Mechanisms hypoxia. Medical search. Frequent questions

A hypoxic cell model prepared with CoCl 2 was developed to detect the effect of hypoxia on the proliferation and apoptosis of renal stem cells. (bjbms.org)
The effect of hypoxia on Hydrogen Sulfide concentration of brain tissue in AD transgenic mice and its mechanism. (nel.edu)
Cheng X, Ding M, Wei C, Xiao F, Liao J, Li M, Xiao Z, Liu X, Luo Y. The effect of hypoxia on Hydrogen Sulfide concentration of brain tissue in AD transgenic mice and its mechanism. (nel.edu)
Our findings add to a nascent but burgeoning literature on the beneficial effect of hypoxia in a wide variety of neurologic disease models. (fightaging.org)

The northern portion of the Gulf of Mexico experiences an annual summer hypoxia event when over-enrichment of nutrients in the water causes very low levels of dissolved oxygen. (noaa.gov)

The effect and molecular mechanism of hypoxia-inducible factor 1-alpha (HIF-1α) on the proliferation and apoptosis of renal stem cells were also explored. (bjbms.org)
Both hypoxia and HIF-1α significantly promoted the proliferation of renal stem cells and inhibited cell apoptosis. (bjbms.org)
Liu H, Liu C, Qu Y. The effect and molecular mechanism of hypoxia on proliferation and apoptosis of CD133+ renal stem cells. (bjbms.org)
In FH-defective cells, both hypoxia-inducible factor 1α (HIF-1α) and HIF-2α accumulated, but they were not required for apoptosis protection. (ox.ac.uk)
In murine cardiomyocytes miR-21 was found to protect from hypoxia/reoxygenation (H/R)-induced cell apoptosis via regulation of its target gene PDCD4 [ 13 ]. (hindawi.com)
We treated TMZ-resistant cells U251-TMZ and T98G-TMZ to normoxia or hypoxia and silenced NUPR1 in hypoxia-treated U251-TMZ and T98G-TMZ cells to assess cell viability, proliferation, apoptosis, LC3-II/LC3-I and p62 expressions, and autophagic flux under different concentrations of TMZ. (techscience.com)
Wang GW, Zhou Z, Klein JB and Kang YJ: Inhibition of hypoxia/reoxygenation-induced apoptosis in metallothionein-overexpressing cardio-myocytes. (spandidos-publications.com)
Moira Whyte's research interests have focused on molecular mechanisms of innate immune cell apoptosis in the context both of chronic inflammatory lung disease and of host defence against bacterial infection. (ed.ac.uk)

Despite the positive molecular adaptations observed after various IHT modalities, the characteristics of optimal training stimulus in hypoxia are still unclear and their functional translation in terms of whole-body performance enhancement is minimal. (bmj.com)
Here we discuss the transformative experimental strategies that are being leveraged to dissect the key cellular and molecular mechanisms that regulate fibrosis, and the translational approaches that are enabling the emergence of precision medicine-based therapies for patients with fibrosis. (nature.com)
But the underlying molecular mechanisms of Rhizoma coptidis are still far from being fully elucidated. (springer.com)
In this review, we studied on the effects and molecular mechanisms of Rhizoma coptidis on NF-κB/MAPK/PI3K-Akt/AMPK/ERS and oxidative stress pathways. (springer.com)
There are many researches on Rhizoma coptidis, but most of them are only a small part of the whole molecular mechanisms. (springer.com)
As a traditional Chinese medicine, Rhizoma coptidis has excellent therapeutic effects on various diseases, but the underlying systematic molecular mechanisms are still far from being fully elucidated. (springer.com)
Recent advancements on the molecular mechanisms of iron carcinogenesis were also reviewed. (cdc.gov)
Our research focus is to understand molecular mechanisms underpinning tumor and tumor microenvironment interaction, metastatic progression, and treatment resistance. (ohsu.edu)
Dr. Qian is a strong believer of the mechanism-based cancer treatment approach, in particularly through understanding the molecular genetics and biology of tumor hypoxia. (ohsu.edu)
Her research interests have focused on molecular mechanisms underlying acute inflammation in the context both of chronic inflammatory lung diseases such as COPD and of host defence against bacterial infection. (ed.ac.uk)

