• When the Rho protein reaches the RNA polymerase complex, transcription is terminated by dissociation of the RNA polymerase from the DNA. (wikipedia.org)
  • The process of termination by Rho factor is regulated by attenuation and antitermination mechanisms, competing with elongation factors for overlapping utilization sites (ruts and nuts), and depends on how fast Rho can move during the transcription to catch up with the RNA polymerase and activate the termination process. (wikipedia.org)
  • The process of transcriptional termination is less understood in eukaryotes, which have extensive post-transcriptional RNA processing, and each of the three types of eukaryotic RNA polymerase have a different termination system. (wikipedia.org)
  • In RNA polymerase I, Transcription termination factor, RNA polymerase I binds downstream of the pre-rRNA coding regions, causing the dissociation of the RNA polymerase from the template and the release of the new RNA strand. (wikipedia.org)
  • In RNA polymerase II, the termination occurs via a polyadenylation/cleaving complex. (wikipedia.org)
  • Unlike in bacteria and in polymerase I, the termination RNA hairpin needs to be upstream to allow for correct cleaving. (wikipedia.org)
  • Transcription is controlled by factors that remove or modify nucleosomes, allowing RNA polymerase II to contact otherwise occluded DNA. (pitt.edu)
  • To test the hypothesis that stable nucleosomes within termination regions are required to act as physical roadblocks to the polymerase, I integrated a "superbinder" DNA sequence to position a stable nucleosome at a candidate locus. (pitt.edu)
  • She revealed important aspects of the structure of the transcription elongation complex of RNA polymerase and elucidated the mechanisms of transcription pausing and termination. (nih.gov)
  • In eukaryotes the initiation of transcription of protein encoding genes by polymerase II (Pol II) is modulated by general and specific transcription factors. (embl.de)
  • A specific nucleotide sequence to which RNA polymerase attaches to initiate transcription of mRNA from a gene. (brainkart.com)
  • This bi-genomic division is accompanied by profoundly different transcription regulatory system: whereas nDNA-encoded genes are transcribed individually by RNA polymerase 2 and the general nuclear transcription machinery, mtDNA transcription is long known to be regulated mainly by a dedicated RNA polymerase (POLRMT) and mtDNA-specific transcription factors (TFAM and TFB2) ( Shutt and Shadel 2010 ). (biorxiv.org)
  • However, how the C-terminal domain (CTD) of RNA polymerase II recruits, activates, and displaces appropriate processing factors in coordination with the transcription cycle, remains obscure. (muni.cz)
  • In molecular biology, a termination factor is a protein that mediates the termination of RNA transcription by recognizing a transcription terminator and causing the release of the newly made mRNA. (wikipedia.org)
  • Transcription, translation and mRNA degradation all happen simultaneously. (wikipedia.org)
  • Mechanism of mRNA maturation: capping, polyA tail, splicing. (unict.it)
  • If scanning ribosomes encountering uORFs prematurely initiate translation in the 5′UTR, upon reaching the uORF termination codon the ribosome may dissociate from the mRNA transcript, or the 40 s subunit may resume scanning after the 60 s subunit is lost. (nature.com)
  • Using FACS-based isolation of this lineage combined with RNA-seq, we generated a genome-wide transcriptional profile that we further validated through the more systematic analysis of mRNA and protein dynamics of a selected set of transcription factors. (knaw.nl)
  • In addition, each gene may produce more than one variant of mRNA because of alternative splicing, RNA editing, or alternative transcription initiation and termination sites. (labcorp.com)
  • This is part of the process that regulates the transcription of RNA to preserve gene expression integrity and are present in both eukaryotes and prokaryotes, although the process in bacteria is more widely understood. (wikipedia.org)
  • In eukaryotes, DNA is packaged as chromatin, which acts as a barrier between the transcription machinery and genomic material. (pitt.edu)
  • Our approach paves the path towards in vivo, quantitative, reference sequence-free analysis of mtDNA transcription in all eukaryotes. (biorxiv.org)
  • I conducted a genetic screen in Saccharomyces cerevisiae for histone mutations that cause termination defects. (pitt.edu)
  • Chromosome mutations: classification and onset mechanisms. (unict.it)
  • Genetic mutations: somatic and germinals. (uab.cat)
  • Workup in alpha thalassemia relies primarily on laboratory evaluation, hemoglobin electrophoresis, and genetic testing (alpha thalassemia mutations panel). (medscape.com)
  • Mutations and gene amplifications that confer drug resistance emerge frequently during chemotherapy, but their mechanism and timing are poorly understood. (babraham.ac.uk)
