trisphosphate receptor interaction conveys endoplasmic reticulum luminal Ca sensitivity. (rochester.edu)
  • Pivotal role of type-1 inositol 1,4,5-trisphosphate receptor for glucagon-induced gluconeogenesis. (rochester.edu)
  • Activation of NMDA receptors results in the opening of the ion channel that is nonselective to cations, with a combined reversal potential near 0 mV. (wikipedia.org)
  • In contrast, overactivation of NMDAR by NMDA agonists increases the cytosolic concentrations of calcium and zinc, which significantly contributes to neural death, an effect known to be prevented by cannabinoids, mediated by activation of the CB1 receptor, which leads HINT1 protein to counteract the toxic effects of NMDAR-mediated NO production and zinc release. (wikipedia.org)
  • As well as preventing methamphetamine-induced neurotoxicity via inhibition of nitric oxide synthase (nNOS) expression and astrocyte activation, is seen to reduce methamphetamine induced brain damage through a CB1-dependent and independent mechanisms, respectively, and inhibition of methamphetamine induced astrogliosis is likely to occur through a CB2 receptor dependent mechanism for THC. (wikipedia.org)
  • Manzerra, Pasquale, Synaptic Ras GTPase activating protein (SynGAP) regulates N-methyl-D-aspartate receptor (NMDAR)-mediated excitotoxicity via P38 MAPK activation. (usd.edu)
  • The psychophysics of this state clearly emphasize that the pain is evoked by the activation of low threshold mechano-receptors (Aß afferents). (asra.com)
  • Activation of NMDA receptors induces protein kinase A‐mediated phosphorylation and degradation of matrin 3. (google.es)
  • Giordano G, Sanchez-Perez AM, Montoliu C, Berezney R, Malyavantham K, Costa LG, Calvete JJ, Felipo V. Activation of NMDA receptors induces protein kinase A-mediated phosphorylation and degradation of matrin 3. (medlineplus.gov)
  • Rapid regulation of endoplasmic reticulum dynamics in dendritic spines by NMDA receptor activation. (rndsystems.com)
  • Activating NMDA Rs is shown to cause excitation and intracellular calcium elevation, and intracellular perfusion with physiological levels of glutamate leads to a VGLUT -dependent autocrine NMDAR activation. (cam.ac.uk)
  • N-methyl-D-aspartate (NMDA) receptor activation is known to be critical in remifentanil-induced hyperalgesia. (iasp-pain.org)
  • I found that glutamate clearance is slow in the neonatal cortex and, furthermore, this slow glutamate clearance is permissive for extrasynaptic NMDA receptor activation. (tufts.edu)
  • In the early 1980s, NMDA receptors were shown to be involved in several central synaptic pathways. (wikipedia.org)
  • 2021 ). Moreover, the resolution of inflammation is not passive as it engages a biosynthetically active process, regulated by specific mediators and receptor-signaling pathways and driven by specialized pro-resolving mediators (SPMs) (Serhan and Petasis 2011 ). (springer.com)
  • Now, we're particularly interested in calcium signalling pathways and how calcium mediates these kind of effects. (hstalks.com)
  • A wealth of research has begun to identify the genetic, epigenetic, neural, and environmental underpinnings of resilience, and has indicated that resilience is mediated by adaptive changes encompassing several environmental factors, neural circuits, numerous neurotransmitters, and molecular pathways. (cdc.gov)
  • CNQX mediates depolarization thalamic reticular nucleus via α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors (AMPARs). (sigmaaldrich.com)
  • In addition the regulation of these receptors by phosphorylation and the consequences this may have for Ca2+ signaling are also being studied. (rochester.edu)
  • In contrast, tPA-induced delayed IPC required the proteolytic activity of tPA and was mediated by plasmin, the NMDA receptor, and PKB phosphorylation. (jci.org)
  • The study of current-voltage relationship indicates that clozapine preferentially potentiates NMDA receptor-mediated transmission, whereas haloperidol depresses the non-NMDA receptor-mediated response, which probably obscures its potentiating effect on NMDA receptor-mediated EPSPs. (aspetjournals.org)
  • The saturated amplitude of synaptic NMDA receptor-mediated EPSCs from morphine-treated offspring was about twofold larger than that from vehicle-control offspring. (tmu.edu.tw)
  • The 10-90% rise times of NMDA receptor-mediated EPSCs in morphine-treated offspring became longer than those in vehicle-control offspring. (tmu.edu.tw)
  • The decay of NMDA receptor-mediated EPSCs in both morphine-treated and vehicle-control offspring could be described by the sum of a fast and a slow exponential function. (tmu.edu.tw)
  • Second, based on this mechanism, the NMDA-rich neuron is shown to be capable of solving a nonlinear pattern discrimination task. (mit.edu)
  • Neurotransmitters that are released bind to receptors on another neuron. (msdmanuals.com)
  • Neurotransmitters diffuse across the synaptic cleft and bind briefly to specific receptors on the adjoining neuron or effector cell. (msdmanuals.com)
  • Structure-activity relationship for antagonism at the glycine site of the NMDA receptor. (rndsystems.com)
  • Reported as active at the glycine site of the NMDA receptor but having little action at AMPA or kainate receptors. (tocris.com)
  • This issue was investigated here, with a particular focus on the role of voltage-dependent N -methyl-D-asparate (NMDA) channels in the generation of cell responses. (mit.edu)
  • Secreted Amyloid Precursor Protein-Alpha Enhances LTP Through the Synthesis and Trafficking of Ca2+-Permeable AMPA Receptors. (abcam.com)
  • Visualizing synaptic plasticity in vivo by large-scale imaging of endogenous AMPA receptors. (neurotree.org)
