• Mediastinal germ cell tumors are tumors that derive from germ cell rest remnants in the mediastinum. (wikipedia.org)
  • Unlike benign germ cell tumors of the mediastinum, malignant mediastinal tumors are usually symptomatic at the time of diagnosis. (wikipedia.org)
  • Most mediastinal malignant tumors are large and cause symptoms by compressing or invading adjacent structures, including the lungs, pleura, pericardium, and chest wall. (wikipedia.org)
  • The treatment for mediastinal nonseminomatous germ cell tumors should follow guidelines for poor-prognosis testicular cancer. (wikipedia.org)
  • They are much less common than germ cell tumors arising in the testes, and account for only 1 to 5% of all germ cell neoplasms. (wikipedia.org)
  • Syndromes associated with mediastinal germ cell tumors include Hematologic Neoplasia and Klinefelter's syndrome. (wikipedia.org)
  • Malignant mediastinal germ cell tumors of various histologies were first described as a clinical entity approximately 50 years ago. (wikipedia.org)
  • Mediastinal and other extragonadal germ cell tumors were initially thought to represent isolated metastases from an inapparent gonadal primary site. (wikipedia.org)
  • Mediastinal tumors/lesions are frequently encountered in daily cytopathology practice. (allenpress.com)
  • Tumors metastatic to mediastinal lymph nodes represent the most common mediastinal lesions and must be differentiated from primary lesions. (allenpress.com)
  • To provide an updated review on the fine-needle aspiration cytology of mediastinal tumors/lesions, with an emphasis on diagnostic challenges. (allenpress.com)
  • Data were gathered from a PubMed search of peer-reviewed literature on mediastinal tumors. (allenpress.com)
  • 1 The most frequent primary tumor types of anterior mediastinal masses are thymic tumors and lymphoma, with approximate proportions of 35% and 25% among mediastinal lesions, respectively. (allenpress.com)
  • The association of Klinefelter syndrome and mediastinal nonseminomatous germ cell tumors is now well recognized. (health.am)
  • Four of 22 consecutive patients (18%) treated at Indiana University for primary mediastinal germ cell tumors had karyotypic confirmation of Klinefelter syndrome, and an additional patient had clinical features. (health.am)
  • Hematologic Neoplasia A unique association between mediastinal nonseminomatous germ cell tumors and a variety of hematologic neoplasms is now well described. (health.am)
  • All hematologic neoplasms developed in the 287 patients with mediastinal nonseminomatous germ cell tumors, for a 2% incidence in this group. (health.am)
  • Foci of malignant lymphoblasts have been recognized histologically in several mediastinal germ cell tumors. (health.am)
  • However, the specific association of leukemias and other hematologic neoplasms with mediastinal nonseminomatous germ cell tumors, rather than with all germ cell tumors, remains unexplained. (health.am)
  • In addition to hematologic neoplasia, several cases of idiopathic thrombocytopenia in association with mediastinal nonseminomatous germ cell tumors have been reported. (health.am)
  • Mediastinal tumors encompass a wide range of various neoplasms. (blunck-medical-books.de)
  • In this context, the proposed book will provide a comprehensive review of the mediastinal tumors according to different sites of the diseases, including the masses of anterior, middle and posterior mediastinum. (blunck-medical-books.de)
  • Although its overall incidence remains unclear, it likely accounts for less than 1% to 2% of mediastinal neurogenic tumors [ 2 ]. (springeropen.com)
  • While most tumors metastatic to the serous membranes are of epithelial origin, cytologists should be aware that non-epithelial neoplasms can also cause malignant effusions including sarcomas, melanomas, germ cell tumors, and, more rarely, brain tumors. (cytojournal.com)
  • Common non-epithelial neoplasms that may cause malignant effusions include malignant melanoma, sarcomas, and other neoplasms including germ cell tumors [ Figure 1 ]. (cytojournal.com)
  • Dr. Anja C. Roden, M.D., studies mediastinal neoplasms such as thymic epithelial tumors and primary mediastinal germ cell tumors from morphologic, immunophenotypical, molecular, and clinical aspects. (thymiccarcinoma.org)
  • In addition, she actively participates in multidisciplinary global studies of mediastinal neoplasms and multi-institutional studies of malignant mesotheliomas and lung tumors. (thymiccarcinoma.org)
