Mechanisms regulate. Medical search. Frequent questions

Activated p53 transcriptionally regulates hundreds of genes that are involved in multiple biological processes, including in DNA damage repair, cell cycle arrest, apoptosis and senescence. (nih.gov)
In summary, our results support distinct functions of Tsc1 and Tsc2 in cellular signaling as the two genes affect ciliary length control and HH signaling via different mechanisms. (springer.com)
Cells can die in different ways by using precise and highly regulated mechanisms of cell demolition, in which multiple genes evolutionarily conserved participate. (hstalks.com)
If the expression of other genes besides PKMzeta is affected by this pattern of DNA methylation, it must be particularly relevant to brain alterations possibly associated with pathologies, and the authors showed that the mechanism is not confined to the protein PKMzeta. (fapesp.br)
This raises two questions: First, how does GR regulate different subsets of target genes in different tissues? (mpg.de)
Binding to the genome however is just the first step in regulating the expression of genes and transcriptional regulation by GR depends on the recruitment of coregulator proteins that either directly or indirectly influence the recruitment and or activity of RNA polymerase II. (mpg.de)
Ultimately, the integration of inputs including GR isoform, DNA sequence, chromatin and cooperation with coregulators determines which genes are regulated and the direction of their regulation. (mpg.de)
We therefore suggest a new mechanism involving a cofactor that is regulated as well as recruited by one of the master genes to bind to the antagonistic partner that is necessary for bistability and hence switch-like behavior. (lu.se)
Introduction regulate choices of expressed genes as part of the macrophage/ neutrophil lineage. (lu.se)

Loss of ZBTB18 promotes metastasis: this study explores the role of the transcriptional repressor ZBTB18 in metastatic mechanisms. (atlasantibodies.com)
This is the first report of a global transcriptional mechanism that controls the laterality of all floor plate-crossing commissural axons via activating Robo3 expression. (biorxiv.org)
By contrast, the transcriptional programs that specify the laterality of commissural axons, and furthermore, whether a global regulatory mechanism operates for diverse commissural neurons, are little understood. (biorxiv.org)
The expression of key molecules of β-cell function including Insulin, Pdx1, Gck, Glut2, and Insrβ was down-regulated in Chl1 -silenced cells at transcriptional and translational levels. (lu.se)

The results of these studies will enable us to further develop a comprehensive mechanistic picture for how an activated G protein regulates its biological effector in phototransduction, and how this signal is rapidly terminated when its stimulation has ceased, as well as provide fundamentally important insights into key steps essential for other GPCR-sensory responses. (cornell.edu)
In the testes, this protein regulates the division of sperm cells. (medlineplus.gov)

The heterodimeric TSC complex negatively regulates mTORC1 activity via the GTPase activity of TSC2, towards the small G-protein RHEB (Ras homologue enriched in brain) [ 5 ]. (springer.com)

Maintaining the homeostasis of the multiple functionally distinct conventional dendritic cells (cDC) subsets that exist in vivo is crucial for regulating immune responses, with changes in numbers sufficient to break immune tolerance. (frontiersin.org)
Maintenance of cDC homeostasis is crucial for regulating immune responses, with deregulation resulting in infection and autoimmunity ( 19 - 22 ). (frontiersin.org)
Researchers from the University of California, Irvine have discovered that the absence of Adiponectin receptor 1 protein (AdipoR1), one of the principal enzymes regulating ceramide homeostasis in the retina, leads to an accumulation of ceramides in the retina, resulting in progressive photoreceptor cell death and ultimately vision loss. (news-medical.net)
Our results reveal a function of HSF proteins in regulating mtROS homeostasis that is independent of the unfolded protein response. (lu.se)

Release of Vasopressin within the Rat Paraventricular Nucleus in Response to Emotional Stress: A Novel Mechanism of Regulating Adrenocorticotropic Hormone Secretion? (jneurosci.org)
Researchers at the University of Southern California (USC) have identified a novel mechanism in the regulation and differentiation of neural stem cells. (phys.org)

Similarly, primary cilia have been implicated in regulation of mTOR signaling, in which Tuberous Sclerosis Complex proteins 1 and 2 (TSC1/2) negatively regulate protein synthesis by inactivating the mTOR complex 1 (mTORC1) at energy limiting states. (springer.com)
Salk Institute scientists have discovered that an interaction between two key proteins helps regulate and maintain the cells that produce neurons. (neurosciencenews.com)
Moreover we provide evidence that Dlx and R-Smad proteins are co-expressed literally interact and localize to Dlx-regulated enhancers/promoters in the developing subpallium. (bioinbrief.com)

