• The model has the ability to measure mechanistic endpoints and biomarkers which makes it suitable for delineating pathways and mechanisms causing DILI. (scienceboard.net)
  • Assumptions of the DEB theory are delineated in an explicit way, the approach clearly distinguishes mechanisms associated with intra‐ and interspecific variation in metabolic rates, and equations for energy flows are mathematically derived following the principles of physics and simplicity. (wikipedia.org)
  • Given the paucity of effective therapies for CMML, delineating the molecular mechanisms of ASXL1 -mutant CMML (ASXL1 MT ) is of particular interest from a therapeutic standpoint. (nature.com)
  • The project takes advantage of human longitudinal birth cohort data, animal studies and cellular models to test the hypothesis of shared mechanisms and molecular pathways by which ELS shapes an individual's physical and mental health in adulthood. (plos.org)
  • Life-course models will integrate the role of modifying factors as sex, socioeconomics, and lifestyle with the goal to better identify groups at risk as well as inform promising strategies to reverse the possible mechanisms and/or reduce the impact of ELS on multi-morbidity development in high-risk individuals. (plos.org)
  • MIEP is basically focused on the characterization of the mechanisms underlying immune responses to enteric pathogens by integrating mathematical and computational modeling approaches with experimental data (Figure 2). (nimml.org)
  • We will test this model and delineate molecular mechanisms that link activation of CMA with suppression of mitophagy. (elsevierpure.com)
  • 2) delineate the molecular mechanisms downstream of endothelial SOX17 deficiency in mediating pulmonary vascular remodeling and PAH and 3) explore the translational potential of targeting SOX17 signaling. (zhiyudai-lab.com)
  • Here we propose to identify novel HIF-2a modulators and delineate the mechanisms of these molecules in regulating HIF-2a transcription activity. (zhiyudai-lab.com)
  • Our research interests are to 1) uncover the fundamental principles that govern cell polarization and ACD and 2) elucidate the mechanisms underpinning the connections among cell polarization, ACD, and cell differentiation using the stomatal system as a model. (rutgers.edu)
  • The work presented in this thesis builds upon these previous observations and delves into the complex mechanisms and pathways responsible for the synergistic induction of cell death following combined MDM2- and HDAC-inhibition in p53 wild-type models of CRC. (qub.ac.uk)
  • In the second project, newly identified genetic changes are functionally studied to delineate mechanisms underlying leukemia development. (lu.se)
  • His third NIH-NHLBI MPIR01 goal is to assess the contribution of insomnia in cardiovascular disease in Drosophila and humans, to delineate biological pathways linking sleep/circadian rhythms with cardiovascular diseases. (uab.edu)
  • In the next few years, we aim to g advance our mechanistic understanding of cell polarity, ACD, and cell differentiation by 1) delineating new pathways of endosomal trafficking that determine cell polarization and ACD and 2) establishing new functions of cell signaling in balancing self-renewal division and terminal cell fate differentiation during stomatal ACD. (rutgers.edu)
  • The mechanistic basis for these distinct pathways remains obscure. (sdbonline.org)
  • 2006 , p. 158) The view expressed here is that modeling brain structures allows for the simulation of cognitive functions, which in turn provides explanations of actual cognitive functions implemented by the human brain. (springer.com)
  • Sam S. Rakover proposes an original multidimensional model that integrates mechanistic (scientific) explanations for the behavioral elements which can be causally accounted for with mentalistic (existential) explanations for those elements which make sense teleologically in terms of will and belief. (rowman.com)
  • Computational Psychiatry is at least partially motivated by the shortcomings of the current psychiatric classification systems (the Diagnostic and Statistical Manual of Mental Disorders, or DSM-5, 1 and the International Classification of Diseases, or ICD-10 2 ), in which the symptoms entail the diagnosis and which lack mechanistic explanations for mental symptoms. (bmj.com)
  • His lab is generating fruit-fly models of these risk loci, and exploiting them to identify causal genes, discover mechanistic biology and propose new therapeutic hypotheses that can be extended to humans in collaboration with Massachusetts General Hospital/Harvard. (uab.edu)
  • Here I review the recent advances in the field, describe the known mechanistic links between toxic protein aggregation and the aging process, and delineate the future therapeutic potential of IIS reduction as a treatment for various neurodegenerative disorders. (huji.ac.il)
  • Therefore, the planned research group aims to characterize the role of TSPO as a diagnostic and therapeutic target from structural biology over neurology to psychiatry and to delineate the potential of TSPO ligands as a novel therapeutic approach within the nervous system. (uni-regensburg.de)