  • The few mutations reported so far resemble those commonly found in AS, being located in the three largest exons (exons 8, 10 and 16) and predicted to cause premature termination of translation. (springer.com)
  • They will also aid in the development of small molecules altering translational accuracy for the treatment of genetic diseases linked to nonsense mutations. (ox.ac.uk)
  • More than 20 different genetic mutations resulting in the functional deletion of both pairs of alpha-globin genes (--/--) have been identified. (medscape.com)
  • There are more than 15 different genetic mutations that result in decreased production of alpha globin, usually through functional deletion of 1 or more of the 4 alpha-globin genes. (medscape.com)
  • Human genetic studies have identified mutations in the sodium channel SCN5A gene causing tachyarrhythmia disorders, as well as progressive cardiac conduction system diseases, or overlapping syndromes. (medscape.com)
  • There are a myriad of mutations identified in genes encoding cardiac transcription factors, ion channels, gap junctions, energy metabolism regulators, lamins and other structural proteins. (medscape.com)
  • In contrast to most previously characterized accuracy modulators, including antibiotics and the prion state of the S. cerevisiae translation termination factor eRF3, Rps23p hydroxylation can either increase or decrease translational accuracy in a stop codon context-dependent manner. (ox.ac.uk)
  • Puel et al found that the 110_111insC NEMO mutation is the most upstream premature translation termination codon, but it results in a pure immunodeficiency syndrome because a Kozakian methionine codon reinitiates translation. (medscape.com)
  • The most extensively studied and detailed transcriptional termination factor is the Rho (ρ) protein of E. coli. (wikipedia.org)
  • Furthermore, this inhibition is alleviated by placing transcriptional termination signals between the two alpha genes. (ox.ac.uk)
  • Because many eukaryotic genes may be arranged in tandem on a chromosome, these observations suggest that transcriptional termination is an important mechanism for preventing interference between adjacent genes. (ox.ac.uk)
  • Eukaryotic transcription three types of RNA polymerases. (unizg.hr)
  • It works as a sensor of translational status, inhibiting non-productive transcriptions, suppressing antisense transcriptions and resolving conflicts that happen between transcription and replication. (wikipedia.org)
  • Surprisingly, accurate detection of human mtDNA transcription initiation sites (TIS) in the heavy and light strands revealed a novel conserved transcription pausing site near the light strand TIS, upstream to the transcription-replication transition region. (biorxiv.org)
  • Activated ATR kinase-mediated phosphorylation of DDUP induced a drastic 'dense-to-loose' conformational change, which sustained the RAD18/RAD51C and RAD18/PCNA complex at damaged sites and initiated RAD51C-mediated homologous recombination and PCNA-mediated post-replication repair mechanisms. (biomed.news)
  • Introduction into replication, transcription and translation. (unizg.hr)
  • These findings suggest a scenario where collisions between DNA replication and transcription are frequent, leading to increased genetic variability, as seen by the increase SNP levels at chromosome subtelomeres and in DGF-1 genes containing putative origins. (biomedcentral.com)
  • Genome replication is responsible for accurate transmission of genetic information through cell division cycles. (biomedcentral.com)
  • As originally proposed in 1963, cells rely on two genetic elements to duplicate their genome: the replicator, a DNA region where replication begins (now named the replication origin), and the initiator, a protein or a protein complex that recognizes the replicator [ 1 ]. (biomedcentral.com)
  • After origin firing, bidirectional replication forks travel until they reach termination sites. (biomedcentral.com)
  • Collision between replication and transcription is considered especially problematic, as each are catalyzed by large multiprotein machines, and can occur co-directionally, when the replication fork and transcription machinery are moving in the same direction, or on the leading strand and is head-on, when the fork and transcription are moving towards each other. (biomedcentral.com)
  • These structures have been implicated in several biological mechanisms, including gene regulation and DNA replication [1]. (ucdavis.edu)
  • Transcriptional interference and termination between duplicated alpha-globin gene constructs suggests a novel mechanism for gene regulation. (ox.ac.uk)
  • Dr. Komissarova's research focused on fundamental processes of transcription regulation in bacteriophage, bacteria, yeast, and mammals. (nih.gov)