  • Invasive mediastinal tumors have a very poor prognosis, but this tumor located in mediastinum is very rare, so unfortunely aren't many data about it, and estimated survival for this patient. (romanianjournalcardiology.ro)
  • Patients with mediastinal tumors can have specific clinical findings, depending on organ compresion or invasion, but frequently is not specific. (romanianjournalcardiology.ro)
  • Μediastinal lipomas typically arise within the anterior mediastinum and represent only 1.6-2.3% of all primary mediastinal tumors 1 . (hippokratia.gr)
  • Current recommendations include complete en bloc removal of such tumors whenever possible, as this is the only definitive treatment option. (hippokratia.gr)
  • Although primary mediastinal (thymic) large B-cell lymphoma has been primarily studied, its precise phenotype, molecular characteristics, and histogenesis are still a matter of debate. (nih.gov)
  • Primary Mediastinal Large B-Cell Lymphoma (PMBL) is a rare neoplasm that arises in the mediastinum, and then forms a mass. (jcimcr.org)
  • Representative examples include mediastinal (thymic) large B-cell lymphoma and Hodgkin lymphoma. (nih.gov)
  • Abstract Objective To explore the prognostic factors of primary mediastinal large B-cell lymphoma (PMBCL) and the effects of chemoradiotherapy versus chemotherapy alone on patients' prognosis before and after rituximab era. (zlfzyj.com)
  • Effects of Chemoradiotherapy Versus Chemotherapy Alone on Survival of Patients with Primary Mediastinal Large B-cell Lymphoma[J]. Cancer Research on Prevention and Treatment, 2022, 49(03): 205-212. (zlfzyj.com)
  • Prognostic factors, therapeutic approaches, and distinct immunobiologic features in patients with primary mediastinal large B-cell lymphoma on longterm follow-up[J]. Blood Cancer J, 2020, 10(5): 49. (zlfzyj.com)
  • This could be due to primary lung neoplasm, inflammatory process such as sarcoidosis, lymphoma, or metastatic disease. (cancer.org)
  • Primary Mediastinal B-Cell Lymphoma: A 2021 Update on Genetics, Diagnosis, and Novel Therapeutics. (nih.gov)
  • Endosonography for the diagnosis of malignant lymphoma presenting with mediastinal lymphadenopathy. (nih.gov)
  • Magnetic resonance imaging and 67Ga scan versus computed tomography in the staging and in the monitoring of mediastinal malignant lymphoma: a prospective pilot study. (nih.gov)
  • Magnetic resonance imaging and 67gallium scan in mediastinal malignant lymphoma: a prospective pilot study. (nih.gov)
  • Lymphoma is the most common malignancy in the domestic ferret and the third most common neoplasm overall (Willians & Weiss, 2004). (vin.com)
  • Lymphoma has been reported to involve many organs, including the cranial mediastinal lymph nodes and the thymus (Taylor T.G. & Carpenter J.L. 1995). (vin.com)
  • Lymphoma is one of the most commonly reported neoplasm in ferrets. (vin.com)
  • Dose-adjusted EPOCH rituximab therapy in primary mediastinal B-cell lymphoma[J]. N Engl J Med, 2013, 368(15): 1408-1416. (zlfzyj.com)
  • Primary mediastinal B-cell lymphoma and mediastinal gray zone lymphoma: do they require a unique therapeutic approach? (zlfzyj.com)
  • subtypes of cutaneous T-cell lymphoma, SS is a malignant neoplasm originating the most common of which are mycosis from T lymphocytes, which involves the fungoides and Sézary syndrome (SS). (bvsalud.org)
  • Rare cases of adult onset acute megakaryoblastic leukemia are associated with malignant mediastinal germ cell tumor. (wikipedia.org)
  • In these cases, the mediastinal germ cell tumor develops before or concomitantly with but not after acute megakaryoblastic leukemia. (wikipedia.org)
  • The diagnosis of a mediastinal germ cell tumor should be considered in all young males with a mediastinal mass. (wikipedia.org)
  • therefore, the association with mediastinal germ cell tumor seems specific. (health.am)
  • Recent evidence indicates that the hematologic neoplasms in this setting are not treatment related, but rather arise from clones of malignant lymphoblasts or myeloblasts contained within the mediastinal germ cell tumor. (health.am)
  • More importantly, several patients have had an identical chromosomal abnormality (an isochromosome of the short arm of chromosome 12) in the neoplastic cells from the mediastinal germ cell tumor and the hematologic neoplasm, providing strong evidence for a common origin. (health.am)
  • Neurogenic tumor is a common intrathoracic neoplasm, representing approximately 20% of all adult and 35% of all pediatric mediastinal neoplasms [ 1 ]. (springeropen.com)
