Mechanisms underlying tissue morphogenesis early embryo morphogenesis. Medical search. Frequent questions

During embryo development, naïve cell lineages undergo concurrent processes of fate specification and morphogenesis as critical steps towards the generation of differentiated tissues and organs. (elifesciences.org)
Several embryonic tissues and organs originate from small sets of progenitor cells. (elifesciences.org)
Using this spatiotemporal atlas, we uncover embryo and tissue-wide gene expression patterns that govern body plan formation and the architecture of rudimentary organs. (tu-berlin.de)
Tissue development is a key process for life starting from the earliest embryonic stages during which cells differentiate into later organs composing an entire body. (exeter.ac.uk)
This process, known as embryogenesis, involves a series of intricate and coordinated events that give rise to all the different tissues and organs in the body. (fnps-society.org)
It explores the intricate cellular and molecular events that orchestrate the formation of tissues, organs, and body structures, as well as the timing and coordination of these processes. (microbiologynote.com)
Organogenesis: Organogenesis is the process by which organs and organ systems develop from embryonic tissues. (microbiologynote.com)
Stem Cells: Stem cells are undifferentiated cells that have the ability to differentiate into various cell types and contribute to the formation and repair of tissues and organs. (microbiologynote.com)
It involves studying how genes and their interactions regulate the various processes of development, including the formation of body axes, the specification of cell fates, and the patterning of tissues and organs. (microbiologynote.com)
This is illustrated for instance in the development of embryos and organs, and in the function of the immune and nervous systems. (centuri-livingsystems.org)
The neural crest is multipotent, embryonic stem cell-like population which gives rise to a plethora of derivative tissues and organs, such as sensory and autonomic ganglia, adrenal and thyroid glands, smooth muscle of major blood vessels, craniofacial skeleton and the vast majority of body's pigmentation. (ox.ac.uk)
Zebrafish not only have the same genes as humans but also most of the same cell types, tissues, organs and biological circuits, assuring that the lessons from this model can be directly applied to other vertebrate systems and to human health. (ox.ac.uk)
A complex expression pattern of ESRRs during animal development seems to be consistent with the potential roles for ESRRa during appropriate developmental programs of tissues and organs in mouse and zebrafish 9 . (nature.com)
The damage caused by thalidomide was not mutually exclusive, with the majority of children exhibiting damage to multiple organs and tissues [ 3 , 7 ]. (hindawi.com)
Nobel Prize winner Alexis Carrel performed numerous experiments clearly showing that tissue explants, including connective tissue and heart tissue, could be cultured in vitro preserving their characteristics for prolonged periods of time [ 2 ] supporting the notion that entire organs could be cultured in vitro. (intechopen.com)

Here, we examine this question during the early stages of morphogenesis of the embryonic laterality organ, the first organ to form during vertebrate development, using the zebrafish as a model organism. (elifesciences.org)
In our research, we use the zebrafish embryo to investigate how intercellular Wnt protein transport is regulated and how signals are subsequently delivered to the target cell in a living vertebrate organism. (exeter.ac.uk)
Studies on Xenopus laevis intestine reveal biological pathways underlying vertebrate gut adaptation from embryo to adult. (nih.gov)
The group studies a population of coupled genetic oscillators in the vertebrate embryo termed the segmentation clock. (ens-lyon.fr)
1) One of the main efforts in our laboratory is building a systems level understanding of the gene regulatory network that orchestrates early steps of neural crest formation in vertebrate embryos. (ox.ac.uk)
Isolation and expression analysis both in invertebrate and vertebrate embryos of a new homeobox containing gene named Orthopedia (Otp). (cnr.it)

I will describe recent progress in understanding the behavior of individual cells from the zebrafish as they slow their oscillations and differentiate during segmentation, and discuss how this gives rise to the tissue-level wave patterns. (ens-lyon.fr)
We use two developmental models, the chicken (1) and the zebrafish (2) embryo. (ox.ac.uk)
We have developed a versatile, genetically encoded, binary in vivo biotinylation approach in zebrafish, which allows for tissue-specific biotinylation of defined targets. (ox.ac.uk)

