• Whether axon guidance and synaptogenesis require entirely different molecular mechanisms, or whether the same molecules are simply re-used and have context-dependent functions is still largely unclear. (nature.com)
  • This project will examine the molecular mechanisms that control the switch in developmental program from axon guidance to synaptogenesis using automated imaging screening of cell cultures, transcriptome analysis of developing mouse and human neurons, and in vivo analysis of candidate molecules in mouse models. (nature.com)
  • In this review, we discuss the current understanding of cannabinoids as antitumour agents, focusing on recent discoveries about their molecular mechanisms of action, including resistance mechanisms and opportunities for their use in combination therapy. (nih.gov)
  • Wilma Wasco and Rudolph Tanzi bring together in Molecular Mechanisms of Dementia the best and latest thinking by leading scientists on the etiologic and pathogenic events responsible for the onset of Alzheimer's disease and related dementias. (springer.com)
  • Molecular Mechanisms of Dementia is the first major contemporary review of this dramatically advancing field. (springer.com)
  • It provides an invaluable summary of the tremendous progress that has been made in developing testable models of the molecular mechanisms of dementia, as well as critical insights into the necessary direction of future investigations of dementia. (springer.com)
  • It represents a very interesting review for scientists studying the cellular and molecular mechanisms involved in the neurodegeneration of Alzheimer's disease. (springer.com)
  • The contributions span in vivo and in vitro studies that address: state‐dependent plasticity, relevance of firing patterns, membrane properties, calcium flux (including dynamic imaging and homeostasis), and molecular mechanisms of exocytosis, including from non-neuronal secretory cells. (springer.com)
  • Our members work to advance knowledge in the basic mechanisms of inheritance, from the molecular to the population level. (genetics.org)
  • The book addresses the developments in the molecular mechanisms of B and T cell tolerance and describes the failure of tolerance in autoimmunity. (elsevier.com)
  • The Molecular Mechanisms Section studies vitamin A and lipid metabolism, and signaling and regulation processes central to vision and function of the retina and retinal pigment epithelium (RPE). (nih.gov)
  • Despite extensive efforts from a number of labs, the molecular nature of this mechanism has proven elusive. (dkfz.de)
  • What we are currently doing is to elucidate the intricacies of the regulatory mechanism characterize the molecular function of the candidate tumor suppressor genes in the critical region. (dkfz.de)
  • Scientists have revealed more details of the molecular mechanism behind neuronal cell death in amyotrophic lateral sclerosis (ALS), a step forward to find ways to control progression of the disease. (eurekalert.org)
  • An impressive variety of molecular mechanisms ensures that genes are expressed at the appropriate level and under the appropriate conditions. (genetics.org)
  • What this means for people with autism: Dr. Penzes's laboratory has identified one of the few known molecular mechanisms to regulate dendritic spine density. (autismspeaks.org)
  • Molecular structures of Dicer and Argonaute proteins, and of RNA-bound complexes, have offered exciting insights into the mechanisms operating at the heart of RNA-silencing pathways. (nih.gov)
  • Nowadays, with the progress of the research of the cellular and molecular biology, the study of aging mechanism has been from the overall level up to the molecular levels. (scirp.org)
  • Although research on stress-induced aging mechanism is not so much as replicative aging mechanism, phenotypic characteristics and molecular signals from these two types of aging are very similar. (scirp.org)
  • Mechanisms of Development is an international journal that communicates current studies in developmental biology in any model system like animals and plants, these may focus on molecular and/or cellular mechanisms. (elsevier.com)
  • There is an urgent need to understand the molecular and cellular mechanisms of sepsis development, a leading cause of death during infection. (europa.eu)
  • NEW YORK, April 21 â€" There's new light on the molecular mechanisms underlying Glanzmann thrombasthenia, the rare inherited clotting disorder in which the glycoprotein IIb/IIIa (GP IIb/IIIa) complex is either deficient or dysfunctional. (medpagetoday.com)
