Mechanisms early embryo morphogenesis. Medical search. Frequent questions

Her main work with bicaudal allowed her to publish a paper in 1977, "Genetic analysis of pattern-formation in the embryo of Drosophila melanogaster. (wepapers.com)
The dissertation topic focused on genetic patterns in Drosophila embryos and the various mutations that can occur throughout development (Resnik 2012). (wepapers.com)
Dynamic imaging of Drosophila embryonic tracheal morphogenesis demonstrates that SERCA's principal function is to govern cell migration. (caltech.edu)
Likewise, ablation of nerves in Drosophila embryos derails tracheal morphogenesis. (caltech.edu)
Thus, we examined epithelial polarity establishment during early Drosophila development. (rupress.org)
This study aims to understand the function and mechanism of Drosophila Glycine N-acyltransferase (GLYAT) in cell invasion. (sdbonline.org)
We will ask the following question: can a purely reaction-diffusion mechanism help us understand the formation of the sharp concentration patterns observed in the Drosophila blastoderm? (sorbonne-universite.fr)
Using theory and experiment, we have shown that during cellularisation in the Drosophila embryo, cells undergo skew and apical-to-basal neighbour rearrangements to adapt for geometric constraints. (mechanochemistry.org)
We have taken advantage of genetically induced smaller embryos in Drosophila to bring new insights into when and where organ scaling occurs in the embryo. (mechanochemistry.org)
Prelights article on our paper about scaling in the early Drosophila embryo. (mechanochemistry.org)
In the Drosophila embryo, apical constriction in a strip of epithelial cells along the ventral midline results in the folding of the tissue and the internalization of ventral cells, forming a ventral furrow (VF). (nature.com)
She shifted to studying the dynamics of biological development during her postdoc at the IBDM (Marseille, France) in the group of Thomas Lecuit where she studied the physical mechanisms underlying tissue flows in early Drosophila embryogenesis. (univ-mrs.fr)
The posterior endoderm in Drosophila embryos undergoes an epithelial-mesenchymal transition (EMT), driving the collective migration of endoderm cells. (whiterose.ac.uk)
To test for conserved mechanisms of developmental EMTs in disease using Drosophila, fly models first needed to be generated that accurately recapitulate aspects of human metastasis. (whiterose.ac.uk)

In our research, we use the zebrafish embryo to investigate how intercellular Wnt protein transport is regulated and how signals are subsequently delivered to the target cell in a living vertebrate organism. (exeter.ac.uk)
Here, we examine this question during the early stages of morphogenesis of the embryonic laterality organ, the first organ to form during vertebrate development, using the zebrafish as a model organism. (elifesciences.org)
SERCA controls the rate of intersomitic blood vessel sprouting and branching in zebrafish embryos in a dose-dependent manner. (caltech.edu)

Somites are blocks of cells that contain distinct sections that diverge into specific types (axial or limb) of musculature and are an essential part of early vertebrate development. (asu.edu)
This structure-the heart-is the first organ to form in vertebrate embryos, and all subsequent life processes depend on its proper function. (cshlpress.com)

Our work uncovers the role of mechanical forces in this morphogenetic process and will open new venues of research on how molecular genetics and mechanical factors cooperatively regulate morphogenesis in development," says Chen. (dartmouth.edu)
His major contributions include the understanding of how gene activities regulate regionalization processes in the developing embryo and the discovery of mechanisms involved in quality control and organ regeneration. (cnic.es)
A major focus of his work on organogenesis is homeodomain genes, and his research in this area has contributed to the understanding of the molecular interactions that regulate the correct formation of distinct regions in the embryo. (cnic.es)
F-Actin, Myosin, and Microtubules already exist in fungi, sponges, corals and jellyfish, they regulate shape and mechanical properties of cells since the earliest animals, and they remain functional even if swapped between species. (uni-heidelberg.de)

Dr. Torres described how his group's work has "established the first technique for the in vivo microscopy of the developing heart in mouse embryos, and this has enabled us to propose a new model of the formation of the heart tube. (cnic.es)