The remaining delaminated cells follow the movement of apically attached progenitors by a protrusion-dependent cell-cell contact mechanism, avoiding sequestration by the adjacent endoderm, ensuring their collective fate and allocation at the site of differentiation. (elifesciences.org)
These early progenitor cells often travel long distances from their induction site to the site of terminal differentiation, making them vulnerable to environmental cues and movement of neighbouring tissues. (elifesciences.org)
Dominant themes in 21st century plant science are molecular genetics and epigenetics, which study the mechanisms and control of gene expression during differentiation of plant cells and tissues. (wikipedia.org)
M�P) Connexin40 (Cx40 or Gja5) (M and N) or EphB4 -lacZ (O and P) in littermate E9.5 Rasip1+/ and Rasip1 / yolk sacs (M and N) or embryos (O and P) showing failed arterial (M and N) and venous (O and P) differentiation in Rasip1 / vessels. (xenbase.org)
It involves a series of cell divisions, growth, and differentiation, leading to the formation of a multicellular embryo. (microbiologynote.com)
As development progresses, nephron progenitors switch from glycolysis to mitochondrial respiration for energy-mediated by an unknown mechanism-and undergo differentiation. (lww.com)
A switch from glycolysis to mitochondrial respiration drives these cells toward differentiation, but the mechanisms that control this switch are poorly defined. (lww.com)
Recent advances in live imaging and genetics of mammalian division, movement and cell differentiation leading to development which integrate observations of biochemical tissue formation [14 ]. (lu.se)
Embryonic development is driven by a large set of finely orchestrated regulatory programs that control cell fate decisions, differentiation and morphogenesis, leading to formation of a complex organism. (ox.ac.uk)
In the cochlea of mouse embryos, it is highly expressed in prosensory cells and down-regulated at the onset of hair cell differentiation. (encyclopedia.pub)
Thus, Lin28B functions in hair cell regeneration through mitotic and non-mitotic mechanisms, which are dependent on mitotic division or trans-differentiation of supporting cells into hair cells, respectively. (encyclopedia.pub)
In contrast to earlier models that featured nephron-like structures, these advances have improved the differentiation efficiency and similarity to the human kidney. (j-organoid.org)
Neuroendocrine mechanisms, particularly those related to 5-HT, are associated with the differentiation and activation of osteoblasts and osteoclasts. (bvsalud.org)

An essential component for these developmental processes but also for tissue regeneration and stem cell regulation is the communication of cells by chemical signalling. (exeter.ac.uk)
Wnt proteins regulate developmental processes, tissue regeneration and stem cell maintenance. (exeter.ac.uk)
An organism's growth and transformation during its life cycle is a tremendously complex succession of processes and events but even a simplistic and limited theory, dealing with only the general trend and generating a broad vision of tissue organization, can drive specific studies and experiments to further inform this field of research. (nature.com)
Developmental biology is a scientific field that studies the processes and mechanisms by which organisms grow and develop from a single fertilized egg (zygote) to a complex, multicellular organism. (microbiologynote.com)
Morphogenesis: Morphogenesis refers to the processes by which cells and tissues arrange themselves spatially to give rise to the three-dimensional structure of an organism. (microbiologynote.com)
Developmental biology employs a variety of techniques, including genetic analysis, molecular biology, imaging, and experimental manipulations, to investigate the processes underlying development. (microbiologynote.com)
Understanding developmental processes is crucial for elucidating the origins of birth defects, tissue regeneration, evolutionary changes, and disease mechanisms. (microbiologynote.com)
The Turing Centre addresses the nature of the information underlying biological processes, and the organisation and dynamics of biological structures. (centuri-livingsystems.org)
Understanding how these programs, encoded at the genome level, are translated into intricate networks of interacting biological components (genes, proteins, RNA) is essential to our understanding of mechanisms underlying developmental processes and human diseases, triggered when biological circuits go awry. (ox.ac.uk)
We are using this technology to analyze cellular circuitry at as many levels as possible and to address transcriptional and epigenomic mechanisms at play in an array of developmental systems, such as neural crest and hematopoietic lineages, but also in processes activated during inflammatory response to injury and cancer, or during organ regeneration. (ox.ac.uk)
The protein is also predicted to be involved in nutritional processes, and apoptotic processes underlying fetal morphogenesis and re-modeling of feto-maternal tissues. (biomedcentral.com)
The mammary gland is an ideal tissue in which to study a range of developmental processes, as discussed below. (biologists.com)
This simplified approach towards understanding the essence of the mechanisms, underlying the processes determining life and death of a cell has undoubtedly provided scientists with enormous amount of knowledge. (intechopen.com)

