Mediate hypoxia. Medical search. Frequent questions

Conversely, we observed no difference in expression of the homing CXCR4 receptor between cells cultured under normoxic and hypoxic conditions, indicating that hypoxia increased the absolute numbers of LTR-HSCs but not their homing potential after transplantation. (confex.com)
To clarify how hypoxia improved Notch-mediated expansion of LTR-HSCs, we performed scRNA-seq of CD34+ cells treated with Delta1 under normoxic or hypoxic conditions. (confex.com)
Induction of hypoxia was confirmed by flow cytometric analysis and the levels of SIRT1 were noted in a hypoxic condition as well in the cells after blocking SIRT1 activity using sirtinol. (molvis.org)
However, its role has not been evaluated in hypoxic choroidal endothelial cells (CECs), the precursor of VEGF-mediated choroidal angiogenesis. (molvis.org)
Thus, solid tumors seem to build up a hostile hypoxic microenvironment that hampers cell-mediated immunity and dampen the efficacy of the immune response. (nutriforce.cn)
Additionally, TAMs in the hypoxic niches within the tumor are known to mediate resistance to several anticancer treatments and to promote cancer relapse. (nutriforce.cn)
Gene array, TaqMan PCR, Western blotting, and oligonucleotide binding assays identify NF-κB as a novel hypoxia-regulated and HIF-dependent target, with inhibition of NF-κB by gliotoxin or parthenolide resulting in the abrogation of hypoxic survival. (uea.ac.uk)
The present study demonstrated that shRNA-mediated silencing of CREB in HER-2/neu-transformed cells resulted in decreased tumor formation, which was associated with reduced angiogenesis, but increased necrotic and hypoxic areas in the tumor. (uni-halle.de)
These data suggest that the HER-2/neu-mediated CREB activation caused by a hypoxic tumor microenvironment contributes to the neoplastic phenotype of HER-2/neu+ cells at various levels. (uni-halle.de)
The hypoxia-inducible transcription factor-1α (HIF-1α) has central roles in angiogenesis, carcinogenesis, and cell adaptions to hypoxic conditions both transcriptionally dependent and independent [ 1 , 2 ]. (biomedcentral.com)
Hypoxia/reoxygenation (H/R) as well as hypoxic preconditioning (HPC) is widely used for simulating in vivo myocardial I/R and ischemic preconditioning (IPC) in a cell culture model. (spandidos-publications.com)
In addition, inhaled hypoxic air preconditioning including intermittent hypoxia has been suggested a potential non-pharmacological therapeutic intervention to improve some cardiovascular diseases such as hypertension, myocardial infarction. (spandidos-publications.com)
To test this, we pre-exposed immortalized N9 and primary microglia to hypoxia (1% O 2 ) for 16 h and then challenged them with pro-inflammatory lipopolysaccharide (LPS) either immediately or 3-6 days following hypoxic exposure. (frontiersin.org)
Hypoxia and hypoxic states can occur in a range of diseases including in cancer. (mdpi.com)
Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development. (lu.se)
At decreased oxygen tensions, hypoxia-inducible factors (HIFs) 1 and 2 are stabilized and mediate a hypoxic response, primarily by acting as transcription factors. (lu.se)
Different strategies to target hypoxic cancer cells and/or HIFs include hypoxia-activated prodrugs and inhibition of HIF dimerization, mRNA or protein expression, DNA binding capacity, and transcriptional activity. (lu.se)

Fig. 1: Hypoxia induces cell death in a RIPK1-dependent manner. (nature.com)
Our study results demonstrate that hypoxia mimetic cobalt chloride induces SIRT1 and augments HIF-2α, which activates and releases VEGF. (molvis.org)
Here we report that PIASy, a SUMO E3 ligase upregulated in hypoxia, interacts with VHL and induces VHL SUMOylation on lysine residue 171. (unr.edu)
Moreover, PIASy-mediated SUMO1 modification induces VHL oligomerization and abrogates its inhibitory function on tumor cell growth, migration and clonogenicity. (unr.edu)
It has become clear that hypoxia shapes and induces specific macrophage phenotypes that serve tumor malignancy, as hypoxia promotes immune evasion, angiogenesis, tumor cell survival, and metastatic dissemination. (nutriforce.cn)
In summary, results from this study demonstrate that hypoxia induces LIF expression in human cancer cells mainly through HIF-2α, which could be an important underlying mechanism for LIF overexpression in human cancers. (oncotarget.com)

