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  • Igf2
  • Here, we studied effect of transforming growth factor alpha (TGFα) treatment in vitro (10 ng/ml at the morula stage) on the expression of Igf2/H19 locus in mice PE (9.5 days of gestation, 25 somites) and their placentas (PP). Using RT-PCR, we showed that TGFα reactivated maternally imprinted Igf2 gene in parthenogenetic embryos and placentas. (deepdyve.com)
  • gene expression
  • Although imprinting has an important role in the regulation of growth and development through its role in regulating gene expression, its contribution to susceptibility to common complex disorders is not well understood. (biomedcentral.com)
  • These mechanisms contribute to regulating gene expression without changing the sequence of the DNA and may be influenced by exposure to environmental factors and may be heritable from parents. (wikipedia.org)
  • cluster
  • Similarly, the results presented here indicate an important role for the imprinted GNAS cluster in underlying complex performance traits in cattle such as animal growth, calving, fertility and health. (springer.com)
  • occurs
  • A base excision mediated demethylation mechanism would yield double strand breaks if it occurs on large scale in CpG islands. (wikipedia.org)
  • According to the imprinted brain theory there could be a mismatch and more severe problems when extreme genomic imprinting occurs in the opposite sex, which would explain why female autism (and male psychosis) is often particularly severe, which is a problem for the "extreme male brain" theory which predicts the opposite. (wikipedia.org)
  • conflict
  • The conflict theory of imprinting is supported by an extensive amount of empirical evidence and is, according to Bernard Crespi in a 2008 paper, the only comprehensive theory explaining observed patterns of imprinting in humans and other organisms. (wikipedia.org)
  • processes
  • While an understanding of underlying processes is just beginning to emerge, basic questions about how epigenetic processes work and whether diverse processes share underlying mechanisms remain mysterious. (keystonesymposia.org)
  • Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes such as DNA repair, genomic stability, and programmed cell death. (wikipedia.org)