• The present study explored the effect of NAC on LPS‑induced apoptosis of HUVECs and determined the participation of the p38 mitogen‑activated protein kinase (MAPK) pathway in the process of apoptosis. (spandidos-publications.com)
  • A potential mechanism for the role of calcium in prostate cancer development and progression is that intracellular calcium controls the growth of prostate cancer cells and the process of apoptosis (9). (cdc.gov)
  • the process of apoptosis and necrosis. (who.int)
  • There was also no translocation of apoptosis-inducing factor (AIF) from mitochondria to the nucleus in apoptotic keratinocytes, indicating Tan IIA-induced apoptosis occurs mainly through the caspase pathway. (hindawi.com)
  • Protein and gene expression of apoptotic signaling pathway-related proteins such as caspase-3, cytochrome c, and PARP were determined to provide evidence for the mechanisms of action of Tan IIA in the treatment of psoriasis. (hindawi.com)
  • These include regulation of cell cycle, activation of mitochondrial pathway, induction of mitochondrial outer membrane permeabilization, induction of apoptosis, modulation of oxidative stress, amelioration of inflammation, modulation of insulin signaling and inhibition of angiogenesis. (mdpi.com)
  • implying that NQO1 pathway may not be the main target for genistein-induced apoptosis in PC3 cells. (biomedcentral.com)
  • Some, but not all, of the developmental effects of glucocorticoids on eosinophils could be accounted for their ability to prevent generation of nitric oxide through inducible NO synthase, which leads to apoptosis through the CD95-CD95L pathway. (fiocruz.br)
  • Conclusion lncRNA NEAT1 targets to down-regulate the expression of miR-29b-3p and block the TLR4/NF-κB signaling pathway to inhibit the apoptosis of hippocampal neurons in epilepsy models. (magtech.com.cn)
  • 4] Xiang Y, Zhang Y, Xia Y,et al.LncRNA MEG3 targeting miR-424-5p via MAPK signaling pathway mediates neuronal apoptosis in ischemic stroke[J].Aging (Albany NY),2020, 12(4):3156-3174. (magtech.com.cn)
  • Eldadah and Faden, 2000 ), we hypothesized that suppression of apoptotic capability during maturation of mammalian brain results from repression of genes involved in the caspase-3 activation pathway, and that injury-induced neuronal apoptosis in the mature brain results from reactivation of these genes. (jneurosci.org)
  • In the present study, we evaluated the role of the intrinsic pathway in neuronal apoptosis at different stages of rat brain development and during maturation of primary cortical neurons in vivo as well as in response to brain injury. (jneurosci.org)
  • PYM might induce HUVEC apoptosis through the endoplasmic reticulum stress pathway. (geneticsmr.com)
  • The results suggest that remifentanil postconditioning exhibits neuroprotective effects against global cerebral ischemia/reperfusion injury in rats, and its mechanisms might involve inhibition of neuronal apoptosis through the PI3K pathway. (springer.com)
  • Yuan Y, Guo Q, Ye Z et al (2011) Ischemic postconditioning protects brain from ischemia/reperfusion injury by attenuating endoplasmic reticulum stress-induced apoptosis through PI3K-Akt pathway. (springer.com)
  • however, the study of ultrafine Pt NCs is at the beginning stage and there are still plenty of challenges like synthesis of near-infrared (NIR) fluorescent Pt NCs, the explicit signal pathway of cell apoptosis, and attempt in diverse biological applications that need to be urgently tackled in future. (hindawi.com)
  • Overall, the findings suggested that S/V could downregulate the expression of MALAT1, inhibit inflammation and apoptosis and improve endothelial function in ox‑LDL‑induced HUVECs via inactivating the TLR4/NF‑κB signaling pathway. (spandidos-publications.com)
  • The death receptor pathway plays an important role in cell apoptosis ( 12 ). (spandidos-publications.com)
  • The mitochondrial pathway is also referred to as the endogenous apoptosis pathway ( 15 ). (spandidos-publications.com)
