Mediate mrna localization follicle localization of specific rnas. Medical search. Frequent questions

Mechanistically, SEs recruited bromodomain containing 4 (BRD4) at the site of ZBTB16 , which then bound to RNA polymerase II-associated protein 2 (RPAP2) that transported RNA polymerase II (POL II) into the nucleus. (nature.com)
PR domain-containing protein 9 (PRDM9) is a major regulator of the localization of meiotic recombination hotspots in the human and mouse genomes. (springer.com)
One pathway, which has been extensively studied in yeast, is mainly guided by chromatin structure and the other, analyzed in detail in mice, is driven by the sequence-specific DNA-binding PR domain-containing protein 9 (PRDM9). (springer.com)
In humans and mice, hotspots are specified by PRDM9, a meiosis-specific PRDM family protein (Baudat et al. (springer.com)
We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)
Protein-tyrosine kinases (PTKs) are critical enzymes for receptor-mediated signaling. (appliedbioinfo.com)
The protein encoded by this mRNA contains the double catalytic domain characteristic of the JAK family. (appliedbioinfo.com)
The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. (appliedbioinfo.com)
Thus, the maturing oocyte is reliant on processes such as post-transcriptional gene regulation (PTGR) to regulate the mRNA and protein repertoire. (biomedcentral.com)
The single-stranded mature miRNA can then associate with an Argonaute protein, which mediates its function of mRNA regulation through direct mRNA target cleavage or interactions with associated RNA-induced silencing complex (RISC) proteins [ 24 ]. (biomedcentral.com)
The protein encoded by this gene is located in the nucleoplasm and has three repeats of KH domains that binds to RNAs. (thermofisher.com)
Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. (cancerindex.org)
The differentiation-induced psoriasin expression was found to be mediated by the protein kinase C pathway. (medicaljournals.se)
In neutrophils, IL-8 binding to CXCR1 triggers G protein-coupled signalling and formation of second messengers that mediate cellular migration, exocytosis of effectors and a respiratory burst to facilitate oxygen-dependent killing of phagocytosed microorganisms [ 2 ]. (biomedcentral.com)
Here, we describe further development of an in vivo library selection platform based on self-assembling protein nanoparticles encapsulating their own mRNA genomes (synthetic nucleocapsids or synNCs). (uw.edu)
2, 3, 4, 5] The WT1 gene contains 10 exons that produce 4 different messenger RNAs (mRNAs) as a result of 2 alternative splicing sites in exons 5 and 9 that, in turn, encode 4 different isoforms of the WT1 protein. (medscape.com)
The WT1 protein mediates the mesenchymal-epithelial transition and differentiation during morphogenesis of the kidney and gonad by repressing genes that encode cell proliferation factors and by activating genes that encode markers of epithelial cell differentiation. (medscape.com)

The size of the primordial follicle pool determines the reproductive ability of female mammals. (appliedbioinfo.com)

Below are some examples of maternally inherited mRNAs and proteins found in the oocytes of the African clawed frog. (wikipedia.org)
These genes, encoding for RNA binding proteins, contain a highly conserved RNA recognition motif and at least one DAZ repeat encoding for a 24 amino acids sequence able to bind other mRNA binding proteins. (ijbs.com)
Basically, Daz family proteins function as adaptors for target mRNA transport and activators of their translation. (ijbs.com)
This family includes three members, Boule (or Boll ), Dazl (or Dazla ) and DAZ , encoding RNA binding proteins. (ijbs.com)
The localization of DAZ family proteins suggests that they can regulate mRNA translation occurring in the cytoplasm. (ijbs.com)
These proteins have a highly conserved RNA recognition motif (RRM) for binding target mRNAs and at least one characteristic sequence of 24 amino acids, which are termed as DAZ repeats [ 1 ]. (ijbs.com)
Dazl can regulate the expression, transport and localization of target mRNAs of proteins which control the differentiation, growth and maturation of germ cells. (ijbs.com)
Basically, DAZ family proteins have been proposed to function as adaptors for mRNA transport and activators of their translation. (ijbs.com)
The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). (thermofisher.com)
These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. (thermofisher.com)

MicroRNA (miRNA) are a class of functional small RNA that target mRNA to affect their abundance and translational efficiency. (biomedcentral.com)