These findings suggest a link between glucose, fructose, glucosamine synthesis, GAG production, and placental morphogenesis, but the details of these interactions remain unclear. (biomedcentral.com)
Further elucidation of mechanisms of placental morphogenesis and solute transport could provide clues to improving nutrient transport to the pig fetus, potentially increasing litter size and piglet birth weights. (biomedcentral.com)

The characterisation of developmental EMTs provides an understanding of the underlying molecular mechanisms of how EMTs normally occur during tissue morphogenesis. (whiterose.ac.uk)
High throughput single-cell technologies have paved the way for comprehending the topography of cell states that emerge across developmental time and deciphering molecular mechanisms underlying these transitions. (tu-berlin.de)
We define the earliest gene expression patterns in the developing brain, stratifying substructures and molecular boundaries prior to the formation of morphological units during development. (tu-berlin.de)
We investigate the molecular mechanisms of thyroid hormone function during postembryonic development. (nih.gov)
Dr. Yun-Bo Shi is the head of Section on Molecular Morphogenesis and the Associate Scientific Director for budget and administration at NICHD, NIH, USA. (nih.gov)
This system drives the rhythmic, sequential, and precise formation of embryonic body segments, exhibiting rich spatial and temporal phenomena spanning from molecular to tissue scales. (ens-lyon.fr)
Organogenesis is highly regulated by genetic factors and molecular signaling mechanisms. (microbiologynote.com)
Since perturbation of normal homeostatic levels of SRC-3 is linked with common gynecological disorders diagnosed in reproductive age women, this endometrial coregulator-along with its new molecular targets described here-may open novel clinical avenues in the diagnosis and/or treatment of a non-receptive endometrium, particularly in patients presenting non-aneuploid early pregnancy loss. (frontiersin.org)
Accordingly, pregnancy success rates currently achieved by natural or assisted conception for women at high-risk for EPL or RPL can only be increased by an improved understanding of the cellular and molecular mechanisms that control endometrial function during the periimplantation period. (frontiersin.org)
Previous molecular characterizations of mammary stem cells (MaSC) have utilized fluorescence-activated cell sorting or in vitro cultivation of cells from enzymatically dissociated tissue to enrich for MaSC. (frontiersin.org)
Molecular mechanism controlling the expression of the HOX Complex gene family in human teratocarcinoma cells (N-tera2/D1). (cnr.it)
Somatic mutations were identified in NXK2-5 and its molecular partners, TBX5 and GATA4 , as well as the transcription factor HEY2 in formalin fixed tissue taken from a collection of hearts with atrial septal defects (ASD), 8 ventricular septal defects (VSD), and atrioventricular canal defects (AVCD). (cdc.gov)

In the US, where a portion of the population is opposed to destruction of human embryos to obtain stem cells, what avenues are open to scientists for obtaining pluripotent cells that do not offend the moral sensibilities of a significant number of citizens? (asu.edu)
Expression analysis of several Hox genes in human embryos. (cnr.it)