  • Out-of-equilibrium performance of three Lindahl mechanisms: Experimental evidence ," Games and Economic Behavior , Elsevier, vol. 74(1), pages 366-381. (repec.org)
  • The enzyme residue may form a transient covalent bond with the substrate, which is a mechanism known as covalent catalysis. (news-medical.net)
  • The Grotthuss mechanism (also known as proton jumping ) is the process by which an 'excess' proton or proton defect diffuses through the hydrogen bond network of water molecules or other hydrogen-bonded liquids through the formation and concomitant cleavage of covalent bonds involving neighboring molecules. (wikipedia.org)
  • Mechanisms involving covalent binding of reactive metabolites to protein and DNA which can explain the occurrence of aplastic anemia will be discussed. (springer.com)
  • The fundamental difference between the transition states in the bimolecular and unimolecular mechanisms is the degree of covalent bonding between the nucleophile and the substrate in the transition state. (britannica.com)
  • Solving this type of communicative problem requires a mechanism that supports a rapid exploration through a large search space, generating connections between different conceptual structures ( 15 , 16 ). (pnas.org)
  • Applicants may also be awarded an Emory College Collaborative Research Catalyst Award in Neural and Behavioral Mechanisms of Learning , supported by the office of Dean Elliott. (google.com)
  • In presenting the various mechanisms and multifaceted approaches currently being employed, the distinguished contributors review such critical factors as apoptosis, energy metabolism, excitotoxicity and calcium-mediated cell death, free radicals, electrophysiological abnormalities, environmental toxins, degeneration of neural networks, and modification of the cytoskeleton. (springer.com)
  • It is, therefore, important to consider which basic mechanisms of the response to TBI represent potential targets for therapy. (medscape.com)
  • The chapters outline how progress is being made on several fronts ranging from basic mechanisms to invasive treatment for thoracic vein arrhythmias. (worldcat.org)
  • The research group previously discovered similar regulation mechanisms in the mitochondria that were found to be related to the development of diabetes. (redorbit.com)
  • Chun-Yang Fan , Soojin Lee , and Douglas M. Cyr "Mechanisms for regulation of Hsp70 function by Hsp40," Cell Stress & Chaperones 8(4), 309-316, (1 October 2003). (bioone.org)
  • Elucidating the mechanisms at work in HD pathogenesis and determining when they occur in relation to disease is an important step in the pathway to therapeutic interventions. (nih.gov)
  • One component of this initiative would focus on mechanisms that regulate the pathogenesis of milder and chronic forms of HIV-associated CNS disease resulting from long-term treatment and associated confounding factors. (nih.gov)
  • "Mechanisms of Learning across Development and Species " is a National Institutes of Health (NIH) Institutional National Research Service Award (NRSA) Training Grant co-directed by Drs. Patricia Bauer (Cognition and Development program) and Robert Hampton (Neuroscience and Animal Behavior program). (google.com)
  • Sean Morrison's laboratory studies the mechanisms that regulate stem cell self-renewal in the hematopoietic and nervous systems and the role these mechanisms play in cancer. (hhmi.org)
  • and mechanisms that regulate development of CNS-associated immune reconstitution syndromes. (nih.gov)
  • The importance of the interactions between calcium and cyclic-AMP in intestinal secretion is emphasized in a comprehensive chapter that systematically addresses each link in the mechanisms that regulate chloride secretion. (routledge.com)
  • The underlying mechanisms of schizophrenia are not entirely understood in their complexity by medical researchers at this point in time. (news-medical.net)
  • This meeting is for established and early career scientists, post-graduate students and industrial researchers interested in the key aspects of reaction mechanism studies and how this can drive rational design of catalysts. (rsc.org)
  • Adoption studies are often used to understand human inheritance mechanisms, allowing researchers to separate genetic and environmental effects. (brighthub.com)
  • These studies also do not allow researchers to distinguish between core mechanisms responsible for the disease and epiphenomena. (cmaj.ca)
