• Written in terms of differential-algebraic equations, the new sub-model allows to enhance existing Hill-type excitation-contraction models in a straightforward way. (frontiersin.org)
  • describe neural, endothelial and pharmacological mediation of excitation-contraction coupling in vascular smooth muscle. (manchester.ac.uk)
  • The process by which electrical signals trigger muscle contraction is called excitation-contraction (E-C) coupling. (medlineplus.gov)
  • In skeletal muscle, Dantrium dissociates excitation-contraction coupling, probably by interfering with the release of Ca 2+ from the sarcoplasmic reticulum. (druglib.com)
  • Dantrolene depresses excitation-contraction coupling in skeletal muscle by binding to the ryanodine receptor 1, and decreasing intracellular calcium concentration. (druglib.com)
  • Dantrolene sodium is a muscle relaxant that acts by abolishing excitation-contraction coupling in muscle cells, probably by action on the ryanodine receptor. (definitions.net)
  • Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. (definitions.net)
  • The phosphodiesterase 4D3 (PDE4D3) was found in the cardiac ryanodine receptor (RyR2)/calcium-release-channel complex (required for excitation-contraction [EC] coupling in heart muscle). (nih.gov)
  • Luca Fusi obtained a PhD in Physiology from the University of Florence (Italy), during which he investigated the structure-function relation of the molecular motor of skeletal muscle in situ, combining sarcomere mechanics and small-angle X-ray diffraction in single muscle fibres. (kcl.ac.uk)
  • In 2023 he was appointed as Lecturer in Muscle Physiology at the Centre for Human and Applied Physiological Sciences in the School of Basic and Medical Biosciences. (kcl.ac.uk)
  • You will study the normal physiology of the cardiovascular system and the mechanisms underlying its major pathologies such as heart failure, hypertension and stroke. (manchester.ac.uk)
  • To provide an understanding of the normal physiology of the cardiovascular system and the mechanisms underlying its major pathologies. (manchester.ac.uk)
  • The techniques that we use range from single molecule mechanics, (immuno) electron microscopy, exon microarray analysis, in vitro motility assays, low angle X-ray diffraction, cell physiology (including calcium imaging), muscle mechanics, and isolated heart physiology. (bio5.org)
  • Measured time courses of force decay during isometric contractions of rabbit M. gastrocnemius and M. plantaris were employed for model verification, with the finding that our suggested model enhancement proved eminently promising. (frontiersin.org)
  • The question to be answered is if the failure of central drive to the muscle is a responsible mechanism of fatigue induced by different activities than those involving isometric contractions. (nature.com)
  • This system describes how bones are connected to other bones and muscle fibers via connective tissue such as tendons and ligaments. (wikipedia.org)
  • Initiated by neural impulses and subsequent calcium release, skeletal muscle fibers contract (actively generate force) as a result of repetitive power strokes of acto-myosin cross-bridges. (frontiersin.org)
  • The reaction involves a high fever (hyperthermia), a rapid heart rate (tachycardia), muscle rigidity, breakdown of muscle fibers (rhabdomyolysis), and increased acid levels in the blood and other tissues (acidosis). (medlineplus.gov)
  • They also lead to decreases in muscle strength and mass and cause atrophy, especially for type II muscle fibers. (nutraceuticalsworld.com)
  • Strong contractions of longitudinal visceral muscle fibers were observed for the first 2 hours following bacterial ingestion. (sdbonline.org)
  • Accordingly, the volume of SR tubules localized around the myofibrils is strongly reduced in skeletal muscle fibers of 4- and 10-month-old sAnk1 knockout (KO) mice, while additional structural alterations only develop with aging. (mdpi.com)
  • To verify whether the lack of sAnk1 also alters intracellular Ca 2+ handling, cytosolic Ca 2+ levels were analyzed in stimulated skeletal muscle fibers from 4- and 10-month-old sAnk1 KO mice. (mdpi.com)
  • Something was apparently happening in the muscle fibers themselves, and researchers now have a good understanding of what it is. (saveourbones.com)
  • When researchers studied the muscles of mice that were put on an exercise regimen, they observed an astonishing increase in muscle cell nuclei as the muscle fibers grew. (saveourbones.com)
