Mechanisms transcriptional methylation. Medical search. Frequent questions

Rice, J.C. & Allis, C.D. Histone methylation versus histone acetylation: new insights into epigenetic regulation. (nature.com)
This study provides novel evidence for widespread alterations in DNA methylation during postnatal heart maturation and suggests that cardiomyocyte cell cycle arrest during the neonatal period is subject to regulation by DNA methylation. (nih.gov)
A recent study from the Wilkens lab in collaboration with Seoul National University uncovered a novel mechanism of yeast V-ATPase regulation based on biochemical experiments and cryo electron microscopy (cryo-EM) structures of holo V-ATPase and Oxr1 bound V 1 subcomplex. (upstate.edu)
Here, we systematically investigate the potential molecular underpinnings of physiological priming against recurring excess light (EL), specifically DNA methylation and transcriptional regulation: the latter having not been examined with respect to EL priming. (biorxiv.org)
These results uncover a regulation loop where Jarid2 methylation fine-tunes PRC2 activity depending on the chromatin context. (sdbonline.org)
In addition, the density and positioning of nucleosomes have also been linked to transcriptional regulation. (asm.org)
Regulation of nucleosome density is therefore an important mechanism to enable the transcription machinery to access the DNA. (asm.org)
Genomic characterization predicted specific genomic islands highly associated with virulence, transcriptional regulation, and DNA restriction-modification systems. (frontiersin.org)
The Long Non-Coding RNA HOXA-AS2 Promotes Proliferation of Glioma Stem Cells and Modulates Their Inflammation Pathway Mainly through Post-Transcriptional Regulation. (igred.fr)
We are using the regulation of shoot branching as a model system to investigate the mechanisms underlying this developmental plasticity. (ens-lyon.fr)
Together, our results reveal that regulation of crossover patterning in wild-type and SC defective mutants likely act through the same underlying coarsening mechanism, differing only in the spatial compartments through which the pro-crossover factor diffuses. (babraham.ac.uk)
The present study investigated the methylation of CpG sites in the cyclooxygenase (COX)‑2 promoter via nuclear factor (NF)‑κB transcriptional regulation and elucidated its effect on the COX‑2 transcriptional expression in a ketamine‑induced ulcerative cystitis (KIC) animal model. (spandidos-publications.com)
Moreover, DNA hypomethylation of the COX‑2 promoter region located from ‑1,522 to ‑829 bp might contribute to transcriptional regulation of COX‑2 expression and induce a pro‑inflammatory response in KIC. (spandidos-publications.com)
The mechanism of epigenetic regulation involves the CpG site methylation of promoter regions and the modification of DNA and histones by altering chromatin structure ( 9 - 11 ). (spandidos-publications.com)
We expect to design a sensitive and high-throughput approach for assessing the relationship between the methylation profile and transcriptional activity for of Nm23-H1 promoter, to analysis the cis-acting regulatory elements, and define the mechanisms of Nm23-H1 transcriptional regulation. (tmu.edu.tw)
AF10 (MLLT10) prevents somatic cell reprogramming through regulation of DOT1L-mediated H3K79 methylation. (ox.ac.uk)
The Developmental Genetics Research Group studies epigenetic regulation of organ development and stem cell functions, mediated by Polycomb group (PcG) proteins and DNA methylation (5mC) mechanisms. (riken.jp)
Epigenetic regulation of Parkinson's disease risk variant GPNMB cg17274742 methylation by sex and exercise from Taiwan Biobank. (cdc.gov)
We found that the regulation of TE transcription during brain development is essential for the establishment of long-term transcriptional repression carried to adulthood (Paper I and IV). (lu.se)
Genetic Regulation of DNA Methylation Yields Novel Discoveries in GWAS of Colorectal Cancer. (who.int)