  • The researchers add that a larger number of microbial enzymes are similar to the C. difficile toxins, and that nitrosylation may represent a common form of defence mechanism against microbes. (www.nhs.uk)
  • In this study the researchers performed a range of experiments to look at a range of biological and chemical mechanisms behind the body's defences against the bacteria C. difficile. (www.nhs.uk)
  • Now, a team of researchers led by Mikihiro Shibata from Kanazawa University and Osamu Nureki from the University of Tokyo has visualized the dynamics of the CRISPR-Cas9 complex, in particular how it cuts DNA, providing valuable insights into the CRISPR-Cas9-mediated DNA cleavage mechanism. (eurekalert.org)
  • Using the world's highest mountain, Mount Everest, as an outdoor laboratory, a group of British researchers has identified a mechanism involved in the development of adult onset diabetes. (voanews.com)
  • So, researchers with the Mount Everest project sought to identify the mechanisms by which low oxygen levels contribute to disease in patients who are critically ill with diabetes. (voanews.com)
  • Both (n-6) and (n-3) fatty acids are polyunsaturated, compelling one to explore alternative mechanisms to lipid peroxidation as an explanation for both dietary lipid-modulated UV carcinogenesis and its inhibition by BHT. (redorbit.com)
  • Figure 3: Mechanisms and consequences of lipid nephrotoxicity. (nature.com)
  • International negotiations under the United Nations Framework Convention on Climate Change (UNFCCC) spearheaded the development of global carbon markets, first through the CDM and other "flexibility mechanisms" under the Kyoto Protocol (which entered into force in 2005), and more recently through a new market-based mechanism, established under the Paris Agreement (2015), which is slated to replace the Kyoto mechanisms in 2020. (undp.org)
  • Multiple pathogenic mechanisms which hypothesise how the expanded CAG repeat causes manifest disease have been suggested since the mutation was first detected. (nih.gov)
  • This signalling route could constitute the main mechanism of cannabinoid-induced cell death, with some variations inherent to different types of cancer cells. (nih.gov)
  • This book discusses the mechanisms that have been proposed for the main corrosion phenomena, providing a thorough discussion of the pros and cons of the various corrosion mechanisms with support by experimental and theoretical results. (routledge.com)
  • This concept is now one of the most current topics in electrophysiology, and while it is a topic of frequent discussion in the major cardiology and electrophysiology journals, Thoracic Vein Arrhythmias: Mechanisms and Treatment is the first state-of-the art multi-authored textbook that integrates the advances made in this rapidly developing new area of cardiac arrhythmias for the global community. (worldcat.org)
  • The work of Shibata advances our understanding of the CRISPR-Cas9 genome-editing mechanism. (eurekalert.org)
  • The cluster supports inventive studies seeking to address fundamental mechanisms involved in the evolution, organization, dynamics, and utilization of genetic information within cellular systems. (nsf.gov)
  • We study the design of mechanisms that implement Lindahl or Walrasian allocations and whose Nash equilibria are dynamically stable for a wide class of adaptive dynamics. (repec.org)
  • Although dynamical relaying has been validated in empirical and computational studies, the deeper dynamical mechanisms and comparison to dynamics on other motifs is lacking. (plos.org)
  • The study of large-scale brain dynamics, and the cortical networks on which they unfold, is a very active research area, providing new insights into the mechanisms of functional integration and complementing the traditional focus on functional specialization in the brain , . (plos.org)
  • This is an application combining multiple machine learning methods, numeric algorithms and software technology to automatically produce a set of reduced sub-mechanisms (meaning they are computationally faster) to mimic a single full mechanisms. (google.com)
  • In this talk we will consider the problem of designing computationally feasible mechanisms when we relax the common goal (in Computer Science) of dominant strategy incentive compatibility (IC) to Bayesian incentive compatibility (BIC), where truthtelling is a Bayes-Nash equilibrium. (microsoft.com)
  • This discussion will consider mechanisms by which benzene produces decrements in bone marrow function, alters the production of cytokines, and impairs the hematopoietic system. (springer.com)