Hypoxia-inducible factor regulates osteoclast-mediated bone resorption: role of angiopoietin-like 4. (ox.ac.uk)
Here, we review evidence that hypoxia regulates cell plasticity, resistance to cell-mediated cytotoxicity, and immune suppression. (nutriforce.cn)

Hepatocyte-specific Vhl deficiency promoted RIPK1-dependent apoptosis to mediate liver pathology. (nature.com)
Hypoxia lessened the cellular stress response in both progenitors and HSCs, but the mitigation was more apparent in the HSC population (Fig. C, grey plots), and decreased apoptosis was observed only within the HSC-enriched cluster 5 (Fig. D). These findings are consistent with several reports indicating that HSCs are more vulnerable to strong ER stress than downstream progenitors due to their lower protein folding capacity. (confex.com)
Studies have shown that endothelial cells (ECs) are the direct targets of hypoxia and are involved in the pathogenesis process of HPH leading to cell hyperproliferation, inhibition of apoptosis and plexiform intima injuries (Ranchoux et al. (biomedcentral.com)
Recent findings indicate that hypoxia inducible factor-1 (HIF-1) promotes cardiomyocytes apoptosis during chronic IH, but the mechanisms involved remain to be elucidated. (hal.science)
We examined the mechanism by which hypoxia causes an inhibition of neutrophil apoptosis in human and murine neutrophils. (uea.ac.uk)
However, the knockdown of miR‑133b‑5p in the cardiomyocytes blocked HPC‑mediated cardioprotection as reflected by the aggravation of cell injury and apoptosis. (spandidos-publications.com)

These findings provide evidence that hypoxia pre-exposure could lead to persistent and aberrant inflammatory responses in the context of CNS disorders. (frontiersin.org)

The prolyl hydroxylation of hypoxia-inducible factor 1α (HIF-1α) mediated by the EGLN-pVHL pathway represents a classic signalling mechanism that mediates cellular adaptation under hypoxia. (nature.com)
Here we identify RIPK1, a known regulator of cell death mediated by tumour necrosis factor receptor 1 (TNFR1), as a target of EGLN1-pVHL. (nature.com)
Hypoxia is a critical pathological factor in a variety of retinal diseases, including age-related macular degeneration. (molvis.org)
Activated SIRT1 signals hypoxia inducible factor (HIF)-2α, which transactivates vascular endothelial growth factor (VEGF) and erythropoietin. (molvis.org)
The role of SIRT1 in the activation of HIF-2α and nuclear factor-κB (RelA/p65) during hypoxia in the presence or absence of SIRT1 was assessed using immunoblot analysis. (molvis.org)
Hypoxia and the hypoxia-inducible factor (HIF) transcription factor regulate angiogenic-osteogenic coupling and osteoclast-mediated bone resorption. (ox.ac.uk)
Hypoxia-inducible factor 1 (HIF-1) plays a central role in cellular adaptation to changes in oxygen availability. (nih.gov)
We show that neutrophils possess the hypoxia-inducible factor (HIF)-1α and factor inhibiting HIF (FIH) hydroxylase oxygen-sensing pathway and using HIF-1α-deficient myeloid cells demonstrate that HIF-1α is directly involved in regulating neutrophil survival in hypoxia. (uea.ac.uk)
In addition, we identify macrophage inflammatory protein-1β as a novel hypoxia-induced neutrophil survival factor. (uea.ac.uk)
This study was designed to characterize exosome production during hypoxia of rat renal proximal tubular cells (RPTCs), investigate the regulation by hypoxia -inducible factor-1 (HIF-1), and determine the effect of the exosomes on ATP -depletion-induced tubular cell injury . (bvsalud.org)
USP28 controls hypoxia-dependent angiogenesis and metastasis by preventing FBXW7-dependent hypoxia-inducible transcription factor-1α (HIF-1α) degradation during hypoxia. (biomedcentral.com)
Hypoxia-inducible factor-dependent ADAM12 expression mediates breast cancer invasion and metastasis. (nih.gov)