Noma, K., Allis, C.D. & Grewal, S.I. Transitions in distinct histone H3 methylation patterns at the heterochromatin domain boundaries. (nature.com)
Such mechanisms are diverse, ranging from the inheritance of relatively simple feedback loops to the formation of complex self-perpetuating DNA methylation patterns. (fems-microbiology.org)
The transcriptional patterns in each parasite are clonally transmitted over multiple generations of asexual growth, with stochastic switches between the active and silenced states occurring at low frequency ( Figure 1A ). (plos.org)
The analyses revealed unique and overlapping expression patterns in roots, shoots, and reproductive organs, emphasizing the importance of a DNA methylation-demethylation equilibrium. (tennessee.edu)
To establish the DNA methylation patterns of the promoter CpG islands of 14 "drug-resistance" genes in hepatocellular carcinoma (HCC). (wjgnet.com)
The methylation specific polymerase chain reaction in conjunction with sequencing verification was used to establish the methylation patterns of the 14 genes in the liver tissues of four healthy liver donors, as well as tumor and the paired non-cancerous tissues of 30 HCC patients. (wjgnet.com)
Changes in DNA methylation patterns are the first epigenetic event to be described in human cancer and have been observed in both early and late-stage tumors. (creativebiomart.net)
Interestingly, different types of cancer exhibit different methylation patterns, so further studies are needed to clarify the differential methylation patterns of specific cancer types and the correlation of epigenomic mapping with underlying pathology. (creativebiomart.net)
Exogenous E2 and certain polychlorinated biphenyls retain typical methylation patterns observed at MPT (Chapter 4). (utexas.edu)
We propose a general model of how transcription could act as a primary determinant of the patterns of CGI methylation in normal development and differentiation, and in human disease. (ox.ac.uk)
DAT1 5'-Un-Translated-Region Methylation Patterns as Bio-Markers of ADHD Psycho-Pathology: Contribution to Disease Prognosis and to Monitoring of a Successful Therapy. (cdc.gov)
DNA Methylation Patterns in Relation to Acute Severity and Duration of Anxiety and Depression. (cdc.gov)
DNA methylation regulator-mediated modification patterns and risk of intracranial aneurysm: a multi-omics and epigenome-wide association study integrating machine learning, Mendelian randomization, eQTL and mQTL data. (cdc.gov)

In other words, the presence of a specific pRb2/p130 multimolecular complex may dictate a local change of the DNA structure of the estrogen receptor alpha gene and influence its susceptibility to chemical modification (DNA methylation), as well as to different epigenetic alterations leading to estrogen receptor alpha silencing," added Marcella Macaluso, research assistant professor at the Sbarro Institute and the study's lead author. (sciencedaily.com)
in fact, most alterations in primed plants presented as a transcriptional 'dampening' in response to an additional EL exposure, likely a consequential of physiological priming. (biorxiv.org)
and that the majority of the associated transcriptional alterations are a consequence, not cause, of this physiological priming. (biorxiv.org)
Transcriptional alterations in glioma result primarily from DNA methylation-independent mechanisms. (igred.fr)
Alterations in DNA methylation is a hallmark of glioma. (lu.se)
Heatwave resilience of juvenile white sturgeon is associated with epigenetic and transcriptional alterations. (cdc.gov)

H3K9me2 levels are higher at silent compared to active genes in a 10kb region surrounding the transcriptional start site. (wikipedia.org)
To identify genes commonly affected by both mood stabilizers and to assess potential epigenetic mechanisms that may be involved in their mechanism of action, we administered Li (N = 12), VPA (N = 12), and normal chow (N = 12) to Brown Norway rats for 30 days. (nih.gov)
For most genes, we found little evidence of DNA methylation changes in response to the medications. (nih.gov)
Both genes are involved in transcriptional repression and we speculate their involvement in FXN gene silencing. (frontiersin.org)
This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)
Here, I generated 15 transgenic Arabidopsis GUS reporter lines for genes involved in DNA methylation and demethylation pathways. (tennessee.edu)
Summary description of changes in promoter activity of DNA methylation and demethylation-related genes in two-week-old roots in response to phytohormone treatments. (tennessee.edu)
Methylation profile of the promoter CpG islands of 14 "drug-resistance" genes in hepatocellular carcinoma. (wjgnet.com)
Moreover, DNA hypermethylation can also occur during the development of cancer, especially in CpG islands of the promoter region, resulting in transcriptional silencing of affected genes, such as tumor suppressor genes. (creativebiomart.net)
Studies of genes transcribed by RNA polymerase II (Pol II) have shown that open and closed chromatin structures are dynamically regulated through multiple mechanisms, including histone modifications, histone variant incorporation, and DNA methylation (reviewed in reference 17 ). (asm.org)
Epigenetic analysis revealed a specific N 6 -methyl adenine (m 6 A) methylating pattern including methylation of alginate, flagellar and quorum sensing associated genes. (frontiersin.org)
A cis-acting mechanism mediates transcriptional memory at Polycomb target genes in mammals. (babraham.ac.uk)

