• Neuro-immune communication improves survival through multiple complex mechanisms that are poorly understood. (unc.edu)
  • Gut microbiota (GM) modifies the intrahepatic immune microenvironment, but the underlying mechanisms remain poorly understood. (frontiersin.org)
  • Results: The results show that care coordination mechanisms are poorly implemented in general. (urosario.edu.co)
  • While electroacupuncture (EA) pretreatment in migraine has been found to attenuate pain and frequencies of attacks, the underlying mechanism of its antinociceptive effect remains poorly understood. (hindawi.com)
  • Similarly, a neutral, peripherally restricted CB 1 receptor antagonist (AM6545) was able to attenuate the metabolic phenotype caused by chronic corticosterone, suggesting a peripheral mechanism for these effects. (johnshopkins.edu)
  • Fructose consumption may contribute to the hyperinsulinemic phenotype of adolescent obesity through a GLP-1-mediated mechanism. (fructosefacts.org)
  • This mechanism starts from the same idea as the prior mechanism, that hearing loss alters cortical activity, including in the MTL. (skincare.nz)
  • The results suggest a crucial role of NF-kB in alcohol-induced brain damage and support the hypothesis that innate immune gene induction contributes to alcohol-induced frontal cortical damage that could underlie the loss of behavioral control associated with alcohol addiction (Fig. 2). (unc.edu)
  • The specific mechanisms by which GCs modulate these processes remain largely unknown, but GCs increase production of endocannabinoids-potent central and peripheral regulators of appetite, energy balance, and metabolism. (iasvn.org)
  • Our results show that sustained exposure to GCs produces obesity and metabolic syndrome through a peripheral endocannabinoid mechanism. (iasvn.org)
  • These results highlight the importance of targeting specific cognitive- affective mechanisms among early college students to reduce the risk of alcohol use and anxiety-related problems. (unl.edu)
  • A second possible mechanism is that hearing loss leads to the decreased stimulation of cognitive processing. (skincare.nz)
  • A third mechanism is based on the idea that people with hearing impairment use greater cognitive resources for listening, making these resources unavailable for other aspects of higher cognition when they are "occupied" during listening. (skincare.nz)
  • A fourth possible explanation focuses on auditory cognitive mechanisms in the medial temporal lobe (MTL) that may be specifically linked to AD pathology in the same region. (skincare.nz)
  • This Review provides an up-to-date overview of the classification of chronic migraine, basic mechanisms and risk factors of migraine chronification, and the currently established treatment options. (nature.com)
  • Repeated infections can contribute to chronic lung disease. (medlineplus.gov)
  • consequently, it induces the manifestation of wide variety of genes, such as those encoding several cytokines, proteases, protein involved in leukocyte recruitment, production of reactive oxygen varieties and phagocytosis, which contribute to start and to amplify the local inflammation. (rawveronica.com)
  • In this issue, we generally review the mechanisms of cellular senescence in diabetic nephropathy, which involve telomere attrition, DNA damage, epigenetic alterations, mitochondrial dysfunction, loss of Klotho, Wnt/ β -catenin signaling activation, persistent inflammation, and accumulation of uremic toxins. (hindawi.com)
  • We are interested in the study of the underlying molecular mechanisms of higher organisms that ensure the proper segregation of the genetic material upon cell division. (brookes.ac.uk)
  • The aberrant cell-cycle progression of HIV-1-infected kidney cells plays a major role in the pathogenesis of HIV-associated nephropathy, however the mechanisms whereby HIV-1 induces infected glomerular podocytes or infected tubular epithelium to exit quiescence are largely unknown. (biomedcentral.com)
  • Yet, the mechanisms are largely unknown whereby HIV-1 subverts the cell-cycle controls that normally maintain renal epithelial in G 0 . (biomedcentral.com)
  • Fig. 6: GFP- and RFP-based biosensor structures provide insight into the mechanism of the fluorescence response. (nature.com)