Prolyl hydroxylation of RIPK1 mediated by EGLN1 promotes the binding of RIPK1 with pVHL to suppress its activation under normoxic conditions. (nature.com)
Prolonged hypoxia promotes the activation of RIPK1 kinase by modulating its proline hydroxylation, independent of the TNFα-TNFR1 pathway. (nature.com)
Our findings illustrate a key role of the EGLN-pVHL pathway in suppressing RIPK1 activation under normoxic conditions to promote cell survival and a model by which hypoxia promotes RIPK1 activation through modulating its proline hydroxylation to mediate cell death and inflammation in human diseases, independent of TNFR1. (nature.com)
Moreover, we revealed that hypoxia promotes VSIG4 expression in cultured bone marrow M2 macrophages, ultimately leading to the conversion of CFs to myofibroblasts. (thno.org)

To corroborate these findings molecularly, we performed transcriptomic analyses and found significant upregulation of a distinct HSC gene expression signature in cells cultured with Delta1 in hypoxia (Fig. A). Collectively, these data show that hypoxia supports a superior ex vivo expansion of human HSCs with LTR activity compared with normoxia at optimized densities of Delta1. (confex.com)
This was accompanied by upregulation of the hypoxia-inducible genes GLUT1 and VEGF, increased cell migration and matrix metalloproteinase-mediated invasion. (uni-halle.de)
Upregulation of miR‑133b‑5p contributes to HPC‑mediated cardioprotection in cardiomyocytes, and the mechanism may be associated with inhibition of caspase‑8 and caspase‑3 apoptotic signaling. (spandidos-publications.com)

Hypoxia is a common feature of solid tumors and is associated with poor patient prognosis, therapy resistance and metastasis. (ox.ac.uk)

Here, we report that A. fumigatus SREBP, SrbA, mediates regulation of iron acquisition in response to hypoxia and low iron conditions. (nau.edu)
These results support a role for SREBP-mediated iron regulation in fungal virulence, and they lay a foundation for further exploration of SREBP's role in iron homeostasis in other eukaryotes. (nau.edu)
The in vitro deubiquitinating activity assay was used to determine the regulation of USP28 by hypoxia. (biomedcentral.com)
In summary, our data suggest that the activation of AMPK and its regulation of cell surface GLUT3 expression is critical in mediating neuronal tolerance to excitotoxicity. (jneurosci.org)

Choroidal endothelial cells (RF/6A) were maintained in a semiconfluent state and hypoxia was induced by exposing the cells to cobalt chloride for 24 h. (molvis.org)
Experimentally induced oscillatory shear stress (OSS) and hypoxia reduce endothelial function in humans. (southwales.ac.uk)
Endothelial function was assessed before and after each intervention by reactive hyperemia flow-mediated dilation (FMD). (southwales.ac.uk)
however, imposed OSS did not appear to worsen endothelial function during acute or sustained hypoxia. (southwales.ac.uk)
Hypoxia triggers a proangiogenic pathway involving cancer cell microvesicles and PAR-2-mediated heparin-binding EGF signaling in endothelial cells. (lu.se)

We present further evidence showing that ARD1-mediated acetylation enhances interaction of HIF-1alpha with pVHL and HIF-1alpha ubiquitination, suggesting that the acetylation of HIF-1alpha by ARD1 is critical to proteasomal degradation. (nih.gov)
The ubiquitin-specific protease 28 (USP28) is an oncogenic deubiquitinase, which plays a critical role in tumorigenesis via antagonizing the ubiquitination and degradation of tumor suppressor protein FBXW7-mediated oncogenic substrates. (biomedcentral.com)
Indeed, the E3 ubiquitin ligase, von Hippel-Lindau (VHL) mediates the ubiquitination and degradation of HIF-1α in normoxia condition [ 3 ]. (biomedcentral.com)
However, it is well-known that the HIF-1α protein was accumulated with increased protein stability during hypoxia, suggesting that either the elements that promoted HIF-1α degradation were repressed or that stabilized HIF-1α were enhanced. (biomedcentral.com)
SENP1-mediated deSUMOylation of USP28 enhanced its deubiquitinating activity towards HIF-1α, and thereby prevented FBXW7-dependent degradation of HIF-1α during hypoxia. (biomedcentral.com)
Several research groups showed that HIF-1α, which is normally rapidly degraded, is protected from degradation in hypoxia. (sciencedaily.com)