  • [ 1 ] The central neuroplastic changes may affect regulation of peripheral mechanisms and can lead to increased pericranial muscle activity or release of neurotransmitters in myofascial tissues. (medscape.com)
  • In 2014 he was awarded a King's Prize Fellowship to study a novel form of regulation of contractility in skeletal muscle based on the myosin filament. (kcl.ac.uk)
  • During his Fellowship he extended the study of thick filament-based regulation to cardiac muscle and he contributed to develop a novel paradigm of regulation of contractility in striated muscle. (kcl.ac.uk)
  • Current areas of interest include thin and thick filament-based regulation of contraction in human cardiac and skeletal muscle, the molecular basis of length-dependent activation in cardiac muscle, and alteration of these mechanisms in ageing and diseases. (kcl.ac.uk)
  • They also participate in the regulation of the contraction of smooth muscles, including the smooth muscles of blood vessels. (selfgrowth.com)
  • Purpose ATP could play an important role in skeletal muscle blood flow regulation by inducing vasodilation via purinergic P2 receptors. (researchgate.net)
  • For these reasons, we suggest that force and central drive to the muscle might not be key elements of neural adaptations of fatiguing repetitive movements. (nature.com)
  • The mechanism of shifting weight from one limb to another is assumed to require muscle contraction and coordination adaptations. (holistichorse.com)
  • [ 4-6 ] Although the mechanisms are poorly understood, statins have been shown to reduce muscle mitochondrial oxidative capacity and content in humans [ 7-10 ] and impair exercise-mediated mitochondrial adaptations in skeletal muscle. (medscape.com)
  • On the basis of bio-chemical kinetics, we present a model of muscle fiber exhaustion based on hydrolytic ATP-ADP-P i dynamics, which are assumed to be length- and calcium activity-dependent. (frontiersin.org)
  • We discuss implications of our model approach for enhancing muscle models in general, as well as a few aspects regarding the significance of phosphate kinetics as one contributor to muscle fatigue. (frontiersin.org)
  • Myosin binding protein-C (MyBP-C) is a muscle regulatory protein that speeds actomyosin cycling kinetics in response to adrenaline (b-adrenergic stimuli) and is one of the two most commonly affected proteins linked to HCM. (bio5.org)
  • These biological mechanisms compromise the muscle repair mechanism, alter the kinetics of muscle contraction, and compromise musculoskeletal function. (nutraceuticalsworld.com)
  • Small-angle X-ray diffraction indicated increased separation between thick and thin filaments, possibly contributing to changes in muscle kinetics. (bvsalud.org)
  • Commonly, muscle fatigue, i.e., the decline of the generable force level over time, is differentiated between central fatigue , i.e., the inability of the neural network to provide sufficient stimulation, and peripheral fatigue , i.e., the inability of the muscle cells to provide energy through metabolic activities (cf. (frontiersin.org)
  • Muscle fatigue induced by sustained contractions may develop at the muscle but also at neural levels (i.e., central fatigue) 1 . (nature.com)
  • Here's what happens: when you engage in movement of any kind, your brain communicates with your muscles along neural pathways. (saveourbones.com)
  • The musculoskeletal system refers to the system having its muscles attached to an internal skeletal system and is necessary for humans to move to a more favorable position. (wikipedia.org)
  • Researchers from the University of Helsinki and the Folkhälsan Research Center, together with their international partners, have identified the genetic background of dilated cardiomyopathy, a disease that enlarges the heart muscle, in dogs and humans. (news-medical.net)
  • The identical genetic background suggests that, to a degree, similar problems with the functioning of the heart muscle lead to dilated cardiomyopathy in both humans and dogs. (news-medical.net)
  • Rhythmic movements such as walking and swimming require the coordinated contraction of many different muscles. (elifesciences.org)
  • Rhythmic repetitive movements are also fundamental in activities of daily living and require low levels of muscle force (gait, typewriting, etc). (nature.com)
  • 20 mmHg) applied at rest and simultaneously during low- (15% maximum contraction) and moderate-intensity (30% maximum contraction) rhythmic handgrip. (researchgate.net)