Here, we uncovered a mechanism of progenitor cell allocation that stems from an incomplete process of epithelial delamination that allows progenitors to coordinate their movement with adjacent extra-embryonic tissues. (elifesciences.org)
How epithelial cells actively respond to mechanical constraints by adjusting how they generate force is important to understand tissue morphogenesis. (nature.com)

developmental processes such as cell differentiation, morphogenesis and related regulatory mechanisms in normal and disease models, assisted reproductive technologies in model systems and in a clinical environment, and reproductive endocrinology, immunology and physiology. (wikipedia.org)
Alternative splicing of pre-mRNAs is an important means of regulating developmental processes, yet the molecular mechanisms governing alternative splicing in embryonic contexts are just beginning to emerge. (xenbase.org)
During embryo development, naïve cell lineages undergo concurrent processes of fate specification and morphogenesis as critical steps towards the generation of differentiated tissues and organs. (elifesciences.org)
The contributors discuss early cardiac morphogenesis and anatomy, the origins of contractile activity, the control of cardiac growth and size, and the signaling pathways and transcription programs that underpin these processes. (cshlpress.com)
Insight into the dynamics of single cellular building blocks is key to our understanding of tissue development, homeostasis and disease: shape change, active motility and collective cell behavior establish the architecture of complex multi-cellular tissue patterns in early morphogenesis and similar processes are activated during tissue homeostasis and pathological conditions. (irbbarcelona.org)

Using single-cell profiling of mutant phenotype, we in- vestigate the fundamental principles governing cell fate specification, morphogenesis, and tissue patterning. (tu-berlin.de)

Tissue development is a key process for life starting from the earliest embryonic stages during which cells differentiate into later organs composing an entire body. (exeter.ac.uk)
By understanding Wnt dissemination mechanisms, we will be able to control Wnt signalling in development, and regeneration. (exeter.ac.uk)
This accumulation of pigment granules around nuclei during development indicates that the granules are transported toward the nuclei during the cleavage period, suggesting some sort of directional flow of cytoplasm in blastomeres of early amphibian embryos. (silverchair.com)
Here, we reveal essential roles for PQBP1 and a binding partner, WBP11 , in early development of Xenopus embryos. (xenbase.org)
Recording and contextualizing the science of embryos, development, and reproduction. (asu.edu)
Throughout this paper I will detail the early career of Dr. Nusslein-Volhard and the ways in which her research helped to revolutionize the field of developmental biology as it pertains to embryonic development and gene analysis/function. (wepapers.com)
The development of a single-cell zygote into a multi cellular organism with a plethora of cell and tissue types necessitates the precise spatiotemporal coordination of numerous mechanisms in the developing embryo, including the regulation of gene expression, morphogenesis, and tissue patterning. (tu-berlin.de)
We define the earliest gene expression patterns in the developing brain, stratifying substructures and molecular boundaries prior to the formation of morphological units during development. (tu-berlin.de)
Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology describes recent progress in our understanding of early heart development and the various cell lineages involved, as well as mechanisms and models of congenital heart disease. (cshlpress.com)
This volume is therefore a valuable reference for all cell and developmental biologists, geneticists, and cardiologists who are interested in the early development and abnormalities of this complex, vital organ. (cshlpress.com)
Together, these finding reveal that SERCA regulates cell migration, and this serves as a conserved mechanism that governs branch formation in various cell types and species during development. (caltech.edu)
Physica A 352 (2005) 113-130 A cell-centered approach to developmental biology Roeland M.H. Merks, James A. Glazier Department of Physics, Biocomplexity Institute, Indiana University, Swain Hall West 159, 727 East 3rd Street, Bloomington, IN 47405-7105, USA Available online 13 January 2005 Explaining embryonic development of multicellular organisms requires insight into complex interactions between genetic regulation and physical, generic mechanisms at multiple scales. (2medicalcare.com)
By investigating factors that influence placental development and function, FNPS aims to improve our understanding of these conditions and develop strategies for early detection and intervention. (fnps-society.org)
Understanding these early stages of development is crucial not only for unraveling the mysteries of life's origins but also for providing insights into potential causes of developmental disorders. (fnps-society.org)
We take inspiration from early embryo development to engineer synthetic biochemical systems that are capable of spatio-temporal self-organization. (sorbonne-universite.fr)
The objective here is to use a model in vitro system to try to shed light into the molecular patterning process taking place during early embryo development. (sorbonne-universite.fr)
Marine tests showed an inhibition of growth with the two different algal species (P. tricornutum and D. tertiolecta), an inhibition of bioluminescence in the bacterium A. fischeri, an alteration on the correct early development of the serpulid F. enigmaticus larvae and immobilization of the copepod A. tonsa individuals at both 24 and 48 hours of exposure. (easychair.org)
We are particularly interested in how mechanical interactions guide morphogenesis, and how such mechanics interact with signalling networks during development. (mechanochemistry.org)
My lab studies how complex three-dimensional tissue shape emerges during embryo development. (mechanochemistry.org)
Such scaling begins early in the embryo development. (mechanochemistry.org)
The rightward torsion of the brain is one of the earliest organ-level left-right asymmetry events in development," explains Dartmouth engineering professor Zi Chen , lead author on a paper entitled, " How the embryonic chick brain twists ," published online yesterday by the Royal Society journal, Interface . (dartmouth.edu)
In development, a combination of intricately orchestrated biochemical and physical cues combine to generate embryonic form in a process termed "morphogenesis. (dartmouth.edu)
This work clarifies, for the first time, the mechanical origin of brain torsion and the progression of left-right asymmetry in early development. (dartmouth.edu)
Embryogenesis or embryogeny may be defined as the formation and development of embryos. (biologydiscussion.com)
In some lower animals the amount of yolk is less in egg, so that the embryo hatches in earlier stages of development, called a larva. (biologydiscussion.com)
Their embryos continue development until they attain a form resembling the adult. (biologydiscussion.com)
EMBO Director Maria Leptin explained that "EMBO members are expert scientists who carry out pioneering research across all disciplines in the life sciences, from computer models or analysis of individual molecules and cell mechanisms to the study of higher-level systems in development, cognitive neuroscience, and evolution. (cnic.es)
His contributions in this area demonstrate the importance of cell competition in maintaining pluripotency in early embryonic development and its possible role in cardiac regeneration. (cnic.es)
Flies are easy to keep in the lab and their embryos all follow comparable steps of development. (uni-heidelberg.de)
But how are single cell dynamics regulated at specific spatial and temporal time-points of development and which mechanisms guarantee the robustness of dynamic tissue formation in the presence of stress and errors? (irbbarcelona.org)
Using a combination of simplistic 3D in-vitro assays and live-cell in-vivo imaging we study the control mechanisms of cellular dynamics and motile cell transformations during early development. (irbbarcelona.org)
Note that in early human development (week 2) a transient structure called the "primitive yolk sac" forms from the hypoblast layer, this is an entirely different structure. (edu.au)
Expression of thyroid hormone regulator genes in the yolk sac membrane of the developing chicken embryo [1] "Thyroid hormones (THs) are essential for the correct development of nearly every structure in the body from the very early stages of development, yet the embryonic thyroid gland is not functional at these stages. (edu.au)
New development of the yolk sac theory in diabetic embryopathy: molecular mechanism and link to structural birth defects [2] "Maternal diabetes mellitus is a significant risk factor for structural birth defects, including congenital heart defects and neural tube defects. (edu.au)
Human embryonic stem cells (hESc) can also be used to analyze the in vitro development from undifferentiated pluripotent cells leading to terminally differentiated cell types, recapitulating the process of early embryonic development [5] . (plos.org)