Recently, we found that hypoxia also leads to the robust accumulation of R-loops, which led us to question here both the mechanism and consequence of hypoxia-induced R-loops. (ox.ac.uk)
Interestingly, we found that the mechanism of R-loop accumulation in hypoxia is dependent on non-DNA damaging levels of reactive oxygen species. (ox.ac.uk)
Our results indicate a novel mechanism by which SENP1-mediated deSUMOylation of USP28 stabilized HIF-1α during hypoxia. (biomedcentral.com)

Here, we investigated whether ex vivo culture of HSPCs under hypoxia might limit cellular ER stress and thus offer a simple approach to preserve functional HSCs under high proliferative conditions, such as those promoted in culture with Delta1. (confex.com)
Hypoxia changes the cellular redox state and activates class III histone deacetylase sirtuin1 (SIRT1). (molvis.org)
In addition, a local RAS is expressed in many tissues and mainly acts at the cellular level, where it mediates cell proliferation, growth, and metabolism. (nutriforce.cn)
The cAMP-responsive element-binding protein (CREB) is involved in the tumorigenicity of HER-2/neu-overexpressing murine and human tumor cells, but a link between the HER-2/neu-mediated CREB activation, its posttranslational modification and localization and changes in the cellular metabolism, due to an altered (tumor) microenvironment remains to be established. (uni-halle.de)
Such HPC may enhance cellular tolerance to subsequent hypoxia-induced oxidative stress, simulating the protective effects of IPC, taking advantage of convenient and non-invasive intervention ( 3 , 4 ). (spandidos-publications.com)
Semenza wished to identify the cellular components mediating this response. (sciencedaily.com)

Quercetin is noted to be a direct antagonist of PDE-5 in the lungs of rats under hypoxia, which by abrogating oxidative stress, prevents fluid accumulation in the lungs as a consequence of HAPE. (heraldopenaccess.us)
However, literature has also elaborated on the putative roles of hypoxia-induced oxidative stress in causing vasoconstriction which finally ends-up to the fluid build-up in the lungs [4]. (heraldopenaccess.us)

Human adult mobilized CD34+ cells were cultured for 21 days under normoxia (21% O 2 ) or hypoxia (2% O 2 ) in vessels coated with optimized concentrations of Delta1. (confex.com)
To assess the relative impact of normoxia and hypoxia on the HSC compartment, we performed gene set enrichment analysis (GSEA) of cells within HSC cluster 5 from each culture condition. (confex.com)
means ± SD) participated in three OSS interventions: two interventions at sea level [normoxia and after 20 min of normobaric hypoxia (acute hypoxia, 11% O 2 )] and one intervention 5-7 days after a 9-day ascent to 5,050 m (sustained hypoxia). (southwales.ac.uk)
0.001), and OSS was elevated in sustained hypoxia versus normoxia (P = 0.011). (southwales.ac.uk)
however, exposure to experimentally induced oscillatory shear stress only impaired flow-mediated dilation in normoxia. (southwales.ac.uk)
Here, we report that USP28 is a SUMOylated protein in normoxia with moderate deubiquitinating activity towards HIF-1α in vitro, while hypoxia and HIF-1α activate USP28 through SENP1-mediated USP28 deSUMOylation to further accumulate HIF-1α protein in cells. (biomedcentral.com)
We found that USP28 is SUMOylated in normoxia but rapidly deSUMOylated under hypoxia condition. (biomedcentral.com)