  • When PDE5 is active, cGMP is degraded, causing the vascular smooth muscle contraction, thereby limiting blood flow. (nih.gov)
  • Relaxation of vascular smooth muscle in the corpus cavernosum leads to penile erection when the cavernosal sinusoids engorge with blood to compress the subtunical veins against the tunica albuginea. (nih.gov)
  • The question is if force loss and the failure of central drive to the muscle are responsible mechanisms of fatigue induced by un-resisted repetitive movements. (nature.com)
  • Our data suggest that force and central drive to the muscle are not determinants of fatigue induced by short-lasting un-resisted repetitive finger movements, even in the presence of increased inhibition of the motor cortex. (nature.com)
  • Researchers will quantify how horses adapt muscle function and limb and upper body movements to cope with lameness, providing a greater understanding of clinical signs that can guide assessment and earlier intervention. (useventing.com)
  • Researchers will use a noninvasive technique called surface electromyography (EMG) to measure and compare muscle function associated with resulting limb and upper body movements during normal equine locomotion and during unilateral forelimb and hindlimb lameness. (useventing.com)
  • DENVER/June 29, 2021 - Morris Animal Foundation is funding researchers at the University of Central Lancashire , alongside colleagues at Utrecht University and Delsys Inc., to quantify how a horse's muscles and limb movements adjust to accommodate lameness. (holistichorse.com)
  • The muscles that control breathing and neck and limb movements can also be affected. (doctorbhatia.com)
  • When you repeat the same movements over and over day after day without any variation, it can cause muscle fatigue and even nerve damage. (saveourbones.com)
  • Throughout the animal kingdom, from insects to mammals, animals possess specialized circuits of neurons that are responsible for producing these patterns of muscle contraction. (elifesciences.org)
  • The data collected from these trials were used to establish a baseline for each horse's movement and muscle activity patterns when they were clinically sound. (holistichorse.com)
  • Activity patterns at leisure are dynamic contractions of large muscle groups with relatively high intensity and low duration (often less than 1.5 hour), increasing whole body metabolism and cardiac output. (cdc.gov)
  • The circuit structure and functional imaging indicated that the commands to contract one segment promote the relaxation of the next segment, revealing a mechanism for wave propagation in peristaltic locomotion. (elifesciences.org)
  • These are one of the generative mechanisms and functional advantages derived from brain criticality. (google.com)
  • Mechanisms define the functional relationships between cause and effect within and between levels of organism organization. (reed.edu)
  • Deduce the structural and functional l roles of My-BP-C in muscle contraction, collaboration with University of Massachusetts Medical School. (iit.edu)
  • Deduce the structural and functional and structural roles of nebulin in muscle contraction and their role in nemaline myopathy, collaboration with University of Arizona/NIH. (iit.edu)
  • We know that horses alter their movement pattern when they're lame, but we don't know much about the functional changes in muscles that facilitate these changes in movement," said Dr. Lindsay St. George, Research Fellow at UCLan, and the study's primary investigator. (holistichorse.com)
  • Contracting skeletal muscle can overcome sympathetic vasoconstrictor activity (functional sympatholysis), which allows for a blood supply that matches the metabolic demand. (researchgate.net)
  • Functional sympatholysis has been identified as an underappreciated cause of poor contracting muscle perfusion (53) and may result in functional changes in exercise capacity (12). (researchgate.net)
  • Herein, we tested the hypothesis that a single high-fat Western meal would impair the ability of contracting skeletal muscle to offset vascular responsiveness to sympathetic activation during exercise, termed functional sympatholysis. (researchgate.net)
  • Weakness is loss of muscle strength, although many patients also use the term when they feel generally fatigued or have functional limitations (eg, due to pain or limited joint motion) even though muscle strength is normal. (msdmanuals.com)
  • Functional analysis showed that the muscle contraction, immune system/inflammation, and extracellular matrix pathways were the most affected pathways. (cdc.gov)
