• Prof. Chen's research into the neurobiology and neuroendocrinology of stress focuses on the genomic, epigenomic and cellular mechanisms by which the brain regulates the response to stressful challenges and how this response may be linked to a number of psychiatric and physiological disorders. (whsmith.co.uk)
  • It is an irreversible phenomenon involving a series of biochemical, physiological, and organoleptic changes [ 2 ]. (hindawi.com)
  • tuberculosis, malaria, cholera…) by understanding different physiological stages of the environmental and disease-causing microbes at cellular and molecular level, host-pathogen and intra/inter-species microbial interactions, cell-cell communications and virulence factors, biotechnological interventions, elucidate mode(s) of antibiotic action and mechanisms of antimicrobial resistance (AMR). (lon.ac.uk)
  • The process of burning body fat is a complex metabolic phenomenon that involves various physiological and biochemical mechanisms. (well-choices.com)
  • Growing interest in this phenomenon has fueled recent physiological, biochemical, and genomic insights into the mechanistic basis of desiccation tolerance. (uky.edu)
  • Because Radiofrequency (RF) energy has been shown to renew and restore spatial structural arrangement of collagen fibers, treatment of ED with RF could lead to anatomical and physiological changes at the penile tissue level and could lead to improvement in the erectile mechanism. (researchgate.net)
  • Understanding the mechanisms involved in guiding at least under homeostatic or physiological conditions. (lu.se)
  • However, the physiological mechanism of this phenomenon is unknown. (medscape.com)
  • Clinical neurochemistry is the field of neurological biochemistry which relates biochemical phenomena to clinical symptomatic manifestations in humans. (wikipedia.org)
  • Metabolomics provides good potential in understanding biochemical mechanisms such as disease biochemistry, because metabolite profiles offer a snapshot of the ongoing biochemical phenomena. (thetabiomarkers.com)
  • A continuation of MB&B 600a that considers the chemistry and metabolism of nucleic acids, the mechanism and regulation of protein and nucleic acid synthesis, and selected topics in macromolecular biochemistry. (yale.edu)
  • Through a series of biochemical reactions, acetyl-CoA is further oxidized, leading to the production of reducing agents, such as NADH and FADH2, which are crucial for energy generation through oxidative phosphorylation. (well-choices.com)
  • Our results demonstrate mechanisms that can be used to switch between extensile and contractile stresses, as well as a range of new dynamical pathways and structures that are reminiscent of those observed in equilibrium amphiphilic systems. (aps.org)
  • The essence of Behe's argument from IC in Darwin's Black Box is that given any amount of time and natural selection, the jump between nothing and a novel irreducibly complex entity like the bacterial flagellum is larger than the neo-Darwinian mechanism can span and thus it does not account for the IC structures and biochemical pathways that abound in nature. (grisda.org)
  • Production of novel new molecular machines or biochemical pathways - with one or two possible exceptions like antifreeze proteins, which Behe discusses - appears beyond its abilities irrespective of time. (grisda.org)
  • The remethylation pathway comprises 2 intersecting biochemical pathways and results in the transfer of a methyl group (CH3) to homocysteine from methylcobalamin, which receives its methyl group from S-adenosylmethionine (SAM), from 5-methyltetrahydrofolate (an active form of folic acid), or from betaine (trimethylglycine). (medscape.com)
  • The mechanism leading to this unusual phenomenon was investigated by various biochemical and biophysical techniques. (lookformedical.com)
  • This graduate course introduces the theory and application of biochemical and biophysical methods to study the structure and function of biological macromolecules. (yale.edu)
  • Our observations allow us to generate mechanistic, thermodynamic, and evolutionary hypotheses about the effect of temperature on structure-function relationships, which we test using traditional biochemical and biophysical measurements. (thompsonlab.science)
  • It includes a wide range of basic molecular knowledge on the potential associations between resilience phenomenon and biochemical balance, but also focuses on the molecular and cellular mechanisms underlying stress resilience. (whsmith.co.uk)
  • The integration of knowledge concerning the molecular and cellular actions of a drug within the brain circuitry leads to an overall understanding of a neurological drug's action mechanisms. (wikipedia.org)
  • The most basic and fundamental neurological phenomena in neuropharmacology is the binding of a drug or neurologically active substance to a cellular target. (wikipedia.org)
  • Fluorescent reporter proteins in the Drosophila model system offer a degree of specificity that allows monitoring cellular and biochemical phenomena in vivo, such as autophagy, mitophagy, and changes in the redox state of cells. (intechopen.com)
  • We are interested in the cellular, biochemical and/or genetic mechanisms underlying immunological phenomena. (lon.ac.uk)
  • In our laboratory, we aim to understand the biochemical link between protein pyrophosphorylation and cellular phenomena regulated by inositol pyrophosphates. (org.in)