Rhodiola crenulata root extract (RCE) has been shown to possess protective activities against hypoxia both in vitro and in vivo. (mdpi.com)

Mechanistically, R-loops accumulate on the rDNA in hypoxia and promote the deposition of heterochromatic H3K9me2 which leads to the inhibition of Pol I-mediated transcription of rRNA. (ox.ac.uk)
I n this highly cited paper , we identify heparan sulfate proteoglycan as a novel receptor and potential target for inhibition of exosome mediated glioma tumor development. (lu.se)

Hypoxia did not change the average sizes of exosomes secreted by RPTCs, but it significantly increased exosome production in a time -dependent manner. (bvsalud.org)
HIF-1 induction with dimethyloxalylglycine also promoted exosome secretion , whereas pharmacological and genetic suppression of HIF-1 abrogated the increase of exosome secretion under hypoxia . (bvsalud.org)
It is concluded that hypoxia stimulates exosome production and secretion in renal tubular cells . (bvsalud.org)
HIF-1 mediates exosome production during hypoxia and contributes to the cytoprotective effect of the exosomes . (bvsalud.org)

However, little is known about how hypoxia affects the ability of microglia, resident CNS macrophages, to respond to subsequent inflammatory challenges that are often present during neurodegenerative processes. (frontiersin.org)

The activation of these surface receptors leads to the activation of signaling mediators, which transcriptionally regulate the production of pro- or anti-inflammatory mediators, including cytokines, chemokines, and adhesion molecules, thereby mediating tissue inflammation and regenerative repair processes. (thno.org)

We found that microglia exhibited enhanced responses to LPS 3 days and 6 days post-hypoxia. (frontiersin.org)
Here, we exposed oysters to acidification and hypoxia to examine their physiological responses (molecular defense and immune response), changes in community structure of their associated microbial community, and changes in water nutrient concentrations to evaluate how acidification and hypoxia will alter the oyster holobiont's ecological role. (frontiersin.org)

Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. (nature.com)
These results have shown that A1 adenosine receptor and β2-adrenoceptor-induced protection against simulated hypoxia/reoxygenation occurs in a TG2 and Gi/o-protein dependent manner in H9c2 cardiomyoblasts. (ntu.ac.uk)
Collectively, our results reveal a novel SENP1-USP28-HIF-1α positive feedback loop to maximize the concentration of HIF-1a protein and amplify its downstream effects during hypoxia response. (biomedcentral.com)
Enstrom A, Carlsson R, Ozen I, and Paul G. RGS5: a novel role as a hypoxia-responsive protein that suppresses chemokinetic and chemotactic migration in brain pericytes. (lu.se)

Hypoxia of CEC was induced by exposing the cells to cobalt chloride (Sigma-Aldrich, St. Louis MO) in serum media, as described previously [ 12 , 13 ], and the induction was confirmed by cytotoxicity and cell cycle analysis. (molvis.org)
Knockdown of endogenous HIF-2α but not HIF-1α by siRNA largely abolished the induction of LIF by hypoxia in cells. (oncotarget.com)

Here, we report that hypoxia, a hallmark of solid tumors, induced LIF mRNA expression in human colorectal cancer cells. (oncotarget.com)
Researchers have understood for numerous years that the hypoxia found in tumors leads to more aggressive and harder to treat disease and ultimately, poor patient outcome. (mdpi.com)