  • Dantrolene is classified as a direct-acting skeletal muscle relaxant. (druglib.com)
  • Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants. (definitions.net)
  • Here, we report on a novel circuit for the propagation of waves of muscle contraction, using the peristaltic locomotion of Drosophila larvae as a model system. (elifesciences.org)
  • For example, during axial locomotion such as lamprey swimming and Drosophila larval crawling, muscles present in each segment are sequentially activated along the body axis in a stereotypic temporal and spatial pattern ( Grillner, 2003 ). (elifesciences.org)
  • This study characterized a new mechanism of defense, independent of the immune system, in Drosophila melanogaster. (sdbonline.org)
  • St. George's team uses surface electromyography (sEMG) to quantify muscle function and 3D motion capture technology to quantify movement in horses. (holistichorse.com)
  • There is insufficient scientific evidence to conclude that wearing back belts reduces risk of injury to the back based on changes in intra-abdominal pressure (IAP) and trunk muscle electromyography (EMG). (cdc.gov)
  • In addition to central fatigue, fatigue at peripheral level also reduces muscle performance. (nature.com)
  • Peripheral polyneuropathies tend to be most noticeable in the longest nerves (ie, weakness is more prominent in the distal limb than the proximal and in legs more than arms) and produce signs of lower motor neuron dysfunction (eg, decreased reflexes and muscle tone). (msdmanuals.com)
  • His laboratory uses a combination of mechanical and structural methods, such as small-angle X-ray diffraction and fluorescence polarisation microscopy, to study the molecular mechanisms that control force generation in striated muscle at cellular and subcellular level. (kcl.ac.uk)
  • These findings provide evidence that involuntary facial expressions can evoke emotions, and suggest that the brain mechanisms involved in experiencing emotions are also used in understanding the emotional content of language. (scienceblogs.com)
  • In the anesthetic-induced malignant hyperthermia syndrome, evidence points to an intrinsic abnormality of skeletal muscle tissue. (druglib.com)
  • Our research is focused on elucidating the structure and function of titin and nebulin, two large filamentous proteins found in muscle. (bio5.org)
  • A new publication from King's researchers describes a new mechanism required for muscle contraction, which could have important implications for understanding. (kcl.ac.uk)
  • Researchers have proposed two mechanisms to explain how RYR1 gene mutations underlie muscle weakness in people with central core disease. (medlineplus.gov)
  • Researchers suspect that disruption of the RYR1 channel may play a role in the muscle weakness and other features of congenital fiber-type disproportion, although the role of RYR1 gene mutations in this condition is unclear. (medlineplus.gov)
  • The drug, a member of a class of compounds known as phosphodiesterase (PDE) type I inhibitors, shows promising effects on dog and rabbit hearts, as well as on isolated rabbit heart cells, most notably an increase in the strength of the heart muscle's contractions, the researchers say. (news-medical.net)
  • However, in their study, described in a report published in the journal Circulation on July 20, the Johns Hopkins researchers demonstrate that the new compound works differently than current drugs, suggesting its use may be a safer way to increase heart contraction strength. (news-medical.net)
  • Other researchers have shown that reading words describing emotions can activate the muscles involved in producing the facial expressions associated with those emotions. (scienceblogs.com)
  • The researchers assume that the increase in reading time means that paralysis of the frown muscles hindered the participants' understanding of the emotional content of the sad sentences. (scienceblogs.com)
  • Analyzing both sEMG and 3D kinematic data will allow the researchers to accurately measure the relationships between changes in muscle function and movement during lameness. (holistichorse.com)
  • [ 12 ] STOMP researchers found that more patients in the atorvastatin group than in the placebo group developed muscle complaints, but there were no differences in muscle strength and endurance, aerobic performance, or physical activity levels after 6 months of treatment. (medscape.com)