Further techniques are organized by the level of visualization they provide, from cells to tissues and organs to whole embryos. (cshlpress.com)

Using this spatiotemporal atlas, we uncover embryo and tissue-wide gene expression patterns that govern body plan formation and the architecture of rudimentary organs. (tu-berlin.de)
Only gradually did these "globules" organise into rudiments (germ layers) which, in turn, took on the characteristics of the various organs of the embryo. (biologydiscussion.com)

These dark spots were formed at early blastula stage, and persisted until the end of yolk plug stage. (silverchair.com)
The inert yolk or vitellin furnishes nourishment for the developing embryo. (biologydiscussion.com)
The yolk sac is an early extra-embryonic membrane which is endoderm origin and covered with extra-embryonic mesoderm . (edu.au)
Yolk sac lies outside the embryo connected by a yolk stalk ( vitelline duct , omphalomesenteric duct ) to the midgut with which it forms a continuous connection. (edu.au)
To clarify the roles of the egg yolk as a source of THs, the TH content in the yolk and the expression of TH regulator genes in the yolk sac membrane were evaluated throughout the 21-day incubation period of chicken embryos. (edu.au)
It is assumed that the chicken yolk sac inactivates THs contained abundantly in the yolk and supplies the hormones to the developing embryo in appropriate concentrations until the second week of incubation, while THs may be activated in the yolk sac membrane in the last week of incubation. (edu.au)
Additionally, the yolk sac could serve as a source of iodine for the embryo. (edu.au)

Confocal analysis of fixed specimens revealed that each secondary bronchus forms by apical constriction of the dorsal epithelium of the primary bronchus, a morphogenetic mechanism distinct from that used to create branches in mammalian lungs. (biomedcentral.com)

Her laboratory specializes in using engineered tissues and computational models to understand how mechanical forces direct developmental patterning events during tissue morphogenesis and during disease progression. (royalsociety.org)