2 , 3 However, the question as to how effectively prolonged altitude exposure can improve athletic performance and its underpinning physiological mechanisms and signalling pathways remains contentious. (bmj.com)
ERS pathways are triggered by the unbalance of ER environment, including hypoxia, disturbance of Ca 2+ homeostasis and glucose starvation. (springer.com)
Through cDNA microarray analyses, we have recently identified novel interaction / crosstalk between signaling pathways initiated by hypoxia and androgen, the prostate cancer driving hormone. (ohsu.edu)
An important future goal is to define the mechanism by which chronic continuous hypoxia is extending lifespan in this model, and the extent to which this mechanism overlaps with that of pathways known to be involved in aging, such as mTOR and insulin signaling . (fightaging.org)
Succinate acts as an oxygen sensor in the cell and can help turn on specific pathways that stimulate cells to grow in a low-oxygen environment (hypoxia). (medlineplus.gov)

We hypothesized that an interplay between aryl hydrocarbon receptor (AhR) and cysteine-related thiolome at the kidney cortex underlies the mechanisms of (mal)adaptation to chronic intermittent hypoxia (CIH), promoting arterial hypertension (HTN). (unl.pt)
Using a rat model of CIH-HTN, we investigated the impact of short-term (1 and 7 days), mid-term (14 and 21 days, pre-HTN), and long-term intermittent hypoxia (IH) (up to 60 days, established HTN) on Cyp1a1 protein level (a sensitive hallmark of AhR activation) and cysteine-related thiol pools. (unl.pt)
The purpose of the current study was to determine if the intermittent hypoxia (IH) stimulus that characterizes OSA causes insulin resistance in the absence of obesity. (atsjournals.org)
Intermittent hypoxia produces insulin resistance in lean mice. (atsjournals.org)
Insulin resistance during intermittent hypoxia was not dependent on the autonomic nervous system. (atsjournals.org)

Total atmospheric pressure decreases as altitude increases, causing a lower partial pressure of oxygen, which is defined as hypobaric hypoxia. (wikipedia.org)
Systemic hypoxia was created in a hypobaric chamber to simulate 5000 m high altitude by adjusting the inner pressure and oxygen content for 6 days. (bvsalud.org)
We investigated the changes in physiological and performance parameters after a Live High-Train Low (LHTL) altitude camp in normobaric (NH) or hypobaric hypoxia (HH) to reproduce the actual training practices of endurance athletes using a crossover-designed study. (frontiersin.org)

We investigated whether inhibition of hypoxia-inducible factor prolyl 4-hydroxylase-2 (HIF-P4H-2), a key cellular oxygen sensor whose inhibition stabilizes HIF, would protect from NAFLD by subjecting HIF-P4H-2-deficient ( Hif-p4h-2 gt/gt ) mice to a high-fat, high-fructose (HFHF) or high-fat, methionine-choline-deficient (HF-MCD) diet. (springer.com)
The primary mechanism of injury is cellular hypoxia from Complex IV (CIV) inhibition. (lu.se)

These findings reveal a new mechanism of tumorigenesis due to FH loss and an unexpected pro-oncogenic role for AMPK that is important in considering AMPK reactivation as a therapeutic strategy against cancer. (ox.ac.uk)
In order to fully understand the mechanisms of I/R injury and to find novel therapeutic strategies, further research is stilled urgently needed [ 3 ]. (hindawi.com)

Hypoxia is a known regulator of stem cell fate, the effects of which can be mimicked using hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors such as dimethyloxalylglycine (DMOG). (amrita.edu)
We focus on the central enzymes regulating these two fundamental biological processes: 1) the prolyl 4-hydroxylases (P4Hs) that control the hypoxia response pathway via determination of the oxygen-dependent fate of the hypoxia-inducible transcription factor HIF, and 2) the key enzymes of collagen synthesis, the collagen P4Hs, lysyl hydroxylases (LHs) and lysyl oxidase (LOX). (oulu.fi)

mechanisms of carcinogenesis chapter 15. (who.int)