  • A detailed explanation of the hierarchy and temporal progression of these lineages is provided as well as an overview of the genetic mechanisms underlying their biology, mainly focused on the regulation of their migration. (knaw.nl)
  • Research on vitamin D regulation of thymocyte selection, Th1 and Th17 cells, T-cell programed cell death, and T-regulatory (Treg) cells is summarized and integrated into model mechanisms. (frontiersin.org)
  • Membrane structure and function: Structure of model membrane, lipid bilayer and membrane protein diffusion, osmosis, ion channels, active transport, ion pumps, mechanism of sorting and regulation of intracellular transport, electrical properties of membranes. (pathfinderacademy.in)
  • Control of gene expression at transcription and translation level: Regulation of phages, viruses, prokaryotic and eukaryotic gene expression, role of chromatin in regulating gene expression and gene silencing. (pathfinderacademy.in)
  • Physiology of Excretion: Kidney structure, urine formation, counter current mechanism, regulation of electrolyte and water balance of the body. (aadharinstitute.com)
  • Understanding the molecular mechanisms that trigger the production of antibiotic compounds, especially through the regulation of gene expression, could help scientists advance the search for new natural antimicrobial agents. (medicilon.com)
  • The upshot is that our discovery expands the basic knowledge of processive antitermination-a type of genetic regulation-and demonstrates that the mechanism is more widespread among bacteria than previously thought," explained co-senior study investigator Paul Straight, Ph.D., associate professor in the department of biochemistry and biophysics at Texas A&M AgriLife Research. (medicilon.com)
  • To express these giant gene clusters requires special regulation mechanisms. (medicilon.com)
  • Transcription in prokayiotes: start and termination of rho-dependent and-independent transcription. (unict.it)
  • The selective use of termination signals may provide a novel way of regulating the activity of eukaryotic genes. (ox.ac.uk)
  • Our results suggest translation disrupting mechanisms relating uORF variation to reduced protein expression, and demonstrate that translation at uORFs is genetically constrained in 50% of human genes. (nature.com)
  • The diagrammatic representation of distances between the adjacent genes which is directly proportional to the frequency of recombination between them is called genetic mapping. (brainkart.com)
  • While a few important genes for tomato inflorescence-branching development have been identified, the regulatory mechanism underlying inflorescence branching is still unclear. (nature.com)
  • However, as mtDNA transcription was mostly studied in vitro, little remains known about the mode and tempo of in vivo OXPHOS genes' transcription residing on the mtDNA. (biorxiv.org)
  • Control of gene expression at transcription and translation level (regulating the expression of phages, viruses, prokaryotic and eukaryotic genes, role of chromatin in gene expression and gene silencing). (aadharinstitute.com)
  • The Chedin lab at UC Davis proposes the theory that R loops prevent the methylation of transcription start sites, thereby promoting the transcription of certain genes [4]. (ucdavis.edu)
  • Variants unclassified, falling into the categories of missense, silent, and splice site variants where there is no functional evidence, as well as loss-of-function changes in new genes where there is no proven disease mechanism. (labcorp.com)
  • Next, the importance of embryonic developmental genes such as homeobox and T-box transcription factors are highlighted in conduction system development and function. (medscape.com)
  • Inhibition of Rho dependent termination by bicyclomycin is used to treat bacterial infections. (wikipedia.org)
  • I demonstrate that transcriptional interference causes substantial inhibition of the downstream alpha gene by transcription of the upstream alpha gene. (ox.ac.uk)
  • We identified CD24 as an actionable adaptive mechanisms in cancer cells induced upon KRAS G12C inhibition and blocking CD24 sensitizes PDAC to KRAS inhibitors in preclinical models. (bvsalud.org)
  • Using Q lineage RNA-seq and functional genetic studies we discover that this pathway activates a specific transcriptional program, and that two of its direct targets, the Slt - Robo pathway component EVA-1/EVA1C and the Rho GTPase activating protein RGA-9b/ARHGAP, are necessary and sufficient for migration inhibition. (knaw.nl)
  • ERKi treatment of cells drives the poly-ubiquitylation and proteasome-dependent turnover of ERK2 and pharmacological or genetic inhibition of Cullin-RING E3 ligases prevents this. (babraham.ac.uk)
  • Here we use translated uORFs mapped through ribosome-profiling experiments and a deep catalog of human genetic variation to characterize patterns of selection acting on single nucleotide variants (SNVs) in uORF sequences. (nature.com)