We observed enhanced progenitor cell activity within the CD34+ cell population treated with Delta1 in hypoxia, but the benefits provided by low-oxygen cultures were most notable in the primitive HSC compartment. (confex.com)
G9a drives hypoxia-mediated gene repression for breast cancer cell survival and tumorigenesis. (atsbio.com)
H9c2 cells were exposed to 8 h hypoxia (1% O2) followed by 18 h reoxygenation, after which cell viability was assessed by monitoring mitochondrial reduction of MTT, lactate dehydrogenase release and caspase-3 activation. (ntu.ac.uk)
Pharmacological pre- and post-conditioning with CPA and isoprenaline significantly reduced hypoxia/reoxygenation-induced cell death. (ntu.ac.uk)
We have characterized an AMP-mediated activation of AMPK that facilitates the translocation of GLUT3 to the neuronal cell surface after excitation. (jneurosci.org)
Bladder Cancer Extracellular Vesicles Elicit a CD8 T Cell-Mediated Antitumor Immunity. (rochester.edu)
He received his Ph.D. degree in the laboratory of Dr. En-Duo Wang in Biochemistry and Molecular Biology from Shanghai Institute of Biochemistry and Cell Biology of Chinese Academy of Science in 2008, where he studied the structural and functional interplay of transfer RNA (tRNA) and tRNA synthetase in bacteria, yeast and human. (rochester.edu)
However, changes in cell signalling in response to hypoxia that are mediated by RGS5 stroke. (lu.se)

Exposure to hypoxia occurs as a consequence of insufficient blood supply. (nutriforce.cn)
An increase in the vascular permeability of alveolar epithelium has found to be the major manifestation of hypoxia exposure. (heraldopenaccess.us)
Exposure to an altered magnitude and pattern of shear stress at baseline in hypoxia may contribute to the insensitivity to further acute augmentation of OSS. (southwales.ac.uk)
Surprisingly, however, the majority of primed genes were not enriched for H3K4me3 acutely following hypoxia exposure. (frontiersin.org)

Upon depletion of R-loops, we observed a rescue of both rRNA transcription and nucleolin translocation in hypoxia. (ox.ac.uk)

Neonatal rat cardiomyocytes were isolated and subjected to hypoxia/reoxygenation (H/R) injury, with or without HPC. (spandidos-publications.com)

A1 adenosine receptor agonist), formoterol (β2-adrenoceptor agonist) or isoprenaline (non-selective β-adrenoceptor agonist) were added before hypoxia/reoxygenation (pre-conditioning) or at the start of reoxygenation following hypoxia (post-conditioning). (ntu.ac.uk)

Insufficient tissue oxygenation, or hypoxia, contributes to tumor aggressiveness and has a profound impact on clinical outcomes in cancer patients. (lu.se)

As a consequence, HIFs mediate resistance to chemo- and radiotherapy and are associated with poor prognosis in cancer patients. (lu.se)

Overall, this study highlights the contribution of transcriptional stress to hypoxia-mediated tumorigenesis. (ox.ac.uk)

In addition to the carotid body-controlled rapid adaptation to low oxygen levels ( hypoxia ), there are other fundamental physiological adaptations. (sciencedaily.com)
The term hypoxia is used to describe biological situations where insufficient levels of oxygen exist. (mdpi.com)

A key physiological response to hypoxia is the rise in levels of the hormone erythropoietin (EPO), which leads to increased production of red blood cells (erythropoiesis). (sciencedaily.com)
We found clear physiological stress in oysters exposed to acidification, hypoxia, and their combination but low mortality. (frontiersin.org)
Therefore, we suggest the oyster holobiont may lose some of its nutrient cycling properties under hypoxia and multi-stressor conditions although the oysters can regulate their physiological processes to maintain homeostasis on the short-term. (frontiersin.org)

This study examined the efficacy of quercetin in preventing the hypoxia-mediated increase in Phosphodiesterase-5 (PDE-5) levels in the lung, leading to the diminution of alveolar smooth muscles vasoconstriction and curtailed transvascular leakage. (heraldopenaccess.us)
Research had also confirmed that exacerbation in ROS production due to hypoxia is amongst major factors for the occurrence of vasoconstriction in the smooth muscles of lung endothelium [5,6]. (heraldopenaccess.us)
Chest radiography is useful for excluding interstitial and alveolar processes that may cause hypoxia-mediated pulmonary vasoconstriction. (medscape.com)

Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury. (nature.com)

A hypoxia-induced mouse model of pulmonary hypertension (PH) was used to test preventive effect of conserved fragment TFO2 of FENDRR. (biomedcentral.com)

