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  • chemically
  • Penicillin G benzathine is prepared by the reaction of dibenzylethylene diamine with two molecules of penicillin G. It is chemically designated as (2S, 5R, 6R )-3,3-Dimethyl-7-oxo-6(2-phenylacetamido)-4-thia-1-azabicyclo[3.2.eptane-2-carboxylic acid compound with N,N' dibenzylethylenediamine (2:1), tetrahydrate. (rxlist.com)
  • suspension
  • Bicillin L-A (penicillin G benzathine injectable suspension) is available for deep intramuscular injection. (rxlist.com)
  • Bicillin L-A contains penicillin G benzathine in aqueous suspension with sodium citrate buffer and, as w/v, approximately 0.5% lecithin, 0.6% carboxymethylcellulose, 0.6% povidone, 0.1% methylparaben, and 0.01% propylparaben. (rxlist.com)
  • effective
  • Rheumatic fever and/or chorea- Prophylaxis with penicillin G benzathine has proven effective in preventing recurrence of these conditions. (rxlist.com)
  • vancomycin
  • Vancomycin and ristocetin are shown to inhibit the hydrolysis of sensitive peptides by the Streptomyces albus G D-alanyl-D carboxypeptidase and the mechanism of inhibition is discussed. (ac.be)
  • Benzathine
  • According to the U.S. Centers for Disease Control and Prevention (CDC) 2006 guidelines, the recommended treatment for uncomplicated, early syphilis in adults is penicillin G benzathine administered intramuscularly (i.m.) as a single dose of 2.4 million units (MU) ( 4 ). (asm.org)
  • Because there are no proven alternatives to penicillin for treatment of infected pregnant women, those who are penicillin allergic should be desensitized and then treated with penicillin G benzathine. (asm.org)
  • Bicillin L-A (penicillin G benzathine injectable suspension) is available for deep intramuscular injection. (rxlist.com)
  • Penicillin G benzathine is prepared by the reaction of dibenzylethylene diamine with two molecules of penicillin G. It is chemically designated as (2S, 5R, 6R )-3,3-Dimethyl-7-oxo-6(2-phenylacetamido)-4-thia-1-azabicyclo[3.2.eptane-2-carboxylic acid compound with N,N' dibenzylethylenediamine (2:1), tetrahydrate. (rxlist.com)
  • Bicillin L-A contains penicillin G benzathine in aqueous suspension with sodium citrate buffer and, as w/v, approximately 0.5% lecithin, 0.6% carboxymethylcellulose, 0.6% povidone, 0.1% methylparaben, and 0.01% propylparaben. (rxlist.com)
  • Intramuscular penicillin G benzathine is indicated in the treatment of infections due to penicillin-G-sensitive microorganisms that are susceptible to the low and very prolonged serum levels common to this particular dosage form. (rxlist.com)
  • Rheumatic fever and/or chorea- Prophylaxis with penicillin G benzathine has proven effective in preventing recurrence of these conditions. (rxlist.com)
  • synthesis
  • Wise EMJ, Park JT (1965) Penicillin: its basic site of action as an inhibitor of a peptide cross-linking reaction in the cell wall mucopeptide synthesis. (springer.com)
  • serine
  • en] The monofunctional penicillin-binding DD-peptidases and penicillin-hydrolyzing serine beta-lactamases diverged from a common ancestor by the acquisition of structural changes in the polypeptide chain while retaining the same folding, three-motif amino acid sequence signature, serine-assisted catalytic mechanism, and active-site topology. (ac.be)
  • Recombination
  • Perhaps more importantly, the findings provide evidence that the mechanism of genetic change in S. pneumoniae is primarily not through acquisition of point mutations but more often 88 percent of the time through genetic recombination. (bio-medicine.org)
  • carboxypeptidases
  • Rasmussen JR, Strominger JL (1978) Utilization of a depsipeptide substrate for trapping acyl-enzyme intermediates of penicillin-sensitive D-alanine carboxypeptidases. (springer.com)
  • genes
  • Moreover, non-PBP genes have been discovered that contribute to resistance. (springer.com)
  • Erythromycin resistance genes ( mefA , ermB , ermTR ) were detected by PCR. (alliedacademies.org)
  • Thus, the present study was aimed to determine the distribution of erythromycin ( mefA , ermB , ermTR ) resistance genes among VGS isolated from blood samples of endocarditis and plaque samples of periodontitis population. (alliedacademies.org)
  • antibacterial
  • Concerns about the rising rates of antibacterial resistance and the growing costs of antibacterial prescriptions have focused the attention of the medical community and the general public on the need for judicious use of antibacterial agents. (aappublications.org)