  • OBERON will combine 1) experimental methods (in vitro e.g. on 2D and 3D human-derived cells and tissues, and in vivo i.e. in zebrafish at different stages), 2) high throughput omics technologies, 3) epidemiology and human biomonitoring studies and 4) advanced computational models (in silico and systems biology) on functional endpoints related to metabolism. (muni.cz)
  • The results we have found include a causal and mechanistic link between mutualistic interactions that positively affect population size which in turn promote evaluability and trait evolution. (lu.se)
  • Sustained expression of some of the selected protein markers identified also suggests their potential role in MWCNT-induced toxicity and proposes hypotheses for future mechanistic studies. (cdc.gov)
  • Our results investigate a series of hypotheses driven by computational and mathematical modeling and suggest one mechanism required by macrophages to ensure survival and intracellular H. pylori without overzealous inflammatory signaling. (nimml.org)
  • Therefore, there must be discrepancies between the results produced from liver toxicity observed in animal models and the responses later seen in humans. (scienceboard.net)
  • Moreover, the researchers confirmed the mechanism of toxicity of JNJ-1 in the Liver-Chip model that has been observed in previous studies with genetically modified mice. (scienceboard.net)
  • Such interdisciplinary framework will help at deciphering EDs based on mechanistic understanding of toxicity by providing and making available more effective alternative test methods relevant for human health that are in line with regulatory needs. (muni.cz)
  • Area A will delineate the diagnostic potential of TSPO imaging by means of positron emission tomography (PET) in brain tumors in vivo and will enable the complementary characterization of brain tissue in vitro to delineate the neurobiological characteristics underlying TSPO PET labeling in the human brain. (uni-regensburg.de)
  • The overall objectives of my research are to develop clinically translatable tissue regeneration and drug delivery strategies, and three-dimensional, in vitro human disease models using biologically-derived biomaterials. (wpi.edu)
  • To achieve our objectives, we use start of the art next-generation sequencing technologies, in vitro and in vivo models of acute leukemia, cell sorting, single-cell sequencing and advanced bioinformatics. (lu.se)
  • To predict binary biomarkers (high-risk group defined as the most adverse quartile) linear WNHAHtR or WWHOHtR terms entered logistic models. (cdc.gov)
  • In addition, the text would benefit from clearer subsections that delineate discrete mechanistic discoveries. (elifesciences.org)
  • The modeling platform developed here uncovers insights into lipid participation in antibodies' recognition of membrane proteins and highlights antibody features to prioritize in vaccine design. (elifesciences.org)
  • Experimentally characterized genetic interaction networks in model organisms provide important insights into relationships between different biological functions. (researchgate.net)
  • The CM model successfully deals with human behavior (e.g., crisis of life and suicide) as well as alternative approaches based on philosophy (e.g., existentialism) and science (e.g., evolution). (rowman.com)
  • His lab has been at the forefront of developing and using clinically-relevant genetic models of human systemic metabolic abnormalities, cardiometabolic disease, myopathies, neuropathies, and aging using pathophysiological, cell-molecular, genetics, and nutritional approaches. (uab.edu)
  • Such approaches can be used more broadly for nanomaterial risk profiling studies to evaluate decisions related to dose/time-response relationships that could delineate experimental variables from exposure markers. (cdc.gov)
  • The integration of modeling and experimental approaches provides unprecedented opportunities for systems-level knowledge discovery. (nimml.org)
  • I'll end by discussing some of our ongoing efforts to use - and improve -- model-based £MRI and EEG approaches to reconstruct the internal contents of attention under both static and dynamic scenarios. (brandeis.edu)
  • These rates also suggest that battery technologies developed for stationary applications, where restrictions on volume and mass are relaxed, might achieve faster cost declines, though engineering-based mechanistic cost modeling is required to further characterize this potential. (rsc.org)
  • We describe a computational methodology allowing to systematically and quantitatively characterize a Boolean mathematical model of a biological network in terms of genetic interactions between all loss of function and gain of function mutations with respect to all model phenotypes or outputs. (researchgate.net)
  • mTORC1 activity is communicated by means of specific transcription factors, and in yeast, which is a primary model system in which transcriptional coordination has been delineated, transcription factors involved in regulation of ribosomal protein genes include Fhl1p and its cofactors, Ifh1p and Crf1p. (lsu.edu)