Using theory and experiment, we have shown that during cellularisation in the Drosophila embryo, cells undergo skew and apical-to-basal neighbour rearrangements to adapt for geometric constraints. (mechanochemistry.org)
We have taken advantage of genetically induced smaller embryos in Drosophila to bring new insights into when and where organ scaling occurs in the embryo. (mechanochemistry.org)
Prelights article on our paper about scaling in the early Drosophila embryo. (mechanochemistry.org)
She shifted to studying the dynamics of biological development during her postdoc at the IBDM (Marseille, France) in the group of Thomas Lecuit where she studied the physical mechanisms underlying tissue flows in early Drosophila embryogenesis. (univ-mrs.fr)
The posterior endoderm in Drosophila embryos undergoes an epithelial-mesenchymal transition (EMT), driving the collective migration of endoderm cells. (whiterose.ac.uk)
To test for conserved mechanisms of developmental EMTs in disease using Drosophila, fly models first needed to be generated that accurately recapitulate aspects of human metastasis. (whiterose.ac.uk)
Isolation and expression analysis in murine embryos of Dlx5 and Dlx6, two murine homologues of the Drosophila Distal-less gene. (cnr.it)

Here, we uncovered a mechanism of progenitor cell allocation that stems from an incomplete process of epithelial delamination that allows progenitors to coordinate their movement with adjacent extra-embryonic tissues. (elifesciences.org)
Morphogenesis of epithelial tubes: Insights into tube formation, elongation, and elaboration. (xenbase.org)
Par proteins, like Cdc42, play conserved roles in cell polarity in many contexts, from early embryos to epithelial apical-basal polarity ( Goldstein and Macara, 2007 ). (rupress.org)
ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. (thermofisher.com)
The precise mechanism by which Lin28B and let7 miRNA regulate mTORC1 activity in cochlear epithelial cells awaits further investigation. (encyclopedia.pub)
One such mechanism is likely to be improved development of the folded placental-epithelial/maternal-epithelial bilayer. (biomedcentral.com)
On the fetal side of the placenta, the epithelial bilayer is embedded in stromal tissue. (biomedcentral.com)
In addition, recent placental epithelial transcriptome analysis identified several glucose, amino acid, lipid, vitamin, mineral and hormone transporter mechanisms within the placenta. (biomedcentral.com)

Furthermore, the deletion of Hnscr promoted an increase in body weight and adipose tissue weight by upregulating the expression of lipogenesis genes and downregulating lipolysis genes in inguinal white adipose tissue (iWAT) and brown adipose tissue. (bvsalud.org)
There are currently 20 retinal genes whose mutations cause the phenotype of LCA, accounting for about 70% of the cases, while the genes underlying the remaining 30% of patients await discovery. (aao.org)

We previously demonstrated the critical involvement of SRC-2 in murine embryo implantation as well as in human endometrial stromal cell (HESC) decidualization, a cellular transformation process required for trophoblast invasion and ultimately placentation. (frontiersin.org)
There is growing evidence that resident progenitor cell populations exist in murine lung tissues and differentiate into a mesenchymal cell lineage [1, 2]. (keio.ac.jp)

Mesenchymal cells derived from the dermomyotome condense within connective tissue (mesenchymal) scaffolds to form 2 common muscle masses. (medscape.com)

Using single-cell profiling of mutant phenotype, we in- vestigate the fundamental principles governing cell fate specification, morphogenesis, and tissue patterning. (tu-berlin.de)
Dissection of Otx2 roles during gastrulation: requirement of Otx2 in the visceral endoderm for specification of anterior identity, and in the early neuroectoderm for maintenance of the anterior identity (forebrain and midbrain). (cnr.it)

To test this theory further, I exposed embryos to exogenous sources of 20E, which recapitulated phenotypes observed during EMT at far earlier stages of embryogenesis than is normal. (whiterose.ac.uk)
The future body plan is formed during the gastrulation and early organogenesis stages when cells commit to their fates and organize into discrete anatomical units. (tu-berlin.de)
Understanding these early stages of development is crucial not only for unraveling the mysteries of life's origins but also for providing insights into potential causes of developmental disorders. (fnps-society.org)
Soon after embryo attachment and the early stages of implantation, further invasion into the maternal compartment requires a functional decidua ( 6 ). (frontiersin.org)