  • For example, some favorite modifications can lead to the protein being degraded which provides a mechanism to get rid of proteins which cause disease. (upenn.edu)
  • Herein, we found that DNA damage provoked the association of ribosomes with IRES region in lncRNA CTBP1-DT, which overcame the negative effect of upstream open reading frames (uORFs), and elicited the novel microprotein DNA damage-upregulated protein (DDUP) translation via a cap-independent translation mechanism. (biomed.news)
  • Membrane structure and function: Structure of model membrane, Lipid bilayer and membrane protein, diffusion, osmosis, ion channels, Active transport membrane pumps, mechanism of solving and regulations of intracellular transport, Electrical properties of membrane. (aadharinstitute.com)
  • We established Bacillus amyloliquefaciens LoaP as a paradigm for this protein subgroup and showed that it regulated the transcriptional readthrough of termination sites located within two different antibiotic biosynthesis operons. (medicilon.com)
  • Some studies have suggested a role for this protein in maintaining centriole-nucleated sensory organelles termed primary cilia, and AS is now considered to belong to the growing class of human genetic disorders linked to ciliary dysfunction (ciliopathies). (springer.com)
  • Activation of the transcription factor nuclear factor KB (NF-KB) requires the NEMO protein. (medscape.com)
  • Using genetic variation from 71,702 human genomes, we assess patterns of selection in translated upstream open reading frames (uORFs) in 5'UTRs. (nature.com)
  • Cytosine C5 methylation is an important epigenetic control mechanism in a wide array of eukaryotic organisms and generally carried out by proteins of the C-5 DNA methyltransferase family (DNMTs). (mdpi.com)
  • The classic view of information processing in the cell by gene expression occurs through transcription followed by translation. (nature.com)
  • We assess evidence for the functional importance of translation at uORFs, and explore possible phenotypic consequences associated with genetic variation in these sequences. (nature.com)
  • Using the allele frequency spectrum of SNVs from 71,702 whole genome sequences in gnomAD, we find that SNVs introducing new stop codons, or creating stronger translation termination signals in uORFs are under strong selective constraints within 5′UTRs. (nature.com)
  • Transcription takes place in nucleus and translation in cytoplasm. (brainkart.com)
  • We leveraged ad hoc somatic mosaic genome engineering, lineage tracing and ablation technologies and dynamic genetic reporters to trace and ablate tumor-specific lineages along the phenotypic spectrum of epithelial to mesenchymal plasticity. (bvsalud.org)
  • Although most operons in DNA are Rho independent, Rho dependent termination is also essential to maintain correct transcription. (wikipedia.org)
  • Scientists have known a great deal about how proteins that control certain gene clusters get their start-referred to as transcription initiation. (medicilon.com)
  • However, much less is known about transcription elongation where proteins keep gene expression going through "roadblocks" in the DNA sequence. (medicilon.com)
  • In this study, we analysed the phylogenetic distribution of the large, widespread NusG family of transcription elongation proteins and found that it includes a cohesive outgroup of paralogues (herein coined LoaP), which are often positioned adjacent or within gene clusters for specialized metabolites," the authors wrote. (medicilon.com)
  • A deep understanding of molecular mechanisms relevant to gene-environment interactions is needed to deliver etiology-based autoimmune disease prevention and treatment strategies. (frontiersin.org)
  • The effects of ginseng oligosaccharides (GSOs) on neuronal oxidative injury induced by glutamate (GLU) and the molecular mechanisms involved were investigated. (sdbonline.org)
  • Rho factor is widely present in different bacterial sequences and is responsible for the genetic polarity in E. coli. (wikipedia.org)
  • This pausing site correlated with the presence of a bacterial pausing sequence motif, yet the transcription pausing index varied quantitatively among the cell lines. (biorxiv.org)
  • Bacterial transcription, postranscriptional modifications. (unizg.hr)
  • The first genome sequenced is Arabidopsis thaliana , which is a potential genetic tool to study the development and metabolism in plants. (brainkart.com)
  • Structures that threaten the overall stability and structure of an organism's genome, therefore, are of high importance in the scientific community, as they may provide insight into several biological mechanisms. (ucdavis.edu)
  • A transcriptome represents that small percentage of the genetic code that is transcribed into RNA molecules estimated to be less than 5% of the genome in humans. (labcorp.com)
  • This combined approach will provide us with the entirely new structural information that will go significantly beyond the-state-of-the-art in the research fields of transcription and RNA processing. (muni.cz)