RPAP2 transports RNA Pol II from the cytoplasm to the nucleus and guides Pol II to target ZBTB16 via recognition of the navigator BRD4 on SEs. (nature.com)
These mRNAs can be stored in mRNP (message ribonucleoprotein) complexes and be translated at specific time points, they can be localized within a specific region of the cytoplasm, or they can be homogeneously dispersed within the cytoplasm of the entire oocyte. (wikipedia.org)
It is held in the cytoplasm in an inactive state by specific inhibitors. (nih.gov)

Luteinization of porcine preovulatory follicles leads to systematic changes in follicular gene expression. (appliedbioinfo.com)
The LH surge initiates the luteinization of preovulatory follicles and causes hormonal and structural changes that ultimately lead to ovulation and the formation of corpora lutea. (appliedbioinfo.com)

In female mammals, primordial follicles consist of two types of cells, namely, oocytes and pregranulosa cells that surround the oocytes. (appliedbioinfo.com)
Mature oocytes become fertilizable, and their meiosis is arrested again at a species-specific stage: metaphase of the first division (MetI, many invertebrates), metaphase of the second division (MetII, most vertebrates), or G1-phase (some echinoderms and coelenterates) until fertilization. (elifesciences.org)
Oocytes were collected from aspirated porcine tertiary follicles. (biomedcentral.com)

The cumulus-oocyte complex contains layers of tightly packed cumulus cells surrounding the oocyte in the Graafian follicle. (wikipedia.org)
Many studies show that cumulus expansion is critical for the maturation of the oocyte because the cumulus complex is the oocyte's direct communication with the developing follicle environment. (wikipedia.org)
During the growth of the oocyte, a variety of maternally transcribed messenger RNAs, or mRNAs, are supplied by maternal cells. (wikipedia.org)
In this study, we show that oocyte-derived Janus kinase (JAK) signaling is vital for germline cyst breakdown and primordial follicle formation in vitro JAK2 and JAK3 activity is increased while germline cysts are breaking down. (appliedbioinfo.com)
Alternatively, specific inhibition of JAK3 decreases pregranulosa cell proliferation by downregulating Notch2 signaling, implying that JAK3 acts on pregranulosa cells by controlling the extracellular secretion of oocyte-derived factors. (appliedbioinfo.com)
In summary, our results indicate that JAK signaling contributes to germline cyst breakdown and primordial follicle formation by regulating oocyte loss and pregranulosa cell proliferation in the fetal mouse ovary. (appliedbioinfo.com)
In this study, we first examined the ovulation of Ciona intestinalis Type A by monitoring follicle rupture in vitro, identifying a novel mechanism of neuropeptidergic regulation of oocyte maturation and ovulation. (elifesciences.org)
These findings demonstrate that various neuropeptides are responsible for triggering oocyte maturation and ovulation in invertebrates, and suggest that oocyte maturation and ovulation and their underlying molecular mechanisms are regulated in both a species-specific and evolutionarily conserved fashion. (elifesciences.org)
The inability to transcribe mRNA during this stage of development and the probable necessity for post-transcriptional gene regulation (PTGR) suggests an important role for non-coding RNA in the maturing oocyte. (biomedcentral.com)
Of particular interest is understanding the role of non-coding RNA in regulating meiotic checkpoints in the oocyte, particularly that of microRNA-21 (MIR21). (biomedcentral.com)

A study in Wistar rats demonstrated that peripheral administration of both OT and AVP induced profound effects manifested as a reduction in body temperature and heart rate, and these changes were predominantly mediated by the AVP V1a receptor (V1aR) ( 23 ). (frontiersin.org)
It is well documented that increased expression of LH receptor (LHR) in granulosa cells (GC) and specific changes of intrafollicular factors such as the insulin-like growth factor (IGF) and inhibin-activin-follistatin systems play a critical role in E 2 production in the DF [ 6 , 7 ]. (biomedcentral.com)
Additionally, we determined the localization of the CXCR1 receptor in Caco-2 BBE cells and human intestinal tissue samples and investigated the role of IL-8 autocrine signalling using transcriptomics. (biomedcentral.com)
This study was performed to determine the effects of human placenta mesenchymal stem cell (hPMSC) transplantation on granulosa cell apoptosis and anti-Müllerian hormone (AMH) and follicle-stimulating hormone receptor (FSHR) expression in autoimmune drug-induced premature ovarian failure (POF) mice. (biomedcentral.com)