The goal of this study was to determine whether DNA methylation plays an important role in guiding transcriptional changes during the first 2 wk of mouse heart development, which is an important period for cardiomyocyte maturation, loss of proliferative capacity and loss of regenerative potential. (nih.gov)

To identify potential mechanisms underlying expression changes, genomic DNA was bisulfite treated for pyrosequencing of key CpG island 'shores' and promoter regions, and chromatin was prepared from both hippocampal tissue and a hippocampal-derived cell line to assess modifications of histones. (nih.gov)
Mechanistic mathematical models-describing the dynamics of histone modifications at individual genomic loci-offer an alternative way to investigate these mechanisms. (babraham.ac.uk)
DNMT1 preserves the methyltransferase by binding to hemi-methylated CpG sites and methylates the cytosine on the newly synthesized strand after DNA replication, whereas DNMT3a/DNMT3b are required for the de novo genomic methylation of DNA ( 15 ). (spandidos-publications.com)
In this study, we describe the TERT hypermethylated oncological region (THOR), a 433-bp genomic region encompassing 52 CpG sites located immediately upstream of the TERT core promoter, as a cancer-associated epigenetic mechanism of TERT upregulation. (jci.org)

H3K9me2 is strongly associated with transcriptional repression. (wikipedia.org)
In contrast, accumbal G9a hyperexpression results in markedly increased H3K9 dimethylation and blocks the induction of this neural and behavioral plasticity by chronic drug use, which occurs via H3K9me2-mediated repression of transcription factors for ΔFosB and H3K9me2-mediated repression of various ΔFosB transcriptional targets (e.g. (wikipedia.org)
Epigenetic modifications, including DNA methylation can result in chromatin condensation and gene repression and these modifications may be induced by environmental stimuli and are heritable. (cam.ac.uk)
Polycomb Group (PcG) proteins maintain transcriptional repression throughout development, mostly by regulating chromatin structure. (sdbonline.org)

His fields of research comprise RNA-mediated gene silencing processes with a focus on epigenetic phenomena, including studies on RNA-directed DNA methylation, the characterization of virus silencing suppressor proteins, the development of plant bioreactor platforms and viroid research. (degruyter.com)
These are frequently activated by fusion to other transcriptional proteins resulting in chimeric transcription factors. (stanford.edu)
We are studying the effects and consequences of protein fusion on the transcriptional and transforming activities of these proteins using in vitro and animal models. (stanford.edu)
Our hypothesis is that the sequence of epigenetic events for establishing and maintaining the silenced state of the estrogen receptor gene alpha during the breast cancer progression is mediated by pRb2/p130 in association with specific proteins that modified the DNA structure through specific mechanisms," said Giordano, who discovered the Rb2 gene while working at Temple's Fels Cancer Institute in the early 1990s. (sciencedaily.com)
The researchers reported their findings, "Epigenetic Modulation of Estrogen Receptor-α by pRb Family Proteins: A Novel Mechanism in Breast Cancer," in the Aug. 15 issue of the journal Cancer Research (abstract 67/16/7731). (sciencedaily.com)
Methylated CpGs, that are not bound by PcG proteins, are substrates of DNA methylation machinery. (riken.jp)

Post-transcriptional gene, Cardiovascular disease, Pulmonary hypertension. (alliedacademies.org)
Finally, we will use novel biochemical methods to explore the mechanisms underpinning howLINE-1 RNAs control transcriptional and post-transcriptional programs in glioma cells. (lu.se)
We show that human and chimpanzee cells differentiate in a similar man¬ner and that the difference in interspecies protein abundance is higher than transcript-level differences, suggesting that post-transcriptional mechanisms play a role in the difference between human and chim¬panzee brain development. (lu.se)
Taken together, our results suggest that post-transcriptional mechanisms play an important role in the brain both during development and in the adult brain. (lu.se)