  • ont permis la publication de plus de 370 articles et monographies, dont une 44 en 2020. (u-paris.fr)
  • Trypanosoma cruzi , the etiological agent of Chagas disease, presents high variability in both chromosomes size and copy number among strains, though the underlying mechanisms are unknown. (biomedcentral.com)
  • Understanding these mechanisms could help a great deal in the search for new antibiotics produced by bacteria. (medicilon.com)
  • The researchers noted that while the Earth has an abundant and diverse supply of microbes such as bacteria, many of them with useful biomedical purposes, a modern limitation to antibiotic discovery is the murky understanding of the genetic regulatory mechanisms that oversee their production. (medicilon.com)
  • Termination in E. coli may be Rho dependent, utilizing Rho factor, or Rho independent, also known as intrinsic termination. (wikipedia.org)
  • This entry represents a zinc finger motif found in transcription factor IIs (TFIIS). (embl.de)
  • Starting from a Q lineage-specific transcriptional profiling, we unveil a novel list of targets regulated by this transcription factor, and demonstrate that vab-8, eva-1, and ebax-1 are involved in this migratory process. (knaw.nl)
  • Role of heat shock transcription factor 2 in the NMDA-dependent neuroplasticity induced by chronic ethanol intake in mouse hippocampus. (u-paris.fr)
  • their catalytic domain is closely related to transcription factor prolyl trans-4-hydroxylases that act as oxygen sensors in the hypoxic response in animals. (ox.ac.uk)
  • As the material increased in purity, there are more high-aspect-ratio particulates and a corresponding distinct increase in cytotoxicity, nuclear factor-B transcription, and inflammasome activation. (cdc.gov)
  • The use of this mechanism along with other classes of antibiotics is being studied as a way to address antibiotic resistance, by suppressing the protective factors in RNA transcription while working in synergy with other inhibitors of gene expression such as tetracycline or rifampicin. (wikipedia.org)
  • Further investigation is underway to determine whether the function of the DNA entry-exit site in transcription termination depends on interaction with other chromatin-related factors. (pitt.edu)
  • Transcription factors. (unict.it)
  • There are a number reasons for the medical condition including genetic defects, reproductive system abnormalities, endocrine disorders, immune disorders, infection, thrombosis and environmental factors ( 2 ). (spandidos-publications.com)
  • The general transcription factors operate through common promoters elements (such as the TATA box). (embl.de)
  • Multiple sclerosis and T1D have distinct target organs, genetic risk factors, onset ages, and female to male ratios, but target organ-specific T cells as initiators unite these diseases. (frontiersin.org)
  • Type 1 diabetes (T1D) is a heritable polygenic autoimmune disease in which both genetic and environmental factors contribute to pathogenesis. (biomedcentral.com)
  • Oligomerization is a frequently encountered physical characteristic of biological molecules that occurs for a wide number of transcription factors, ion channels, oxygen-carrying macromolecules such as hemocyanin and enzymes. (baumaschinen-knell.de)
  • A large superfamily of transcription factors that contain a region rich in BASIC AMINO ACID residues followed by a LEUCINE ZIPPER domain. (lookformedical.com)
  • These results illustrate the combined impact of genetic, lifestyle, and environmental factors in modulating immunological responsivity and emphasize the importance of the exposome in shaping biological responses. (cdc.gov)
  • Despite a few studies showing that transcription-coupled histone modifications and select chromatin remodelers are important for proper termination, little else is known about the role of chromatin at this step. (pitt.edu)
  • Together, these data implicate the DNA entry-exit site as an important player in maintenance of chromatin organization that supports proper transcription, including termination. (pitt.edu)
  • DNA damage triggers chromatin remodeling by mechanisms that are poorly understood. (cipsm.de)
  • Transcription termination is essential to define boundaries in transcriptional units, a function necessary to maintain the integrity of the strands and provide quality control. (wikipedia.org)
  • Strand-specific RNAseq data show a nearly full transcription of both plastomic strands and detect C-to-U RNA-editing sites at both sense and antisense transcripts. (biomedcentral.com)
  • We took advantage of this to (1) investigate the full transcription capability of both plastomic strands, (2) estimate the relative number of plastid coding and antisense transcripts, and (3) identify plastid C-to-U RNA-editing sites separately at sense and antisense transcripts in conifers. (biomedcentral.com)