  • Although the overall structure of transcriptional activation by recruitment continues to be delineated in wide outline, certain essential details stay elusive because of experimental difficulties. (bio-biz-navi.com)
  • The longitudinal analysis of the unsmoothed data fitted a mixed model that involved both fixed and random regression modelling with splines, as well as allowing for unequal variances and autocorrelation between time points. (biomedcentral.com)
  • For prediction of continuous biomarker outcomes, baseline WNHAHtR or WWHOHtR entered semiparametric regression models employing restricted cubic splines. (cdc.gov)
  • To further delineate complex immune responses and pathway crosstalk between effector and regulatory PRRs we built a computational model calibrated using time-series RNAseq data. (nimml.org)
  • The validity of this approach has been tested and confirmed in mammals as reducing the activity of the IGF-1 signaling pathway-protected Alzheimer's model mice from the behavioral and biochemical impairments associated with the disease. (huji.ac.il)
  • Further in-depth research are merited to define the precise response as well as the mechanistic function of Nrf2 aimed antioxidant pathway in the pathogenesis of HCV induced liver organ damage. (mingsheng88.org)
  • It can unite many levels of description in a mechanistic and rigorous fashion, while avoiding biological reductionism and artificial categorisation. (bmj.com)
  • RC50 was defined as the been proposed using current mechanistic understanding of the concentration of electrophile required to deplete 50% of the thiol chemical and biological basis of skin sensitization ( 4 ). (cdc.gov)
  • The need for suitable clinical pharmacokinetics data for the purposes of delineating mechanistic aspects of kidney models in various scenarios is highlighted. (manchester.ac.uk)
  • The aim of this project is to explain variability in clinical and anatomical patterns and the effects of individual differences in pre-clinical stages of AD in order to develop a more inclusive anatomo-functional model of AD. (unil.ch)
  • The antitumor activity of BME by oral feeding in breast cancer models suggested the high potential for a clinical application. (oncotarget.com)
  • Its main hypothesis is that a model of a cognitive system is satisfactory and explanatory to the extent that it bridges phenomena at multiple mechanistic levels, such that at least several of these mechanistic levels are shown to implement computational processes. (springer.com)
  • Our hypothesis was that we would be able to delineate markers of slowed information processing in this paradigm removed from the phenomenological presentation with a movement disorder. (ox.ac.uk)
  • His research team has developed Drosophila cardiac and skeletal muscle disease models of laminopathies and validated Drosophila phenotypes in human muscle biopsy tissue from laminopathy patients (recently completed NIH R21 and pending R01 grants). (uab.edu)
  • sec5 mutations have been identified and characterized in Drosophila in order to delineate the role of the protein in neurons and particularly at synapses. (sdbonline.org)
  • Genetic interaction can be defined as a deviation of the phenotypic quantitative effect of a double gene mutation from the effect predicted from single mutations using a simple (e.g., multiplicative or linear additive) statistical model. (researchgate.net)
  • I have several years of experience in multidisciplinary research with deep knowledge and expertise in two key domains mathematical/statistical modelling and in neuroscience/psychology. (unil.ch)
  • We used Bayesian inference to calibrate region-specific models for consistency with daily reports of confirmed cases in the 15 most populous metropolitan statistical areas in the United States. (cdc.gov)
  • To contribute to situational awareness of COVID-19 transmission dynamics, we developed a mathematical model for the daily incidence of COVID-19 in each of the 15 most populous US metropolitan statistical areas (MSAs) ( 10 ). (cdc.gov)
  • The predictive coding in music themy (PCM1) hypothesizes that brain-bound predictiveprocesses build models of music through statistical learning and minimize prediction errors by updating top-down generative models. (brandeis.edu)
  • Traditional longitudinal or repeated measures analyses that model growth using statistical models are common. (biomedcentral.com)
  • Also discussed are the statistical models that need to be considered for traditional longitudinal analyses and it is demonstrated that the oft-omitted unequal variances and autocorrelation may be required for a valid longitudinal analysis. (biomedcentral.com)
  • Model covariates included demographic characteristics, pertinent medication use, and (for prospective predictions) the follow-up time since baseline. (cdc.gov)
  • A complementary focus of Dr. Melkani's research is to understand the genetic and mechanistic basis of cardiomyopathies, skeletal myopathies, and lipodystrophies that arise from mutations of LMNA. (uab.edu)