  • Therefore, based on clinical experience as well as cytotoxic activity against multiple human cancer cells, we hypothesized that induction of apoptosis is the underlying mechanism for the treatment of psoriasis. (hindawi.com)
  • Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine, whose numerous cell and tissue activities include cell-cycle control, the regulation of early development, differentiation, extracellular matrix formation, hematopoesis, angiogenesis, chemotaxis, immune functions, and the induction of apoptosis. (nih.gov)
  • Many studies have described an interaction of TGF-beta with other signaling cascades as exemplified by the requirement of AP1 transcription factor for the induction of apoptosis in liver cells. (nih.gov)
  • Several modes of apoptosis induction and responsible viral genes have been proposed ( 8 - 13 ). (cdc.gov)
  • Discover pathways on apoptosis induction, caspase activation and phagocytosis of apoptotic cells. (abcam.com)
  • In this Review, we discuss the multiple molecular mechanisms of p53 regulation and how they modulate the induction of apoptosis or cell cycle arrest following DNA damage. (nih.gov)
  • The recognition of blood-borne inflammatory and immune cells inside the atheroma, led us to postulate the involvement of an immune-inflammatory mechanism in atherogenesis, from plaque formation to the induction of its complication (1). (rawveronica.com)
  • Induction of macrophage apoptosis by BPs in vivo may also account, at least in part, for the anti-inflammatory properties of BPs as well as the ability of BPs to cause an acute phase response. (elsevierpure.com)
  • Mohanty C, Fayad W, Olofsson MH, Larsson R, De Milito A, Fryknäs M and Linder ST. Massive induction of apoptosis of multicellular tumor spheroids by a novel compound with a calmodulin inhibitor-like mechanism . (hoajonline.com)
  • Tan IIA inhibited proliferation of mouse keratinocytes in a dose- and time-dependent manner and induced apoptosis, resulting in S phase arrest accompanied by down-regulation of pCdk2 and cyclin A protein expression. (hindawi.com)
  • The article also underscores the various possible mechanisms by which honey may inhibit growth and proliferation of tumors or cancers. (mdpi.com)
  • A vast amount of research exists on the possible molecular mechanisms through which vitamin D affects cancer cell proliferation, cancer progression, angiogenesis, and inflammation. (mdpi.com)
  • They also noted that the characteristic structural changes of apoptosis were present in cells that died in order to maintain an equilibrium between cell proliferation and death in a particular tissue. (wikipedia.org)
  • A hypoxic cell model prepared with CoCl 2 was developed to detect the effect of hypoxia on the proliferation and apoptosis of renal stem cells. (bjbms.org)
  • The effect and molecular mechanism of hypoxia-inducible factor 1-alpha (HIF-1α) on the proliferation and apoptosis of renal stem cells were also explored. (bjbms.org)
  • Both hypoxia and HIF-1α significantly promoted the proliferation of renal stem cells and inhibited cell apoptosis. (bjbms.org)
  • Liu H, Liu C, Qu Y. The effect and molecular mechanism of hypoxia on proliferation and apoptosis of CD133+ renal stem cells. (bjbms.org)
  • PYM could obviously inhibit the proliferation and promote the apoptosis of HUVEC. (geneticsmr.com)
  • Correlation between TRAIL and caspase-8 expression and their relationship with cell proliferation and apoptosis in human osteosarcoma. (geneticsmr.com)
  • JAM3 knockdown additionally inhibited trophoblast proliferation and increased the number of trophoblasts in the sub-G1 and G2/M phases, indicating cell-cycle disturbance and apoptosis. (bioone.org)
  • Although they cannot encode proteins, they are involved in many biological processes as regulators, such as proliferation, apoptosis, migration and invasion ( 9 ). (spandidos-publications.com)
  • Specify the components and their interactions and set up cluding proliferation, differentiation, apoptosis, embryonic the system of equations. (lu.se)
  • Furthermore, Tan IIA-induced apoptosis and mitochondrial membrane potential changes were also further demonstrated by DNA fragmentation, single-cell gel electrophoresis assay (SCGE), and flow cytometry methods. (hindawi.com)