When I started working on transcriptional control by bacterial DNA methylation, the field was very small, and the few labs interested in bacterial epigenetics formed a little club. (fems-microbiology.org)

Additionally, promoter activities suggest hormone-linked methylome regulatory mechanisms facilitate tissue differentiation. (tennessee.edu)
2015) . Jarid2 methylation via the PRC2 complex regulates H3K27me3 deposition during cell differentiation . (sdbonline.org)
Jarid2 methylation is shown to be important to promote PRC2 activity at a locus devoid of H3K27me3 and for the correct deposition of this mark during cell differentiation. (sdbonline.org)
Chapter 3 identifies the gonad-specific promoter and the temperature-dependent DNA methylation signatures of the aromatase gene during gonadal differentiation. (utexas.edu)
DNA methylation of intragenic CpG islands depends on their transcriptional activity during differentiation and disease. (ox.ac.uk)
SNHG1 directly interact with the histone methyltransferase enhancer of the zeste homolog 2 (EZH2) and modulate the histone methylation of promoter of Kruppel-like factor 2 (KLF2) and altered the progress osteogenic differentiation of PDLSCs. (biomedcentral.com)
Taken together, SNHG1 inhibited the osteogenic differentiation of PDLSCs through EZH2-mediated H3K27me3 methylation of KLF2 promotor and provided a novel class of therapeutic targets for regenerate dental tissues. (biomedcentral.com)
Therefore, better understanding of the mechanism that governs PDLSCs osteogenic differentiation would greatly be beneficial to the development of novel therapeutic strategies for tissue regeneration. (biomedcentral.com)
In brief, lncRNA plays an important role in osteogenic differentiation of PDLSCs and our study will further investigate the effects of lncRNA SNHG1 in osteogenic differentiation of PDLSCs and explore the underlying mechanism. (biomedcentral.com)

It is a mark that indicates the di-methylation at the 9th lysine residue of the histone H3 protein. (wikipedia.org)
H3K9me2 indicates dimethylation of lysine 9 on histone H3 protein subunit: This diagram shows the progressive methylation of a lysine residue. (wikipedia.org)
Lachner, M. & Jenuwein, T. The many faces of histone lysine methylation. (nature.com)
Strahl, B.D., Ohba, R., Cook, R.G. & Allis, C.D. Methylation of histone H3 at lysine 4 is highly conserved and correlates with transcriptionally active nuclei in Tetrahymena . (nature.com)
Polycomb Repressive Complex 2 (PRC2), a component of the Polycomb machinery, is responsible for the methylation of histone H3 lysine 27 (H3K27me2/3). (sdbonline.org)
Immunocytochemical analyses was performed with specific antibodies to dJmj and tri-methylation at lysine 27 on histone H3 (H3K27me3). (sdbonline.org)

The information is mainly transmitted in the primary sequence of the genome (genetic information), but there are heritable traits that are transmitted by other mechanisms. (plos.org)
It is mainly manifested in the reduction of whole-genome DNA methylation level, hypermethylation of the promoter region, changes in specific histone modification, abnormal chromatin conformation, changes in non-coding RNA (ncRNA) molecules, etc . (creativebiomart.net)
Analyzing specific loci and using a genome-wide analysis, we show that transcription running across CGIs, associated with specific chromatin modifications, is required for DNA methyltransferase 3B (DNMT3B)-mediated DNA methylation of many naturally occurring intragenic CGIs. (ox.ac.uk)
Any approach relying on genome-wide bioinformatic analyses alone offers limited scope for dissecting the molecular mechanisms involved in maintenance and switching. (babraham.ac.uk)
Alteration of genome-wide DNA methylation in non-uranium miners induced by high level radon exposure. (cdc.gov)

These results suggest methylation-dependent mechanisms similarly and differentially regulate plant responses to infection by two distinct nematode species. (tennessee.edu)
This discovery on ageing underscores the importance of basic research in understanding the mechanisms that regulate stem cell properties and function to pave the way for future development of innovative diagnostic or therapeutic strategies. (pasteur.fr)
In contrast, the Ten-Eleven-Translocation (TET) dioxygenase family, including TET1, TET2 and TET3, mediates active DNA demethylation and hydroxylate-methylated DNA by converting 5-methylcyto-sine to 5-hydroxymethylcytosine to regulate DNA methylation status. (spandidos-publications.com)