The aims of the present review are therefore threefold: first, to summarise the main mechanisms for interval training and repeated sprint training in normoxia. (bmj.com)
Although surgery (flow probe implantation) reduced the U crit of normoxia-acclimated cod by 14% (from 1.74 to 1.50 BL s −1 ) under normoxic conditions, exposure to acute hypoxia lowered the U crit of both groups (surgery and non-surgery) by ~30% (to 1.23 and 1.02 BL s −1 , respectively). (biologists.com)

This report describes the role of neuroprotection in acute disorders such as stroke and injuries of the nervous system as well as in chronic diseases such as neurodegenerative disorders because many of the underlying mechanisms of damage to neural tissues are similar in all these conditions and several products are used in more than one disorder. (researchandmarkets.com)
However, we have a poor understanding of the degree to which diminished cardiac function contributes to the reduction in fish swimming performance concomitant with acute exposure to hypoxia, or how fish cardiorespiratory physiology is altered by, or adapts to, chronic hypoxia. (biologists.com)
Chronic continuous hypoxia has been reported as beneficial in at least three other mouse models of neurologic disease. (fightaging.org)

We are also actively exploring ways to target these chemoresistance mechanisms in order to improve the efficacy of chemotherapy. (ohsu.edu)

Mechanism of Traditional Tibetan Medicine Grubthobrildkr Alleviated Gastric Ulcer Induced by Acute Systemic Hypoxia in Rats. (bvsalud.org)
GTB exerted a gastroprotective effect to alleviate gastric ulceration induced by acute systemic hypoxia in rats . (bvsalud.org)
The effect of GTB increasing the volume and pH of gastric juice in rats under acute systemic hypoxia could be regulated by gastrointestinal hormones , including MTL and ET-1. (bvsalud.org)
However, the mechanism of renal stem cells in the repair of acute kidney impairment remains unclear. (bjbms.org)
Cannon RO III: Mechanisms, management and future directions for reperfusion injury after acute myocardial infarction. (spandidos-publications.com)

However, the population living in the United States is genetically mixed and has varied responses to the added stress of altitude-induced hypoxia. (medscape.com)
Possible genomic mechanism involved in control systems responses to hypoxia. (uchicago.edu)
It is most likely that any effect on normal mice would be smaller, and also likely that any form of life extension achieved through manipulation of stress responses, such as the response to hypoxia, will produce much smaller effects in long-lived mammals than in short-lived mammals. (fightaging.org)

The data support a role for the fetal liver as a source of elevated circulating levels of IGFBP-1 in fetuses with in utero hypoxia and IUGR. (ox.ac.uk)
Preterm fetuses (67-70% gestation) were subjected to sustained global hypoxia. (jneurosci.org)

Several companies mimic hypoxia using normobaric artificial atmosphere. (wikipedia.org)

Here, we review evidence that hypoxia regulates cell plasticity, resistance to cell-mediated cytotoxicity, and immune suppression. (nutriforce.cn)
In addition, the data demonstrate that hypoxia up-regulates fetal hepatocyte IGFBP-1 mRNA steady-state levels and protein, with this being the major IGFBP derived from the fetal hepatocyte. (ox.ac.uk)

As such, HIF degradation under hypoxic conditions is an essential homeostatic and tumour-suppressive mechanism. (york.ac.uk)
In severe hypoxia, homeostatic mechanisms maintain function of the brainstem respiratory network. (nature.com)

Hypoxia leads to impaired reproduction of remaining fish via endocrine disruption. (wikipedia.org)
2012). Some authors even suggest that the problem of endocrine disruption caused by hypoxia could potentially be more serious than that caused by known anthropogenic chemicals (Goldberg 1995;Diaz 2001). (researchgate.net)

In two mitochondrial disease models, hypoxia corrects defects that arise as a consequence of the genetic lesion. (fightaging.org)
As development progresses, nephron progenitors switch from glycolysis to mitochondrial respiration for energy-mediated by an unknown mechanism-and undergo differentiation. (lww.com)
A switch from glycolysis to mitochondrial respiration drives these cells toward differentiation, but the mechanisms that control this switch are poorly defined. (lww.com)