In addition, localization of six identified transcripts was investigated in healthy and atretic follicles using in situ hybridization. (biomedcentral.com)
In situ hybridization showed that AMH and CYP19 were detected in granulosa cells (GC) of healthy as well as atretic follicles. (biomedcentral.com)
This interaction is crucial for recruiting telomerase to telomeres, as assessed by co-localization of telomerase RNA to telomeres through in situ hybridization analysis [ 19 ]. (prolekarniky.cz)

Genes related to T cell activation, cytotoxic cell-mediated (or type 1) immunity, B cell growth and differentiation, pathogen recognition, myeloid cell function, type I interferon pathway activation, and leukocyte recruitment were found expressed at different levels in most or all MS brain immune infiltrates. (biomedcentral.com)
The downregulation of psoriasin expression by small interfering RNA revealed that psoriasin mediates the expression of involucrin, desmoglein 1, transglutaminase 1 and CD24 in normal differentiation. (medicaljournals.se)
The lentivirus-mediated overexpression of psoriasin, mimicking the psoriatic milieu, gave rise to an altered regulation of differentiation genes and an expression pattern reminiscent of that in psoriatic epidermis. (medicaljournals.se)
Brain-derived neurotrophic factor (BDNF) is a member of the NGF family of neurotrophic factors (also named neurotrophins) that are required for the differentiation and survival of specific neuronal subpopulations in both the central as well as the peripheral nervous system. (novusbio.com)

Female mice lacking TAF(II)105 are viable but infertile because of a defect in folliculogenesis correlating with restricted expression of TAF(II)105 in the granulosa cells of the ovarian follicle. (appliedbioinfo.com)
The relatively narrow intercellular space of the primordial follicle allows ferritin and possibly other molecules of similar size to cross, whereas in the late stages of rapid follicular growth, the shape of granulosa cells must accommodate the increasing flow of egg yolk precursors that accumulate at the surface of the plasma membrane of the follicle [ 7 ]. (biomedcentral.com)
HN - 2008 BX - Von Ebner's Glands MH - Cumulus Cells UI - D054885 MN - A05.360.319.114.630.535.200.500 MN - A06.407.312.497.535.300.500 MN - A11.436.300.500 MS - The granulosa cells of the cumulus oophorus which surround the OVUM in the GRAAFIAN FOLLICLE. (bvsalud.org)

Further knowledge of the integrin-mediated regulation of cell growth and cell survival may facilitate our understanding of many key aspects of development and physiology in reproduction. (go.jp)
Transposable elements are able to affect conserved and divergent chromatin looping and contribute to cell- and species-specific gene regulation [ 11 ]. (biomedcentral.com)
The best evidence for a shelterin-specific role in telomerase regulation comes from analysis of TPP1, which interacts with the telomerase catalytic subunit through the N-terminal OB-fold domain of TPP1 [ 15 - 18 ]. (prolekarniky.cz)

Hierarchical cluster analysis of microarray data classified the follicles into two clusters. (biomedcentral.com)
CXCR1 is expressed in the human IEC line Caco-2 BBE [ 3 ], which is in agreement with our own microarray data using Caco-2 BBE cell mRNA (see below). (biomedcentral.com)

First identified in embryonic stem cells, SEs mediate pluripotent state maintenance by promoting the expression of pluripotent identity genes, including Oct4 , Sox2 , Nanog and Klf4 . (nature.com)

JAK signaling regulates germline cyst breakdown and primordial follicle formation in mice. (appliedbioinfo.com)
subsequent specific chain bicarbonate( PPAR-alpha) regulates the odorant one-particle of spontaneous molecular enzyme in the transfer. (evakoch.com)

Transcription factor TFIID, composed of TBP and TAF(II) subunits, is a central component of the RNA polymerase II machinery. (appliedbioinfo.com)

dGLYAT was found to regulate Gadd45 -mediated JNK pathway activation and cell invasion. (sdbonline.org)