  • The discovery of genetic linkage: recombination. (uab.cat)
  • We have long been puzzled by these findings because it is then unclear whether plastomic rearrangements affect plastid gene transcription. (biomedcentral.com)
  • The mechanisms by which nucleosome organization is controlled are well understood in regard to transcription initiation and elongation. (pitt.edu)
  • Dr Gosling says the multi-disciplinary team aims to understand how there could have been historical benefits of genetic variants that now cause disease, which will provide insight into the prevalence of metabolic disease in Pacific populations. (otago.ac.nz)
  • Genetic variants in the orthologous region encompassing SLC11A1 in human chromosome 2q35 have been reported to be associated with various immune-related diseases including T1D. (biomedcentral.com)
  • This has led to the development of a range of ERK1/2 inhibitors (ERKi) that either inhibit kinase catalytic activity (catERKi) or additionally prevent the activating pT-E-pY dual phosphorylation of ERK1/2 by MEK1/2 (dual-mechanism or dmERKi). (babraham.ac.uk)
  • Our study reveals common and distinct oncogenic KRAS allele-specific biology and identifies a clinically actionable adaptive mechanism that may improve the efficacy of oncogenic KRAS inhibitor therapy in PDAC. (bvsalud.org)
  • Identifying and targeting resistance mechanisms to G12Ci treatment is therefore crucial. (bvsalud.org)
  • Significance: Lack of faithful preclinical models limits the exploration of resistance mechanisms to KRAS G12C inhibitor in PDAC. (bvsalud.org)
  • Lenacapavir's unique mechanism of action and resistance profile offer promise for patients who have run out of ARV treatment options. (uspharmacist.com)
  • Innate or acquired resistance to small molecule BRAF or MEK1/2 inhibitors (BRAFi or MEKi) typically arises through mechanisms that sustain or reinstate ERK1/2 activation. (babraham.ac.uk)
  • These resistance mechanisms frequently involve reinstatement of ERK1/2 signalling and BRAFi are now deployed in combination with one of three approved MEK1/2 inhibitors (MEKi) to provide more durable, but still transient, clinical responses. (babraham.ac.uk)
  • 5) To know the sources of genetic variability, how measuring and interpret it from a perspective of genetic improvement, conservation and evolution. (uab.cat)
  • Analysis of non-human organisms enabled de novo mtDNA sequence assembly, as well as detection of previously unknown mtDNA TIS, pausing, and transcription termination sites with unprecedented accuracy. (biorxiv.org)
  • These obstacles interfered with comparative in-vivo investigation of mtDNA transcription in diverse conditions, and hampered expanding the study of mtDNA nascent transcripts to organisms lacking an mtDNA reference sequence. (biorxiv.org)
  • Finally, mtDNA transcription termination sites have been either mapped in-vitro, or were associated with MTERF binding sites ( Christianson and Clayton 1986 ), thus, again, limiting the capability to in-vivo map transcription terminations sites in diverse organisms. (biorxiv.org)
  • Gene-environment interactions, sunlight and vitamin D, and T lymphocytes as autoimmune disease initiators and vitamin D targets are discussed to explain the rationale for reviewing vitamin D mechanisms in T cells. (frontiersin.org)
  • Finally, unanswered questions relating to vitamin D mechanisms in CD4 + T cells are highlighted to promote further research that may lead to a deeper understanding of autoimmune disease molecular etiology. (frontiersin.org)
  • We drew mainly on MS and T1D research because intensive investigation has generated detailed insights into vitamin D mechanisms in these diseases and provided valuable guidance for research on other autoimmune diseases. (frontiersin.org)
  • A recent chapter ( 6 ) and a review ( 7 ) have summarized vitamin D mechanisms in autoimmune diseases more generally. (frontiersin.org)
  • University of Otago researchers are the recipients of an inaugural Marsden Fund Council Award worth $3 million to investigate genetic predisposition to metabolic diseases like diabetes and gout among Pacific people. (otago.ac.nz)
  • The aim of their project is to investigate genetic markers associated with metabolic diseases like diabetes and gout in Pacific people and how these diseases might have evolved. (otago.ac.nz)
  • This study aims to understand the function and mechanism of Drosophila Glycine N-acyltransferase (GLYAT) in cell invasion. (sdbonline.org)
  • Whereas mammals (chimpanzee, rhesus macaque, rat, and mouse) showed a human-like mtDNA transcription pattern, the invertebrate pattern (Drosophila and C. elegans) profoundly diverged. (biorxiv.org)
  • If they do, what are the underlying mechanisms and consequences of such changes? (biomedcentral.com)
  • In contrast, less is known about the impact of genetic variation within translated uORFs. (nature.com)