The crosstalk between hypoxia signaling and hormonal signaling determines cancer progression and hormonal therapy resistance. (ohsu.edu)
For decades, tumor hypoxia is known to be associated with solid tumor progression, treatment resistance, and patient mortality. (ohsu.edu)
This study investigated the mechanism of NUPR1 in TMZ resistance in hypoxia-treated glioma cells and its mechanism in modulating autophagy. (techscience.com)
We found that hypoxia upregulated NUPR1 expression and autophagy while NUPR1 silencing suppressed hypoxia-induced TMZ resistance and autophagy in glioma cells. (techscience.com)
However, there is no direct evidence of a cause-and-effect relationship or potential mechanisms linking sleep apnea and insulin resistance. (atsjournals.org)

leaves alleviate hypoxia/reoxygenation (H/R) injury in H9c2 cardiomyocytes and to explore potential mechanisms. (hindawi.com)
The ability of hypoxia to alleviate brain degeneration in such diverse models points either to the pleiotropic effects of oxygen restriction, or alternatively, the existence of a downstream and convergent neuroprotective mechanism. (fightaging.org)

IGFBP-1 is elevated in the fetal circulation of human and animal pregnancies complicated by IUGR caused by placental insufficiency and in utero hypoxia and is believed to restrict fetal growth by sequestering IGFs. (ox.ac.uk)
12 PAHs may also lead to periods of fetal hypoxia through reduced placental blood flow. (cdc.gov)

Exposure to hypoxia occurs as a consequence of insufficient blood supply. (nutriforce.cn)
In this study, we aimed to examine the effects of RCE in endothelial cells challenged with hypoxic exposure and to elucidate the underlying mechanisms. (mdpi.com)
Biologic changes: Toxic mechanisms that cause damage to tissues following an exposure and an absorbed dose. (cdc.gov)
For example, hypoxia is caused by carbon monoxide (CO) exposure. (cdc.gov)
These results provide important insights into how fish cardiorespiratory physiology is impacted by short-term and prolonged exposure to hypoxia, and further highlight the tremendous capacity of the fish cardiorespiratory system to deal with environmental challenges. (biologists.com)

Gestational hypoxia is a major contributor to fetal growth restriction (FGR) and perinatal morbidity and mortality and has been closely linked to the activation of the unfolded protein response (UPR) in the placenta. (researchgate.net)

In view of the major contribution of intrapartum risk factors and prematurity to subsequent neurological morbidity and mortality, studies are needed that address the underlying mechanisms of brain injury that occur in utero to the immature and near-term fetal CNS. (jneurosci.org)

While much research is, and has been, carried out to investigate the effects of hypoxia, this is usually done using experimental models which employ stable levels of hypoxia. (mdpi.com)
In this study, we developed a protocol to establish highly pure primary cultures of human fetal hepatocytes in vitro and investigated their expression of IGFBP-1 messenger RNA (mRNA) and protein and the effects of hypoxia on their expression of IGFBP-1 mRNA and protein. (ox.ac.uk)
However, the effects of RCE on response to hypoxia in the endothelium remain unclear. (mdpi.com)
The mechanisms underlying off-target effects of the synthetic glucocorticoids mostly used, Dexamethasone (Dex) and Betamethasone (Beta), are unknown. (researchgate.net)
Developmental hypoxia has profound and persistent effects on the vertebrate cardiovascular system, but the nature, magnitude and long-term outcome of the hypoxic consequences are species-specific. (researchgate.net)
In the present study, the protective effects of EGCG with zinc were assessed on cultures of rat cardiac myoblasts exposed to hypoxia/reoxygenation (H/R) injury. (spandidos-publications.com)

The exact mechanism by which diabetes causes retinopathy remains unclear, but several theories have been postulated to explain the typical course and history of the disease. (medscape.com)

Sodium tanshinone IIA sulfonate can inhibit hypoxia induced retinal neovascularization in a dose-dependent manner, and its mechanism may be related to the regulation of vascular endothelial growth factor pathway related proteins by sodium tanshinone IIA sulfonate. (ijpsonline.com)

Researchers have understood for numerous years that the hypoxia found in tumors leads to more aggressive and harder to treat disease and ultimately, poor patient outcome. (mdpi.com)
In solid tumors, these include limited oxygen supply (hypoxia) and the accumulation of reactive oxygen species (ROS) that modulate the optimal function of cytotoxic T lymphocytes. (masterib.es)