Patterns are ubiquitous in living systems and underlie the dynamic organization of cells, tissues, and embryos. (mpi-cbg.de)
1) The PEN DNA toolbox, a molecular programming language based on short DNA strands and three enzymes that can be maintained out of equilibrium for tens of hours and self-organize into various concentration patterns through a reaction-diffusion mechanism that we can finely control. (sorbonne-universite.fr)

For example, purely physical mechanisms can account for branching morphogenesis of the embryonic mouse airway epithelium, when cultured ex vivo in the absence of biochemical patterning 14 . (nature.com)

Where researchers once struggled to connect events at static timepoints, imaging tools now offer the ability to visualize the dynamic form and function of molecules, cells, tissues, and whole embryos throughout the entire developmental process. (cshlpress.com)
The remaining delaminated cells follow the movement of apically attached progenitors by a protrusion-dependent cell-cell contact mechanism, avoiding sequestration by the adjacent endoderm, ensuring their collective fate and allocation at the site of differentiation. (elifesciences.org)
These early progenitor cells often travel long distances from their induction site to the site of terminal differentiation, making them vulnerable to environmental cues and movement of neighbouring tissues. (elifesciences.org)
The future body plan is formed during the gastrulation and early organogenesis stages when cells commit to their fates and organize into discrete anatomical units. (tu-berlin.de)
of the most critical events which lead to tissue patterning involves mechanisms going beyond single cells. (lu.se)
As we know it today, the mitral and tricuspid valves develop at 21 days gestation in the human embryo when endocardial cells migrate into the developing cushion. (medscape.com)
cells or their nuclei) lacking in any arrangement, i.e., these globules do not reveal any resemblance with the form or structure of the future embryo. (biologydiscussion.com)
This experimental framework recently allowed us to uncover a contractility-based polarization mechanism that drives the rapid transformation of cells into a fast-amoeboid migration mode. (irbbarcelona.org)
Two mechanisms can contribute to this sharpening: switching of the identity of ectopic cells to that of the new neighbors (asterisked cell in b), or segregation of cells into territory that has the same identity (asterisked cell in c). (sdbcore.org)
Evidence for switching comes from transplantation experiments in which it is found that at early (but not late) stages, ectopic single cells will switch identity in the new environment (d). (sdbcore.org)

Both genes are expressed in the nascent mesoderm and neurectoderm , and morpholino knockdown of either causes defects in differentiation and morphogenesis of the mesoderm and neural plate . (xenbase.org)

The hereditary and natural mechanisms in charge of IS remain understood credited largely to limited experimental choices poorly. (academicediting.org)
Yet, the mechanisms underlying scaling are poorly understood. (mechanochemistry.org)
Although these agents have been used for decades, their pharmacological and toxicological mechanisms remain poorly understood. (plos.org)

On the one hand, by studying simple, physics-like and controllable molecular systems that retain the essential features of their biological analogues we hope to provide new insights on the emergence of complex biological behaviors -such as gene regulation, and morphogenesis. (sorbonne-universite.fr)
Membrane structure and function: Structure of model membrane, lipid bilayer and membrane protein diffusion, osmosis, ion channels, active transport, ion pumps, mechanism of sorting and regulation of intracellular transport, electrical properties of membranes. (pathfinderacademy.in)

Taken together, we generate a high-resolution atlas of gastrulation and early organo- genesis and perform a comprehensive dissection of the spatiotemporal architecture of complex embryonic structures using high-throughput single-cell technologies, paving the way for the in- vestigation of congenital and developmental disorders. (tu-berlin.de)

We illustrate where such mechanisms of pattern formation arise in biological systems from cellular to tissue scales, with an emphasis on morphogenesis. (mpi-cbg.de)
More precisely we work with three experimental systems that self-organize in space and time through different mechanisms and at different scales. (sorbonne-universite.fr)
On the one hand, the developing heart scales precisely with embryo length, yet the developing central nervous system has a more absolute length. (mechanochemistry.org)

Analysis of beta 2-microglobulin gene expression in the developing mouse embryo and placenta. (ulaval.ca)

These findings demonstrate a key role of the ARHGAP1 protein in the disruption of the cell adhesion and simultaneously allow for a better understanding of the molecular mechanism of the reduced cell adhesion leading to the subsequent metastasis. (bvsalud.org)