Epigenetic information can be transmitted by several different molecular mechanisms, which include but are not limited to DNA methylation and histone post-translational modifications (PTMs). (plos.org)
A closely related debate around chromatin modifications is about causality: several histone PTMs correlate with specific transcriptional states, but in many cases they are not responsible for a transcriptional outcome but rather are a consequence of it [7] . (plos.org)
Finally, the regulatory mechanism through which miR778 induces histone modifications, DNA methylation, and transcriptome reprogramming during H. schachtii parasitism of Arabidopsis was investigated. (tennessee.edu)
This study also confirmed that age-related DNA methylation is associated to a certain extent with transcriptional modifications. (pasteur.fr)
In mammalian cells, active and silent rDNA promoters are characterized by specific histone modifications, DNA methylation, and positioning of the promoter-bound nucleosome (reviewed in reference 22 ). (asm.org)
The maintenance of transcriptional states regulated by histone modifications and controlled switching between these states are fundamental concepts in our understanding of nucleosome-mediated epigenetic memory. (babraham.ac.uk)

While there are various post-translational mechanisms underpinning photoprotection, an unresolved question is the relative importance of transcriptional changes towards stress priming and, consequently, the potential contribution from DNA methylation - a heritable chemical modification of DNA capable of influencing gene expression. (biorxiv.org)
Based on this genetic analysis, we propose a three phase model for the establishment of heritable DNA methylation. (cam.ac.uk)

Since then, he has been working as a postodoc in Dr. Wassenegger's lab (RLP AgroScience GmbH, AlPlanta) and his main field of interest is RNA-interference (RNAi) and RNA-directed DNA methylation (RdDM) in plants. (degruyter.com)
At least in plants, DNA regions that become de novo methylated can be defined by homologous RNA molecules in a process termed RNA-directed DNA methylation (RdDM). (degruyter.com)

A particular focus has been the Polycomb epigenetic system, where we have proposed an all-or-nothing epigenetic switching mechanism, with epigenetic gene silencing directly antagonised by transcription. (babraham.ac.uk)
Using a specific example-transcriptional silencing by Polycomb-mediated H3K27 methylation-we demonstrate how to construct and simulate a stochastic histone modification model. (babraham.ac.uk)
This promotes deposition of H3K27me3 by the polycomb repressive complex 2 (PRC2), and subsequent recruitment of the canonical PRC1 (cPRC1)- leading to transcriptional silencing. (riken.jp)

The mechanisms that silence the estrogen receptor gene alpha (ER-α) in certain breast cancer cell lines may be closer to being unlocked, according to a study by researchers at Temple University's Sbarro Institute for Cancer Research and Molecular Medicine. (sciencedaily.com)
In this review, I describe the molecular mechanism underlying the extreme stability of unboiled NAD-dependent glutamate dehydrogenase from the hyperthermophile Pyrobaculum islandicum . (go.jp)
This research will transform our understanding of the underlying molecular mechanisms driving glioma initiation and progression and thereby generate much-needed new hypotheses on pathological processes in this devastating disease. (lu.se)
infecTion and oTher co-facTorS elucidate molecular mechanisms of both 2015). (who.int)

Blood cell DNA methylation biomarkers in preclinical malignant pleural mesothelioma: The EPIC prospective cohort. (who.int)

We hypothesize that a key event following loss of DNA methylation in glioma is the activation of transposable elements (TEs). (lu.se)

In normal human somatic cells, DNA methylation usually occurs on dinucleotide CpG. (creativebiomart.net)
In somatic cells and induced pluripotent stem cells (iPSCs) higher order H3K79 methylation is dependent on AF10 expression. (ox.ac.uk)
CONCLUSIONS: Our findings establish AF10 as a novel barrier to reprogramming by regulating H3K79 methylation and thereby sheds light on the mechanism by which cell identity is maintained in somatic cells. (ox.ac.uk)