  • Human referential communication is often thought as coding-decoding a set of symbols, neglecting that establishing shared meanings requires a computational mechanism powerful enough to mutually negotiate them. (pnas.org)
  • A common language might help to achieve the latter by providing access to previously established shared symbols, but those symbols presuppose a computational mechanism powerful enough to negotiate them across interlocutors ( 3 ). (pnas.org)
  • The principal problem in algorithmic mechanism design is to merge the incentive constraints imposed by selfish behavior with the algorithmic constraints imposed by computational intractability. (microsoft.com)
  • For welfare maximization in single-parameter agent settings, we give a general black-box reduction that turns any approximation algorithm into a BIC mechanism with essentially the same approximation factor and computational efficiency. (microsoft.com)
  • His research is focused mainly on computational issues in mechanism design and the theory of social networks. (microsoft.com)
  • Several computational mechanisms have been proposed to account for such isochronous synchronization in the presence of long conduction delays: Of these, the phenomenon of "dynamical relaying" - a mechanism that relies on a specific network motif - has proven to be the most robust with respect to parameter mismatch and system noise. (plos.org)
  • This review describes the history of overexpression, the mechanisms that are responsible for overexpression phenotypes, tests that begin to distinguish between those mechanisms, the varied ways in which overexpression is used, the methods and reagents available in several organisms, and the relevance of overexpression to human disease. (genetics.org)
  • Herein, literature is reviewed that describes the mechanisms by which Hsp40 proteins interact with Hsp70 to specify its cellular functions. (bioone.org)
  • Robust Implementation in General Mechanisms ," Cowles Foundation Discussion Papers 1666R, Cowles Foundation for Research in Economics, Yale University, revised Jan 2010. (repec.org)
  • Robust Implementation in General Mechanisms ," Levine's Working Paper Archive 122247000000002286, David K. Levine. (repec.org)
  • Mechanism Design with Incomplete Information: A Solution to the Implementation Problem ," Journal of Political Economy , University of Chicago Press, vol. 97(3), pages 668-691, June. (repec.org)
  • 1987. " Mechanism Design with Incomplete Information: A Solution to the Implementation Problem ," Working Papers 658, California Institute of Technology, Division of the Humanities and Social Sciences. (repec.org)
  • The features of each mechanism and the keys for successful implementation are illustrated. (worldbank.org)
  • Rationalizable Implementation ," World Scientific Book Chapters ,in: Robust Mechanism Design The Role of Private Information and Higher Order Beliefs, chapter 11, pages 375-404 World Scientific Publishing Co. Pte. (repec.org)
  • Another Kyoto mechanism, Joint Implementation (JI) , similarly provides for Emission Reduction Units (ERUs) to be sold by economies in transition. (undp.org)
  • A defence mechanism is an unconscious psychological mechanism that reduces anxiety arising from unacceptable or potentially harmful stimuli. (wikipedia.org)
  • An ego defence mechanism becomes pathological only when its persistent use leads to maladaptive behaviour such that the physical or mental health of the individual is adversely affected. (wikipedia.org)
  • Newer research also indicates that the neurotransmitter serotonin may also be involved in the mechanism, as atypical antipsychotic medications, which act primarily on serotonin, also have a similar effect on positive symptoms. (news-medical.net)
  • The relevance of these receptors has been supported by further research, which found that drugs with a mechanism that blocked the glutamate receptors tended to precipitate symptoms of the condition. (news-medical.net)
  • Creating New Instruments and Research Techniques to Study Cell Mechanisms: 15. (cambridge.org)
  • The introductory chapter of the book summarizes the dawn of the insight into immunological tolerance, and provides an overview of research on the underlying mechanisms. (elsevier.com)
  • Exploring the mechanisms of aging is an ancient and new field of scientific research. (scirp.org)
  • Each year, students in the seminar host the Mechanisms of Learning Forum, an intimate and interactive conference involving investigators and graduate students from other universities. (google.com)