Activity-regulated cytoskeleton-associated protein is a plasticity protein that in humans is encoded by the ARC gene. (wikipedia.org)

However, the role of Ryk in neural stem cells and the molecular mechanism of Ryk signaling have not previously been known. (phys.org)
This study aims to explore the molecular mechanism of TLR3 in the occurrence and development of post-cataract EMT, and to provide new ideas for the prevention and treatment of posterior capsule opacification (PCO). (researchsquare.com)
In mammals, most commissural axons from the spinal cord to the midbrain, cross the midline via the floor plate, guided predominantly by a conserved molecular mechanism, i.e. (biorxiv.org)

Vega R, Carretero M, Travasso RDM, Bonilla LL (2020) Notch signaling and taxis mechanisms regulate early stage angiogenesis: A mathematical and computational model. (uc3m.es)

Researchers found that the protein receptor Ryk has a key role in the differentiation of neural stem cells, and demonstrated a signaling mechanism that regulates neuronal differentiation as stem cells begin to grow into neurons. (phys.org)
They found that during neurogenesis, when neural stem cells start to grow into neurons, Ryk protein is cleaved and translocates to the cell nucleus to regulate neuronal differentiation. (phys.org)
Further research is needed to explore how Ryk regulates neuronal gene expression, Lu says. (phys.org)

Such a phenomenon has inspired us to apply the pro-oxidative mechanism of GA-Fe to anticancer therapy. (nature.com)
In this review, we studied on the effects and molecular mechanisms of Rhizoma coptidis on NF-κB/MAPK/PI3K-Akt/AMPK/ERS and oxidative stress pathways. (springer.com)
Oxidative stress pathways regulate redox balance by Nrf2 and other ways. (springer.com)

TSC1 and TSC2 also play a role in regulating pathways other than mTORC1/2. (springer.com)
Despite these advances, the roles of TSC1 and TSC2 in regulating signaling pathways independently of mTORC1/2 remain poorly understood. (springer.com)

Here we report that TSC1 and TSC2 regulate Smoothened (SMO)-dependent HH signaling in mouse embryonic fibroblasts (MEFs). (springer.com)
Our work is at the stage of understanding the molecular mechanisms by which the aging of the regenerative potential of organ stem cells can be reversed by particular human embryonic factors that are capable of neutralizing the affects of aged niches on tissue regenerative capacity. (ca.gov)

1 . Pernelle G, Nicola W, Clopath C (2018) Gap junction plasticity as a mechanism to regulate network-wide oscillations. (yale.edu)

OPN through interaction with CD44 or several integrins is known to regulate multiple macrophage functions. (cdc.gov)

To understand the mechanism, the researchers used epigenetics, the science of how environmental stimuli activate or inhibit gene expression without altering the DNA sequence. (fapesp.br)
The fact that we were able to connect transcription factors, which are mobile switches, to the pore complex, which is a very stable structure, offers a clue as to how cells maintain their identity through regulated gene expression," says Tomohisa Toda, a Salk research associate and first author of the paper. (neurosciencenews.com)

In this Review, we discuss the multiple molecular mechanisms of p53 regulation and how they modulate the induction of apoptosis or cell cycle arrest following DNA damage. (nih.gov)
The Government said on Saturday a mechanism for the regulation of websites is to be implemented within the next two weeks. (ft.lk)
The Board has been considering whether entities that operate in rate-regulated environments should recognise assets and liabilities arising from the effects of rate regulation, and issued a Discussion Paper in September 2014. (iasplus.com)
Asserting that there is no statutory vacuum, the central government has told the Supreme Court there exists a robust mechanism for regulation of content of private television channels. (lawtrend.in)
There is no statutory vacuum, in so far as regulation of the broadcast of irresponsible reporting and grievance redressal mechanism for the viewers is concerned. (lawtrend.in)
It is respectfully submitted that the answering respondent has a robust mechanism of regulation of the content of private television channels as laid down under the Cable Television Networks (Regulation) Act and the rules framed thereunder. (lawtrend.in)
As such, the Central Government, since inception, has purposefully imposed a self-restraint on itself and has adopted a regime of forbearance so as to promote a mechanism of self-regulation by media houses and journalists," the ministry said in its affidavit. (lawtrend.in)