  • One of the first books addressing (muscle as well as whole body) fatigue was published at the beginning of the 20th century ( Mosso, 1904 ) and a multitude of research has followed since, see Gandevia (2001) for a thorough review. (frontiersin.org)
  • This study sought to characterize muscle loading and fatigue during static shoulder abductions with varying force. (cdc.gov)
  • Changes in EMG root-mean-square (RMS) and spectral measures (derived from 1-s windows at peaks in the cyclic contractions) were used as manifestations of muscle fatigue. (cdc.gov)
  • Overall, the use of CPDE and EVA to characterize task differences and predict muscle fatigue was found to have limited value. (cdc.gov)
  • The central drive to the muscle reduces when muscle force wanes during sustained MVC, and this is generally considered the neurophysiological footprint of central fatigue. (nature.com)
  • The twitch-interpolation technique evaluates central fatigue by assessing the level of central drive to the muscle (also called voluntary activation, VA). It involves a first percutaneous electric stimulation (PNS) of a nerve (or muscle motor point) during a maximal voluntary contraction (MVC), which normally increases the ongoing force-torque developed by the muscle (interpolated twitch). (nature.com)
  • Statin use attenuated substrate use during maximal exercise performance, induced muscle fatigue during repeated muscle contractions, and decreased muscle mitochondrial oxidative capacity. (medscape.com)
  • The contraction of one segment is accompanied by relaxation of the segment immediately in front. (elifesciences.org)
  • The result of smooth muscle cell target protein phosphorylation is a decrease in intracellular calcium, increased efflux of potassium, and deactivation of myosin light chain kinase, ultimately causing smooth muscle relaxation. (nih.gov)
  • In isolated nerve-muscle preparation, Dantrium has been shown to produce relaxation by affecting the contractile response of the muscle at a site beyond the myoneural junction. (druglib.com)
  • The PMC coordinates the urethral sphincter relaxation and detrusor contraction to facilitate urination. (medscape.com)
  • These visceral muscle contractions are induced by immune reactive oxygen species (ROS) that accumulate in the lumen and depend on the ROS-sensing TRPA1 receptor. (sdbonline.org)
  • It was then demonstrated that both ROS and TRPA1 are required in a subset of anterior enteroendocrine cells for the release of the DH31 neuropeptide which activates its receptor in the neighboring visceral muscles. (sdbonline.org)
  • The resulting contractions of the visceral muscles favors quick expulsion of the bacteria, limiting their presence in the gut. (sdbonline.org)
  • The tachyphylactic effect of barium on intestinal smooth muscle. (cdc.gov)
  • describe the intracellular mechanisms by which it may be possible to alter the contractile state of the heart and the changes in ion channel function that occur in various heart diseases. (manchester.ac.uk)
  • In the past, various mechanisms including vascular, muscular (ie, constant overcontraction of scalp muscles), and psychogenic factors were suggested. (medscape.com)
  • In this study, we sought to investigate the effects of an ACTN2 missense variant of unknown significance (p.A868T) on cardiac muscle structure and function. (bvsalud.org)
  • Abdominal muscles may be both morphologically and functionally affected by pregnancy. (mdpi.com)
  • In mice, Kass notes, PDE1 inhibitors had been reported to shrink abnormally thick heart muscle caused by high blood pressure and dilate blood vessels. (news-medical.net)
  • It did this, Kass says, by increasing the strength of the heart's contractions by almost 30 percent and by dilating the blood vessels. (news-medical.net)
  • In various experimental blocks, we validated a 3D-printed hand-fixation system permitting the execution of finger-tapping and maximal voluntary contractions (MVC). (nature.com)
  • Improvement in cardiorespiratory fitness requires physical activity involving large muscle groups at a relatively high level of intensity (>60% of maximal heart rate or maximal oxygen consumption), with continuous duration of at least 3 min. (cdc.gov)
  • Maximal incremental cycling tests, involuntary electrically stimulated isometric quadriceps-muscle contractions, and biopsy of vastus lateralis muscle. (medscape.com)
  • Then we summarized the mechanisms of these alkaloid components of Rhizoma coptidis on cardiovascular and cerebrovascular diseases, diabetes and diabetic complications. (springer.com)