  • Mitochondrial regulation of apoptosis further downstream was investigated, showing changes in the mitochondrial membrane potential, cytochrome c release into the cytoplasm, and enhanced activation of cleaved caspase-3 and Poly ADP-ribose polymerase (PARP). (hindawi.com)
  • Hepatitis B virus X protein modulates apoptosis in primary rat hepatocytes by regulating both NF-kappaB and the mitochondrial permeability transition pore[J]. J Virol, 2009, 83(10):4718-4731. (zgddek.com)
  • Accumulated intracellular ROS, decreased mitochondrial membrane potential ( MMP ), activated metacaspase activity and condensed chromatin , were induced by surfactin in F. graminearum hyphae , suggesting that growth inhibition of fungus is mainly caused by apoptosis -like cell death . (bvsalud.org)
  • Collectively, this study provides evidence that surfactin induces a ROS-mediated mitochondrial apoptosis in F. graminearum hyphae , and may exert its antifungal activity against F. graminearum by activating apoptosis . (bvsalud.org)
  • BAP +/− fibroblasts exhibited reduced IP3R3 protein levels, decreased mitochondrial Ca 2+ uptake, and reduced apoptosis compared to wild-type fibroblasts. (aacrjournals.org)
  • Although these cells accumulated increased DNA damage, they could not execute apoptosis due to reduced mitochondrial Ca 2+ . (aacrjournals.org)
  • Taken together, these studies elucidate mechanisms by which BAP1 or PTEN stabilize IP3R3 to promote mitochondrial Ca 2+ overload and apoptosis, thereby limiting tumor growth. (aacrjournals.org)
  • Using an apoptosis-specific enzyme-linked immunosorbent assay, we showed that Acanthamoeba induces programmed cell death in brain microvascular endothelial cells. (asm.org)
  • Mechanism of pingyangmycin-induced apoptosis of cultured human umbilical vein endothelial cells. (geneticsmr.com)
  • In this study, we investigated the effects of pingyangmycin (PYM) on the growth inhibition and apoptosis of human umbilical vein endothelial cells (HUVEC). (geneticsmr.com)
  • The present study aimed to investigate the effects of S/V on the expression of metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1), inflammation and apoptosis in human umbilical vein endothelial cells (HUVECs) induced by oxidized low‑density lipoprotein (ox‑LDL) and to elucidate its possible mechanism. (spandidos-publications.com)
  • However, the effects of NAC on LPS‑induced apoptosis of human umbilical vein endothelial cells (HUVECs) and the associated mechanisms are not well characterized. (spandidos-publications.com)
  • However, few studies have investigated LPS-induced apoptosis of vascular endothelial cells. (spandidos-publications.com)
  • The apoptosis of endothelial cells is a key event that may impair the integrity of the vessel wall and lead to the formation of atherosclerotic plaques ( 9 ). (spandidos-publications.com)
  • The aim of the present investigation was to elucidate the cellular mechanisms whereby Tanshinone IIA (Tan IIA) leads to cell cycle arrest and apoptosis in vitro in keratinocytes, the target cells in psoriasis. (hindawi.com)
  • PS >PI) accompanied macrophage apoptosis in vitro. (cdc.gov)
  • The aim of this review is (1) to summarize and classify data in the TGF-beta apoptosis literature with respect to the affected cell types, (2) to provide insights into the intracellular mechanisms involved in TGF-beta-mediated apoptosis, and (3) to set TGF-beta-mediated apoptosis in a physiological context. (nih.gov)
  • Work across many laboratories is geared toward elucidating the genetics behind cancer, discovering cellular mechanisms that lead to cancer, and elucidating intracellular and intercellular interactions that allow this progression. (medscape.com)
  • The molecular mechanism(s) and intracellular mediators of both spontaneous-and treatment-induced apoptosis are not fully elucidated. (biomedcentral.com)
  • However, the host intracellular signaling pathways and the molecular mechanisms associated with Acanthamoeba -mediated HBMEC cytotoxicity have not been determined. (asm.org)