Atrioventricular (AV) valve morphogenesis is a complex process comprised of cell migration, proliferation, apoptosis, and remodeling, all geared towards forming an annulus, AV valve leaflets, and a subvalvar support apparatus comprised of tendinous cords and papillary muscles. (medscape.com)
Serotonergic neurotransmission modulates cell proliferation in several tissues, but is involved mainly in the morphogenesis of the craniofacial region 8 . (bvsalud.org)
Extensive renovation of the epithelium, cell proliferation, apoptosis and changes in the shape and positioning of cell groups are determined by morphogenetic gradients that play critical roles during the morphogenesis of teeth 13 . (bvsalud.org)

Amphibian embryos have been used as suitable materials for investigation of developmental biology. (silverchair.com)

In an abnormal chick embryo, the heart loops to the left-hand side and the brain also turn leftwards, forming a shape that resembles a question mark. (dartmouth.edu)

H) Phenotypes of tailbud stage embryos dorsally targeted with control (CT) or the indicated amount of pqbp1 MO1. (xenbase.org)
To test this theory further, I exposed embryos to exogenous sources of 20E, which recapitulated phenotypes observed during EMT at far earlier stages of embryogenesis than is normal. (whiterose.ac.uk)

The group aims to understand the mechanisms of morphogenesis and cell differentiation within an embryo. (royalsociety.org)

However, she had a breakthrough discovering a second gene that seemed to influence pattern formation in the embryos of flies, a gene later called dorsal. (wepapers.com)

Our work aims at providing insights into (1) the interplay between the dynamic organization of cytoskeletal filaments and cell shape changes, and (2) the reciprocal links between tissue growth, morphogenesis and tissue mechanics. (fresnel.fr)
Dr Nelson's contributions to the fields of tissue mechanics and morphogenesis have been recognized by a number of awards, including a Burroughs Wellcome Fund Career Award at the Scientific Interface (2007), a Packard Fellowship (2008), a Sloan Fellowship (2010), the MIT TR35 (2010), the Allan P. Colburn Award (2011), a Dreyfus Teacher-Scholar Award (2012), and a Faculty Scholars Award from the Howard Hughes Medical Institute (2016). (royalsociety.org)

Our findings revealed a novel mechanism that Nr2f1 and Nr2f2 converge to govern the differentiation and integration of distinct characteristics of the hippocampus in mice. (elifesciences.org)

This figure depicts the mechanisms that underlie the sharpening of segment borders in the hindbrain . (sdbcore.org)

Here, we employ single-cell technologies to chart the emerging cell states and map their precise spatial locations within the developing mouse embryo during gastrulation and early organogenesis. (tu-berlin.de)

In the last ten years, his research has extended to the investigation of how tissue morphogenesis and homeostasis are determined by cell behaviour. (cnic.es)

How is organ formation coordinated to ensure robust morphogenesis? (mechanochemistry.org)

Here we explain zygotic (Zmutants (MZ(mutant embryos (MZmutant embryos, highlighting a significant role for early maternal gene function in developmental morphogenesis and patterning. (academicediting.org)
Outcomes Zmutants develop late-onset vertebral curves that model Is normally Zmutant embryos usually do not present flaws in embryonic patterning or morphogenesis, as maternal Ptk7 is enough to recovery early advancement24. (academicediting.org)

It is therefore conceivable that the accumulation of pigment granules around nuclei is of general occurrence in early amphibian embryos. (silverchair.com)
The accumulation of pigment granules suggests intracellular movement toward the nuclei in blastomeres of early amphibian embryos. (silverchair.com)
Stain of actin and nuclei in an embryonic lung from a bearded dragon embryo. (royalsociety.org)

Whether this morphogenetic mechanism and morphometric scaling are conserved in other avian species is unknown. (biomedcentral.com)

E) Expression of pqbp1 and ncam mRNA in the neural plate of early neurula embryos. (xenbase.org)

Anatomy64

Organisms24

Diseases2

Chemicals and Drugs59

Analytical, Diagnostic and Therapeutic Techniques and Equipment36

Phenomena and Processes67

Disciplines and Occupations4

Technology, Industry, Agriculture2

Information Science7

Health Care1

Drosophila14

Zebrafish3

Vertebrate2

Regulate4

Mouse Embryos1

Epithelial2

Processes5

Specification1

Development35

Tissues and organs1

Organs2

Yolk7

Mammalian1

Computational1

Patterns2

Airway1

Cells10

Mesoderm1

Poorly3

Regulation2

Spatiotemporal1

Scales3

Gene expression1

Understanding of the molecular1

Proliferation3

Biology1

Chick1

Phenotypes2

Aims to understand1

Dorsal1

Mechanics2

Distinct1

Underlie1

Spatial1

Homeostasis1

Organ1

Maternal2

Nuclei3

Morphogenetic1

Neural1