  • Synaptic NMDA receptors promote gene expression, plasticity-related events, and acquired neuroprotection. (wikipedia.org)
  • Since shRNA-mediated suppression of STIM2 decreased store-operated calcium uptake, we have speculated that high expression of STIM2 underlies the excessive entry through store-operated calcium channels in HD pathology. (frontiersin.org)
  • In situ hybridization analysis of AMPA receptor subunit gene expression in the developing rat spinal cord. (bcm.edu)
  • 13. Fu X, Wang Y, Wang J, Yu J, Wu G. Changes in expression of nociceptin/orphanin FQ and its receptor in spinal dorsal horn during electroacupuncture treatment for peripheral inflammatory pain in rats. (bvsalud.org)
  • NMDA receptors: neuroprotective or excitotoxic? (hstalks.com)
  • Fine-structural alterations and clustering of developing synapses after chronic treatment with low levels of NMDA. (bcm.edu)
  • These data indicate that NMDA and non-NMDA receptors make similar contributions to the responses of ON- and OFF-center and X and Y cells in the LGN. (umn.edu)
  • Lagged and nonlagged cells are not differentiated with respect to the contribution of non-NMDA receptors to their visual responses. (umn.edu)
  • It is possible, then, that the degree of participation of NMDA receptors in the visual responses of LGN cells is a function of the response characteristics of cells rather than a fundamental distinguishing feature of LGN cell types. (umn.edu)
  • The bath administration of either haloperidol or clozapine produced a marked facilitation (300-400%) of NMDA-evoked responses in a concentration-dependent manner. (aspetjournals.org)
  • Acute psychosis is not an uncommon presenting feature in immune-mediated encephalitides. (bvsalud.org)
  • Encephalitis causes high rates of illness and death, yet increasing recognition of novel immune-mediated forms its epidemiology remains poorly understood. (cdc.gov)
  • Pocklington, A. J., Cumiskey, M., Armstrong, J. D. & Grant, S. G. The proteomes of neurotransmitter receptor complexes form modular networks with distributed functionality underlying plasticity and behaviour. (nature.com)
  • Subproject B, "Synaptic Localization of NMDA Receptor Subunits in a PCP Model of Schizophrenia. (usd.edu)
  • I discovered that ambient glutamate tonically activates NMDA receptors containing GluN2C and/or GluN2D subunits. (tufts.edu)
  • Ephenidine was a potent inhibitor of 3H-MK-801 binding (Ki: 66 nM), implying that it acts at the PCP site of the N-methyl-d-aspartate (NMDA) receptor. (erowid.org)
  • aspartate receptors. (tocris.com)
  • aspartate receptor complex. (tocris.com)
  • N-Methyl-D-Aspartate(NMDA) Receptor and Voltage-Gated Potassium Channel (VGKC) Antibody-Associated Encephalitides Presenting as First Episode Acute Psychosis. (bvsalud.org)
  • Our study aimed to describe the frequency, clinical spectrum, and long-term outcomes in patients presenting with acute psychosis who have anti- N-methyl-D-aspartate ( NMDA ) receptor or anti- voltage-gated potassium channel (VGKC) encephalitis . (bvsalud.org)
  • Furthermore, we discuss novel pharmacologic approaches, including the N-methyl-d-aspartate (NMDA) receptor ketamine and neuropeptide Y (NPY), as exciting new prospects for not only the treatment of PTSD but as new targets to enhance resilience. (cdc.gov)
  • Glutamate stimulates its own release in a positive feedback loop by its interaction with the non-NMDA receptor subtypes. (nih.gov)
  • Secondly, reductions of NMDA receptor-mediated excitation of GABAergic interneurons can result in glutamatergic overactivity. (berkeley.edu)
  • Receptor subunit selectivity was discovered in the early 1990s, which led to recognition of a new class of compounds that selectively inhibit the NR2B subunit. (wikipedia.org)
  • The NMDA receptor is thought to be very important for controlling synaptic plasticity and mediating learning and memory functions. (wikipedia.org)
  • Ca2+ flux through NMDA receptors in particular is thought to be critical in synaptic plasticity, a cellular mechanism for learning and memory, due to proteins which bind to and are activated by Ca2+ ions. (wikipedia.org)
  • However, hypofunction of NMDA receptors (due to glutathione deficiency or other causes) may be involved in impairment of synaptic plasticity and could have other negative repercussions. (wikipedia.org)
  • NMDA receptor modulates spinal iron accumulation via activating DMT1(-)IRE in remifentanil-induced hyperalgesia. (iasp-pain.org)
  • Regulated internalization of NMDA receptors drives PKD1-mediated suppression of the activity of residual cell-surface NMDA receptors. (rndsystems.com)
  • From this it was considered that NMDA receptors were associated with a variety of neurological disorders such as epilepsy, Parkinson's, Alzheimer's, Huntington's and other CNS disorders. (wikipedia.org)
  • Current knowledge of Slc6a1 -related disorders: GABA transporter (GAT1) mediated disorders. (albany.edu)
  • It functions as a translational repressor that governs the synthesis of the AMPA receptor GluR2 through binding GluR2 mRNA. (nih.gov)
  • CPEB-4 is an RNA-binding protein that mediates meiotic mRNA cytoplasmic polyadenylation and translation. (nih.gov)
  • Selective GluR2 lacking AMPA receptor blocker. (abcam.com)
  • Selective, Ca 2+ permeable GluR2-lacking AMPA receptor blocker (IC 50 values are 2.6 and 1102 μM for GluR2-lacking and GluR2-containing receptors, respectively). (abcam.com)
  • The anaesthetic and analgesic effects of the drugs ketamine and nitrous oxide are also partially due to their effects at blocking NMDA receptor activity. (wikipedia.org)
  • Blocking of NMDA receptors could therefore, in theory, be useful in treating such diseases. (wikipedia.org)