  • Surfactin inhibits Fusarium graminearum by accumulating intracellular ROS and inducing apoptosis mechanisms. (bvsalud.org)
  • Furthermore, accumulated intracellular ROS was evidenced to act as a key mediator of surfactin-induced apoptosis . (bvsalud.org)
  • TGF-beta-mediated growth inhibition and apoptosis can be correlated with its function as a tumor suppressor. (nih.gov)
  • After 48 hours of intervention under different experimental conditions, flow cytometry was used to measure the apoptosis of MPC5 cells, and quantitative real-time PCR and Western blot were used to measure the mRNA and protein expression of slit diaphragm-related proteins (nephrin, CD2AP, and synaptopodin) and the cytoskeleton-related protein transient receptor potential cation channel 6 (TRPC6). (zgddek.com)
  • RNA-Seq, Western blotting, qRT-PCR and flow cytometry were used to identify the underlying molecular mechanisms. (lu.se)
  • The rate of apoptosis was determined using flow cytometry. (spandidos-publications.com)
  • In a signal article published in 1972, John F. Kerr, Andrew H. Wyllie and A. R. Currie, coined the term "apoptosis" in order to differentiate naturally occurring developmental cell death, from the necrosis that results from acute tissue injury. (wikipedia.org)
  • This study helped to determine the proper concentration of PYM to induce more apoptosis than necrosis, which is critical to minimize inflammation, enhance the healing of the skin, and maintain safety for the patient. (geneticsmr.com)
  • In this review, we studied on the effects and molecular mechanisms of Rhizoma coptidis on NF-κB/MAPK/PI3K-Akt/AMPK/ERS and oxidative stress pathways. (springer.com)
  • With the development of research, the currently recognized mechanisms include lipid metabolism disorder, inflammatory response, oxidative stress and so on ( 3 , 4 ). (spandidos-publications.com)
  • Oxidative lipidomics of macrophage activation and apoptosis induced by phagocytosis of particles and pathogens. (cdc.gov)
  • The molecular mechanisms involved in these processes seem to involve the activation of SMAD proteins. (nih.gov)
  • In this Commentary, we discuss the implications of these findings for the regulation of apoptosis by Bcl-2 family proteins. (biologists.com)
  • Our resources and products to study apoptosis include apoptosis kits and antibodies to key proteins such as caspases and the Bcl-2 family. (abcam.com)
  • Among other important work at Horvitz's laboratory, graduate students Hilary Ellis and Chand Desai had made the first discovery of genes that encode apoptosis-inducing proteins: ced-3 and ced-4. (wikipedia.org)
  • Results MPC5 cells transfected by pEX-HBx had the highest expression of HBx mRNA at 48 hours after transfection (P P P P Conclusions INF-α can inhibit the apoptosis of podocytes induced by HBx, possibly through improving the abnormal expression of slit diaphragm-related proteins (CD2AP, nephrin, and synaptopodin) and cytoskeleton-related protein (TRPC6) induced by HBx. (zgddek.com)
  • 17] Raghav PK,Kumar R,Kumar V,et al.Docking-based approach for identification of mutations that disrupt binding between Bcl-2 and Bax proteins:Inducing apoptosis in cancer cells[J].Mol Genet Genomic Med,2019,7(11):e910-e925. (magtech.com.cn)
  • Annexin V-FITC/propidium iodide stain was used to detect apoptosis, and western blot was used to detect the expression of glucose-related protein 78 (GPR78) and C/EBP homologous protein (CHOP) endoplasmic reticulum stress proteins. (geneticsmr.com)
  • Several molecular mechanisms with antifungal agents have been reported for C. albicans where insertions, deletions, and point mutations in genes codifying target proteins are frequently related to the antifungal drug resistance. (intechopen.com)
  • Related studies identified two tumor suppressor proteins, BAP1 and PTEN, that promote IP3R3-mediated Ca 2+ flux to promote apoptosis and suppress oncogenic transformation. (aacrjournals.org)
  • A series of caspases proteins have been shown to be activated by the death induced signal complex [a form of death ligand that binds to the corresponding death receptor on the cell surface ( 13 )], which in turn induces apoptosis. (spandidos-publications.com)