  • It is envisaged that application of mechanistic models will improve prediction of changes in renal disposition due to drug-drug interactions, genetic polymorphism in enzymes and transporters and/or renal impairment. (manchester.ac.uk)
  • We demonstrate this methodology on three published models for each of which we derive the genetic interaction networks and analyze their properties. (researchgate.net)
  • This project aims to delineate the neurobiology underlying TSPO overexpression in the human brain together with projects A2 and A3. (uni-regensburg.de)
  • These studies will employ multiple innovative reagents including mouse models of inducible, cardiomyocyte-specific L2A deletion and overexpression, a recently developed small molecule activator of CMA, and a new CMA reporter mouse. (elsevierpure.com)
  • Aim 1, will define the functional role of CMA in heart failure, using both pressure overload and MI models. (elsevierpure.com)
  • 3) To use multivariate methods based on anatomo-functional features in order to build a predictive model of patients outcomes. (unil.ch)
  • In this study, we took the temporal discrimination threshold as a paradigm that can be used to model sensory processing in functional movement disorders. (ox.ac.uk)
  • We have designed and analysed an eco-evolutionary and functional-trait-based model of three interacting trophic levels and we have simulated adaptation and diversification in traits as a response to eco-evolutionary feedbacks. (lu.se)
  • Subsequently, further mechanistic analyses demonstrated that p53-mediated FLIPL upregulation blocks the induction of apoptosis by inhibiting caspase-8 activation at a TRAIL-R2/DR5 death inducing signalling complex. (qub.ac.uk)
  • Given the complexity of the host- H. pylori interactions at the systems level and the broad range of possible outcomes, our team has developed a computational model of the gastric mucosal immune response towards H. pylori infection. (nimml.org)
  • This work will be guided by predictions made using an information theoretic approach and a computational model of the human auditory system. (ens.fr)
  • 25th-29th October 2015) which focuses on IVIVE and mechanistic prediction of renal drug disposition. (manchester.ac.uk)
  • In addition, the use of mechanistic models in prediction of renal drug-drug interactions and potential for application in determining suitable adjustment of dose in kidney disease are discussed. (manchester.ac.uk)
  • In line with our initial idea, our model includes several ecological interactions including (1) within-trophic-level competitive interactions for resources, (2) between-trophic-level antagonistic and mutualistic interactions, and (3) the way in which species interacts with the abiotic environments. (lu.se)
  • Here, we systematically tested evolutionary models of paralog function using the ribosomal protein paralogs Rps27 (eS27) and Rps27l (eS27L) as a case study. (stanford.edu)
  • Computational Psychiatry aims first to model the computations that the brain performs-that is, the brain's solutions to the problems it faces-and second to thereby understand how the 'abnormal' perceptions, thoughts and behaviours that are currently used to define psychiatric disorders relate to normal function and neural processes. (bmj.com)
  • The Liver-Chip system allowed researchers to use drug concentrations that bridged those measured in the plasma of nonclinical models or humans in the present study, and suggesting that the model has the potential to be used for human risk assessment. (scienceboard.net)
  • Animal models have many facets that mimic various disease conditions in humans representing the importance for its tremendous use in biomedical research (Mukherjee et al. (springer.com)
  • We substantiate the idea of cognitive models as simulators, by having AI systems interact with, and collect feedback from, cognitive models instead of humans, thereby making their training process both less costly and faster. (tomshultz.net)
  • The theory presents simple mechanistic rules that describe the uptake and allocation of energy (and nutrients) and the consequences for physiological organization throughout an organism's life cycle, including the relationships of energetics with aging and effects of toxicants. (wikipedia.org)
  • by contrast,"static" energy budget models describe a specific life stage or size of an organism. (wikipedia.org)
  • We describe how computational models of cognition can infer the current state of the environment and weigh up future actions, and how these models provide new perspectives on two example disorders, depression and schizophrenia. (bmj.com)
  • Using mice, the International Mouse Phenotyping Consortium (IMPC) aims to target each protein-coding gene and phenotype multiple organ systems in single-gene knockout models by a global network of mouse clinics. (springer.com)
  • This work represents a major achievement for the Organ Chip field because it shows the power of this technology to provide insight into human-relevant responses where current preclinical animal models often fail. (scienceboard.net)
