• Apolipoprotein B is the primary apolipoprotein of chylomicrons, VLDL, Lp(a), IDL, and LDL particles (LDL-commonly known as "bad cholesterol" when in reference to both heart disease and vascular disease in general), which is responsible for carrying fat molecules (lipids), including cholesterol, around the body to all cells within all tissues. (wikipedia.org)
  • A variety of clinical studies have demonstrated that elevated levels of total cholesterol (total-C), low density lipoprotein cholesterol (LDL-C), and apolipoprotein B (apo B), an LDL membrane complex, are associated with human atherosclerosis. (nih.gov)
  • Similarly, decreased levels of high density lipoprotein cholesterol (HDL-C) and its transport complex, apolipoprotein A (apo AI and apo AII) are associated with the development of atherosclerosis. (nih.gov)
  • Fenofibric acid, the active metabolite of fenofibrate, produces reductions in total cholesterol, LDL cholesterol, apolipoprotein B, total triglycerides and triglyceride rich lipoprotein (VLDL) in treated patients. (nih.gov)
  • Recent studies have demonstrated that ATP-binding cassette protein A1 (ABCA1) is highly regulated in macrophages and mediates the efflux of cholesterol and phospholipids to apolipoproteins, a process necessary for HDL formation. (jci.org)
  • ABCA1 is expressed in many organs and is thought to mediate HDL maturation by facilitating the efflux of cellular phospholipids and cholesterol onto apolipoproteins. (jci.org)
  • Conflicting results also concern the frequency of the association between the two protein misfolding disorders and the issue of whether the apolipoprotein E gene ( APOE ) and the prion protein gene ( PRNP ), the major modifiers of Aβ- and PrP-related pathologies, also have a pathogenic role in other proteinopathies, including tau neurofibrillary degeneration. (biomedcentral.com)
  • Apolipoprotein E (APOE) is a lipid-transport protein abundantly expressed in most neurons in the central nervous system. (dovepress.com)
  • The apolipoprotein E (APOE) gene is located on chromosome 19 and encodes a glycoprotein that is 299 amino acids long. (dovepress.com)
  • Apolipoprotein B (ApoB) is a protein that in humans is encoded by the APOB gene. (wikipedia.org)
  • Through mechanisms only partially understood, high levels of ApoB, especially associated with the higher LDL particle concentrations, are the primary driver of plaques that cause vascular disease (atherosclerosis), commonly first becoming obviously symptomatic as heart disease, stroke and many other body wide complications after decades of progression. (wikipedia.org)
  • ApoB 48 is a unique protein to chylomicrons from the small intestine. (wikipedia.org)
  • The mechanism of antagonism entails binding ApoB, to a S. aureus autoinducer pheromone, preventing signaling through its receptor. (wikipedia.org)
  • Overproduction of apolipoprotein B can result in lipid-induced endoplasmic reticulum stress and insulin resistance in the liver. (wikipedia.org)
  • However, the mechanisms underlying inflammation-mediated lipid metabolism dysregulation in accelerated atherosclerosis in ESRD are not completely understood. (medsci.org)
  • An assessment on the associations of iron status with apolipoproteins and lipid ratios would be informative for maintenance of metabolic homeostasis and hinderance of disease progression. (biomedcentral.com)
  • Hence, this study aims to establish the relationships of iron status with apolipoproteins and lipid ratios. (biomedcentral.com)
  • This review summarizes the recent experimental and clinical results of nine representative single Chinese herbs and seven classic TCM formulae that could improve lipid profiles so as to help understand and compare their underlying mechanisms. (hindawi.com)
  • Investigation of the mechanism leading to the triglyceride accumulation showed that both a diminution of apolipoprotein B secretion and an increase in phosphoenolpyruvate carboxykinase messenger RNA may be involved. (unige.ch)
  • Plasma concentrations of fenofibric acid after administration of three 48 mg or one 145 mg tablets are equivalent under fed conditions to one 200 mg capsule. (nih.gov)
  • We found a unique mechanism in which N- and C-terminal peptides associated into amyloid fibrils in a 1:1 ratio at pH 2.5. (nii.ac.jp)
  • Hemoglobin were also independently associated with unfavorable apolipoprotein B and apolipoprotein B/apolipoprotein A1 ratio both in men and women. (biomedcentral.com)
  • In the present study, we investigated the effects of resveratrol (RSV), a bioactive ingredient extracted from Chinese herb rhizoma polygonum cuspidatum , on permeability in vitro and the molecular mechanisms involved. (springer.com)