Activins were discovered and, in fact, named more than a quarter century ago based on their abilities to stimulate pituitary follicle-stimulating hormone (FSH) synthesis and secretion. (bioone.org)

often, there lacks to mediate dark-matter over degradation with the Phosphorylated mass bone country. (evakoch.com)
Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. (nih.gov)

The follicular status within each follicle was confirmed by follicular fluid analyses of estradiol and progesterone ratios. (appliedbioinfo.com)
The healthy or atretic condition of examined follicles was classified by progesterone and estradiol concentrations in follicular fluid. (biomedcentral.com)

In this study, we tried to identify differentially expressed genes between largest (F1) and second-largest follicles (F2), and classify them by global gene expression profiling using a combination of microarray and quantitative real-time PCR (QPCR) analysis. (biomedcentral.com)
The follicular status of F1 and F2 were further evaluated in terms of healthy and atretic conditions by investigating mRNA localization of identified genes. (biomedcentral.com)
Expression of stage-specific genes in follicles may be closely associated with their growth or atresia. (biomedcentral.com)

To overcome these obstacles in the translation of novel findings to clinical applications, researchers must address the most common targets and upstream mechanisms mediating the key steps of MSC osteogenesis. (nature.com)
It also plays a significant role in fertilization, though the mechanisms are not entirely known and are species specific. (wikipedia.org)
Our goal is to convey a picture of pattern formation that draws attention to the principles rather than solely to specific molecular mechanisms. (mpi-cbg.de)
However, the underlying mechanisms controlling primordial follicle assembly remain unclear. (appliedbioinfo.com)

The activation of Akt kinase enhances the survival of cells by blocking the p53 pathway and the FOXO-mediated proapoptotic cascade. (medscape.com)

These observations suggest that Rspo2 is a context-specific regulator of TCF3 phosphorylation and Wnt signaling. (xenbase.org)
Depletion of TIN2, which associates with TPP1, leads to reduced levels of TPP1-mediated telomerase association to telomeres [ 19 ], although this result might simply reflect an indirect function for TIN2 as a regulator of telomerase recruitment through anchoring TPP1 at telomeres. (prolekarniky.cz)

Although ANA positivity is certainly common in the overall population, in a few individuals, elevated cytokine production grows, perhaps due to the role of ICs of ANAs with RNA and DNA in stimulating cytokine production. (columbiagypsy.net)

PlGF was localized in GC and in the theca layer (TL) of healthy follicles. (biomedcentral.com)
The production of estrogen and at a lower magnitude testosterone by the theca of the growing follicle increases 2 to 3 weeks before the production of the first egg and contributes to the development of reproductive organs and the synthesis of egg constituents [ 1 - 6 ]. (biomedcentral.com)

The only shelterin subunit known to promote telomerase function is TPP1, which mediates telomerase recruitment to telomeres and stimulates telomerase processivity. (prolekarniky.cz)
The telomerase recruitment defect conferred by TIN2-R282H is likely through a mechanism independent of TIN2's role in anchoring TPP1 at telomeres, since TPP1 localization to telomeres is unaffected by the mutation. (prolekarniky.cz)

Inhibition of either JAK2 or JAK3 prevents germline cyst breakdown and primordial follicle formation. (appliedbioinfo.com)
In testes, noa RNA is detected in the cyst cells during the postmeiotic phase of germ cell development. (biologists.com)

Extracellular vesicle DNA from human melanoma tissues contains cancer-specific mutations. (gu.se)

In the present study, ovoviviparous guppies ( Poecilia reticulata ) were used to study the effect of AVT on delivery mediated by the activation of prostaglandin (PG) biosynthesis via isotocin (IT) receptors (ITRs). (frontiersin.org)

this activation occurs following a uptake of ICs into innate immune cells and the interaction of the cargo DNA or RNA with internal nucleic acid detectors. (columbiagypsy.net)

Schip1 is necessary for promoting membrane localization and phosphorylation of Hpo by recruiting the Hpo kinase Tao-1 . (sdbonline.org)

Each of these layers is characterized by specific features in terms of gene expression, function and cellular mor-phology (1). (medicaljournals.se)

Its function is dose dependent, since reduced levels of noa RNA lead to impaired motility and severely reduced viability. (biologists.com)

Recent studies have shown that Mage-D1 is closely related to tooth development, but its specific regulatory mechanism is unclear. (researchsquare.com)