  • Within Rakover's model, the meaning of life is conceived of as an immune system against its loss, which in extreme cases might lead to suicidal responses. (rowman.com)
  • Each day, at varying times of day, we updated the model using cumulative data since January 21, 2020. (cdc.gov)
  • This paper discusses the relevance of models for cognitive science that integrate mechanistic and computational aspects. (springer.com)
  • As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. (oncotarget.com)
  • Finally, in vivo studies using our well-established murine tibia fracture model were performed and a single injection of the β-NGF loaded PEGDMA microrods, non-loaded PEGDMA microrods, or soluble β-NGF was administered to assess the extent of fracture healing using Micro-computed tomography (µCT) and histomorphometry. (frontiersin.org)
  • In vivo studies using our murine tibia fracture model show that PEGDMA microrods injected at the site of fracture remained adjacent to the callus for over 7 days. (frontiersin.org)
  • In our previous studies, we showed that bitter melon extract (BME) exerts a strong anti-proliferative effect by inducing caspase-dependent apoptosis in breast cancer cells [ 6 ], although the in vivo effect of BME was not examined in breast cancer model. (oncotarget.com)
  • We combined computational modeling, bioinformatics and experimental validation in order to investigate interactions between macrophages and intracellular H. pylori . (nimml.org)
  • to learn a great deal about brain function and dysfunction from accurate models of the brain. (springer.com)
  • These findings open the door to a mechanistic understanding of alveolar angiogenesis, which is proposed to occur through intussusceptive angiogenesis, but is poorly understood on the molecular and cellular level. (mdanderson.org)
  • There have been many in silico studies based on a Boolean network model to investigate network sensitivity against gene or interaction mutations. (researchgate.net)
  • In order to grasp the essence of this philosophical debate that has seen a large number of contributions especially over the last 30 years, it is instructive to look at two ideals of modeling and explanation that have played a prominent role in the discussion. (springer.com)
  • Experimental rodent models play a central role in cardiovascular disease research by effectively simulating human cardiovascular diseases. (springer.com)
  • Area C will address the role of TSPO for neurodegeneration within the peripheral nervous system, the retina and the brain using newly established animal models and PET imaging. (uni-regensburg.de)
  • In addition, the role of TSPO for behavior such as anxiety, fear and stress in relation to the modulating effects of TSPO ligands will be studied in respective animal models including PET labeling in relation to neurosteroidogenesis and spine plasticity. (uni-regensburg.de)
  • However, the mechanistic role of endothelial SOX17 in regulating pulmonary vascular remodeling in the pathogenesis of PAH has not been reported. (zhiyudai-lab.com)
  • We will 1) define the novel role of endothelial SOX17 in the pathogenesis of PH using multiple transgenic mouse and rat models. (zhiyudai-lab.com)
  • Stochasitic dominance is widely considered a pillar of rational choice and has played a major role in the history of theorizing and developing models of human decision-making. (tomshultz.net)
  • In order to delineate the role of Entinostat mediated FLIPL downregulation in the cell death resulting from the combined Nutlin-3A/Entinostat treatment, siRNA-mediated FLIPL depletion was used to successfully phenocopy this result. (qub.ac.uk)
  • The main advantage of the DEB-theory based model over most other models is its description of energy assimilation and utilization (reserve dynamics) simultaneously with decoupled processes of growth, development/ maturation, and maintenance. (wikipedia.org)
  • However, developing and validating mechanistic kidney models is challenging due to the number of processes that may occur (filtration, secretion, reabsorption and metabolism) in this complex organ. (manchester.ac.uk)
  • We study these questions using neural recordings from the auditory cortex, a new paradigm for studying temporal integration in the brain, and computational models derived from deep neural networks. (ens.fr)
  • The reaction rates of the electrophiles correlated positively with their EC3 values within the same mechanistic domain. (cdc.gov)
  • To increase situational awareness and support evidence-based policymaking, we formulated a mathematical model for coronavirus disease transmission within a regional population. (cdc.gov)
  • Recent work in our lab has demonstrated that combination of direct (MDM2 inhibition) or indirect (DNA-damaging chemotherapy) p53 activation with inhibitors of nuclear Class-I Histone deacetylases (HDACi) is effective in enhancing p53- dependent apoptotic cell death in multiple models of CRC. (qub.ac.uk)
  • Models based on the DEB theory have been successfully applied to over a 1000 species with real-life applications ranging from conservation, aquaculture, general ecology, and ecotoxicology (see also the Add-my-pet collection). (wikipedia.org)