  • The underlying physiological mechanisms behind the increased risk for cardiovascular disease remain unresolved. (cdc.gov)
  • Recently he has worked on the molecular mechanism of muscle contraction. (webofstories.com)
  • In this study, proteomics and metabonomics techniques were used to analyze the tissue and plasma of DOX-induced heart failure (HF) in rats and to clarify the molecular mechanism of the harmful effects of DOX on cardiac metabolism and function in rats from a new point of view. (frontiersin.org)
  • However, cardiotoxicity is the adverse reaction of drug dose cumulative toxicity, but the mechanism is still unclear. (frontiersin.org)
  • Findings will provide a better understanding of the underlying role of muscles in producing gait abnormalities recognized as lameness. (useventing.com)
  • In addition, because vitamin D is necessary to healthy immune function, the authors theorized that deficiency could result in a chronic, low-grade systemic inflammation which could contribute to conditions such as hypertension, diabetes, obesity, and cancer, and these multiple mechanisms might represent additional risk factors for the development of disability. (nutraceuticalsworld.com)
  • Their body's natural mechanisms work to expel the matter by increasing the muscle contractions of the intestines and flushing out the bowels. (petwellbeing.com)
  • The nuclei contain the genetic blueprint for making more muscle cells, so their presence and number is pivotal in the body's ability to retain muscle memory. (saveourbones.com)
  • It is made up of the bones of the skeleton, muscles, cartilage, tendons, ligaments, joints, and other connective tissue that supports and binds tissues and organs together. (wikipedia.org)
  • The human skeleton is composed of both fused and individual bones supported by ligaments, tendons, muscles and cartilage. (wikipedia.org)
  • Your muscles, joints, and tendons have sensors called proprioceptors, and these send messages back along the pathways to your brain. (saveourbones.com)
  • The question is important from both basic science and clinical perspectives because mutations in sarcomere proteins of muscle are a leading cause of hypertrophic cardiomyopathy (HCM), the most common cause of sudden cardiac death in the young and a prevalent cause of heart failure in adults. (bio5.org)
  • Currently, the major research focus in my lab is understanding the mechanisms by which cMyBP-C regulates contractile speed and mechanisms by which mutations in cMyBP-C cause disease. (bio5.org)
  • These mutations change the structure of the RYR1 channel, which alters the normal flow of stored calcium ions within muscle cells. (medlineplus.gov)
  • At least 11 mutations in the RYR1 gene have been found to cause congenital fiber-type disproportion, a disorder that causes general muscle weakness that typically does not worsen over time. (medlineplus.gov)
  • describe the risk factors for hypertension and the mechanisms underlying the development of primary and secondary hypertension. (manchester.ac.uk)
  • In this review, we studied on the effects and molecular mechanisms of Rhizoma coptidis on NF-κB/MAPK/PI3K-Akt/AMPK/ERS and oxidative stress pathways. (springer.com)
  • And the more you use these pathways, the more ingrained your muscle memory gets. (saveourbones.com)
  • I am especially interested in how contractile proteins of muscle sarcomeres regulate the force and speed of contraction in the heart. (bio5.org)
  • The ACTN2 gene encodes α-actinin 2, located in the Z-disc of the sarcomeres in striated muscle. (bvsalud.org)
  • To my knowledge, no study had reported increased heart contraction strength from a PDE1 inhibition before. (news-medical.net)
  • Muscles are innervated, whereby nervous signals are communicated by nerves, which conduct electrical currents from the central nervous system and cause the muscles to contract. (wikipedia.org)
  • Myoelectric (EMG) signals were continuously obtained from the middle deltoid muscle throughout experimental exercise (60min max). (cdc.gov)
  • Human heart failure is a chronic condition often marked by weakening of the heart muscle and its subsequent failure to pump enough blood. (news-medical.net)
  • Currently, dozens of drugs are available to treat or manage heart failure symptoms, but drugs that improve the strength of the heart muscle's contractions, such as dobutamine, carry the risk of dangerous complications such as developing an irregular heartbeat. (news-medical.net)