The sickle erythrocyte presents reduced flexibility and becomes more adherent to vascular endothelium, developing vaso-occlusion of microvasculature and subsequent local hypoxia 1,7 . (bvsalud.org)

The term hypoxia is used to describe biological situations where insufficient levels of oxygen exist. (mdpi.com)
It is used to detect hypoxia, defined as abnormally low levels of oxygen in the body. (who.int)

Third, to discuss the potential mechanisms underpinning the effectiveness of those methods, and their inherent limitations, along with the new research avenues surrounding this topic. (bmj.com)

Atmospheric hypoxia is also the basis of altitude training, which is a standard part of training for elite athletes. (wikipedia.org)

H9c2 cells were subjected to 3‑h hypoxia, followed by 1‑h reperfusion. (spandidos-publications.com)

Atmospheric hypoxia occurs naturally at high altitudes. (wikipedia.org)

Accumulating data also suggest that hypoxic stress in the tumor microenvironment promotes tumor escape mechanisms through the emergence of immune-resistant tumor variants and immune suppression. (nutriforce.cn)

Because HIF-1 gains increasing importance in hypoxia during inflammatory settings the role of HIF-1 activation in dendritic cells and macrophages was studied in vivo in a mouse model of inflammatory bowel disease. (hku.hk)
The mechanism of corticosteroid action includes a reduction of the inflammatory reaction by limiting the capillary dilatation and permeability of the vascular structures. (medscape.com)

Rhodiola crenulata root extract (RCE) has been shown to possess protective activities against hypoxia both in vitro and in vivo. (mdpi.com)

Antenatal hypoxia-ischemia at preterm gestation results in hypertonia and abnormalities in motor control. (jneurosci.org)
Maintenance of oxygen and extracellular matrix (ECM) homeostases is crucial for normal development and physiology, and several pathologies are associated with hypoxia or ECM abnormalities. (oulu.fi)

The expression of vascular endothelial growth factor, vascular endothelial growth factor-2 and hypoxia-inducible factor-1 were detected by Western blot. (ijpsonline.com)
The activation of hypoxia-inducible factor-1 (HIF-1) has been recognized as the key event in adaptation to hypoxia. (hku.hk)

Hypoxia and hypoxic states can occur in a range of diseases including in cancer. (mdpi.com)
Understanding these mechanisms will help to develop differentiated approaches to cancer immunotherapy, including monoclonal antibodies and cell therapies. (masterib.es)
Hypoxia is a pathological hallmark of cancer microenvironment. (ohsu.edu)
He received a B.S. in Biochemistry from Alma College, Ph.D. in Toxicology from Johns Hopkins University, and postdoctoral training in tumor angiogenesis, hypoxia, epigenetics, and experimental therapeutics from Johns Hopkins Kimmel Cancer Center. (ohsu.edu)

Taken together, this study clarified the effect of age on the content of human renal stem cells and determined the regulatory mechanism of hypoxia on renal stem cells. (bjbms.org)
The first-in-class small-molecule HIF-P4H inhibitor that activates the hypoxia response has been approved for treatment of renal anemia and several others are in clinical trials [ 10 , 11 ]. (springer.com)

Then we summarized the mechanisms of these alkaloid components of Rhizoma coptidis on cardiovascular and cerebrovascular diseases, diabetes and diabetic complications. (springer.com)

were significantly lower in hypoxia-acclimated cod at both levels of oxygenation, because of lower values for V S . However, hypoxia-acclimated cod were able to consume more oxygen for a given cardiac output. (biologists.com)
We have demonstrated that continuous hypoxia (11% oxygen) - or "oxygen restriction" - significantly extends lifespan of Ercc1 Δ/- mice and delays neurologic morbidity . (fightaging.org)

The large effect size for hypoxia in this model in turn might imply that hypoxic stress is good at improving DNA repair efficiency, but more research would be needed to confirm that hypothesis. (fightaging.org)

It has become clear that hypoxia shapes and induces specific macrophage phenotypes that serve tumor malignancy, as hypoxia promotes immune evasion, angiogenesis, tumor cell survival, and metastatic dissemination. (nutriforce.cn)