  • Our long term goal is to understand the mechanisms by which inositol polyphosphates mediate cellular events that are relevant to human physiology and disease. (org.in)
  • Understanding cellular function requires structural and biochemical studies at an ever-increasing level of complexity. (yale.edu)
  • These adaptive molecular and structural mechanisms increase respiration to maintain basic processes specific to cell types and tissues. (nature.com)
  • The genetic code in our DNA is not "set in stone" but can be changed by biochemical processes. (bionity.com)
  • Molecular machines participate in various essential biological processes, including catalyzing biochemical reactions, converting biochemical energy into mechanical work, transporting cargo and small molecules, signaling environmental changes to cells, and fulfilling numerous other functions within living organisms. (lon.ac.uk)
  • Several intricate mechanisms and processes contribute to this metabolic phenomenon. (well-choices.com)
  • When a cell receives a signal from its extracellular environment or from other cells, it triggers a cascade of biochemical processes collectively termed signal transduction . (org.in)
  • Energy metabolism, hormone signaling, and muscle contraction as examples of complex biological processes whose underlying mechanisms can be understood by identifying and analyzing the molecules responsible for these phenomena. (yale.edu)
  • Collectively, these experiments allow us to map the interconversion of conformational states that underlie biochemical phenomena such as enzyme catalysis, ligand binding, and allosteric signal transduction. (thompsonlab.science)
  • Several mechanisms cause deterioration of food and limit their shelf life: biochemical or microbial decay, chemical changes - especially oxidation (rancidity of fats, respiration of fruits and vegetables, discoloration, vitamin loss) -, physical deterioration (moisture migration, water loss or uptake). (eurekaselect.com)
  • The mechanism of coordinated coupling of exergonic and endergonic oxidation-reduction reactions by a single enzyme complex has been elucidated through optical and paramagnetic spectroscopic studies revealing unprecedented features. (elsevierpure.com)
  • The formation of superoxide radicals in the aqueous humor and in lens and its derivatization to other potent oxidants may be responsible for initiating various toxic biochemical reactions leading to the formation of cataract. (ukessays.com)
  • A new study by Michael R. Kreutz's group at the Leibniz Institute of Neurobiology Magdeburg (LIN) reveals a mechanism by which the activity of synapses controls the protein levels of a de novo DNA methylating enzyme. (bionity.com)
  • He has made significant contributions to the fields of protein structure and function, enzyme kinetics and mechanism, metabolic regulation, oxidative stress and antioxidant defense, molecular signaling, gene expression and regulation, DNA damage and repair, apoptosis and cancer, and drug design and development. (schalkstrees.com)
  • In particular, we investigate the spatial relationship between the mitochondria and a very recently discovered protein quality control mechanism, called the Unfolded Protein Response activated by mistargeted proteins (UPRam). (keystonesymposia.org)
  • The recently realized biochemical phenomenon of energy conservation through electron bifurcation provides biology with an elegant means to maximize utilization of metabolic energy. (elsevierpure.com)
  • Metabolites can be directly linked with physiology and phenotype because metabolites are further down the biochemical pathway compared with genes or proteins. (thetabiomarkers.com)
  • Although, desiccation tolerance is often viewed as binary and monolithic, substantial variation exists in the phenotype and underlying mechanisms across diverse lineages, heterogeneous populations, and throughout the development of individual plants. (uky.edu)
  • And if we are indeed biochemical structures (as biologists in general believe), why might not appropriately designed future machines (advanced AI) likewise have the capacity to exercise free will (should free will exist)? (askphilosophers.org)
  • Collagen is an essential component of the structures involved in the erectile mechanism and as such, impaired collagen may hinder it. (researchgate.net)
  • Ripening is a genetically programmed highly coordinated irreversible phenomenon which includes many biochemical changes including tissue softening, pigment changes, aroma and flavour volatile production, reduction in astringency, and many others. (hindawi.com)
  • Understanding the mechanisms by which the body burns body fat is crucial for developing effective strategies to combat obesity and promote overall health. (well-choices.com)
  • Understanding this phenomenon is fundamental to our understanding of life on Earth and how it might be affected by climate change, as well as to our understanding of human health and disease. (thompsonlab.science)
  • We are using the regulation of shoot branching as a model system to investigate the mechanisms underlying this developmental plasticity. (ens-lyon.fr)
  • The biochemical mechanisms underlying those phenomena are not well understood. (cdc.gov)
  • Genetic and biochemical studies have identified "molecular thermometers," for which small changes in temperature cause large differences in functional output, but the atomic details of the underlying mechanisms remain poorly understood. (thompsonlab.science)