The development of a single-cell zygote into a multi cellular organism with a plethora of cell and tissue types necessitates the precise spatiotemporal coordination of numerous mechanisms in the developing embryo, including the regulation of gene expression, morphogenesis, and tissue patterning. (tu-berlin.de)
We are using the regulation of shoot branching as a model system to investigate the mechanisms underlying this developmental plasticity. (ens-lyon.fr)
The role of ESRRs during animal development may also be linked to metabolic regulation by which developing embryos meet their high energy demand for growth. (nature.com)

Thus, we reveal that incomplete delamination serves as a cellular platform for coordinated tissue movements during development. (elifesciences.org)
We are particularly interested in how mechanical interactions guide morphogenesis, and how such mechanics interact with signalling networks during development. (mechanochemistry.org)
My lab studies how complex three-dimensional tissue shape emerges during embryo development. (mechanochemistry.org)
Such scaling begins early in the embryo development. (mechanochemistry.org)
The highly conserved family of Wnt proteins represents important regulators of cell behaviour, tissue development and homeostasis by inducing responses in a concentration-dependent manner. (exeter.ac.uk)
By understanding Wnt dissemination mechanisms, we will be able to control Wnt signalling in development, and regeneration. (exeter.ac.uk)
Recording and contextualizing the science of embryos, development, and reproduction. (asu.edu)
In the spring of 1891 Driesch performed experiments using two-celled sea urchin embryos, the results of which challenged the then-accepted understanding of embryo development. (asu.edu)
Our studies have revealed likely conserved mechanisms of adult intestinal stem cell development in vertebrates, prompting us to adapt the mouse model for comparative studies. (nih.gov)
By investigating factors that influence placental development and function, FNPS aims to improve our understanding of these conditions and develop strategies for early detection and intervention. (fnps-society.org)
Epigenetics is an emerging field within prenatal development research that explores how gene expression can be influenced by environmental factors without altering the underlying DNA sequence. (fnps-society.org)
Embryogenesis: Embryogenesis is the early stage of development that occurs after fertilization. (microbiologynote.com)
During development, cells undergo changes in gene expression patterns, leading to the development of distinct cell types and tissues. (microbiologynote.com)
They play a crucial role in development and are also important in adult organisms for tissue maintenance and regeneration. (microbiologynote.com)
Developmental Genetics: Developmental genetics focuses on the genetic mechanisms that control development. (microbiologynote.com)
Nephron progenitors, the self-renewing cells that give rise to nephrons, are particularly metabolically active, relying primarily on glycolysis for energy generation early in development. (lww.com)
Classic descriptions of upper limb development and embryology relied solely on detailed descriptions of the gross morphology of the developing embryo. (medscape.com)
In order to mechanistically dissect GRNs during development, we are adapting systems level approaches, such as epigenomic and transcriptional profiling, to defined cell populations in the developing embryo. (ox.ac.uk)
We use the chicken embryo, a classical model for studying neural crest, whose mode of early development closely resembles human. (ox.ac.uk)
Laboratory work has centered on the mechanisms of how cells acquire specific fates during growth and development, providing insights into normal and abnormal mechanisms of growth control. (stanford.edu)
Hyaluronidases and heparanases are present within placental tissues, and likely play roles in modification of stromal components to facilitate fold development. (biomedcentral.com)
However, aside from muscle development, the roles of ESRRs in other tissues including bone and cartilage have just begun to be investigated 10 . (nature.com)
The development of new tools and culture techniques has also enabled the factors that influence branching morphogenesis in the embryonic and pubertal gland to be identified. (biologists.com)
After birth, mammary development is arrested until puberty, when extensive elongation of the ducts, accompanied by secondary branching, takes place, thus providing a readily accessible system in which to study branching morphogenesis. (biologists.com)

They play major roles in the tissue- and stage-specific expression of protein isoforms as well as in the maintenance of protein homeostasis. (encyclopedia.pub)
Extensive renovation of the epithelium, cell proliferation, apoptosis and changes in the shape and positioning of cell groups are determined by morphogenetic gradients that play critical roles during the morphogenesis of teeth 13 . (bvsalud.org)

S�V) Transverse sections of E8.5 embryos, through the trunk region, posterior to the heart . (xenbase.org)
Two morphologically distinct parts comprise the secondary palate, soft tissue (posterior), and bony palatal components. (medscape.com)