This work contributes to a better understanding of the mechanisms underlying the phenotype of OSA-HTN, mimicked by this model, which is in line with precision medicine challenges in OSA. (unl.pt)

It is important to understand the mechanisms of action and the pharmacokinetics of antiepileptic drugs (AEDs) so that these agents can be used effectively in clinical practice, especially in multidrug regimens (see the image below). (medscape.com)

i) Hypoxia-induced release of chemoattractants results in enhanced TAM recruitment, which further amplifies the protumoral response. (nutriforce.cn)
The adaptive cellular response to low oxygen tensions is mediated by the hypoxia-inducible factors (HIFs), a family of heterodimeric transcription factors composed of HIF-α and HIF-β subunits. (york.ac.uk)

To investigate the mechanism of sodium tanshinone IIA sulfonate inhibiting hypoxia induced retinal neovascularization in rats. (ijpsonline.com)
This study was aimed at investigating the potential mechanism of Grubthobrildkr (GTB) on systemic hypoxia -induced gastric ulcers in rats and at detecting the chemical profile of GTB. (bvsalud.org)
Male Sprague-Dawley rats were separated into control, hypoxia , hypoxia + omeprazole , and hypoxia +GTBs (0.25, 0.5, and 1.0 g·kg-1·d-1) groups. (bvsalud.org)
GTB decreased the ulcer index in rats under hypoxia for six days, which was related to increased pH and volume of gastric juice , enhanced MTL and PGE2 levels, and decreased ET-1 and PLA2 levels of gastric mucosa . (bvsalud.org)

The main groups include sodium channel blockers, calcium current inhibitors, gamma-aminobutyric acid (GABA) enhancers, glutamate blockers, carbonic anhydrase inhibitors, hormones, and drugs with unknown mechanisms of action (see the image below). (medscape.com)

a protein component of a ubiquitin ligase complex) and hypoxia-inducible factors (a family of transcription factors activated by hypoxia). (lww.com)

To cite this article: Martin SF, Esser PR, Weber FC, Jakob T, Freudenberg MA, Schmidt M, Goebeler M. Mechanisms of chemical-induced innate immunity in allergic contact dermatitis. (cdc.gov)

A redistribution of arteriolar flow produces stasis and hypoxia at the injury site. (medscape.com)

These findings provide a unique behavioral model to define mechanisms and sequelae of perinatal brain injury from antenatal hypoxia-ischemia. (jneurosci.org)

Despite the recent surge about miRNA discoveries for cardiac I/R injury, there is still very little known about the mechanism details because of the complexity of cellular events and the interference of other risk factors. (hindawi.com)

Intrauterine growth restriction (IUGR) can be a consequence of decreased uterine blood flow (uteroplacental insufficiency) and maternal and fetal hypoxia. (ox.ac.uk)

Anatomy41

Organisms14

Diseases28

Chemicals and Drugs73

Analytical, Diagnostic and Therapeutic Techniques and Equipment33

Psychiatry and Psychology1

Phenomena and Processes74

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Information Science2

Health Care3

Geographicals1

Effect of hypoxia4

Dissolved oxygen1

Apoptosis8

Molecular10

Pathways5

Intermittent hypoxia5

Hypobaric3

Inhibition2

Therapeutic2

Prolyl2

Carcinogenesis1

Normoxia2

Chronic3

Efficacy1

Acute5

Responses3

Fetuses2

Normobaric1

Regulates2

Homeostatic2

Endocrine disruption2

Mitochondrial3

Resistance5

Alleviate2

Placental2

Exposure5

Fetal growth rest1

Utero1

Effects6

Unclear1

Regulation1

Tumors2

Endothelium1

Levels of oxygen2

Methods1

Altitude1

H9c21

Occurs1

Tumor microenvironment1

Inflammatory2

Vitro1

Abnormalities2

Factor2

Cancer4

Renal2

Cardiovascular1

Significantly2

Hypoxic stress1

Immune1

Phenotype1

Understand the mechanisms1

Response2

Rats4

Hormones1

Transcription factors1

Innate1

Produces1

Behavioral1

Cardiac1

Consequence1