  • Chest computed tomography (CT) and magnetic resonance imaging (MRI) revealed a posterior mediastinal tumor (Figure 1 A,B). The patient was asymptomatic and had no signs of intraspinal canal extension on the imaging studies. (springeropen.com)
  • Diagnosing non-epithelial malignancies in effusion specimens based entirely upon their cytomorphologic features is difficult because these neoplasms often exhibit considerable morphological overlap and their cytomorphology can differ from the original tumor. (cytojournal.com)
  • We present you a case of a young caucasian man, recently diagnosticated with myastenia gravis, that had a CT scan and discovered a mediastinal tumor, probably a thymoma. (romanianjournalcardiology.ro)
  • mediastinal tumor, liposarcoma, atypical lipomatous tumor. (romanianjournalcardiology.ro)
  • Mediastinal tumor as a cause of Brugada-like ECG pattern is reported only once in the international literature 7 . (hippokratia.gr)
  • In several of these cases, the genetic aberrations in the malignant megakaryoblasts were similar to those in the malignant mediastinal germ cells. (wikipedia.org)
  • Differential diagnosis of mediastinal fatty masses may include benign lipomas, thymolipomas, liposarcomasand germ cell neoplasms 1,3-6 .Differentiating a lipoma from a liposarcoma can be challenging in many cases, especially if it is a low-grade malignancy 2 . (hippokratia.gr)
  • Thymoma is a neoplasm of thymic epithelial cells. (medscape.com)
  • Mediastinitis Mediastinal fibrosis Mediastinum Alan Sandler (1997). (wikipedia.org)
  • Thymoma , the most common neoplasm of the anterior mediastinum , originates within the epithelial cells of the thymus . (findmeacure.com)
  • The 2016 revision of the World Health Organization classification of lymphoid neoplasms[J]. Blood, 2016, 127(20): 2375-2390. (zlfzyj.com)
  • Integrated Genomic DNA/RNA Profiling vs Fluorescence in Situ Hybridization in the Detection of MYC and BCL2 (and BCL6) Rearrangements in Large B-Cell Lymphomas: Updates Amid the New WHO Classification of Lymphoid Neoplasms. (cdc.gov)
  • This study aims to introduce an optimized method named "non-grasping en bloc mediastinal lymph node dissection (MLND)" through video-assisted thoracoscopic surgery (VATS). (medscape.com)
  • Background Anterior mediastinal masses are a rare but well documented finding in Graves disease. (ecu.edu)
  • Invited Commentary: New Paradigm for Imaging Evaluation of Pediatric Mediastinal Masses-ITMIG Classification System. (harvard.edu)
  • Tuberculosis has not been reported to be a cause of mediastinal masses in previous case series of mediastinal masses in children. (ox.ac.uk)
  • They may appear as discrete, well encapsulated or infiltrative masses, around the great vessels and mediastinal structures. (vin.com)
  • BACKGROUND: Endobronchial ultrasound (EBUS) was introduced in the last decade, enabling real-time guidance of transbronchial needle aspiration (TBNA) of mediastinal and hilar structures and parabronchial lung masses. (bvsalud.org)
  • 4. Noji T, Morikawa T, Kaji M, Ohtake S, Katoh H. Successful resection of a recurrent mediastinal liposarcoma invading the pericardium: report of a case. (hippokratia.gr)
  • Fine-needle aspiration cytology (FNAC) was first introduced by Martin and Ellis 4 and has been used as an easy and safe procedure for diagnosing primary and metastatic mediastinal diseases. (allenpress.com)
  • Mediastinal Diseases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • This graph shows the total number of publications written about "Mediastinal Diseases" by people in Harvard Catalyst Profiles by year, and whether "Mediastinal Diseases" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Mediastinal Diseases" by people in Profiles. (harvard.edu)
  • Lymphomas are part of the broad group of diseases called hematological neoplasms. (newworldencyclopedia.org)
  • Background We reviewed our experience with ectopic mediastinal parathyroidectomy. (elsevierpure.com)
  • Hauck F, Heine S, Beier R, Wieczorek K, Müller D, Hahn G. Chronic granulomatous disease (CGD) mimicking neoplasms: a suspected mediastinal teratoma unmasking as thymic granulomas due to X-linked CGD, and 2 related cases. (medscape.com)
  • Ectopic Anterior Mediastinal Pancreas: An Unusual Case of New Onset Hemoptysis. (harvard.edu)
  • TAFRO Syndrome with an Anterior Mediastinal Mass and Lethal Autoantibody-Mediated Thrombocytopenia: An Autopsy Case Report. (harvard.edu)
  • This area is limited anterior - by the sternum, posterior - the spinal column, laterally - the mediastinal pleura, inferiorlly - the diafragm, superior by a plan that crosses inferior to the clavicules. (romanianjournalcardiology.ro)