  • Moreover, we showed that Acanthamoeba produces severe HBMEC cytotoxicity by secreting extracellular proteases, as well as using contact-dependent mechanisms such as phagocytosis ( 12 ), which may play an important role in blood-brain barrier perturbations. (asm.org)
  • Then, we will discuss several principles that govern macrophage phagocytosis of apoptotic cells (efferocytosis), including the existence of redundant recognition mechanisms ("find-me" and "eat-me") that lead to a tight coupling between apoptosis and phagocytosis. (frontiersin.org)
  • However, the mechanisms of apoptosis and its links with phagocytosis are largely unknown. (cdc.gov)
  • We conclude that anionic phospholipid-mediated signaling may participate in phagocytosis induced macrophage apoptosis. (cdc.gov)
  • Effect and mechanism of long non-coding RNAnuclear-enriched abundant transcript 1 on hippocampal neuronal apoptosis in epilepsy model[J]. Chinese Journal of Child Health Care, 2021, 29(11): 1193-1197. (magtech.com.cn)
  • 11] He C, Su C, Zhang W, et al.Modulatory Potential of LncRNA Zfas1 forinflammation and neuronal apoptosis in temporal lobe epilepsy[J].Yonsei Med J,2021, 62(3):215-223. (magtech.com.cn)
  • Neuronal apoptosis plays an essential role in early brain development and contributes to secondary neuronal loss after acute brain injury. (jneurosci.org)
  • Recent studies have provided evidence that neuronal susceptibility to apoptosis induced by traumatic or ischemic injury decreases during brain development. (jneurosci.org)
  • However, the molecular mechanisms underlying such age-dependent differences in apoptotic response to neuronal injury have not been identified. (jneurosci.org)
  • Apoptosis is one of the major mechanisms that lead to neuronal death after cerebral ischemia and reperfusion. (springer.com)
  • We found remifentanil postconditioning markedly improved the spatial learning and memory as well as attenuated neuronal apoptosis in hippocampus caused by cerebral ischemia/reperfusion injury. (springer.com)
  • Morphological and biochemical features that are definitive of apoptosis (chromatin condensation, nuclear fragmentation, and endonuclease-mediated internucleosomal cleavage of DNA) could be identified in mouse macrophage-like J774 and RAW264 cells, following treatment with 100 microM pamidronate, alendronate, and ibandronate for 24 h or more. (elsevierpure.com)
  • Apoptosis was partially blocked by the caspase-3 inhibitor Ac-DEVD-CHO. (hindawi.com)
  • Broad-spectrum caspase inhibitor Z-VAD-FMK treatment indicated that surfactin induces caspase -independent apoptosis in F. graminearum. (bvsalud.org)
  • AA005 induces a unique type of cell death in colorectal adenocarcinoma cells, characterized by lack of caspase-3 activation or apoptotic body formation, sensitivity to poly (ADP-ribose) polymerase inhibitor Olaparib (AZD2281) but not pan-caspase inhibitor Z-VAD.fmk, and dependence on apoptosis-inducing factor (AIF). (biomedcentral.com)
  • The adenoviral protein E3-14.7K (14.7K) is an inhibitor of TNF-induced apoptosis, but the molecular mechanism underlying this protective effect has not yet been explained exhaustively. (jci.org)
  • The results of CCK‑8 and flow cytometric analyses showed that pretreatment of HUVECs with NAC or p38MAPK inhibitor (SB203580) attenuated LPS‑induced decrease in cell viability and increase in cell apoptosis. (spandidos-publications.com)
  • The importance of TGF-beta in the control of liver cell apoptosis and cell death of prostate epithelial cells has been confirmed in many studies. (nih.gov)
  • Apoptosis was observed in alveolar epithelial cells, which is the major target cell type for the viral replication. (cdc.gov)
  • Our data suggest that apoptosis may play a major role in the pathogenesis of influenza (H5N1) virus in humans by destroying alveolar epithelial cells. (cdc.gov)
  • Several years later, Kerr and co-workers 2 defined the morphological changes in cells undergoing this process, also known as apoptosis. (nature.com)