In this context, we work with both histone modification memory systems, as well as on DNA methylation, collaborating with experimentalists in systems ranging from plants to mammalian stem cells. (babraham.ac.uk)
We are now elucidating novel molecules that function upstream of NP95-DNMT1, and couple DNA replication with maintenance methylation in mammalian cells. (riken.jp)
This mechanism of transmission contrasts with that of the two subspecies of African trypanosomes that cause human disease, Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense , which are transmitted via the saliva of their vectors, and with the mechanism by which a nonpathogenic trypanosome found in the Americas, Trypanosoma rangeli , is transmitted to its mammalian hosts. (medscape.com)

We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)
The vast majority (~80%) of DMRs were hypermethylated between P1 and P14, and these hypermethylated regions were associated with transcriptional shut down of important developmental signaling pathways, including Hedgehog, bone morphogenetic protein, TGF-β, fibroblast growth factor, and Wnt/β-catenin signaling. (nih.gov)
In line with our previous results, we found that there are marked differences between HD patients and controls at the protein level but not at the transcriptional level. (lu.se)

In the current study, lead by Antonio Giordano, M.D., Ph.D., director of the Sbarro Institute, the researchers showed that the presence of specific pRb2/p130 multimolecular complexes bound to the estrogen receptor gene strongly correlates with the methylation (chemical modification) of the gene. (sciencedaily.com)
Importantly, we also show that a subgroup of intragenic CGIs is not sensitive to this process of transcription-mediated methylation and that this correlates with their individual intrinsic capacity to initiate transcription in vivo. (ox.ac.uk)

We have recently described transcriptional control by DNA methylation in two Salmonella operons: opvAB, which controls lipopolysaccharide structure, and std, which encodes fimbriae and pleiotropic regulators of transcription. (fems-microbiology.org)
Moreover, in the ketamine group, the level of Ten‑Eleven‑Translocation methylcytosine dioxygenase for demethylation as determined by reverse transcription‑quantitative PCR assay was increased in comparison with the control group, but that was not the case for the level of DNA methyltransferases for methylation. (spandidos-publications.com)

VPA-mediated effects on histones are well established, whereas the Li effects constitute a novel mechanism of transcriptional derepression for this drug. (nih.gov)

The recruitment of this machinery results in the production of viroid-derived small RNAs (vd-sRNAs) that mediate RNA degradation and DNA methylation of cognate sequences. (degruyter.com)

Their mutagenic potential and gene regulatory effect have shaped the evolution of transcriptional networks involved in development, pluripotency, and inflammation. (lu.se)

The most common cause of morbidity and mortality worldwide is cardiovascular disease (CVD), and its complicated pathological mechanisms. (alliedacademies.org)
DNA methylation profiling reveals a pathological signature that contributes to transcriptional defects of CD34(+) CD15(-) cells in early chronic-phase chronic myeloid leukemia. (igred.fr)

H3K9me2 represses gene expression both passively, by prohibiting acetylation as therefore binding of RNA polymerase or its regulatory factors, and actively, by recruiting transcriptional repressors. (wikipedia.org)

Thus, we propose that THOR hypermethylation is a prevalent telomerase-activating mechanism in cancer that can act independently of or in conjunction with TPMs, further supporting the utility of THOR hypermethylation as a prognostic biomarker. (jci.org)

Our results shed light on the mechanism whereby HDAC inhibitors increase FXN mRNA levels in FRDA neuronal cells. (frontiersin.org)

Using MRD1 as a model for a genetic analysis of epiallele establishment, we targeted DNA methylation to this region via small RNA molecules which are produced by endogenous RNA silencing pathways. (cam.ac.uk)
oncogenic viruses share the ability to deregulate the same cel ular pathways, In addition, ICB and ICE have performed although via different mechanisms. (who.int)

These models, in conjunction with quantitative experimental data-ChIP data, quantification of mRNA levels, and single-cell fluorescence tracking in clonal lineages-can generate predictions that drive more targeted experiments, allowing us to understand mechanisms that would be challenging to unravel by a purely experimental approach. (babraham.ac.uk)