M2 macrophage-mediated tissue repair plays an important role in acute myocardial infarction (AMI). (thno.org)
0.001) and was unaltered during acute or sustained hypoxia. (southwales.ac.uk)
NEW & NOTEWORTHY We investigated whether the endothelium remains sensitive to experimental increases in oscillatory shear stress in acute (11% O 2 ) and sustained (2 wk at 5,050 m) hypoxia. (southwales.ac.uk)
The present study tested the hypotheses that elevated jet velocity affects 10% of pediatric patients, is associated with both hemolysis and hypoxia, and has clinical correlates with acute chest syndrome, stroke, transfusion requirement and abnormal 6-minute walk test results. (haematologica.org)

This, in turn, initiates a massive autonomic discharge mediated by preganglionic centers within the cervical spine. (medscape.com)

Thus, we conclude that the fungal SREBP, SrbA, is critical for coordinating genes involved in iron acquisition and ergosterol biosynthesis under hypoxia and low iron conditions found at sites of human fungal infections. (nau.edu)

However, it remains unclear how USP28 activation and HIF-1α signaling are coordinated in response to hypoxia. (biomedcentral.com)
However, the effects of RCE on response to hypoxia in the endothelium remain unclear. (mdpi.com)

Rationale: Intermittent hypoxia (IH) is one of the main features of sleep-disordered breathing (SDB). (hal.science)

We, therefore, tested the hypothesis that hypoxia would enhance or "prime" microglial pro-inflammatory gene expression in response to a later inflammatory challenge without programmatically increasing basal levels of pro-inflammatory cytokine expression. (frontiersin.org)

Hypoxia-induced transcriptional stress is mediated by ROS-induced R-loops. (ox.ac.uk)
We show that hypoxia-induced R-loops play a critical role in the transcriptional stress response, evidenced by the repression of ribosomal RNA synthesis and the translocation of nucleolin from the nucleolus into the nucleoplasm. (ox.ac.uk)

i) Hypoxia-induced release of chemoattractants results in enhanced TAM recruitment, which further amplifies the protumoral response. (nutriforce.cn)
By using gene-modified mice, specific DNA segments located next to the EPO gene were shown to mediate the response to hypoxia. (sciencedaily.com)
Involved in heat shock-mediated polytene chromosome puffing and response to hypoxia. (nih.gov)

In addition, a siRNA-mediated knockdown of GLUT3 expression was found to sensitize CGNs to glutamate excitation. (jneurosci.org)

Hypoxia induced pCREBSer133, but not pCREBSer121 expression in HER-2/neu-transformed cells. (uni-halle.de)
Treatment of HER-2/neu+ cells with signal transduction inhibitors targeting in particular HER-2/ neu was able to revert hypoxia-controlled CREB activation. (uni-halle.de)
HIF-1-mediated production of exosomes during hypoxia is protective in renal tubular cells. (bvsalud.org)
Exosomes are nano-sized vesicles produced and secreted by cells to mediate intercellular communication . (bvsalud.org)

In this study, we investigated the role of hypoxia induced SIRT1 in choroidal neovascularization in relation to age-related macular degeneration. (molvis.org)
The Bötzinger complex plays an important role in controlling breathing and responding to hypoxia. (wikipedia.org)

Anatomy40

Organisms14

Diseases28

Chemicals and Drugs71

Analytical, Diagnostic and Therapeutic Techniques and Equipment33

Psychiatry and Psychology1

Phenomena and Processes74

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

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Health Care3

Geographicals1

Hypoxic17

Induces6

Regulates2

Apoptosis6

Evidence that hypoxia1

Factor12

Promotes4

Upregulation3

Metastasis1

Regulation4

Endothelial5

Degradation6

Mechanism3

Cellular6

Oxidative stress2

Normoxia7

Vitro1

Inhibition2

Exosome4

Macrophages1

Inflammation1

Responses2

Protein4

Induction2

Tumors2

Cell8

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Transcription1

Cardiomyocytes1

Reoxygenation1

Contributes1

Resistance1

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Oxygen2

Physiological3

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Ischemia1

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Acute4

Initiates1

Genes1

Unclear2

Intermittent1

Gene expression1

Transcriptional2

Response3

Knockdown1

Cells4

Role2