  • A dermatology work-up was initiated, and the síndrome de Sézary initial diagnosis of malignant T-cell neoplasm was confirmed. (bvsalud.org)
  • 摘要: Objective To explore the features of various mediastinal lymphadenopathies using computed tomography perfusion (CTP).Methods CTP parameters (CTPs) of the selected mediastinal nodes from 59 patients with pathology-proven malignant lymph nodes and of those from 29 patients with clinically diagnosed or pathology-proven inflammatory lymphadenopathies were collected. (cams.cn)
  • Features of Computed Tomography Perfusion of Mediastinal Lymphadenopathies: a Pathology-based Retrospective Study[J].Chinese Medical Sciences Journal, 2015, 30(3): 162-169. (cams.cn)
  • Extensive checkup revealed an isolated mediastinal metastasis of an undifferentiated carcinoma. (medscimonit.com)
  • BACKGROUND: Previously, only six cases of mixed neuroendocrine-non-neuroendocrine neoplasm (MiNENs) with squamous cell carcinoma (SCC) component have been described in the colorectum, and the molecular landscape of MiNENs is also poorly understood. (bvsalud.org)
  • By definition, pseudomesotheliomatous carcinoma refers to an epithelial neoplasm that secondarily involves the pleura and encases the lung, thereby simulating the radiologic and macroscopic appearance of malignant mesothelioma. (medscape.com)
  • Pure mediastinal seminomas are curable in the large majority of patients, even when metastatic at the time of diagnosis. (wikipedia.org)
  • Therefore we evaluated the number of mediastinal lymph nodes as a prognostic factor in locally advanced NSCLC after multimodality treatment, observing a significant effect of the number of lymph nodes in terms of OS (p<0.01) and DFS (p<0.001): patients with a low number of positive mediastinal nodes have a better prognosis. (unint.eu)
  • 0.001): patients with a low number of positive mediastinal nodes have a better prognosis. (unint.eu)
  • Mediastinal neoplasms in patients with Graves disease: a possible link between sustained hyperthyroidism and thymic neoplasia? (ecu.edu)
  • Methods Between March 1980 and September 2010, mediastinal parathyroidectomy was performed in 33 patients with hypercalcemia secondary to hyperparathyroidism. (elsevierpure.com)
  • Between February 2009 and July 2013, 402 patients with clinical stage I non-small cell lung cancer (NSCLC) underwent "non-grasping en bloc MLND" conducted by one surgical team. (medscape.com)
  • The radiologist's impression reads "interval development of extensive hyper metabolic and pathologically enlarged hilar/mediastinal adenopathy. (cancer.org)
  • Synovial sarcoma is a malignant soft-tissue neoplasm that most commonly affects the extremities near to, but not in continuity with, large joints. (medscape.com)
  • Evaluation of AI performance in detecting lung opacities in chest radiographs and charecterizing them into diffrent subgroups (atelectasis, calcification, cardiomegaly, fibrosis, mediastinal widening, nodule and pleural effusion). (who.int)
  • Case 16-2022: A 55-Year-Old Man with Fevers, Night Sweats, and a Mediastinal Mass. N Engl J Med. (harvard.edu)
  • A 31-Year-Old Man With Fever, Atypical Chest Pain, and Mediastinal Mass. Chest. (harvard.edu)
  • An unusual cause of a superior mediastinal mass in an infant. (ox.ac.uk)
  • We report the case of a 7-month-old infant with a superior mediastinal mass extending into the right chest, who was referred to the paediatric surgical team for biopsy and further management. (ox.ac.uk)
  • A Brugada-like ECG pattern (right bundle branch block with coved ST segment elevation in leads V1-V3, Figure 1) and a large mediastinal mass were noted. (hippokratia.gr)
  • The importance of CT scan in the clinical-morphological and anatomical assessment of mediastinal lymphomas. (nih.gov)
  • Initial management consisted of en una paciente con topical corticosteroids and oral antihistamines with little clinical response. (bvsalud.org)
  • Clinical Utility of In Situ Hybridization Assays in Head and Neck Neoplasms. (cdc.gov)
  • This often poses diagnostic challenges because of the complexity of the mediastinal anatomic structures. (allenpress.com)
  • Nonmesotheliomatous cancers of the pleura include an assortment of malignant neoplasms that primarily or secondarily involve pleura. (medscape.com)
  • Managing Incidental Findings on Thoracic CT: Mediastinal and Cardiovascular Findings. (harvard.edu)
  • 4 Malignant effusions caused by non-epithelial neoplasms are more frequently encountered in children than in adults. (cytojournal.com)