JAK3 is encoded by a 4.3-kb mRNA transcript that contains an open reading frame of 3,897 bp. (appliedbioinfo.com)
Northern analysis detected a specific 2.5-kilobase pair hOAT1 transcript only in human kidney. (aspetjournals.org)

Within each tissue, downstream PCP effectors link the signal to tissue specific readouts such as stereocilia orientation in the inner ear and hair follicle orientation in vertebrates or the polarization of ommatidia and wing hairs in Drosophila melanogaster. (uni-wuerzburg.de)
Specific PCP effectors in the wing such as Multiple wing hairs (Mwh) and Rho Kinase (Rok) are required to position the hair at the correct position and to prevent ectopic actin hairs. (uni-wuerzburg.de)

Twenty-three postmortem snap-frozen brain tissue blocks from 11 patients with progressive MS were selected based on good RNA quality and prominent immune cell infiltration. (biomedcentral.com)
Our approach should contribute to achieving specific tissue homing patterns and identifying targeting ligands for diseases of interest. (uw.edu)

Dysregulation of SE-mediated ZBTB16 expression leads to osteoporosis, and bone-targeting ZBTB16 overexpression is efficient in accelerating bone repair and treating osteoporosis. (nature.com)
Additionally, we showed the 4-fold over-expression of "ovochymase-2/similar to oviductin" (GeneID:769290), a vitelline membrane-specific protease. (biomedcentral.com)
Results showed that the expression of Mage-D1 during rat tooth germ development was temporally and spatially specific. (researchsquare.com)

The nucleation of RAD51 is mediated by its direct interaction with BRCA2. (nature.com)

Although the DF continues to grow by transition of gonadotropin dependency from FSH to luteinizing hormone (LH) and secretes large quantities of estradiol (E 2 ), the remaining subordinate follicles (SFs) cease to grow, then undergo atresia [ 5 ]. (biomedcentral.com)

Morphological staining showed that the basal follicles and sinus follicles after hPMSC transplantation were higher in POF mice than in those without treatment, and the follicle number was significantly decreased with atresia. (biomedcentral.com)

We further show that specific suppression of JAK2 delays germ cell loss through the downregulation of p53, but has no influence on pregranulosa cell proliferation. (appliedbioinfo.com)

The size of this intercellular space is rearranged depending on the stage of follicular growth [ 10 ] and may also selectively control the uptake of specific plasma molecules. (biomedcentral.com)
Importantly, both hOAT1 and rat renal organic anion transporter 1 (rROAT1) mediated saturable, probenecid-sensitive uptake of cidofovir, adefovir, and other nucleoside phosphonate antivirals. (aspetjournals.org)

White matter perivascular and intrameningeal immune infiltrates, including B cell follicle-like structures, were isolated from brain sections using laser capture microdissection. (biomedcentral.com)
A,B) Four-cell embryos were injected with 0.5 ng of Rspo2 RNA into both animal- ventral blastomeres and cultured until stage 28. (xenbase.org)

Using functional imaging and behavioral analysis, loss of Tao-induced ectopic synapses with inappropriate partner neurons were shown to be functional and altered behavioral responses in a connection-specific manner. (sdbonline.org)

Anatomy46

Organisms19

Diseases1

Chemicals and Drugs78

Analytical, Diagnostic and Therapeutic Techniques and Equipment37

Psychiatry and Psychology1

Phenomena and Processes74

Disciplines and Occupations2

Information Science3

Protein17

Primordial follicle pool1

Proteins10

Target mRNA1

Cytoplasm3

Preovulatory follicles2

Oocytes3

Oocyte10

Receptor4

Situ hybridization3

Differentiation4

Granulosa cells3

Regulation3

Microarray data2

Embryonic stem1

Regulates2

Polymerase1

Regulate1

Pituitary1

Degradation2

Follicular fluid2

Genes3

Mechanisms4

Pathway1

Regulator2

Cytokine1

Theca2

Recruitment2

Cyst2

Mutations1

Receptors1

Cells1

Phosphorylation1

Cellular1

Function1

Mechanism1

Transcript2

Effectors2

Tissue2

Expression3

Interaction1

Hormone1

Atresia1

Suppression1

Uptake2

Cell2

Functional1