  • This paper identified a mechanism that operates in host organisms to reduce the cleavage of the toxins, and explored the potential of exploiting this mechanism to treat mice with C. difficile infections. (www.nhs.uk)
  • Cervical Spine Injury Mechanisms," SAE Technical Paper 831616, 1983, https://doi.org/10.4271/831616 . (sae.org)
  • Retrieved on June 18, 2019 from https://www.news-medical.net/health/Schizophrenia-Mechanisms.aspx. (news-medical.net)
  • They also examine mechanisms by which ischemia and hypoxia result in dementia. (springer.com)
  • This webinar will examine how identification of dysregulated cell-death mechanisms underpinning various pathologies can be exploited to develop novel treatments for cancer and neurodegenerative diseases that directly activate the cell-death machinery. (sciencemag.org)
  • In this tolerance mechanism, a self‐reactive B cell encountering its target autoantigen will undergo a state of functional silencing, but will persist in the immune repertoire. (els.net)
  • Fuzzy logic was key in this analysis giving essentially the information yes-no-maybe with "maybe" being the fuzzy transition between the species absolutely needs to be in the mechanism or absolutely does not need to be in the mechanisms. (google.com)
  • The mechanisms controlling this transition are largely unknown. (nature.com)
  • The significant consideration in this reaction mechanism is the initial separation of the bromide ion (by way of a transition state showing partial separation of the ion) to give a free positively charged organic ion ( carbonium ion ). (britannica.com)
  • Fellows are required to enroll in the Mechanisms of Learning Project, a seminar course that emphasizes improvement of writing and other professional development. (google.com)
  • Nonetheless, the initial period following concussion might represent an important therapeutic window during which mechanisms underlying the development of chronic headache could be prevented. (medscape.com)
  • The Cranfield De-Orbit Mechanism (DOM) is a drag sail technological demonstrator currently under development at Cranfield University. (esa.int)
  • These mechanisms-e.g. the Clean Development Mechanism (CDM) -put a price on carbon, helping to internalize the environmental and social costs of carbon pollution, and permit trading, which lowers the economic cost of reducing emissions. (undp.org)
  • We also identified ways in which self-renewal mechanisms change with age, conferring temporal changes in stem cell properties that match the changing growth and regeneration demands of tissues. (hhmi.org)
  • In this issue of the JCI , a group of experts have provided reviews that dive deeply into the mechanisms by which obesity-induced inflammation influences metabolic homeostasis, surveying the modes and mechanisms of inflammation in different tissues and how they might contribute to disease. (jci.org)
  • We are interested in RPE-specific metabolic mechanisms, and especially that of the visual cycle, the process by which dietary vitamin A (all- trans retinol) is converted to the "chromophore" form (11- cis retinal) required for vision. (nih.gov)
  • These features of obesity-induced inflammation present a challenge to understanding the underlying mechanisms and the manner by which they impact metabolic systems. (jci.org)
  • Besides pedigree analysis and twin studies , adoption studies are a third technique often used to study human inheritance mechanisms. (brighthub.com)
  • It is known that expression of the prostaglandin synthesizing enzyme cyclooxygenase 2 (COX-2) is crucial for the mechanisms underlying inflammation-induced anorexia, and that prostaglandin E2 (PGE2) is involved in anorexia induced by interleukin-1 beta (IL-1β). (diva-portal.org)
  • Dyn also provides update mechanisms for making hostnames work with your dynamic IP address, delivery of your DNS records to five DNS servers in five Tier 1 bandwidth datacenters around the world, fast propagation/reliable static IP caching for DNS TTL values and more. (ucl.ac.uk)
  • Laws have traditionally been regarded as the primary vehicle of explanation, but in the emerging philosophy of science it is mechanisms that do the explanatory work. (cambridge.org)
  • This article reviews the history, applications, methods, mechanisms, and interpretation of overexpression phenotypes, focusing on its application in genetic screens but also providing examples of the utility of targeted overexpression. (genetics.org)