  • The objective of the current studies was to examine the role of caspase 3 (CPP32) and NAD(P)H:quinone oxidoreductase (NQO1) in the signaling of genistein-and β-lapachone (bLap)-induced apoptosis in human prostate carcinoma cells PC3. (biomedcentral.com)
  • Taken together, this study clarified the effect of age on the content of human renal stem cells and determined the regulatory mechanism of hypoxia on renal stem cells. (bjbms.org)
  • However, the mechanism of renal stem cells in the repair of acute kidney impairment remains unclear. (bjbms.org)
  • Renal stem cells inhibited apoptosis and improved damaged local microenvironment through intrinsic paracrine effects, thereby contributing to the repair and regeneration of renal tissue injury. (bjbms.org)
  • Nearly half of neural cells die by apoptosis during brain development. (jneurosci.org)
  • A chemical library was used to screen for compounds capable of reducing viability and inducing apoptosis of colon carcinoma cells grown as multicellular spheroids. (hoajonline.com)
  • Interestingly, quiescent cells in spheroid cores were resistant to NSC647889-induced apoptosis and appeared to die by other mechanisms. (hoajonline.com)
  • We also found that viable NK reg cells may be isolated by sorting on CD56 + and CD16 - NK cells, and this population can suppress allogeneic CD4 + T cells, but not T reg cells or CD8+ T cells through a non-cytolytic, cell-cell contact dependent mechanism. (haematologica.org)
  • With further investigation we may decipher the mechanism of NK reg suppression and operationalize expansion of NK reg cells associated with cGvHD suppression. (haematologica.org)
  • The importance of apoptosis is exemplified by the vertebrate adaptive immune system, in which B lymphocytes, as they differentiate from their precursor cells, rearrange the DNA of immunoglobulin genes to generate a vast number of potential antibodies. (the-scientist.com)
  • 14.7K protects NIH 3T3 cells from TNF-induced apoptosis. (jci.org)
  • FBXL2 depletion increased Ca 2+ release from the ER and sensitized cells to apoptosis. (aacrjournals.org)
  • We previously found that carbamate pesticides induced significant apoptosis in human natural killer cells. (researchgate.net)
  • Apoptosis refers to the self-regulated and orderly death of cells controlled by genes in order to maintain the stability of internal environment ( 8 ). (spandidos-publications.com)
  • In other cells, apoptosis may be augmented, increasing cell death and thus worsening organ function. (msdmanuals.com)
  • Despite the tremendous progress that has been made in the therapeutic use of Tan IIA, the molecular mechanism(s) involved in the treatment of psoriasis remain(s) unresolved. (hindawi.com)
  • Researchers led by Dr Luke Clifton at the Science and Technology Facilities Council (STFC) ISIS Neutron and Muon Source (ISIS) in Oxfordshire and including partners from the University of Umea and European Spallation Source in Sweden, have been able to characterise the molecular mechanism of the early stages of programmed cell death (apoptosis) a process which plays a crucial role in the prevention of cancer. (labmate-online.com)
  • The finding builds on previous studies by the team on the molecular mechanism of membrane-bound Bcl-2 to inform a full understanding of the early stages of apoptosis. (labmate-online.com)
  • Abstract Objective To investigate the effect and molecular mechanism of interferon-α (INF-α) on the apoptosis of the mouse podocyte cell line MPC5 induced by hepatitis B virus X (HBx) protein. (zgddek.com)
  • To investigate the mechanisms of retinal iron regulation, the lab uses conditional knockout mouse models, human retinal tissue, and retinal cell tissue culture. (upenn.edu)
  • 1)Study mechanisms of retinal iron regulation by performing histology and immunofluorescence on retinal sections from conditional knockout mice. (upenn.edu)
  • Apoptosis is a mechanism of programmed cell death that occurs in multicellular organisms. (abcam.com)
  • Apoptosis is the process of programmed cell death. (wikipedia.org)