  • Dr. Fulton Crews, John Andrews Distinguished Professor, Professor of Pharmacology and Psychiatry, and Director of UNC's Bowles Center for Alcohol Studies, has advanced the understanding of the role of innate immune signaling in the brain including the discovery that ethanol induction of innate immune signals contributes to the neurobiology of addiction. (unc.edu)
  • Figure 1: Mechanisms of Alcohol Induction of Brain Innate Immune Genes. (unc.edu)
  • Infections usually become less frequent with age in people with MDA5 deficiency, as the body's immune system matures and develops other mechanisms for fighting viruses. (medlineplus.gov)
  • The recognition of blood-borne inflammatory and immune cells inside the atheroma, led us to postulate the involvement of an immune-inflammatory mechanism in atherogenesis, from plaque formation to the induction of its complication (1). (rawveronica.com)
  • So far, most of the neurobiological mechanisms underlying this complex phenomenon have been studied in the field of pain and analgesia, although recent investigations have successfully been performed in the immune system, motor disorders, and depression. (jneurosci.org)
  • In comparison to the two general alternative mechanisms utilized by known transforming viruses to promote cell-cycle progression, namely, by activating or bypassing endogenous D-type cyclins (herein, referred to as "cyclin D"), it has not been established whether HIV-1 gene products trigger either cyclin D-dependent or cyclin D-independent proliferation in non-lymphoid tissues [ 15 ]. (biomedcentral.com)
  • Professionals point to numerous problems in the use of existing mechanisms, such as the insufficient recording of information in referral forms, low frequency and level of participation in shared clinical sessions, low adherence to the few available clinical guidelines and the lack of or inadequate referral of patients by the patient referral centres, particularly in the Brazilian networks. (urosario.edu.co)
  • The placebo effect is a psychobiological phenomenon that can be attributable to different mechanisms, including expectation of clinical improvement and pavlovian conditioning. (jneurosci.org)
  • To promote vaccination in all settings, health-care providers should implement standing orders to identify adults recommended for hepatitis B vaccination and administer vaccination as part of routine clinical services, not require acknowledgment of an HBV infection risk factor for adults to receive vaccine, and use available reimbursement mechanisms to remove financial barriers to hepatitis B vaccination. (cdc.gov)
  • In this review, the clinical trials about curcumin supplementation on diabetes and DCM are presented, and the specific mechanisms by which curcumin might mitigate diabetes and DCM are fully discussed. (frontiersin.org)
  • In conclusion, the complexity of the mechanisms underlying clinical bleeding complicates the ability to use TG tests as reliable predictors of bleeding. (lu.se)
  • HIV-1 expression induces cyclin D 1 and phospho-pRb (Ser780) expression in infected podocytes, suggesting that HIV-1 activates cyclin D1-dependent cell-cycle mechanisms to promote proliferation of infected renal epithelium. (biomedcentral.com)
  • SIGNIFICANCE STATEMENT Few studies have combined measurement of brain dopamine with examination of the neural basis of cognition in youth and aging to delineate the underlying mechanisms of these associations. (jneurosci.org)
  • In the present review, we will focus on the role of cellular senescence and its related mechanisms in DN. (hindawi.com)
  • Maternal steroids and contaminants in common tern eggs: A mechanism of endocrine disruption? (usgs.gov)
  • Figure 1: Multiple factors contribute to migraine chronification. (nature.com)
  • Vasospasm reducing the arterial circulation can also contribute to increasing hypoxia that precipitates the endothelium dysfunction leading to the reduced production of vasodilatative factors (PG, and nitric oxide) and the increase of vasoactive substances like endothelins and tromboxane. (rawveronica.com)
  • Factors contributing to pediatric farm injury were described. (cdc.gov)
  • Crews and his laboratory discovered that these positive loops of activation of proinflammatory signals contribute to a slow, progressive degeneration that changes the brain and behavior. (unc.edu)
  • These data reveal that estrogens negatively modulate cannabinoid-induced changes in energy balance via G q -coupled membrane ER-and ERα-mediated mechanisms involving activation of PKC and PKA. (elsevierpure.com)