Here, we employ single-cell technologies to chart the emerging cell states and map their precise spatial locations within the developing mouse embryo during gastrulation and early organogenesis. (tu-berlin.de)

If left untreated, it can spread to nearby tissues, lymph nodes, and even bones. (bvsalud.org)

We identify and characterize continuous gene expression changes influencing tissue patterning along developmental axes. (tu-berlin.de)
Also, the study will look at whether there are gene expression profiles in the tumor tissue that can predict pathologic complete response. (stanford.edu)

In the future, this model has the potential to be used to investigate and compare mechanisms of developmental EMTs with those involved in cancer metastasis, in particular if steroid hormones play a role in co-activating the process during disease progression. (whiterose.ac.uk)
We further use gastric cancer cells to investigate how cytonemes mobilize Wnts in tumour tissue. (exeter.ac.uk)

Facial tissues, including lip and palate, are produced from mesenchymal migration, penetration, and fusion of cranioneural crest cells. (medscape.com)

Taken together, we generate a high-resolution atlas of gastrulation and early organo- genesis and perform a comprehensive dissection of the spatiotemporal architecture of complex embryonic structures using high-throughput single-cell technologies, paving the way for the in- vestigation of congenital and developmental disorders. (tu-berlin.de)

Because of the profound implication of this finding, we attempted to replicate it using fresh frozen tissue obtained in the current era from 28 patients with septal defects who underwent cardiac surgery and who were enrolled in our congenital heart disease tissue bank. (cdc.gov)

Typically occurring in individuals aged 50 and above, this malignant tumor originates from abnormal cells in the prostate tissue. (bvsalud.org)
The invasion of neoplastic cells into healthy brain tissue is a pathologic hallmark of Gliomas and contributes to the failure of current therapeutic modalities (surgery, radiation and chemotherapy). (proteinlounge.com)
In the present model, the bioelectric context of cells and tissue is the field responsible for organization, as it regulates cell proliferation and the level of communication driving the system's evolution. (nature.com)
Carcinogenesis is introduced through a localized event (a spot of depolarized cells) or by random depolarization of cells in the tissue, which returns cells to their initial proliferative state. (nature.com)
This simplified model of embryogenesis, tissue organization and carcinogenesis, based on non-excitable cells' bioelectric properties, can be made more realistic with the introduction of other components, like biochemical fields and mechanical interactions, which are fundamental for a more faithful representation of reality. (nature.com)
Driesch showed that the cells of an early embryo, when separated, could each continue to develop into normal larval forms. (asu.edu)
of the most critical events which lead to tissue patterning involves mechanisms going beyond single cells. (lu.se)
However, experiments demonstrate that even at this early stage, cells are already polarized in some sense and carry positional information. (medscape.com)
We propose that quantitative experimental embryology offers essential ways to explore the reaction of cells and tissues to targeted cell addition, removal, and confinement. (mdpi.com)
This suggests that coactivation of Lin28B and Follistatin may represent an endogenous mechanism mediating reprogramming of supporting cells for hair cell regeneration. (encyclopedia.pub)

Studies in Spermatogenesis described early examples of chromosomal XY sex-determination. (asu.edu)
After embryo aneuploidy, parental chromosomal translocations, maternal thrombophilic anomalies, immunological disorders, and obvious uterine ultrastructural abnormalities are excluded as etiologic contributors, implantation failure intrinsic to the endometrium is commonly suspected as an underlying cause of early pregnancy loss [EPL ( 1 )] and recurrent pregnancy loss [RPL ( 2 )], the latter defined as the loss of two or more consecutive pregnancies in the first trimester ( 2 - 5 ). (frontiersin.org)

This homeobox transcription factor is expressed during early cardiac morphogenesis and serves as a master regulatory protein. (cdc.gov)