  • However, although bcl-2 was the first component of the cell death mechanism to be cloned in any organism, identification of other components of the vertebrate mechanism had to await the linking of apoptosis with the mechanism for programmed cell death in the worm. (wikipedia.org)
  • In 1992, it was shown by David Vaux and Stuart Kim at Stanford that human bcl-2 gene could inhibit programmed cell death in the worm, thus linking programmed cell death and apoptosis - revealing them to be the same, evolutionarily conserved process. (wikipedia.org)
  • Both genistein and bLap produced dose-dependent growth inhibition and treatment-induced apoptosis in PC3. (biomedcentral.com)
  • Ding ZM, Wu B, Zhang WQ et al (2012) Neuroprotective Effects of Ischemic Preconditioning and Postconditioning on Global Brain Ischemia in Rats through the same effect on inhibition of apoptosis. (springer.com)
  • The results demonstrated that NAC pretreatment alleviated LPS‑induced apoptosis and inhibition of NO production in HUVECs. (spandidos-publications.com)
  • Infection with virulent influenza (H5N1) virus was also shown to induce lymphopenia and lymphocyte apoptosis in vivo ( 14 ). (cdc.gov)
  • Objective To investigate the effect and mechanism of long non-coding RNA (lncRNA) nuclear-enriched abundant transcript 1(NEAT1)on hippocampal neuron apoptosis in epilepsy cell model, in order to provide evidence for NEAT1 being the new target of epilepsy treatment. (magtech.com.cn)
  • Data from cell-culture experiments and in vivo studies argue for a pivotal role of TGF-beta-mediated apoptosis in the maintenance of B- and T-cell homeostasis. (nih.gov)
  • COYA 301 is a proprietary investigational recombinant human low dose IL-2 biologic for subcutaneous administration intended to enhance Treg function and expand Treg numbers in vivo, and COYA 302 is a dual-mechanism investigational biologic combination comprised of proprietary low dose IL-2 and CTLA-4 Ig. (businesswire.com)
  • This review explores evolving knowledge of the immunopathogenic mechanisms, pharmacogenomic associations, in vivo and ex vivo diagnostics for causality assessment, and medication cross-reactivity data related to SCAR syndromes. (medscape.com)
  • [ 4 ] The aim of this article is to provide a complementary review of emerging immunopathogenic mechanisms, established pharmacogenomic associations, in vivo and ex vivo causality assessment tools and medication cross-reactivity data related to SCAR syndromes. (medscape.com)
  • TNF-mediated apoptosis is initiated by ligand-induced recruitment of TNF receptor-associated death domain (TRADD), Fas-associated death domain (FADD), and caspase-8 to the death domain of TNF receptor 1 (TNFR1), thereby establishing the death-inducing signaling complex (DISC). (jci.org)
  • Inactivation of TGF-beta in animal models via a knockout approach or neutralizing antibodies suggests that TGF-beta-mediated apoptosis plays an important part during tissue formation and remodeling and during the phase of ontogenetic neuron death. (nih.gov)
  • From the lung, some fibers can migrate into the pleural space by different mechanisms [National Academy of Sciences, 2006]. (cdc.gov)
  • In the second part, we will compare the mechanisms that mediate recognition and engulfment and their epigenetic, transcriptional, metabolic, and immunological consequences. (frontiersin.org)
  • Since macrophages, like osteoclasts, are particularly susceptible to BPs, these observations support the recent suggestion that the mechanism by which BPs inhibit bone resorption may involve osteoclast apoptosis. (elsevierpure.com)
  • Mechanisms may involve decreased circulating volume, decreased cardiac output, and vasodilation, sometimes with shunting of blood to bypass capillary exchange beds. (msdmanuals.com)
  • Environmental factors that can detect specific IgE antibodies against most low-molecular- affect the initiation of occupational asthma include the intrinsic weight agents has resulted in a search for alternative or characteristics of causative agents as well as the influence of the complementary physiopathologic mechanisms leading to airway level and route of exposure at the workplace. (cdc.gov)