  • Subsequently, we demonstrated that BME feeding effectively inhibited breast cancer growth in syngeneic and xenograft mouse models. (oncotarget.com)
  • However, many existing estimates of past cost decline, which often serve as starting points for forecasting models, rely on limited data series and measures of technological progress. (rsc.org)
  • The use of this methodology for validating mathematical models from experimental data and designing new experiments is discussed. (researchgate.net)
  • Dr. Albers develops mathematical models of physiology, machine learning models, and their associated inference methods to support the extraction and creation of new knowledge from data related to diabetes, to support clinician-centric decision support, and to support patient-centric decision support for chronic disease self-management. (cuanschutz.edu)
  • We then used a well-established model for decision-making (the drift diffusion model) that uses both response accuracy and reaction time data to estimate mechanistic physiological dimensions of decision-making and sensory processing. (ox.ac.uk)
  • However, often the variation in the data is inappropriately modelled, in part because the required models are complicated and difficult to fit. (biomedcentral.com)
  • The Consciousness-Meaning (CM) model is founded on two major assumptions: (a) consciousness is a necessary condition for meaning and understanding, and (b) there are two types of life-meaning, innate and acquired. (rowman.com)
  • Understanding Human Conduct offers an emotionally-driven, logically-delineated answer to the age-old existential question of whether the inevitability of death renders life devoid of meaning and purpose. (rowman.com)
  • The findings from this simple and rapid absorbance model show that for the same mechanistic domain, skin sensitization is driven mainly by electrophilic reactivity. (cdc.gov)
  • The goal of the study is to build a predictive model of patients with aphasia after brain injury. (unil.ch)
  • This is an important milestone in the effort to improve the drug discovery and development process that was achieved by leveraging the Wyss Institute's unique translational model, which allowed us to evaluate the promise of Organ-Chips both technically and commercially early on in the development of the technology," said corresponding author Geraldine A. Hamilton, PhD, President and Chief Scientific Officer of Emulate. (scienceboard.net)
  • Yet, the mouse shares a similar developmental trajectory to the human heart and a comparable four-chamber morphology that greatly enhances its translational value as a model organism, despite the substantial differences in size (Krishnan et al. (springer.com)
  • Currently, the model is able to predict the distinct time-dependent behavior of the three main CD4+ T cells (Th1, Th17 and iTreg) showing an increased Th17 response at the early stage of infection that switches to a Th1 predominance in the chronic phase of the infection. (nimml.org)
  • He also works with model-based control, e.g., like the artificial pancreas project, but in the context of type-2 diabetes, cystic fibrosis related diabetes, and within the intensive care unit unrelated to diabetes. (cuanschutz.edu)
  • It describes the various mechanistic kidney models that may be used to investigate renal drug disposition. (manchester.ac.uk)
  • The teaching include training to basic statics, advanced multivariate approach, Bayesian models and machine learning. (unil.ch)
  • Several popular empirical models are special cases of the DEB model, or very close numerical approximations. (wikipedia.org)
  • We show that a resource-rational process model, sample-based expected utility (SbEU), provides a unified account of a broad range of empirical results on violation of stochastic dominance. (tomshultz.net)
  • In addition, we suggest several computational tools for studying the distribution of double mutants in the space of model phenotype probabilities. (researchgate.net)
  • Lineage-Specific Induced Pluripotent Stem Cell-Derived Smooth Muscle Cell Modeling Predicts Integrin Alpha-V Antagonism Reduces Aortic Root Aneurysm Formation in Marfan Syndrome Mice. (stanford.edu)
  • We have delineated a two-step AT1 cell morphogenesis process, cell flattening and cell folding, which leads to its ultrathin and yet expansive morphology. (mdanderson.org)
  • In our lab we use precisely engineered, two-dimensional and three-dimensional constructs as model systems to study the effects of external internal (cell-generated) forces on cell behavior, matrix biochemistry, and the biomechanics of soft tissues and biomaterials. (wpi.edu)
  • Within an HCV replicating cell lifestyle model, HCV blunted Nrf2 activation and inhibited the induction of ARE-regulated genes12. (mingsheng88.org)
  • Mechanistic investigations revealed another unexpected relationship: Inhibition of CMA induces mitophagy, a process that maintains the overall health of the mitochondrial pool by eliminating defective organelles. (elsevierpure.com)