  • This research helps us understand the genetic risk factors related to fatal diseases of the heart muscle and the mechanisms underlying the disease, and offers new tools for their prevention. (news-medical.net)
  • Based on a dataset encompassing more than 500 Dobermanns, the disease was associated with two nearby genomic loci, where changes were identified in genes that affect the functioning, energy metabolism and structure of the heart muscle. (news-medical.net)
  • The study revealed that these same risk genes cause heart muscle disease in human patients. (news-medical.net)
  • In patients, PDE inhibitors have been linked to heart failure and cardiac arrhythmias, although the mechanisms are not understood. (nih.gov)
  • [4] Since the heart muscle is stimulated differently, it is never affected by MG. (doctorbhatia.com)
  • Hypertrophic cardiomyopathy (HCM) is a genetic heart muscle disease that frequently causes sudden cardiac death (SCD) among young adults. (bvsalud.org)
  • Only skeletal and smooth muscles are part of the musculoskeletal system and only the muscles can move the body. (wikipedia.org)
  • The authors said that the role of vitamin D in the musculoskeletal system is one of the main mechanisms by which they believe this risk occurs. (nutraceuticalsworld.com)
  • As a traditional Chinese medicine, Rhizoma coptidis has excellent therapeutic effects on various diseases, but the underlying systematic molecular mechanisms are still far from being fully elucidated. (springer.com)
  • Few studies have examined the effects of statins on muscle contractile function and exercise performance, and even fewer studies have examined this in statin users with muscle complaints. (medscape.com)
  • The aim of the current study was to examine whether differences exist in aerobic exercise performance, muscle contractile function, and muscle mitochondrial oxidative capacity and content between long-term symptomatic and asymptomatic statin users, and control subjects who did not use a statin drug. (medscape.com)
  • Smooth muscles are used to control the flow of substances within the lumens of hollow organs, and are not consciously controlled. (wikipedia.org)
  • like the smooth muscles, these muscles are not under conscious control. (wikipedia.org)
  • In order for blood to flow to the above-mentioned structures, it is necessary to relax the smooth muscles of the corpora cavernosa and to widen the arteries supplying blood to the penis, which causes compression of the intracavernous veins, which is seen as an erection. (selfgrowth.com)
  • Here, we introduce sarcApp, an image analysis tool that quantifies several components of the cardiac sarcomere and their alignment in muscle cells and tissue. (bvsalud.org)
  • The mechanism of penile erection is the temporary filling of blood in the cavernous bodies of the penis when sexual arousal is felt. (selfgrowth.com)
  • In most cases, the first noticeable symptom is weakness of the eye muscles. (doctorbhatia.com)
  • The degree of muscle weakness involved in MG varies greatly among patients, ranging from a localized form, limited to eye muscles (ocular myasthenia), to a severe or generalized form in which many muscles - sometimes including those that control breathing - are affected. (doctorbhatia.com)
  • Weakness may affect a few or many muscles and develop suddenly or gradually. (msdmanuals.com)
  • Weakness of specific muscle groups can cause disorders of eye movement, dysarthria, dysphagia, or respiratory weakness. (msdmanuals.com)
  • Further research is necessary to understand and clarify the mechanisms of TTH. (medscape.com)
  • Deduce the structural mechanism of delayed stretch activation in striated muscle, collaboration with Duke University Medical School. (iit.edu)
  • When the bladder becomes full, the stretch receptors of the detrusor muscle send a signal to the pons, which in turn notifies the brain. (medscape.com)
  • The results may suggest that botox can impair emotional reactivity, but this is by no means conclusive, and the news stories completely overlook the more profound implication of the results - that by paralyzing the muscles involved in producing facial expressions, botox may actually diminish the experience of emotion in those who use it. (scienceblogs.com)
  • In mammals, when a muscle contracts, a series of reactions occur. (wikipedia.org)
  • This suggests disturbances in mitochondrial oxidative capacity occur with statin use even in patients without statin-induced muscle complaints. (medscape.com)