  • Could electrical coupling contribute to the formation of cell assemblies? (degruyter.com)
  • We here argue that electrical coupling - in addition to chemical synapses - may therefore contribute to the formation of at least some cell assemblies in adult animals. (degruyter.com)
  • T2DM and its complications have contributed tremendously to the burden of mortality and health cost worldwide. (frontiersin.org)
  • Despite the relationship between anxiety and alcohol use problems, little is known about the cross-cutting mechanisms that explain their relationship and comorbidity. (unl.edu)
  • To address the relationship gap,, the current study examined how changes in anxiety sensitivity, alcohol expectancies, valuations, peer resistance, and drinking motives contributed to changes in alcohol and anxiety interference across three waves of time. (unl.edu)
  • In a series of studies, Crews first found an important role for chemokines, cytokines, proteases and oxidase enzymes that contribute to alcohol-induced neurodegeneration. (unc.edu)
  • Of the many reasons why this has been the case, a critical one has been a general black-box view of biosensor structure and mechanism. (nature.com)
  • aceclofenac increases effects of glipizide by unknown mechanism. (medscape.com)
  • Patients Referred for Bleeding Symptoms of Unknown Cause : Does Evaluation of Thrombin Generation Contribute to Diagnosis? (lu.se)
  • Web1 lacked the mechanisms for average users to contribute content easily. (forbes.com)
  • Do existing mechanisms contribute to improvements in care coordination across levels of care in health services networks? (urosario.edu.co)
  • The aim is to analyze the use of coordination mechanisms in healthcare networks and its implications for the delivery of health care. (urosario.edu.co)
  • Emotional labor has contributed to poor health and work outcomes. (cdc.gov)
  • As a result of the missing preload stretch in our model, the Anrep effect differs from the slow force response and has a different mechanism. (uni-luebeck.de)
  • This comes in the wake of increased use of USMCA's Rapid Response Labor Mechanism. (corn.org)
  • The website gives a clear guide of how and when to use the web-based tip hotline for labor issues in Canada and Mexico, the Rapid Response Labor Mechanism, and the Labor Chapter Petition in USMCA. (corn.org)
  • Find out more about our Company Response Mechanism. (business-humanrights.org)
  • Is this because similar mechanisms of cell and tissue damage disrupt both the function of the brain and nerve cells in the ears, or is this because hearing is important in the ongoing operation of the brain? (skincare.nz)
  • Similar variation in yolk androgen levels has been seen in bird species like the American coot, though the mechanism of effect has yet to be established. (wikipedia.org)
  • Finally, we address a mechanism by which GelE and SprE may modify the cell wall affinity of proteolytically processed AtlA resulting in either a pro- or anti-lytic outcome. (nih.gov)
  • The Mechanisms of Regulation of Cell Division Group (MRCDG) undertakes both basic and applied research in the field of cell division control. (brookes.ac.uk)
  • There are a number of possible mechanisms for the relationship between hearing loss and dementia. (skincare.nz)
  • The absence or limited use of care coordination mechanisms leads, according to informants, to the inadequate follow-up of patients, interruptions in care and duplication of tests. (urosario.edu.co)
  • Vascular mechanisms are therefore potential contributors to the hearing loss associated with cases of vascular dementia . (skincare.nz)
  • All of them contribute to a high risk of death [ 5 ]. (hindawi.com)
  • It provides an ideal mechanism for accessing public mailing list archives as well as private and shared message stores. (ietf.org)
  • For example, a placebo can reduce pain by both opioid and non-opioid mechanisms ( Colloca and Benedetti, 2005 ) ( Fig. 1 ). (jneurosci.org)
  • I believe one of the areas on which you OSEE folks were looking for interested parties to contribute to the environment was 'Documentation' (just from a brief glance at your list of areas post BoF, Don). (eclipse.org)
  • Labor Immobility and the Transmission Mechanism of Monetary Policy in a Monetary Union ," Working Papers w201019, Banco de Portugal, Economics and Research Department. (repec.org)
  • WinSCP startup mechanism, why does it takes so long without utilising the resurces fully? (winscp.net)