Activation of monocytes by pathological factors (i.e. obesity, hypercholesterolemia and hyperglycemia) serves as the key mechanism to promote the disease development. (ki.se)

These results indicate that the two intestinal secretory peptides antagonistically regulate adult lifespan and intestinal senescence through multiple pathways, irrespective of insulin, which implicates a complementary gradient distribution of each of the hormone-producing EEs, consistent with local requirements for cell activity along the posterior midgut. (bioone.org)

During brain development, neural stem cells respond to the surrounding environment by either proliferation or differentiation, but the molecular mechanisms underlying the development of neural stem cells and neurons are unclear, Lu notes. (phys.org)

Our analysis revealed that DNA methylation regulates expression of this gene, which plays a role in several pathologies," said Deborah Schechtman , last author of the article and a professor at the University of São Paulo's Institute of Chemistry (IQ-USP) in Brazil. (fapesp.br)
However, Dad-lacZ expression within the germline is present only in GSCs and to a lower level in CBs, suggesting there are mechanisms that actively restrict Dpp signaling in germ cells. (biologists.com)

In terms of mechanism, the functional gain and loss experiments of human LEC show that TLR3 regulates the proliferation, migration, invasion of LEC and EMT induced by TGF-β2 by targeting the Jagged-1/Notch signaling pathway to affect the development of fibrotic cataract. (researchsquare.com)
These findings indicate that TLR3 prevents the progression of lens fibrosis by targeting the Jagged-1/Notch signaling pathway to regulate LEC proliferation, migration, invasion and TGF-β2-induced EMT. (researchsquare.com)

Working at the University of São Paulo in Brazil, the researchers used epigenetics to study the mechanism, which could be associated with pathologies such as Alzheimer's. (fapesp.br)
Researchers affiliated with institutions in Brazil and the United States have now discovered a mechanism that helps explain the link and could pave the way to future medical innovations. (fapesp.br)
Using data generated from patients and mice with genetic mutation for the disorder Usher syndrome, researchers from the University of Maryland School of Medicine, the National Institutes of Health's National Eye Institute, and National Institute on Deafness and Other Communication Disorders, documented the natural history of vision impairment in patients and identified the cell mechanism behind progressive vision loss. (news-medical.net)

These courses offer students training in specific areas of neurobiology, including current techniques in neuroscience, neuropharmacology, quantitative methods in neurobiology, and mechanisms underlying neurological and neuropsychiatric disorders. (sc.edu)

It is generally accepted that dysregulated liver lipid metabolism and inflammation are two crucial mechanisms involved in NAFLD development, although the transcription network and the related epigenome remodeling events remain largely unclarified. (ki.se)

He also said the Press Council Act should be amended in a way that would protect the dignity of the citizens and said the media should be regulated. (ft.lk)
The said IBF has set up a Broadcasting Content Complaints Council (BCCC) as a self-regulatory mechanism to examine the complaints relating to content being telecast in this category of broadcasters. (lawtrend.in)

A new study conducted for the Mercatus Center at George Mason University shows that reputational feedback mechanisms-buyers' and sellers' abilities to rate one another and share information about their interactions-can help correct these information deficiencies better than traditional regulatory approaches. (mercatus.org)
Mechanisms of rice protein hydrolysate regulating the in vitro digestibility of rice starch under extrusion treatment in terms of structure, physicochemical properties and interactions. (bvsalud.org)

and (3) frequency-dependent inhibition of the second spike that is relatively independent of first spike amplitude and probably due to a combination of feedforward and feedback mechanisms. (nih.gov)
The combination of feedforward and feedback mechanisms results in strong, maximal duration, granule cell inhibition. (nih.gov)

We subsequently discuss how β-TCP can regulate osteogenic processes to aid bone repair/healing, namely osteogenic differentiation of mesenchymal stem cells, formation of blood vessels, release of angiogenic growth factors, and blood clot formation. (frontiersin.org)
Some extend regulated cell death can be considered an extreme form of cell differentiation that happens when cells fails to perform their normal intracellular routines. (hstalks.com)
Cells can therefore regulate the length of the flagellum either by changing the growth rate or by changing the time when locking is applied. (pasteur.fr)
Here, we investigated the mechanism of MWCNT- and asbestos-induced OPN/CD44 using in vitro model, Raw 264 cells. (cdc.gov)