183:1129-1143) provide new insights into how Cdc42 and Par proteins work together to modulate cell adhesion and polarity during embryonic morphogenesis by regulating the traffic of key cell junction proteins. (rupress.org)
Despite facing numerous challenges due to his early arrival, including underdeveloped lungs and an immature immune system, this tiny patient was able to thrive with appropriate medical interventions based on insights gained from FNPS research findings. (fnps-society.org)

42 pathologic cardiac tissue samples were sequenced. (cdc.gov)

Yet, the mechanisms underlying scaling are poorly understood. (mechanochemistry.org)

Cardiac tissue samples were collected both from diseased tissue located immediately adjacent to the defect and from anatomically normal tissue located at a site remote from the defect (right atrial appendage). (cdc.gov)

Developing organisms are three-dimensional, yet much research into tissue mechanics and interactions has focused on relatively flat tissues due to accessibility. (mechanochemistry.org)

However, even in late gestation, mechanisms still exist that maintain fetal growth when the size of the placenta is reduced. (biomedcentral.com)

Also known as pregnancy specific protein-B (PSPB) or pregnancy specific protein (PSP)-60, these are putatively known to act as immunosuppressants that allow the immunological acceptance of the embryo by the dam. (biomedcentral.com)

How does mechanics impact cell and tissue organisation and dynamics? (centuri-livingsystems.org)

To test the idea that loss of Rab11 may promote cancer progression, archival human patient tissues were analyzed and 51 out of 70 colon cancer tissues had lower Rab11 protein staining. (sdbonline.org)
Tissue extracts of Mouse Testis (Lane 6) and Mouse Kidney (Lane 7) were electrophoresed using NuPAGE™ 3-8% Tris-Acetate Protein Gel (Product # EA0378BOX). (thermofisher.com)

On the one hand, the developing heart scales precisely with embryo length, yet the developing central nervous system has a more absolute length. (mechanochemistry.org)
Developing embryo at 28 days, 40 days, and 46 days. (medscape.com)
Identification of an Otx gene-dosage dependent mechanism required for patterning of developing brain and proper positioning of midbrain-hindbrain isthmic organizer. (cnr.it)

E�H) E9.5 littermate mouse embryos showing defects in Rasip1 / embryos (F) and yolk sacs (H). (I�L) Whole-mount Flk1 -lacZ beta-galactosidase staining of Rasip1+/ (I and K) and Rasip1 / (J and L) yolk sacs (I and J) and embryonic heads (K and L), showing narrow Rasip1 / blood vessels that fail to remodel. (xenbase.org)

By deciphering GRNs that orchestrate early steps of neural crest formation, we aim to understand the mechanistic basis of their multipotency and stem-cell like potential, as well as and the biochemical hierarchy that controls the maintenance of those properties. (ox.ac.uk)

In particular, I will explore in more detail a core assumption this epistemic bet is based on-namely, that intelligent behaviour, as exhibited by different types of systems, both natural and artificial, share underlying principles which we can study and exploit. (alignmentforum.org)
Furthermore, intelligent behaviour - as we can observe it in different types of systems - shares underlying principles of functioning. (alignmentforum.org)

In 1991, Hugo de Garis' article 'Genetic Programming: Artificial Nervous Systems, Artificial Embryos and Embryological Electronics' was published in the book Parallel Problem Solving from Nature. (asu.edu)
Recent reports have suggested a novel genetic mechanism for CHD. (cdc.gov)

How is organ formation coordinated to ensure robust morphogenesis? (mechanochemistry.org)

It has been postulated that Wnt/β-catenin signalling forms concentration gradients across responsive tissues and act as morphogens. (exeter.ac.uk)

Organ-Specific Requirements for Thyroid Hormone Receptor Ensure Temporal Coordination of Tissue-Specific Transformations and Completion of Xenopus Metamorphosis. (nih.gov)

The number of living conceptuses that the uterus is capable of supporting is greater during early gestation compared to later gestation. (biomedcentral.com)
Plots of log fetal weight versus log placental weight also indicate that fetal weights are less sensitive to reduced placental weight (and therefore reduced intrauterine space) in early gestation compared to late gestation. (biomedcentral.com)

However, the supporting mechanisms of this process are not fully understood. (sdbonline.org)

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