The capacity for physiological priming of photosynthetic and photoprotective parameters following a recurring EL treatment was not impaired in Arabidopsis mutants with perturbed establishment, maintenance and removal of DNA methylation, nor was the transmission of this priming into naive tissues developed in the absence of excess light. (biorxiv.org)

B. Duplicated pseudogenes: DNA duplication generates a more-or-less faithful copy of the original gene, including introns and, in many cases, promoter and other transcriptional regulatory elements. (pandasthumb.org)

Here we will describe our current knowledge of the biological processes and mechanisms that can be considered bona fide epigenetic phenomena in Plasmodium biology, and attempt to distinguish them from those unlikely to involve epigenetic flow of information, even if chromatin changes occur. (plos.org)

Right here, we investigate the systems where TGF- adversely regulates TRIII messenger RNA (mRNA) manifestation in the transcriptional level in both breasts and ovarian tumor model systems. (accessibletech4all.org)

Figure 4: Stereochemical mechanism of methyl group transfer. (nature.com)
In eukaryotes, DNA methylation refers to the addition of a methyl group to the fifth atom in the six-atom ring of cytosine residues. (degruyter.com)
Moreover, the CpG site methylation is mediated by DNA methyltransferases (DNMTs), which catalyze the addition of a methyl group to cytosine ( 13 , 14 ). (spandidos-publications.com)

One may thus suspect that the known roles of DNA methylation in the prokaryotic world are just the tip of an intriguing iceberg. (fems-microbiology.org)
Epigenetic mechanisms, including histone and DNA methylation and microRNAs, play key roles in mediating transcriptional changes during plant development and stress responses. (tennessee.edu)

The specific aims of this project will be: 1) Design a sensitive and high-throughput approach (methylation-sensitive high resolution melting curve analyze) to assess the DNA methylation status for Nm23-H1 promoter region in different metastasis/invasion and chemoresistance phenotypes of ESCC cell lines. (tmu.edu.tw)
However, the mechanisms by which DOT1L safeguards cell identity and somatic-specific transcriptional programs remain unknown. (ox.ac.uk)

These data support several shared transcriptional targets of Li and VPA, and provide evidence suggesting leptin signaling as an epigenetic target of two mood stabilizers. (nih.gov)

talks.cam : Investigating a mechanism for epiallele establishment in plants. (cam.ac.uk)
Although the mechanism for maintaining DNA methylation at epialleles has been described, the requirements for the establishment of new epialleles are less well understood. (cam.ac.uk)

Hence, the pseudogene product will lack intron and promoter sequences, and will bear characteristic repeat sequences at the insertion site, due to the integration mechanism. (pandasthumb.org)

Level of PI(3,5)P2 elevates by 20X its basal level, under hyperosmotic stress, helping cells to sustain salt toxicity, the mechanism of which is incompletely understood. (upstate.edu)
Seeking understand the decline in function of tissues in organisms, researchers from the Stem Cells and Development unit at Institut Pasteur made a discovery on the still unknown mechanisms of the epigenetic clock in stem cells. (pasteur.fr)
While older stem cells show a slight increase in the methylation of their DNA, this methylation does not correspond to their chronological age. (pasteur.fr)
In AF10 knock-out cells, re-expression wild-type AF10, but not a DOT1L binding-impaired mutant, rescues overall H3K79 methylation and reduces reprogramming efficiency. (ox.ac.uk)

Anatomy21

Organisms5

Diseases25

Chemicals and Drugs103

Analytical, Diagnostic and Therapeutic Techniques and Equipment28

Phenomena and Processes83

Disciplines and Occupations3

Information Science4

Health Care4

Regulation20

Patterns13

Alterations6

Genes12

Guiding transcriptional changes1

Genomic4

Repression4

Proteins6

Post-transcriptional4

Epigenetics1

Differentiation9

Lysine6

Genome5

Regulate3

Modifications6

Heritable2

RdDM2

Polycomb3

Molecular4

Biomarkers1

Glioma1

Somatic cells3

Mammalian3

Protein3

Correlates2

Transcription2

Novel mechanism1

RNAs1

Pluripotency1

Pathological2

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Hypermethylation1

Light on the mechanism1

Pathways2

Quantitative1

Arabidopsis1

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Epigenetic phenomena1

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Targets1

Establishment2

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Cells4