  • Oxidative mechanism plays an important role in biological phenomena including cataract formation. (ukessays.com)
  • The clinical effects of a neural drug are due to both immediate changes in homeostasis and long-term neural adaptations characterized by the phenomena neural plasticity. (wikipedia.org)
  • used two types of biochemical assays to determine the pharmacological characteristics of the allosteric modulators. (elifesciences.org)
  • The authors of the study discovered a mechanism that allows synaptic control of DNMT3A1 levels in neurons, thereby creating a time window for reduced DNA do novo methylation at a group of target genes. (bionity.com)
  • This same phenomenon is also commonly illustrated in bacterial antibiotic resistance. (grisda.org)
  • By gaining insights into these mechanisms, individuals can make informed decisions to optimize their fat-burning potential and achieve their weight loss goals. (well-choices.com)
  • Therefore, we analysed stage-specific gradients of pH i and V mem as well as their dependence on specific ion-transport mechanisms. (biomedcentral.com)
  • This revealed that both LY298 and VU154 display a phenomenon called 'probe dependence', meaning that they had a stronger effect when the orthosteric ligand was acetylcholine rather than iperoxo. (elifesciences.org)
  • This system drives the rhythmic, sequential, and precise formation of embryonic body segments, exhibiting rich spatial and temporal phenomena spanning from molecular to tissue scales. (ens-lyon.fr)
  • 2008). Historically, this concept is highlighted by the experi- factors are key intrinsic regulators of these fate decisions and mental phenomenon of lineage reprogramming, for example, that fate choice involves modulating networks of transcription by the conversion of fibroblasts to muscles cells following trans- factors. (lu.se)
  • Based on regulatory mechanisms leading to fruit ripening, fruits can be divided into two groups: climacteric and nonclimacteric fruits. (hindawi.com)
  • While neurochemistry is mostly associated with the effects of neurotransmitters and similarly functioning chemicals on neurons themselves, clinical neurochemistry relates these phenomena to system-wide symptoms. (wikipedia.org)
  • Neurotransmitters and similarly functioning biochemical messengers elicit effects on postsynaptic neurons at neuronal synapses. (wikipedia.org)
  • We further investigate this phenomenon by using both biochemical and microscopic methods. (keystonesymposia.org)
  • Several theories have been proposed to explain the exact mechanism through which these agents cause neurotoxicity. (ajnr.org)
  • Theories and mechanisms of infection and immunity. (millikin.edu)
  • A long-held claim of Darwin-doubters has been that while the neo-Darwinian mechanism of mutation coupled with selection may be capable of doing something, it is incapable of turning an amoeba into a giraffe or algae into an oak tree. (grisda.org)
  • Plasmodium can be viewed as a natural experiment illustrating what capabilities the neo-Darwinian mutation-selection mechanism possesses. (grisda.org)
  • At this stage we do not know how extensive this phenomenon is in humans, but it may well turn out to be the explanation for some diseases which appear to be sporadic or show only weak genetic linkage. (portlandpress.com)
  • Most studies suggest that there is no difference in biochemical composition and sensory quality in bananas treated with chemicals that induce ripening from naturally ripened bananas. (hindawi.com)
  • Other activities carried out by the IPCS include the development of know-how for coping with chemical accidents, coordination of laboratory testing and epidemiological studies, and promotion of research on the mechanisms of the biological action of chemicals. (cdc.gov)
  • Hormonal mechanisms affect the responses of women's homeostatic, emotional, and attentional brain regions to food cues. (medscape.com)
  • Our findings help to understand biochemical mechanisms underlying sexual dimorphism, a phenomenon which may explain the differential susceptibility to common diseases in males and females. (genomeweb.com)
  • CAVER 3.0 paves the way for the study of important biochemical phenomena in the area of molecular transport, molecular recognition and enzymatic catalysis. (plos.org)
  • [ 2 ] The brain faces multiple hormonal and biochemical signals from organs, but also nonhomeostatic signals from the environment, and coordinates caloric intake and energy expenditure based on the integration of these cues. (medscape.com)
  • Competition between apices for these transport paths can explain a range of phenomena in shoot branching, such as apical dominance. (ens-lyon.fr)
  • The data collected from the resultant spectra were used to assess differences among clones and among ramets of a single clone and to determine the mechanism governing the observed differences. (who.int)
  • to be physically real even when it is clear no one can ever directly experience those things as phenomena. (philpapers.org)
  • Because obesity is considered the epidemic of the 21st century [ 10 ] and because the majority of dietary regimens eventually fail in the long run, [ 11 ] there is growing interest in unraveling mechanisms that drive and modulate eating behavior. (medscape.com)