However, underlying mechanisms are incompletely understood, particularly in fungal species. (lu.se)

The genetic switch, which handles the erythroid-myeloid lineage decision, is an example of a network that implements both a primed and a committed state by regulating cooperativity through recruitment of cofactors. (lu.se)

Summertime activity, whether on the playing field or the construction site, must be balanced with measures that aid the body's cooling mechanisms and prevent heat-related illness. (cdc.gov)

Akerlof is correct that human nature can produce suboptimal behavior in the absence of effective and efficient mechanisms to induce cooperation among buyers and sellers. (mercatus.org)

Based on the simulation results and the implementation of systems such as the Danish VETSTAT (a detailed accounting of farmers' antibiotic use), we anticipate that the proposed mechanism can be effectively used in the future. (ku.dk)
I examine the practice of EU states allocating responsibilities in the internal and external dimensions of EU asylum policy, and I consider jurisprudential developments concerning the interpretation and implementation of relevant EU mechanisms (the Dublin system, relocation, and safe third country rules). (lu.se)

Our anti-ZBTB18 helps to understand the mechanisms regulating metastasis. (atlasantibodies.com)

Our ongoing efforts attempt to validate these candidates and to explore their mechanism of action through a variety of methodologies, including tissue-specific mouse models and next-generation sequencing approaches. (ki.se)

These results enhanced comprehension of how PRHs regulate starch digestibility under extrusion, and offer direction for producing slow-digesting foods . (bvsalud.org)

MP Uddika Premarathna said that the standards of the language used for news should be investigated whilst pointing out that a mechanism should be implemented in that regard. (ft.lk)

You will also provide a molecular description of the major mechanisms regulating cell death in all their forms. (hstalks.com)
Part 1, molecular overview of the main mechanisms of regulated cell death. (hstalks.com)
In contrast to accidental cell death, regulated cell death depends on highly controlled genetic programs and disrupt a specific subcellular functions in a control manner. (hstalks.com)

Their capacity to originate any type of tissue is greater at that stage," said Rodrigo Alexandre Panepucci ( https://bv.fapesp.br/en/pesquisador/57383/rodrigo-alexandre-panepucci/ ), a researcher at the Ribeirão Preto Blood Center and principal investigator of the study. (eurekalert.org)

Institut Pasteur scientists have tried to unravel the mechanisms controlling the length of the appendages in the hope of improving diagnosis of these complex medical conditions and perhaps developing new therapeutic approaches. (pasteur.fr)
The mechanism of Chinese medicine is complex and systematic. (springer.com)

Their study is reported in article published in the journal Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms . (fapesp.br)
In this article, we customize and suggest an efficient and incentive‐compatible regulatory instrument for antibiotic use based on the Montero auction mechanism (2008). (ku.dk)

Here, we show that Cryptococcus neoformans heat shock factor 3 (CnHsf3) exhibits an atypical function in regulating mtROS independent of the unfolded protein response. (lu.se)

Minister of Education Prof. G.L. Peiris said that a new law has been passed in Singapore to control such matters and having studied such, the formulation of a new mechanism should be done. (ft.lk)

Modern reputational feedback mechanisms are becoming more sophisticated and, in the process, are offering consumers a louder voice in transactions and improving trust between strangers. (mercatus.org)

We analytically and empirically demonstrate that the proposed auction mechanism is welfare improving as compared to current regulations. (ku.dk)

Equally important are the innovative experimental systems that have emerged to interrogate molecular mechanisms underlying those effects. (mdpi.com)
As a traditional Chinese medicine, Rhizoma coptidis has excellent therapeutic effects on various diseases, but the underlying systematic molecular mechanisms are still far from being fully elucidated. (springer.com)

Genes9

Transcriptional4

Protein regulates2

Negatively regulates1

Homeostasis4

Novel Mechanism2

Proteins3

Cytoskeleton1

Molecular mechanism3

Angiogenesis1

Neuronal3

Oxidative3

MTORC12

Embryonic2

20181

Macrophage1

Gene expression2

Regulation7

Obesity1

Pathways1

Neurons1

Expression2

Proliferation2

Researchers3

Neurological1

Crucial1

Council2

Interactions2

Inhibition2

Cells4

Understood1

Recruitment1

Activity1

Cooperation1

Implementation2

Helps1

Explore1

Results1

News1

Cell death3

Https1

Complex2

Article2

Function1

Control1

Feedback1

Regulations1

Effects2