  • In this study, we explore different signaling pathways and associated molecular mechanisms of underlying primary breast cancer development, along with the formation of metastases in the bone. (degruyter.com)
  • Altogether, the present results seem to exclude an increased prevalence AD/PART co-pathology in sporadic and genetic CJD, and indicate that largely independent pathogenic mechanisms drive AD/PART and CJD pathology even when they coexist in the same brain. (biomedcentral.com)
  • Here, we analysed 80,660 single-nucleus transcriptomes from the prefrontal cortex of 48 individuals with varying degrees of Alzheimer's disease pathology. (nature.com)
  • 2. Premio para la comunicación ¿Record of preanalytical errors in the laboratory information system¿ en el XXII National Congress of the Spanish Society of Clinical Biochemistry and Molecular Pathology, celebrado en Barcelona del 1 al 5 de Junio de 2003. (unav.edu)
  • AGGREGATION"}]}, "item_6_textarea_68": {"attribute_name": "wosonly abstract", "attribute_value_mlt": [{"subitem_textarea_value": "In mice, amyloidogenic type C apolipoprotein A-II (apoA-II) forms amyloid fibrils in age-associated amyloidosis. (nii.ac.jp)
  • To understand the mechanism of amyloid fibril formation by apoA-II, we examined the polymerization of synthetic partial peptides of apoA-II in vitro. (nii.ac.jp)
  • Flavonoids have been shown to exhibit antiinflammatory, antithrombogenic, antidiabetic, anticancer, and neuroprotective activities through different mechanisms of action in vitro and in animal models. (oregonstate.edu)
  • however, the underlying mechanisms are not fully understood. (springer.com)
  • The mechanisms that translate chronic stress into increased risk of cardiovascular disease (CVD) are poorly understood. (pace-cme.org)
  • Several anti-inflammatory, digestive, antinecrotic, neuroprotective, and hepatoprotective drugs have recently been shown to have an antioxidant and/or radical scavenging mechanism as part of their activity (Perry et al. (sinica.edu.tw)
  • atazanavir increases levels of pitavastatin by unknown mechanism. (medscape.com)
  • Searching for a common mechanism for placenta-mediated pregnancy complications and cardiovascular disease: role of lipoprotein(a). (cdc.gov)
  • These findings suggest that there may be different mechanisms underlying the nucleation and extension phases of apoA-II amyloid fibril formation. (nii.ac.jp)
  • The association between DM and stroke involves the interplay of complex mechanisms, including various hemodynamic and metabolic pathways ( Figure 1 ). (j-stroke.org)
  • The neuropathology of stillbirth - correlation with apolipoprotein genotype in a Scottish population based study. (cdc.gov)
  • The following table summarizes the NHANES III data which are currently available on CD-ROM or through other release mechanisms such as the Internet. (cdc.gov)
  • The results of surveys, analyses, and studies are made known through a number of data release mechanisms including publications, mainframe computer data files, CD-ROMs (Search and Retrieval Software, Statistical Export and Tabulation System (SETS)), and the Internet (http://www.cdc.gov/nchswww/nchshome.htm). (cdc.gov)
  • Early human development 2015 Feb 91 (2): 139-48. (cdc.gov)
  • Here, we discuss the mechanisms underlying the relationship between glucose homeostasis and stroke development, and provide an overview of the efficacy of glucose-lowering treatment in stroke management. (j-stroke.org)
  • Most of single herbs and formulae demonstrated the improvement of hyperlipidemic conditions with multiple and diverse mechanisms of actions similar to conventional Western drugs in spite of their mild side effects. (hindawi.com)
  • women: OR 0.71, 95% CI 0.55-0.91) were found to be negatively associated with a decreased apolipoprotein A1. (biomedcentral.com)
  • Indeed, beyond the lipoprotein lipase cofactor apolipoprotein (apo) CII, recent studies have identified the relevance of apoCIII in controlling the efficiency of TG clearance, and angiopoietin-like protein 3 (ANGPTL3) in modulating lipoprotein lipase activity, suggesting potential as therapeutic targets (14,15) . (eas-society.org)
  • Due to increasing popularity of TCM, more extensive, well-designed preclinical and clinical trials on the potential synergistic and adverse side effects of herb-drug interactions as well as their mechanisms are warranted. (hindawi.com)
  • [ 5 ] Many mechanisms have been postulated to explain this association ( i.e., more severe insulin resistance, subclinical inflammation, ectopic fat accumulation with potential cardiolipotoxicity, and worse dyslipidemia). (medscape.com)